{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:38:46Z","timestamp":1791927526592,"version":"4.3.4"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011437","name":"State Key Laboratory of Marine Environmental Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42376089"],"award-info":[{"award-number":["42376089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bioorg.2026.109651","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:02:14Z","timestamp":1771488134000},"page":"109651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A novel antimicrobial peptide Anguinin55\u201372 identified from Anguilla japonica exhibiting protection against Edwardsiella tarda infection"],"prefix":"10.1016","volume":"173","author":[{"given":"Wenbin","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109651_bb0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1297-9716-43-67","article-title":"Pathogenesis of and strategies for preventing Edwardsiella tarda infection in fish","volume":"43","author":"Park","year":"2012","journal-title":"Vet. Res."},{"key":"10.1016\/j.bioorg.2026.109651_bb0010","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2331\/suisan.28.162","article-title":"On a new bacterium, Paracolobactrum anguillimortiferum n. sp","volume":"28","author":"Hoshina","year":"1962","journal-title":"Nippon Suisan Gakkaishi"},{"key":"10.1016\/j.bioorg.2026.109651_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.740771","article-title":"Protective effects of OmpA exposure via Bacillus subtilis spore bathing on Japanese eel (Anguilla japonica) against Edwardsiella anguillarum infection","volume":"586","author":"Chen","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.bioorg.2026.109651_bb0020","doi-asserted-by":"crossref","DOI":"10.1007\/s10499-024-01741-8","article-title":"D dietary intervention of propolis and\/or turmeric boosted growth, hematology, biochemical profile, and antioxidant-immune responses and their associated gene expression in Nile tilapia (Oreochromis niloticus) challenged with Edwardsiella tarda","volume":"33","author":"Edrees","year":"2025","journal-title":"Aquac. Int."},{"key":"10.1016\/j.bioorg.2026.109651_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.960554","article-title":"Dietary supplementation of Bacillus sp. PM8313 with \u03b2-glucan modulates the intestinal microbiota of red sea bream (Pagrus major) to increase growth, immunity, and disease resistance","volume":"13","author":"Jang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0030","article-title":"Host-associated Bacillus velezensis T20 improved disease resistance and intestinal health of juvenile turbot (Scophthalmus maximus)","volume":"35","author":"Yu","year":"2024","journal-title":"Aquacult. Rep."},{"key":"10.1016\/j.bioorg.2026.109651_bb0035","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1111\/jfd.13691","article-title":"Pathology and virulence of Edwardsiella tarda, Edwardsiella piscicida, and Edwardsiella anguillarum in channel (Ictalurus punctatus), blue (Ictalurus furcatus), and channel \u00d7 blue hybrid catfish","volume":"45","author":"Armwood","year":"2022","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.bioorg.2026.109651_bb0040","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/raq.12743","article-title":"Bacterial diseases of tilapia, their zoonotic potential and risk of antimicrobial resistance","volume":"15","author":"Haenen","year":"2023","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.bioorg.2026.109651_bb0045","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1007\/s11259-024-10538-2","article-title":"Bacterial diseases in Siniperca chuatsi: status and therapeutic strategies","volume":"48","author":"Zeng","year":"2024","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.bioorg.2026.109651_bb0050","first-page":"603","article-title":"The antibiotic paradox: how the misuse of antibiotics destroys their curative powers","volume":"46","author":"Lee","year":"2003","journal-title":"Int. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.glmedi.2024.100081","article-title":"Antimicrobial resistance: impacts, challenges, and future prospects","volume":"2","author":"Ahmed","year":"2024","journal-title":"J. Med. Surg. Public Health"},{"key":"10.1016\/j.bioorg.2026.109651_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.microb.2024.100083","article-title":"Overview of antimicrobial resistance and mechanisms: the relative status of the past and current","volume":"3","author":"Devi","year":"2024","journal-title":"Microbe"},{"key":"10.1016\/j.bioorg.2026.109651_bb0065","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/d41586-024-03033-w","article-title":"40 million deaths by 2050: toll of drug-resistant infections to rise by 70%","volume":"633","author":"Naddaf","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2026.109651_bb0070","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3390\/microorganisms7060180","article-title":"Antibiotic pollution in the environment: from microbial ecology to public policy","volume":"7","author":"Kraemer","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.bioorg.2026.109651_bb0075","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.peptides.2012.07.001","article-title":"Overview on the recent study of antimicrobial peptides: origins, functions, relative mechanisms and application","volume":"37","author":"Li","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.bioorg.2026.109651_bb0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41573-019-0058-8","article-title":"Antimicrobial host defence peptides: functions and clinical potential","volume":"19","author":"Mookherjee","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2026.109651_bb0085","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3389\/fcell.2016.00111","article-title":"Antimicrobial activity of cationic antimicrobial peptides against gram-positives: current progress made in understanding the mode of action and the response of bacteria","volume":"4","author":"Omardien","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0090","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/biom8010004","article-title":"Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo","volume":"8","author":"Kumar","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioorg.2026.109651_bb0095","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1089\/sur.2018.194","article-title":"Antimicrobial peptides","volume":"19","author":"Fry","year":"2018","journal-title":"Surg. Infect."},{"key":"10.1016\/j.bioorg.2026.109651_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2019.10.008","article-title":"Efficacy of newly generated short antimicrobial cationic lipopeptides against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"55","author":"Greber","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bioorg.2026.109651_bb0105","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.3390\/molecules27092675","article-title":"Antimicrobial mechanisms and clinical application prospects of antimicrobial peptides","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.109651_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111682","article-title":"Advances of peptides for antibacterial applications","volume":"202","author":"Yan","year":"2021","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioorg.2026.109651_bb0115","doi-asserted-by":"crossref","first-page":"7047","DOI":"10.3390\/ijms21197047","article-title":"A new era of antibiotics: the clinical potential of antimicrobial peptides","volume":"21","author":"Browne","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109651_bb0120","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.4194\/1303-2712-v18_9_11","article-title":"Innate immune responses in fish: antigen presenting cells and professional phagocytes","volume":"18","author":"Kordon","year":"2018","journal-title":"Turk. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.bioorg.2026.109651_bb0125","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10930-011-9346-9","article-title":"Isolation and identification of a novel inducible antibacterial peptide from the skin mucus of Japanese eel, Anguilla japonica","volume":"30","author":"Liang","year":"2011","journal-title":"Protein J."},{"key":"10.1016\/j.bioorg.2026.109651_bb0130","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.fsi.2012.08.022","article-title":"Isolation and characterization of a novel antibacterial peptide derived from hemoglobin alpha in the liver of Japanese eel, Anguilla japonica","volume":"35","author":"Zhang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0135","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1021\/acs.jnatprod.3c01115","article-title":"Antimicrobial and anti-inflammatory cyclic tetrapeptides from the co-cultures of two marine-derived fungi","volume":"87","author":"Li","year":"2024","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.109651_bb0140","article-title":"A new C-type lectin homolog SpCTL6 exerting immunoprotective effect and regulatory role in mud crab Scylla paramamosain","volume":"12","author":"Qiu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0145","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.fsi.2018.07.028","article-title":"Characterization of MyD88 in Japanese eel, Anguilla japonica","volume":"81","author":"Huang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0150","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.fsi.2015.12.012","article-title":"Identification and molecular characterization of peroxiredoxin 6 from Japanese eel (Anguilla japonica) revealing its potent antioxidant properties and putative immune relevancy","volume":"51","author":"Priyathilaka","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0155","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bioorg.2026.109651_bb0160","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3389\/fmicb.2016.01140","article-title":"The new antimicrobial peptide SpHyastatin from the mud crab Scylla paramamosain with multiple antimicrobial mechanisms and high effect on bacterial infection","volume":"7","author":"Shan","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116344","article-title":"A 14-amino acid cationic peptide Bolespleenin334-347 from the marine fish mudskipper Boleophthalmus pectinirostris exhibiting potent antimicrobial activity and therapeutic potential","volume":"226","author":"Bai","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0170","article-title":"A truncated peptide Spgillcin177-189 derived from mud crab Scylla paramamosain exerting multiple antibacterial activities","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0175","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/ijms23010015","article-title":"A novel antimicrobial peptide Sparanegtin identified in Scylla paramamosain showing antimicrobial activity and immunoprotective role in vitro and vivo","volume":"23","author":"Zhu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109651_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115917","article-title":"A novel antimicrobial peptide Scyreptin1-30 from Scylla paramamosain exhibiting potential therapy of Pseudomonas aeruginosa early infection in a mouse burn wound model","volume":"218","author":"Zhang","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0185","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/jac\/dkp486","article-title":"Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death","volume":"65","author":"Wang","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bioorg.2026.109651_bb0190","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3389\/fmicb.2020.01589","article-title":"A novel antimicrobial peptide Scyreprocin from mud crab Scylla paramamosain showing potent antifungal and anti-biofilm activity","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.746006","article-title":"A novel antimicrobial peptide Sparamosin26-54 from the mud crab Scylla paramamosain showing potent antifungal activity against Cryptococcus neoformans","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0200","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.bbamem.2015.11.004","article-title":"Gram-positive bacterial cell envelopes: the impact on the activity of antimicrobial peptides","volume":"1858","author":"Malanovic","year":"2016","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bioorg.2026.109651_bb0205","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biochi.2018.10.016","article-title":"Mo-CBP3-PepI, Mo-CBP3-PepII, and Mo-CBP3-PepIII are synthetic antimicrobial peptides active against human pathogens by stimulating ROS generation and increasing plasma membrane permeability","volume":"157","author":"Oliveira","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.bioorg.2026.109651_bb0210","doi-asserted-by":"crossref","first-page":"D894","DOI":"10.1093\/nar\/gkx1157","article-title":"aBiofilm: a resource of anti-biofilm agents and their potential implications in targeting antibiotic drug resistance","volume":"46","author":"Rajput","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2026.109651_bb0215","series-title":"Bacterial Fish Diseases","first-page":"307","article-title":"Chapter 15 - bacterial diseases in cultured fishes: An update of advances in control measures","author":"Singh","year":"2022"},{"key":"10.1016\/j.bioorg.2026.109651_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741599","article-title":"Current research on bacterial diseases in eel: An immunological perspective","volume":"595","author":"Qi","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.bioorg.2026.109651_bb0225","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.aquaculture.2013.12.001","article-title":"Edwardsiella tarda: an intriguing problem in aquaculture","volume":"431","author":"Xu","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.bioorg.2026.109651_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738199","article-title":"Isolation and characterization of a highly virulent Edwardsiella piscicida strain responsible for mass mortality in marbled eel (Anguilla marmorata) cultured in Korea","volume":"555","author":"Jung","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.bioorg.2026.109651_bb0235","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/raq.12786","article-title":"Review of alternatives to antibiotic use in aquaculture","volume":"15","author":"Bondad-Reantaso","year":"2023","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.bioorg.2026.109651_bb0240","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.3390\/pharmaceutics15092278","article-title":"The contribution of antimicrobial peptides to immune cell function: A review of recent advances","volume":"15","author":"Li","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioorg.2026.109651_bb0245","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.3389\/fimmu.2019.02292","article-title":"A comparison of the innate and adaptive immune systems in cartilaginous fish, ray-finned fish, and lobe-finned fish","volume":"10","author":"Smith","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0250","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.imlet.2012.08.003","article-title":"Immune system and immune responses in fish and their role in comparative immunity study: A model for higher organisms","volume":"148","author":"Rauta","year":"2012","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bioorg.2026.109651_bb0255","article-title":"Effect of charge on the antimicrobial activity of alpha-helical amphibian antimicrobial peptide","volume":"4","author":"Islam","year":"2023","journal-title":"Curr. Res. Microb. Sci."},{"key":"10.1016\/j.bioorg.2026.109651_bb0260","first-page":"1","article-title":"Influence of hydrophobicity on the antimicrobial activity of helical antimicrobial peptides: a study focusing on three mastoparans","author":"Huy","year":"2024","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bioorg.2026.109651_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741137","article-title":"A novel antimicrobial peptide Spasin141-165 identified from Scylla paramamosain exhibiting protection against Aeromonas hydrophila infection","volume":"591","author":"Zhang","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.bioorg.2026.109651_bb0270","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biomaterials.2015.05.014","article-title":"Epinecidin-1 antimicrobial activity: in vitro membrane lysis and in vivo efficacy against helicobacter pylori infection in a mouse model","volume":"61","author":"Narayana","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioorg.2026.109651_bb0275","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1039\/D1TB00728A","article-title":"Reactive oxygen species (ROS): utilizing injectable antioxidative hydrogels and ROS-producing therapies to manage the double-edged sword","volume":"9","author":"He","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioorg.2026.109651_bb0280","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/jam.14632","article-title":"Antibacterial action of lactoferricin B like peptide against Escherichia coli: reactive oxygen species-induced apoptosis-like death","volume":"129","author":"Lee","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0285","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/MMBR.67.4.593-656.2003","article-title":"Molecular basis of bacterial outer membrane permeability revisited","volume":"67","author":"Nikaido","year":"2003","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.bioorg.2026.109651_bb0290","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3390\/ijms22020482","article-title":"Therapeutic potential of antimicrobial peptides in polymicrobial biofilm-associated infections","volume":"22","author":"Batoni","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109651_bb0295","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.710741","article-title":"Characterization of a potent new-generation antimicrobial peptide of Bacillus","volume":"12","author":"Choyam","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0300","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1582863","article-title":"Progress in the classification, optimization, activity, and application of antimicrobial peptides","volume":"16","author":"Su","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0305","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1189\/jlb.0704380","article-title":"Impact of LL-37 on anti-infective immunity","volume":"77","author":"Bowdish","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0310","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.52586\/5029","article-title":"The potentials of short fragments of human anti-microbial peptide LL-37 as a novel therapeutic modality for diseases","volume":"26","author":"Chen","year":"2021","journal-title":"Front. Biosci.-Landmark"},{"key":"10.1016\/j.bioorg.2026.109651_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737383","article-title":"Three naturally occurring host defense peptides protect largemouth bass (Micropterus salmoides) against bacterial infections","volume":"546","author":"Ouyang","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.bioorg.2026.109651_bb0320","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12562-023-01739-w","article-title":"Synbiotic administration in Japanese eels with prebiotic 1-kestose and probiotic Lactiplantibacillus plantarum FM8 improved feed efficiency and significantly reduced the levels of Edwardsiella","volume":"90","author":"Fujii","year":"2024","journal-title":"Fish. Sci."},{"key":"10.1016\/j.bioorg.2026.109651_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111401","article-title":"Mechanism of antimicrobial peptides: antimicrobial, anti-inflammatory and antibiofilm activities","volume":"22","author":"Luo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109651_bb0330","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.it.2014.07.004","article-title":"Host defense peptides: front-line immunomodulators","volume":"35","author":"Mansour","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0335","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fcimb.2019.00128","article-title":"Application of antimicrobial peptides of the innate immune system in combination with conventional antibiotics-a novel way to combat antibiotic resistance?","volume":"9","author":"Zharkova","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0340","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.fsi.2008.05.001","article-title":"Will advances in fish immunology change vaccination strategies?","volume":"25","author":"Secombes","year":"2008","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0345","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1046\/j.1432-1327.2001.01996.x","article-title":"Cloning and expression analysis of rainbow trout Oncorhynchus mykiss tumour necrosis factor-\u03b1","volume":"268","author":"Laing","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bioorg.2026.109651_bb0350","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1128\/IAI.68.6.3587-3593.2000","article-title":"Cooperation between reactive oxygen and nitrogen intermediates in killing of Rhodococcus equi by activated macrophages","volume":"68","author":"Darrah","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bioorg.2026.109651_bb0355","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.fsi.2016.04.023","article-title":"Immunomodulation of lactobacillus pentosus PL11 against Edwardsiella tarda infection in the head kidney cells of the Japanese eel (Anguilla japonica)","volume":"54","author":"Birhanu","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.bioorg.2026.109651_bb0360","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.fshw.2023.03.030","article-title":"Purification and identification of anti-inflammatory peptides from sturgeon (Acipenser schrenckii) cartilage","volume":"12","author":"Yuan","year":"2023","journal-title":"Food Sci. Human Wellness"},{"key":"10.1016\/j.bioorg.2026.109651_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739338","article-title":"High throughput proteomic analysis of Labeo rohita liver infected with Edwardsiella tarda","volume":"569","author":"Pinto","year":"2023","journal-title":"Aquaculture"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826001872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826001872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:01:10Z","timestamp":1777464070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826001872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":73,"alternative-id":["S0045206826001872"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109651","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel antimicrobial peptide Anguinin55\u201372 identified from Anguilla japonica exhibiting protection against Edwardsiella tarda infection","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109651","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109651"}}