{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:26:35Z","timestamp":1776137195565,"version":"3.50.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013099","name":"Scientific Research Fund of Liaoning Provincial Education Department","doi-asserted-by":"publisher","award":["LJKFZ20220287"],"award-info":[{"award-number":["LJKFZ20220287"]}],"id":[{"id":"10.13039\/501100013099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013099","name":"Scientific Research Fund of Liaoning Provincial Education Department","doi-asserted-by":"publisher","award":["JYTQN2023100"],"award-info":[{"award-number":["JYTQN2023100"]}],"id":[{"id":"10.13039\/501100013099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["2060302"],"award-info":[{"award-number":["2060302"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JH2\/102600068"],"award-info":[{"award-number":["2024JH2\/102600068"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009965","name":"Dalian Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023RQ067"],"award-info":[{"award-number":["2023RQ067"]}],"id":[{"id":"10.13039\/501100009965","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bioorg.2026.109750","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T16:05:31Z","timestamp":1773504331000},"page":"109750","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["An efficient natural product-derived theranostic fluorescent probe for carboxylesterase bioimaging and activatable therapy of colon tumors"],"prefix":"10.1016","volume":"174","author":[{"given":"Mingxuan","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binxu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baomin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bioorg.2026.109750_bb0005","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1039\/D1NP00039J","article-title":"Cheminformatic analysis of natural product-based drugs and chemical probes","volume":"39","author":"Stone","year":"2022","journal-title":"Nat. Prod. Rep."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109750_bb0010","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"21","key":"10.1016\/j.bioorg.2026.109750_bb0015","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1016\/j.bmcl.2015.07.014","article-title":"Cheminformatic comparison of approved drugs from natural product versus synthetic origins","volume":"25","author":"Stratton","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.bioorg.2026.109750_bb0020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s40495-023-00313-3","article-title":"Drug discovery from natural sources","volume":"9","author":"Newman","year":"2023","journal-title":"Curr. Pharmacol. Rep."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109750_bb0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"The international natural product sciences taskforce, natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2026.109750_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpa.2018.12.007","article-title":"Natural product derived privileged scaffolds in drug discovery","volume":"52","author":"Davison","year":"2019","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109750_bb0035","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1021\/acscentsci.9b00916","article-title":"Late-stage diversification of natural products","volume":"6","author":"Hong","year":"2020","journal-title":"ACS Cent. Sci."},{"issue":"21","key":"10.1016\/j.bioorg.2026.109750_bb0040","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1021\/jm901241e","article-title":"Escape from flatland: increasing saturation as an approach to improving clinical success","volume":"52","author":"Lovering","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109750_bb0045","doi-asserted-by":"crossref","first-page":"18787","DOI":"10.1073\/pnas.1012741107","article-title":"Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles","volume":"107","author":"Clemons","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"17","key":"10.1016\/j.bioorg.2026.109750_bb0050","doi-asserted-by":"crossref","first-page":"6817","DOI":"10.1073\/pnas.1015024108","article-title":"Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections","volume":"108","author":"Clemons","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"21\/22","key":"10.1016\/j.bioorg.2026.109750_bb0055","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.drudis.2009.07.014","article-title":"The impact of aromatic ring count on compound developability \u2013 are too many aromatic rings a liability in drug design?","volume":"14","author":"Ritchie","year":"2009","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bioorg.2026.109750_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpa.2019.08.008","article-title":"Recent achievements and current trajectories of diversity-oriented synthesis","volume":"56","author":"Gerry","year":"2020","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"12","key":"10.1016\/j.bioorg.2026.109750_bb0065","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1021\/ed1003806","article-title":"A graphical journey of innovative organic architectures that have improved our lives","volume":"87","author":"McGrath","year":"2010","journal-title":"J. Chem. Educ."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109750_bb0070","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12934-022-01865-7","article-title":"Advances in biosynthesis of scopoletin","volume":"21","author":"He","year":"2022","journal-title":"Microb. Cell Factories"},{"issue":"9","key":"10.1016\/j.bioorg.2026.109750_bb0075","first-page":"1","article-title":"Scopoletin from Lasianthus lucidus Blume (Rubiaceae): a potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa","volume":"8","author":"Tiwtawat","year":"2018","journal-title":"J. Appl. Pharm. Sci."},{"issue":"12","key":"10.1016\/j.bioorg.2026.109750_bb0080","doi-asserted-by":"crossref","first-page":"105","DOI":"10.22159\/ijpps.2017v9i12.19841","article-title":"Anti-tubercular activity of extract and coumpounds of noni (Morinda citrifolia Linn)","volume":"9","author":"N.E","year":"2017","journal-title":"Int J Pharm Pharm Sci"},{"issue":"3","key":"10.1016\/j.bioorg.2026.109750_bb0085","first-page":"193","article-title":"Rapid validated high performance thin layer chromatography method for simultaneous estimation of mangiferin and scopoletin in Canscora Decussata (south Indian Shankhpushpi) extract","volume":"25","author":"Sethiya","year":"2015","journal-title":"Rev. Bras"},{"key":"10.1016\/j.bioorg.2026.109750_bb0090","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.indcrop.2015.03.039","article-title":"Confertin and scopoletin from leaf and root extracts of Hypochaeris radicata have anti-inflammatory and antioxidant activities","volume":"70","author":"Jamuna","year":"2015","journal-title":"Ind. Crop. Prod."},{"issue":"02","key":"10.1016\/j.bioorg.2026.109750_bb0095","doi-asserted-by":"crossref","first-page":"126","DOI":"10.18517\/ijaseit.5.2.504","article-title":"Isolation and characterization of Scopoletin from the bark of fagraea ceilanica thumb and antioxidants tests","volume":"5","author":"Ferdinal","year":"2015","journal-title":"Int. J. Adv. Sci. Eng. Inf. Technol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109750_bb0100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/07352689.2011.616039","article-title":"Review Scopoletin \u2013 a Coumarin Phytoalexin with medicinal properties","volume":"31","author":"Gnonlonfin","year":"2012","journal-title":"Crit. Rev. Plant Sci."},{"issue":"7\u20138","key":"10.1016\/j.bioorg.2026.109750_bb0105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1515\/znc-2021-0193","article-title":"Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities","volume":"77","author":"Antika","year":"2022","journal-title":"Z. Naturforsch. C"},{"key":"10.1016\/j.bioorg.2026.109750_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106202","article-title":"An overview of the pharmacological activities of scopoletin against different chronic diseases","volume":"179","author":"Parama","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109750_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/2221-1691.367685","article-title":"Scopoletin: anticancer potential and mechanism of action","volume":"13","author":"Meilawati","year":"2023","journal-title":"Asian Pac. J. Trop. Biomed."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109750_bb0120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/2156587216653660","article-title":"Hypotensive activity of Ethanolic extracts of Morinda citrifolia L. leaves and fruit in dexamethasone-induced hypertensive rat","volume":"22","author":"Wigati","year":"2017","journal-title":"J. Evid.-Based Complement. Altern. Med."},{"key":"10.1016\/j.bioorg.2026.109750_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/2761041","article-title":"Morinda citrifolia and its active principle Scopoletin mitigate protein aggregation and neuronal apoptosis through augmenting the DJ-1\/Nrf2\/ARE signaling pathway","volume":"2019","author":"Narasimhan","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.bioorg.2026.109750_bb0130","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/jpp\/rgab047","article-title":"Modulation of multiple cellular signalling pathways as targets for anti-inflammatory and anti-tumorigenesis action of Scopoletin","volume":"74","author":"Sakthivel","year":"2022","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109750_bb0135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13041-020-0560-2","article-title":"Scopoletin ameliorates anxiety-like behaviors in complete Freund\u2019s adjuvant-induced mouse model","volume":"13","author":"Luo","year":"2020","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bioorg.2026.109750_bb0140","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.phytol.2019.11.005","article-title":"New coumarins isolated from the stem bark of Fraxinus rhynchophylla inhibit human neutrophil elastase and LPS-induced inflammation in RAW 264.7 cells","volume":"35","author":"Lee","year":"2020","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.bioorg.2026.109750_bb0145","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.nutres.2019.12.003","article-title":"Scopoletin increases glucose uptake through activation of PI3K and AMPK signaling pathway and improves insulin sensitivity in 3T3-L1 cells","volume":"74","author":"Jang","year":"2020","journal-title":"Nutr. Res."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109750_bb0150","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4103\/cjp.cjp_9_21","article-title":"Scopoletin and Umbelliferone from cortex Mori as protective agents in high glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis","volume":"64","author":"Liang","year":"2021","journal-title":"Chin. J. Phys."},{"issue":"9","key":"10.1016\/j.bioorg.2026.109750_bb0155","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1080\/03639045.2020.1811302","article-title":"Antihyperuricemic efficacy of Scopoletin-loaded Soluplus micelles in yeast extract\/potassium oxonate-induced hyperuricemic mice","volume":"46","author":"Zeng","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"28","key":"10.1016\/j.bioorg.2026.109750_bb0160","doi-asserted-by":"crossref","first-page":"16593","DOI":"10.1039\/C9RA06056A","article-title":"Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1\/ADAM10 signaling pathway","volume":"10","author":"Gay","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2026.109750_bb0165","doi-asserted-by":"crossref","first-page":"24311","DOI":"10.1039\/D0NR06867E","article-title":"Research advances in integrated theranostic probes for tumor fluorescence visualization and treatment","volume":"12","author":"Xing","year":"2020","journal-title":"Nanoscale"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109750_bb0170","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1039\/D3CS00883E","article-title":"Bioorthogonally activated probes for precise fluorescence imaging","volume":"54","author":"Fu","year":"2025","journal-title":"Chem. Soc. Rev."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109750_bb0175","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.apsb.2018.05.005","article-title":"Human carboxylesterases: a comprehensive review","volume":"8","author":"Wang","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"issue":"6","key":"10.1016\/j.bioorg.2026.109750_bb0180","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1111\/1462-2920.15774","article-title":"Environmental role of aromatic carboxylesterases","volume":"24","author":"Ghodke","year":"2022","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109750_bb0185","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cbi.2016.02.011","article-title":"Carboxylesterases: general detoxifying enzymes","volume":"259","author":"Hatfield","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bioorg.2026.109750_bb0190","first-page":"178","article-title":"Carboxylesterases in lipid metabolism: from mouse to human, protein","volume":"9","author":"Lian","year":"2018","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bioorg.2026.109750_bb0195","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3390\/molecules29051168","article-title":"Recent advances in fluorescent probes for Cancer biomarker detection","volume":"29","author":"Tian","year":"2024","journal-title":"Molecules"},{"issue":"32","key":"10.1016\/j.bioorg.2026.109750_bb0200","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.1039\/D3TB01213A","article-title":"A S -substituted Nile blue-derived bifunctional near-infrared fluorescent probe for in vivo carboxylesterase imaging-guided photodynamic therapy of hepatocellular carcinoma","volume":"11","author":"Wang","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"15","key":"10.1016\/j.bioorg.2026.109750_bb0205","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.3390\/molecules29153660","article-title":"An innovative aggregation-induced emission-based NIR fluorescent probe for visualizing carboxylesterases in living cells, zebrafish, and tumor-bearing mice","volume":"29","author":"Gao","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.109750_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotochem.2024.116088","article-title":"Detection of carboxylesterases by an activatable NIR fluorescence probe with high selectivity in living systems","volume":"459","author":"Wang","year":"2025","journal-title":"J. Photochem. Photobiol., A"},{"key":"10.1016\/j.bioorg.2026.109750_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotochem.2024.116005","article-title":"A fluorescent probe derived from triphenylamine-benzofuranone for monitoring carboxylesterases and its imaging in drug-induced liver cellular injury","volume":"459","author":"Bao","year":"2025","journal-title":"J. Photochem. Photobiol., A"},{"issue":"12","key":"10.1016\/j.bioorg.2026.109750_bb0220","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/s44211-024-00659-8","article-title":"A fluorescent probe for monitoring carboxylesterases in pulmonary cells under permissive hypercapnia condition","volume":"40","author":"Wu","year":"2024","journal-title":"Anal. Sci."},{"issue":"9","key":"10.1016\/j.bioorg.2026.109750_bb0225","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1016\/j.cclet.2022.01.087","article-title":"Lysosome-targeting red fluorescent probe for broad carboxylesterases detection in breast cancer cells","volume":"33","author":"Sun","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.109750_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.123708","article-title":"An ultrasensitive and selective near-infrared fluorescent probe for tracking carboxylesterases with large stokes shift in living cells and mice","volume":"308","author":"Zhang","year":"2024","journal-title":"Spectrochim. Acta A"},{"issue":"11","key":"10.1016\/j.bioorg.2026.109750_bb0235","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1021\/acs.analchem.1c04286","article-title":"Multifunctional fluorescent probe for simultaneously detecting microviscosity, micropolarity, and carboxylesterases and its application in bioimaging","volume":"94","author":"Qi","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.109750_bb0240","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3390\/molecules28052317","article-title":"A turn-on lipid droplet-targeted near-infrared fluorescent probe with a large stokes shift for detection of intracellular carboxylesterases and cell viability imaging","volume":"28","author":"Li","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.109750_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.121529","article-title":"A hemicyanine-based fluorescent probe for simultaneous imaging of carboxylesterases and histone deacetylases in hepatocellular carcinoma","volume":"281","author":"Shu","year":"2022","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.bioorg.2026.109750_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.121329","article-title":"A novel indene-chalcone-based fluorescence probe with lysosome-targeting for detection of endogenous carboxylesterases and bioimaging","volume":"278","author":"Zhang","year":"2022","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.bioorg.2026.109750_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2022.110189","article-title":"Water-soluble meso-ester substituted BODIPY with aggregation-induced emission property for ratiometric detection of carboxylesterases in living hepatoma cell","volume":"201","author":"Zhou","year":"2022","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.bioorg.2026.109750_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.126569","article-title":"Monitoring of carboxylesterases using a tricyanofuran-based near-infrared fluorophore in living organisms","volume":"343","author":"Tang","year":"2025","journal-title":"Spectrochim. Acta A"},{"issue":"4","key":"10.1016\/j.bioorg.2026.109750_bb0265","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1039\/D2AN01874H","article-title":"Rational design of a turn-on near-infrared fluorescence probe for the highly sensitive and selective monitoring of carboxylesterase 2 in living systems","volume":"148","author":"Chen","year":"2023","journal-title":"Analyst"},{"issue":"9","key":"10.1016\/j.bioorg.2026.109750_bb0270","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1021\/acs.analchem.3c04399","article-title":"New near-infrared fluorescence imaging platform with large stokes shift for carboxylesterase 2 detection in thyroid Cancer and inflammatory diseases diagnosis","volume":"96","author":"Wang","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.109750_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.121529","article-title":"A hemicyanine-based fluorescent probe for simultaneous imaging of carboxylesterases and histone deacetylases in hepatocellular carcinoma","volume":"281","author":"Shu","year":"2022","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioorg.2026.109750_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134503","article-title":"Dihydroxanthene-derived fluorescent probe with near-infrared excitation and emission maxima for detecting human carboxylesterase-2 and bioimaging","volume":"395","author":"Yang","year":"2023","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.bioorg.2026.109750_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135609","article-title":"Imaging of carboxylesterase 2 expression changes in colitis and colon cancer chemotherapy via a fluorescent probe","volume":"409","author":"Wang","year":"2024","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.bioorg.2026.109750_bb0290","article-title":"A novel carboxylesterase 2-targeted fluorescent probe with cholic acid as a recognition group for early diagnosis of drug- and environment-related liver diseases","volume":"480","author":"Li","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"8","key":"10.1016\/j.bioorg.2026.109750_bb0295","doi-asserted-by":"crossref","first-page":"8471","DOI":"10.1021\/acs.jmedchem.5c00020","article-title":"Carboxylesterase-triggered Theranostic agent: advancing near-infrared imaging and therapeutic efficacy in hepatocellular carcinoma","volume":"68","author":"Zheng","year":"2025","journal-title":"J. Med. Chem."},{"issue":"32","key":"10.1016\/j.bioorg.2026.109750_bb0300","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.1039\/D3TB01213A","article-title":"A S-substituted Nile blue-derived bifunctional near-infrared fluorescent probe for in vivo carboxylesterase imaging-guided photodynamic therapy of hepatocellular carcinoma","volume":"11","author":"Wang","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"11","key":"10.1016\/j.bioorg.2026.109750_bb0305","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1021\/acs.chemrev.3c00776","article-title":"Fluorescent probes for disease diagnosis","volume":"124","author":"Wang","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109750_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126060","article-title":"Design, synthesis, and evaluation of a carboxylesterase detection probe with therapeutic effects","volume":"274","author":"Lin","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.bioorg.2026.109750_bb0315","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.aca.2019.03.043","article-title":"A sensitive ratiometric fluorescent probe for quantitive detection and imaging of alkaline phosphatase in living cells","volume":"1066","author":"Gao","year":"2019","journal-title":"Anal. Chim. Acta"},{"issue":"5","key":"10.1016\/j.bioorg.2026.109750_bb0320","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/00498254.2015.1082209","article-title":"Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells","volume":"46","author":"Shang","year":"2016","journal-title":"Xenobiotica"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826002865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826002865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:34:27Z","timestamp":1776134067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826002865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":64,"alternative-id":["S0045206826002865"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109750","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An efficient natural product-derived theranostic fluorescent probe for carboxylesterase bioimaging and activatable therapy of colon tumors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109750","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109750"}}