{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T20:46:48Z","timestamp":1777754808557,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022YFS0633"],"award-info":[{"award-number":["2022YFS0633"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2024LCYXZX21"],"award-info":[{"award-number":["2024LCYXZX21"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22367024"],"award-info":[{"award-number":["22367024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2024GXNSFBA010222"],"award-info":[{"award-number":["2024GXNSFBA010222"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M770996"],"award-info":[{"award-number":["2025M770996"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bioorg.2026.109691","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T16:48:31Z","timestamp":1772038111000},"page":"109691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dual-functional near-infrared fluorescent probe for H2S detection and precise COX-2-positive cancer imaging"],"prefix":"10.1016","volume":"173","author":[{"given":"Fei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye-Xin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja-Yun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang Hua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Xiu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109691_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.217165","article-title":"Small organic molecule-based next-generation NIR fluorescent probes for cancer theranostics","volume":"548","author":"Nandanwar","year":"2026","journal-title":"Coord. Chem. Rev."},{"issue":"7","key":"10.1016\/j.bioorg.2026.109691_bb0010","article-title":"NIR fluorescence imaging and treatment for cancer immunotherapy","volume":"10","author":"Kang","year":"2022","journal-title":"J. Immuno. Ther. Cancer"},{"issue":"35","key":"10.1016\/j.bioorg.2026.109691_bb0015","doi-asserted-by":"crossref","first-page":"14789","DOI":"10.1021\/jacs.0c07022","article-title":"Advanced fluorescence imaging technology in the Near-Infrared-II window for biomedical applications","volume":"142","author":"Li","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"13","key":"10.1016\/j.bioorg.2026.109691_bb0020","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1007\/s00259-021-05504-y","article-title":"Targeted optical fluorescence imaging: a meta-narrative review and future perspectives","volume":"48","author":"Schouw","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. I."},{"issue":"21","key":"10.1016\/j.bioorg.2026.109691_bb0025","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1039\/D2CS00722C","article-title":"Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy","volume":"51","author":"Li","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2026.109691_bb0030","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1038\/s41467-024-46834-3","article-title":"Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers","volume":"15","author":"Smith-Byrne","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109691_bb0035","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13073-023-01229-9","article-title":"Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome","volume":"15","author":"Sun","year":"2023","journal-title":"Genome Med."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109691_bb0040","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1002\/jcp.27411","article-title":"Cyclooxygenase-2 in cancer: a review","volume":"234","author":"Goradel","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bioorg.2026.109691_bb0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.pharmtox.38.1.97","article-title":"Cyclooxygenases 1 and 2","volume":"38","author":"Vane","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"35","key":"10.1016\/j.bioorg.2026.109691_bb0050","doi-asserted-by":"crossref","first-page":"11991","DOI":"10.1021\/acs.analchem.1c01978","article-title":"Development of rofecoxib-based fluorescent probes and investigations on their solvatochromism, AIE activity, mechanochromism, and COX-2-targeted bioimaging","volume":"93","author":"Xie","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.109691_bb0055","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.biomaterials.2018.09.006","article-title":"COX-2 inhibition mediated anti-angiogenic activatable prodrug potentiates cancer therapy in preclinical models","volume":"185","author":"Kim","year":"2018","journal-title":"Biomaterials"},{"issue":"19","key":"10.1016\/j.bioorg.2026.109691_bb0060","doi-asserted-by":"crossref","first-page":"13436","DOI":"10.1021\/acs.jmedchem.2c01355","article-title":"Hypoxia-activated prodrugs with dual COX-2\/CA inhibitory effects on attenuating cardiac inflammation under hypoxia","volume":"65","author":"Zhou","year":"2022","journal-title":"J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2026.109691_bb0065","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/anie.201914845","article-title":"An activity-based sensing approach for the detection of Cyclooxygenase-2 in live cells","volume":"59","author":"Yadav","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2026.109691_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.126696","article-title":"A near-infrared AIE probe targeting COX-2 for imaging of cancer cells","volume":"344","author":"Liu","year":"2026","journal-title":"Spectrochim. Acta A"},{"issue":"46","key":"10.1016\/j.bioorg.2026.109691_bb0075","doi-asserted-by":"crossref","first-page":"17469","DOI":"10.1021\/ja4085308","article-title":"Fluorescence discrimination of cancer from inflammation by molecular response to COX-2 enzymes","volume":"135","author":"Zhang","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109691_bb0080","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1021\/acsabm.0c01135","article-title":"Fluorescent probe for monitoring hydrogen peroxide in COX-2-positive cancer cells","volume":"4","author":"Lee","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109691_bb0085","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1021\/acsabm.0c01634","article-title":"One-step transformation from Rofecoxib to a COX-2 NIR probe for human Cancer tissue\/organoid targeted bioimaging","volume":"4","author":"Xie","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioorg.2026.109691_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.129217","article-title":"Imaging and inhibiting cyclooxygenase-2 using aspirin-based fluorescent reporter for the treatment of breast cancer","volume":"329","author":"Xia","year":"2021","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.bioorg.2026.109691_bb0095","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.addr.2016.07.012","article-title":"Molecular imaging of the tumor microenvironment","volume":"113","author":"Zhou","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2\u20133","key":"10.1016\/j.bioorg.2026.109691_bb0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/cac2.12010","article-title":"CXCL5\/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target","volume":"40","author":"Zhang","year":"2020","journal-title":"Cancer Commun."},{"issue":"7","key":"10.1016\/j.bioorg.2026.109691_bb0105","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1021\/acs.chemrev.3c00683","article-title":"Activity-based fluorescent probes for hydrogen sulfide and related reactive sulfur species","volume":"124","author":"Fosnacht","year":"2024","journal-title":"Chem. Rev."},{"issue":"17","key":"10.1016\/j.bioorg.2026.109691_bb0110","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1039\/D4AN00819G","article-title":"A novel NIR fluorescent probe for visualizing hydrogen sulfide in Alzheimer's disease","volume":"149","author":"Hong","year":"2024","journal-title":"Analyst"},{"key":"10.1016\/j.bioorg.2026.109691_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101704","article-title":"Potential role of hydrogen sulfide in diabetes-impaired angiogenesis and ischemic tissue repair","volume":"37","author":"Cheng","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioorg.2026.109691_bb0120","doi-asserted-by":"crossref","first-page":"11573","DOI":"10.1021\/acs.analchem.2c01850","article-title":"Simultaneous sensing of H2S and ATP with a two-photon fluorescent probe in Alzheimer\u2019s disease: toward understanding why H2S regulates glutamate-induced ATP dysregulation","author":"Sun","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.109691_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135994","article-title":"An activated near-infrared fluorescent probe with large stokes shift for discrimination of bio-thiols","volume":"414","author":"Zhou","year":"2024","journal-title":"Sensors Actuators B"},{"key":"10.1016\/j.bioorg.2026.109691_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.124250","article-title":"Near-infrared Rhodols-based fluorescent probe with large stokes shift for tracking of H2S in food spoilage and living cells","volume":"315","author":"Yu","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioorg.2026.109691_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.124762","article-title":"Near-infrared fluorescent probe based on the regulatory dye pKa for imaging of H2S in rice roots and living cells","volume":"321","author":"Mao","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"issue":"11","key":"10.1016\/j.bioorg.2026.109691_bb0140","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1021\/acssensors.0c02005","article-title":"Sensing and bioimaging of the gaseous signaling molecule hydrogen sulfide by near-infrared fluorescent probes","volume":"5","author":"Jose","year":"2020","journal-title":"ACS Sens."},{"key":"10.1016\/j.bioorg.2026.109691_bb0145","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.phrs.2016.09.032","article-title":"A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo","volume":"113","author":"Huang","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109691_bb0150","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.3892\/or.2015.4248","article-title":"Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK\/ERK1\/2-COX-2 pathways","volume":"34","author":"Zhen","year":"2015","journal-title":"Oncol. Rep."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109691_bb0155","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.3892\/or.2016.4691","article-title":"Hydrogen sulfide promotes cell proliferation of oral cancer through activation of the COX2\/AKT\/ERK1\/2 axis","volume":"35","author":"Zhang","year":"2016","journal-title":"Oncol. Rep."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109691_bb0160","first-page":"6562","article-title":"Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway","volume":"15","author":"Zhen","year":"2018","journal-title":"Oncol. Lett."},{"issue":"11","key":"10.1016\/j.bioorg.2026.109691_bb0165","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1021\/acssensors.4c02033","article-title":"Fluorescent sensing for the detection and quantification of sulfur-containing gases","volume":"9","author":"Wang","year":"2024","journal-title":"ACS Sens."},{"key":"10.1016\/j.bioorg.2026.109691_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126869","article-title":"Research progress of hydrogen sulfide fluorescent probes targeting organelles","volume":"281","author":"Xiong","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.bioorg.2026.109691_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125043","article-title":"A NIR ratiometric fluorescent probe for the rapid detection of hydrogen sulfide in living cells and zebrafish","volume":"266","author":"Qin","year":"2024","journal-title":"Talanta"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109691_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/bmm2.12086","article-title":"A simple yet effective H2S-activated fluorogenic probe for precise imaging of hepatitis and arthritis in situ","volume":"3","author":"Liang","year":"2025","journal-title":"BMEMat"},{"issue":"5","key":"10.1016\/j.bioorg.2026.109691_bb0185","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1039\/D3AN01847D","article-title":"A COX2-targeting cancer-specific fluorescent probe for hydrogen sulfide detection in living cells, Caenorhabditis elegans, and zebrafish","volume":"149","author":"Yuan","year":"2024","journal-title":"Analyst"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109691_bb0190","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju358","article-title":"Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer","volume":"107","author":"Cao","year":"2015","journal-title":"JNCI J. Natl. Cancer Inst."},{"issue":"1\u20132","key":"10.1016\/j.bioorg.2026.109691_bb0195","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0165-5728(98)00257-4","article-title":"Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma","volume":"95","author":"Deininger","year":"1999","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109691_bb0200","doi-asserted-by":"crossref","first-page":"20","DOI":"10.20892\/j.issn.2095-3941.2019.0339","article-title":"COX-2 as a potential biomarker and therapeutic target in melanoma","volume":"17","author":"Tudor","year":"2020","journal-title":"Cancer Biol. Med."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826002270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826002270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:06:12Z","timestamp":1777464372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826002270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":40,"alternative-id":["S0045206826002270"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109691","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-functional near-infrared fluorescent probe for H2S detection and precise COX-2-positive cancer imaging","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109691","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109691"}}