{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:25:35Z","timestamp":1776104735802,"version":"3.50.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2024QH099"],"award-info":[{"award-number":["ZR2024QH099"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204212"],"award-info":[{"award-number":["82204212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bioorg.2026.109760","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:54:37Z","timestamp":1773676477000},"page":"109760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A unique compound 3c targets GSK-3\u03b2 and metal ion, interferes with tau and metal dyshomeostasis, promotes neurite outgrowth, decreases A\u03b2 accumulation and ABTS\u2022+, and enhances zebrafish motility"],"prefix":"10.1016","volume":"174","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Qing","family":"Xun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Long","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109760_bb0005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/procel\/pwae026","article-title":"Alzheimer\u2019s disease: insights into pathology, molecular mechanisms, and therapy","volume":"16","author":"Zheng","year":"2025","journal-title":"Protein Cell"},{"key":"10.1016\/j.bioorg.2026.109760_bb0010","first-page":"1","article-title":"Reducing dementia risk: never too early, never too late","volume":"2023","author":"Long","year":"2023","journal-title":"World Alzheimer Report"},{"key":"10.1016\/j.bioorg.2026.109760_bb0015","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1016\/j.neuron.2022.06.021","article-title":"Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer\u2019s disease","volume":"110","author":"Otero-Garcia","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.bioorg.2026.109760_bb0020","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41586-024-07680-x","article-title":"CryoET of \u03b2-amyloid and tau within postmortem Alzheimer\u2019s disease brain","volume":"631","author":"Gilbert","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2026.109760_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106301","article-title":"The metal ion hypothesis of Alzheimer\u2019s disease and the anti-neuroinflammatory effect of metal chelators","volume":"131","author":"Chen","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109760_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101619","article-title":"Oxidative stress: the core pathogenesis and mechanism of Alzheimer\u2019s disease","volume":"77","author":"Bai","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bioorg.2026.109760_bb0035","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00401-024-02790-2","article-title":"Inflammatory aspects of Alzheimer\u2019s disease","volume":"148","author":"Botella Lucena","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0040","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/brain\/awy132","article-title":"The cholinergic system in the pathophysiology and treatment of Alzheimer\u2019s disease","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.bioorg.2026.109760_bb0045","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00401-024-02747-5","article-title":"The necroptosis cell death pathway drives neurodegeneration in Alzheimer\u2019s disease","volume":"147","author":"Balusu","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0050","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jconrel.2024.01.047","article-title":"Alzheimer\u2019s disease current therapies, novel drug delivery systems and future directions for better disease management","volume":"367","author":"Singh","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioorg.2026.109760_bb0055","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/s41591-023-02505-2","article-title":"Emerging diagnostics and therapeutics for Alzheimer disease","volume":"29","author":"Self","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioorg.2026.109760_bb0060","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer\u2019s disease: mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioorg.2026.109760_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177520","article-title":"Exploring Alzheimer\u2019s disease treatment: established therapies and novel strategies for future care","volume":"998","author":"Soni","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0070","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2414176121","article-title":"GSK3\u03b2 phosphorylation catalyzes the aggregation of tau into Alzheimer\u2019s disease-like filaments","volume":"121","author":"Chakraborty","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioorg.2026.109760_bb0075","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.brainresbull.2022.10.006","article-title":"The central role of tau in Alzheimer\u2019s disease: from neurofibrillary tangle maturation to the induction of cell death","volume":"190","author":"Thal","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bioorg.2026.109760_bb0080","doi-asserted-by":"crossref","first-page":"15823","DOI":"10.1074\/jbc.M610708200","article-title":"GSK3\u03b2 activity modifies the localization and function of presenilin 1","volume":"282","author":"Uemura","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2026.109760_bb0085","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1172\/JCI64516","article-title":"Inhibition of GSK3\u03b2-mediated BACE1 expression reduces Alzheimer-associated phenotypes","volume":"123","author":"Ly","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioorg.2026.109760_bb0090","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.2174\/0929867329666220216113517","article-title":"Glycogen synthase kinase 3\u03b2 involvement in neuroinflammation and neurodegenerative diseases","volume":"29","author":"Gianferrara","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109760_bb0095","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1080\/14756366.2022.2086867","article-title":"Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3\u03b2 inhibitors for Alzheimer\u2019s disease","volume":"37","author":"Yan","year":"2022","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109760_bb0100","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13195-025-01846-z","article-title":"Gut microbial metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity decline through modulation of GSK-3\u03b2 activity","volume":"17","author":"Shi","year":"2025","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"10.1016\/j.bioorg.2026.109760_bb0105","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10495-023-01848-y","article-title":"Apoptosis in Alzheimer\u2019s disease: insight into the signaling pathways and therapeutic avenues","volume":"28","author":"Kumari","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.bioorg.2026.109760_bb0110","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3390\/ph18040532","article-title":"An overview of the effects of Lithium on Alzheimer\u2019s disease: a historical perspective","volume":"18","author":"Radanovic","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bioorg.2026.109760_bb0115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-141959","article-title":"A phase II trial of Tideglusib in Alzheimer\u2019s disease","volume":"45","author":"Lovestone","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.bioorg.2026.109760_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117204","article-title":"A review of developments in glycogen synthase kinase-3 regulators over the past 10 years","volume":"242","author":"Wang","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0125","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.tips.2009.05.002","article-title":"Alzheimer\u2019s disease, metal ions and metal homeostatic therapy","volume":"30","author":"Zatta","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bioorg.2026.109760_bb0130","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1021\/acs.accounts.3c00370","article-title":"Metal binding of Alzheimer\u2019s amyloid-\u03b2 and its effect on peptide self-assembly","volume":"56","author":"Abelein","year":"2023","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bioorg.2026.109760_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2023.103009","article-title":"Metal ion mediated aggregation of Alzheimer\u2019s disease peptides and proteins in solutions and at surfaces","volume":"320","author":"Feng","year":"2023","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.bioorg.2026.109760_bb0140","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0145","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40035-020-00189-z","article-title":"Current understanding of metal ions in the pathogenesis of Alzheimer\u2019s disease","volume":"9","author":"Wang","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.bioorg.2026.109760_bb0150","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1001\/archneur.60.12.1685","article-title":"Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting A\u03b2 amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial","volume":"60","author":"Ritchie","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1365-2362.2002.00933.x","article-title":"D-penicillamine reduces serum oxidative stress in Alzheimer\u2019s disease patients","volume":"32","author":"Squitti","year":"2002","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bioorg.2026.109760_bb0160","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/0140-6736(91)92978-B","article-title":"Intramuscular desferrioxamine in patients with Alzheimer\u2019s disease","volume":"337","author":"Crapper McLachlan","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2026.109760_bb0165","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tips.2024.05.005","article-title":"Multi-target drugs for Alzheimer\u2019s disease","volume":"45","author":"Turgutalp","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bioorg.2026.109760_bb0170","doi-asserted-by":"crossref","first-page":"2466846","DOI":"10.1080\/14756366.2025.2466846","article-title":"Identification of a novel pyrrolo[2,3-b]pyridine compound as a potent glycogen synthase kinase 3\u03b2 inhibitor for treating Alzheimer\u2019s disease","volume":"40","author":"Xun","year":"2025","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109760_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117236","article-title":"Synthesis and biological evaluation of novel pyrrolo[2,3-b]pyridine derivatives as potent GSK-3\u03b2 inhibitors for treating Alzheimer\u2019s disease","volume":"285","author":"Xun","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109760_bb0180","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.apsb.2023.01.013","article-title":"8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases","volume":"13","author":"Knez","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2026.109760_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114841","article-title":"Discovery of novel hybrids containing clioquinol-1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer\u2019s disease","volume":"244","author":"Li","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109760_bb0190","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1074\/jbc.M002466200","article-title":"Indirubins inhibit glycogen synthase kinase-3\u03b2 and CDK5\/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer\u2019s disease","volume":"276","author":"Leclerc","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2026.109760_bb0195","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/js980402t","article-title":"Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration","volume":"88","author":"Clark","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bioorg.2026.109760_bb0200","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1002\/j.1460-2075.1990.tb07419.x","article-title":"Molecular cloning and expression of glycogen synthase kinase-3\/Factor A","volume":"9","author":"Woodgett","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.bioorg.2026.109760_bb0205","doi-asserted-by":"crossref","first-page":"7392","DOI":"10.1523\/JNEUROSCI.0889-12.2012","article-title":"Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer\u2019s disease","volume":"32","author":"Hurtado","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bioorg.2026.109760_bb0210","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1007\/s11064-016-1960-7","article-title":"RNA interference silencing of glycogen synthase kinase 3\u03b2 inhibites tau phosphorylation in mice with Alzheimer disease","volume":"41","author":"Bian","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bioorg.2026.109760_bb0215","doi-asserted-by":"crossref","first-page":"688","DOI":"10.34172\/apb.2023.071","article-title":"Role of GSK-3\u03b2 inhibitors: new promises and opportunities for Alzheimer\u2019s disease","volume":"13","author":"Shri","year":"2023","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.bioorg.2026.109760_bb0220","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1007\/s12035-023-03839-1","article-title":"Understanding glycogen synthase kinase-3: a novel avenue for Alzheimer\u2019s disease","volume":"61","author":"Sequeira","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0225","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cell.2004.09.019","article-title":"Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth","volume":"119","author":"Lu","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2026.109760_bb0230","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/jmcb\/mjt051","article-title":"Wnt signaling in the nervous system and in Alzheimer\u2019s disease","volume":"6","author":"Inestrosa","year":"2014","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0235","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/mp.2009.72","article-title":"Activation of Wnt signaling by Lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe\/PSEN1\u0394E9 mouse model of Alzheimer\u2019s disease","volume":"15","author":"Toledo","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bioorg.2026.109760_bb0240","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.conb.2018.06.003","article-title":"Wnt proteins as modulators of synaptic plasticity","volume":"53","author":"McLeod","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0245","doi-asserted-by":"crossref","first-page":"9296092","DOI":"10.1155\/2023\/9296092","article-title":"The molecular basis of Wnt\/\u03b2-catenin signaling pathways in neurodegenerative diseases","volume":"2023","author":"Anand","year":"2023","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.116065","article-title":"CPD47, a novel GSK-3\u03b2 inhibitor, demonstrates antidepressant-like effects via the GSK-3\u03b2\/\u03b2-catenin signaling pathway: involvement of neurogenesis promotion and neuroinflammation inhibition","volume":"169","author":"Gong","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0255","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.7150\/ijbs.57078","article-title":"Interaction between A\u03b2 and tau in the pathogenesis of Alzheimer\u2019s disease","volume":"17","author":"Zhang","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bioorg.2026.109760_bb0260","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41583-019-0240-3","article-title":"Amyloid-\u03b2-independent regulators of tau pathology in Alzheimer disease","volume":"21","author":"van der Kant","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bioorg.2026.109760_bb0265","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3233\/JAD-2010-091363","article-title":"An in vitro model for neuroscience: differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons","volume":"20","author":"Agholme","year":"2010","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"10.1016\/j.bioorg.2026.109760_bb0270","doi-asserted-by":"crossref","first-page":"7355","DOI":"10.1007\/s12035-019-1605-3","article-title":"Cholinergic differentiation of human neuroblastoma SH-SY5Y cell line and its potential use as an in vitro model for Alzheimer\u2019s disease studies","volume":"56","author":"de Medeiros","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118759","article-title":"Environmental aluminum exposure and Alzheimer\u2019s disease risk: evidence from a systematic review and meta-analysis","volume":"302","author":"Soleimani","year":"2025","journal-title":"Ecotoxicol. Environ. Safe."},{"key":"10.1016\/j.bioorg.2026.109760_bb0280","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3233\/JAD-2009-1063","article-title":"Clioquinol decreases amyloid-\u03b2 burden and reduces working memory impairment in a transgenic mouse model of Alzheimer\u2019s disease","volume":"17","author":"Grossi","year":"2009","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"10.1016\/j.bioorg.2026.109760_bb0285","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(01)00317-8","article-title":"Treatment with a copper-zinc chelator markedly and rapidly inhibits \u03b2-amyloid accumulation in Alzheimer\u2019s disease transgenic mice","volume":"30","author":"Cherny","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.bioorg.2026.109760_bb0290","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.3390\/ijms22073380","article-title":"Analytical methods used in determining antioxidant activity: a review","volume":"22","author":"Munteanu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109760_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177776","article-title":"Towards zebrafish model applications in drug discovery targeting central nervous system diseases and neurotoxicity assessment","volume":"1002","author":"Li","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109760_bb0300","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.apsb.2025.02.030","article-title":"Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimer\u2019s disease","volume":"15","author":"Sang","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2026.109760_bb0305","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1007\/s10787-023-01290-1","article-title":"Vitamin K2 protects against aluminium chloride-mediated neurodegeneration","volume":"31","author":"Chatterjee","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bioorg.2026.109760_bb0310","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cbi.2008.04.004","article-title":"Donepezil, an acetylcholinesterase inhibitor, enhances adult hippocampal neurogenesis","volume":"175","author":"Kotani","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bioorg.2026.109760_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108352","article-title":"Efficacy of acetylcholinesterase inhibitors in Alzheimer\u2019s disease","volume":"190","author":"Marucci","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bioorg.2026.109760_bb0320","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejmech.2019.02.001","article-title":"Synthesis and evaluation of novel GSK-3\u03b2 inhibitors as multifunctional agents against Alzheimer\u2019s disease","volume":"167","author":"Shi","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109760_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030649","article-title":"A unique GSK-3\u03b2 inhibitor B10 has a direct effect on A\u03b2, targets tau and metal dyshomeostasis, and promotes neuronal neurite outgrowth","volume":"9","author":"Shi","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bioorg.2026.109760_bb0330","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1021\/acschemneuro.4c00097","article-title":"Fluorescence-based monitoring of early-stage aggregation of amyloid-\u03b2, amylin peptide, tau, and \u03b1-synuclein proteins","volume":"15","author":"Li","year":"2024","journal-title":"ACS Chem. Neurosci."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826002968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826002968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:13:03Z","timestamp":1776100383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826002968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":66,"alternative-id":["S0045206826002968"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109760","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A unique compound 3c targets GSK-3\u03b2 and metal ion, interferes with tau and metal dyshomeostasis, promotes neurite outgrowth, decreases A\u03b2 accumulation and ABTS\u2022+, and enhances zebrafish motility","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109760","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109760"}}