{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T09:52:43Z","timestamp":1774864363287,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023T160600"],"award-info":[{"award-number":["2023T160600"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M722875"],"award-info":[{"award-number":["2022M722875"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301619"],"award-info":[{"award-number":["82301619"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571514"],"award-info":[{"award-number":["82571514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bioorg.2026.109677","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:20:28Z","timestamp":1772641228000},"page":"109677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Verbascoside and echinacoside inhibits the fibrillation of human \u03b1-synuclein and disassembles mature fibrils"],"prefix":"10.1016","volume":"174","author":[{"given":"Jieshi","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suying","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaochong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzhuo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianwen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109677_bb0005","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.3390\/cells11111732","article-title":"Alpha-synuclein aggregation pathway in parkinson\u2019s disease: current status and novel therapeutic approaches","volume":"11","author":"Vidovi\u0107","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bioorg.2026.109677_bb0010","article-title":"The potential of natural products to inhibit abnormal aggregation of \u03b1-synuclein in the treatment of parkinson\u2019s disease","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109677_bb0015","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.bbagen.2012.12.027","article-title":"Oxidized quercetin inhibits \u03b1-synuclein fibrillization","volume":"1830","author":"Zhu","year":"2013","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bioorg.2026.109677_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123194","article-title":"EGCG attenuates \u03b1-synuclein protofibril-membrane interactions and disrupts the protofibril","volume":"230","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2026.109677_bb0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1021\/cn3001203","article-title":"Curcumin modulates \u03b1-synuclein aggregation and toxicity","volume":"4","author":"Singh","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bioorg.2026.109677_bb0030","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1021\/acs.jafc.9b00922","article-title":"Dihydromyricetin inhibits \u03b1-synuclein aggregation, disrupts preformed fibrils, and protects neuronal cells in culture against amyloid-induced cytotoxicity","volume":"67","author":"Jia","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.109677_bb0035","doi-asserted-by":"crossref","first-page":"862","DOI":"10.12688\/f1000research.25634.1","article-title":"Recent developments in the treatment of Parkinson\u2019s disease","volume":"9","author":"Stoker","year":"2020","journal-title":"F1000Res."},{"key":"10.1016\/j.bioorg.2026.109677_bb0040","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3389\/fphar.2016.00289","article-title":"Cistanches herba: a neuropharmacology review","volume":"7","author":"Gu","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109677_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155230","article-title":"EChinacoside exerts neuroprotection via suppressing microglial \u03b1-synuclein\/TLR2\/NF-\u03baB\/NLRP3 axis in parkinsonian models","volume":"123","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.109677_bb0050","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.2147\/NDT.S299685","article-title":"Neuroprotective effects and related mechanisms of eChinacoside in MPTP-induced PD mice","volume":"17","author":"Zhang","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.bioorg.2026.109677_bb0055","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.2147\/NDT.S299810","article-title":"Mechanism of autophagy regulation in MPTP-induced PD mice via the mTOR signaling pathway by eChinacoside","volume":"17","author":"Zhang","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.bioorg.2026.109677_bb0060","article-title":"Targeting ferroptosis: acteoside as a neuroprotective agent in salsolinol-induced parkinson\u2019s disease models","volume":"30","author":"Wang","year":"2025","journal-title":"Front. Biosci.-Landmark"},{"key":"10.1016\/j.bioorg.2026.109677_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162696","article-title":"Acteoside binds to caspase-3 and exerts neuroprotection in the rotenone rat model of parkinson\u2019s disease","volume":"11","author":"Yuan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2026.109677_bb0070","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.bbapap.2010.04.001","article-title":"Molecular mechanism of thioflavin-T binding to amyloid fibrils","volume":"1804","author":"Biancalana","year":"2010","journal-title":"Biochim. Biophys. Acta (BBA) - Proteins Proteom."},{"key":"10.1016\/j.bioorg.2026.109677_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106951","article-title":"EChinacoside: a promising active natural products and pharmacological agents","volume":"197","author":"Wang","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioorg.2026.109677_bb0080","first-page":"0","article-title":"Acteoside as a multifunctional natural glycoside: therapeutic potential across various diseases","author":"Mohammed","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bioorg.2026.109677_bb0085","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.freeradbiomed.2024.07.018","article-title":"Acteoside alleviates lipid peroxidation by enhancing Nrf2-mediated mitophagy to inhibit ferroptosis for neuroprotection in parkinson\u2019s disease","volume":"223","author":"Han","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioorg.2026.109677_bb0090","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1007\/s12640-022-00608-1","article-title":"Salsolinol induces parkinson\u2019s disease through activating NLRP3-dependent pyroptosis and the neuroprotective effect of acteoside","volume":"40","author":"Wang","year":"2022","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.bioorg.2026.109677_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139875","article-title":"Identification of novel phenolic inhibitors from traditional chinese medicine against toxic \u03b1-synuclein aggregation via regulating phase separation","volume":"297","author":"Yu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2026.109677_bb0100","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1038\/s41467-018-05971-2","article-title":"Cryo-EM of full-length \u03b1-synuclein reveals fibril polymorphs with a common structural kernel","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2026.109677_bb0105","doi-asserted-by":"crossref","first-page":"6827","DOI":"10.1021\/acs.jmedchem.1c00086","article-title":"Rationally designed protein-based inhibitor of \u03b1-synuclein fibrillization in cells","volume":"64","author":"Priss","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109677_bb0110","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41589-024-01580-x","article-title":"Discovery of potent inhibitors of \u03b1-synuclein aggregation using structure-based iterative learning","volume":"20","author":"Horne","year":"2024","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.109677_bb0115","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1021\/acs.molpharmaceut.2c00548","article-title":"Structure-based discovery of small-molecule inhibitors of the autocatalytic proliferation of \u03b1-synuclein aggregates","volume":"20","author":"Chia","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioorg.2026.109677_bb0120","unstructured":"L.S. Emani, J.K. Rao, J.K. Dasappa, M. Pecchio, J. Lakey-Beitia, H. Rodriguez, J. Cruz-Mora, P. Narayan, N. Anand, G. Mullur, R. Ajumeera, B.S. Gadad, J.R. Kosagisharaf, Studies on curcumin-glucoside in the prevention of alpha-synuclein aggregation, (2025) 0\u201329."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826002130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826002130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:54:02Z","timestamp":1774860842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826002130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":24,"alternative-id":["S0045206826002130"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109677","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Verbascoside and echinacoside inhibits the fibrillation of human \u03b1-synuclein and disassembles mature fibrils","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109677","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109677"}}