{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:35:10Z","timestamp":1780576510937,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32560107"],"award-info":[{"award-number":["32560107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Department of Education of Guizhou Province","doi-asserted-by":"publisher","award":["[2023] 069"],"award-info":[{"award-number":["[2023] 069"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003459","name":"Guizhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"National Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["zyyzdxk-2023185"],"award-info":[{"award-number":["zyyzdxk-2023185"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bioorg.2026.109614","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:24:43Z","timestamp":1770481483000},"page":"109614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Bioactive treatments against chronic myeloid leukemia from Hypericum lancasteri targeting p53 pathway"],"prefix":"10.1016","volume":"173","author":[{"given":"Xi-Ying","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan-Pan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109614_bb0005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s12185-022-03510-w","article-title":"Genetic landscape of chronic myeloid leukemia","volume":"117","author":"Ochi","year":"2023","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.bioorg.2026.109614_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2020.106337","article-title":"Novel therapeutic approaches in chronic myeloid leukemia","volume":"91","author":"\u00d6zg\u00fcr Yurtta\u015f","year":"2020","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bioorg.2026.109614_bb0015","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1001\/jama.2025.0220","article-title":"Chronic myeloid leukemia: a review","volume":"333","author":"Jabbour","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.bioorg.2026.109614_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscia.2024.100052","article-title":"Novel targeted therapies in chronic myeloid leukemia","volume":"2","author":"Ashaq","year":"2024","journal-title":"Pharm. Sci. Adv."},{"key":"10.1016\/j.bioorg.2026.109614_bb0025","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-023-01347-1","article-title":"Targeting p53 pathways: mechanisms, structures, and advances in therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioorg.2026.109614_bb0030","first-page":"1","article-title":"Structural biology of the tumor suppressor p53 and cancer-associated mutants","volume":"97","author":"Joerger","year":"2007","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.bioorg.2026.109614_bb0035","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1146\/annurev.biochem.77.060806.091238","article-title":"Structural biology of the tumor suppressor p53","volume":"77","author":"Joerger","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bioorg.2026.109614_bb0040","article-title":"Unraveling the guardian: p53's multifaceted role in the DNA damage response and tumor treatment strategies","volume":"25","author":"Zhang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109614_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116121","article-title":"An overview of the functions of p53 and drugs acting either on wild- or mutant-type p53","volume":"265","author":"Huang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109614_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10428194.2016.1272682","article-title":"Induction of p53 suppresses chronic myeloid leukemia","volume":"58","author":"Peterson","year":"2017","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bioorg.2026.109614_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2025.114484","article-title":"Meroterpenoids with bicyclic polyprenylated acylphloroglucinol scaffold and anti-inflammatory activity from Hypericum lancasteri","volume":"235","author":"You","year":"2025","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2026.109614_bb0060","first-page":"457","article-title":"Quantitative phytochemical analysis of 11 Hypericum species growing in China","volume":"24","author":"Zheng","year":"2003","journal-title":"Acad. J. Sec. Mil. Med. Univ."},{"key":"10.1016\/j.bioorg.2026.109614_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113526","article-title":"Hyperforin: a natural lead compound with multiple pharmacological activities","volume":"206","author":"Li","year":"2023","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2026.109614_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.tetlet.2023.154721","article-title":"Novel benzophenone with antiradical activities from the aerial parts of Hypericum lancasteri","volume":"129","author":"Zhang","year":"2023","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2026.109614_bb0075","first-page":"167","article-title":"Study on the chemical constituents from Hypericum lancasteri and their antioxidant activities","volume":"11","author":"Zhang","year":"2023","journal-title":"Hans J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109614_bb0080","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1016\/S0031-9422(00)98010-5","article-title":"Seven xanthonolignoids from Psorospermum febrifugum","volume":"28","author":"Abou-Shoer","year":"1989","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2026.109614_bb0085","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1021\/acs.jnatprod.1c00150","article-title":"Benzophenones from Betula alnoides with Antiausterity activities against the PANC-1 human pancreatic Cancer cell line","volume":"84","author":"Omar","year":"2021","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.109614_bb0090","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1007\/s11426-016-0052-4","article-title":"Polyprenylated acylphloroglucinols from the fruits of Hypericum henryi","volume":"59","author":"Liao","year":"2016","journal-title":"Sci. China Chem."},{"key":"10.1016\/j.bioorg.2026.109614_bb0095","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/05704926908050171","article-title":"Analysis of ABX spectra in NMR spectroscopy","volume":"2","author":"Slomp","year":"1969","journal-title":"Appl. Spectrosc. Rev."},{"key":"10.1016\/j.bioorg.2026.109614_bb0100","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1042\/BST20140070","article-title":"PI3K\/Akt-mediated regulation of p53 in cancer","volume":"42","author":"Abraham","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bioorg.2026.109614_bb0105","article-title":"Intracellular behavior of Nocardia seriolae and its apoptotic effect on RAW264.7 macrophages","volume":"13","author":"Liu","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109614_bb0110","first-page":"16","article-title":"Establishment of K562\/NOD-SCID mouse model with leukemia. J. Exp. Hematol. =","volume":"15","author":"Song","year":"2007","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"10.1016\/j.bioorg.2026.109614_bb0115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-61779-860-3_5","article-title":"Detection of apoptosis by TUNEL assay","volume":"887","author":"Kyrylkova","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bioorg.2026.109614_bb0120","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/ijms22010412","article-title":"TUNEL assay: a powerful tool for kidney injury evaluation","volume":"22","author":"Moore","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109614_bb0125","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12967-025-06136-8","article-title":"Mitochondrial apoptosis in response to cardiac ischemia-reperfusion injury","volume":"23","author":"Wang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bioorg.2026.109614_bb0130","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1101\/gad.11.15.1974","article-title":"Repression of p53-mediated transcription by MDM2: a dual mechanism","volume":"11","author":"Thut","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.bioorg.2026.109614_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-022-01314-3","article-title":"Targeting p53-MDM2 interaction by small-molecule inhibitors: learning from MDM2 inhibitors in clinical trials","volume":"15","author":"Zhu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bioorg.2026.109614_bb0140","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1126\/science.274.5289.948","article-title":"Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain","volume":"274","author":"Kussie","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bioorg.2026.109614_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2024.103636","article-title":"A first-in-human phase I study of a novel MDM2\/p53 inhibitor alrizomadlin in advanced solid tumors","volume":"9","author":"Zhang","year":"2024","journal-title":"ESMO Open"},{"key":"10.1016\/j.bioorg.2026.109614_bb0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0065-230X(01)82002-9","article-title":"p53-dependent apoptosis pathways","volume":"82","author":"Shen","year":"2001","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.bioorg.2026.109614_bb0155","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1182\/blood.V122.21.1465.1465","article-title":"p53 and c-Myc are critical signaling hubs that maintain chronic myeloid leukemia","volume":"122","author":"Abraham","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bioorg.2026.109614_bb0160","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22655-6","article-title":"Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis","volume":"12","author":"Wei","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2026.109614_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103788","article-title":"Polyphyllosides A-F, six new spirostanol saponins from the stems and leaves of Paris polyphylla var. chinensis","volume":"99","author":"Qin","year":"2020","journal-title":"Bioorg. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826001501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826001501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:05:15Z","timestamp":1777464315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826001501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":33,"alternative-id":["S0045206826001501"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109614","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioactive treatments against chronic myeloid leukemia from Hypericum lancasteri targeting p53 pathway","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109614"}}