{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:36:50Z","timestamp":1791959810651,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024RS-CXTD-67"],"award-info":[{"award-number":["2024RS-CXTD-67"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42376127"],"award-info":[{"award-number":["42376127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277099"],"award-info":[{"award-number":["22277099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404476"],"award-info":[{"award-number":["82404476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["2025Y0080"],"award-info":[{"award-number":["2025Y0080"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["2024Y0077"],"award-info":[{"award-number":["2024Y0077"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bioorg.2026.109768","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:39:15Z","timestamp":1773851955000},"page":"109768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Discovery of novel ten-membered lactones as osteoblastogenesis agents targeting Wnt\/\u03b2-catenin signaling pathway"],"prefix":"10.1016","volume":"175","author":[{"given":"Yi-Jie","family":"Zhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Xuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109768_bb0005","doi-asserted-by":"crossref","first-page":"11965","DOI":"10.1021\/acs.jmedchem.3c00601","article-title":"Synthesis and biological evaluation of heterocyclic ring-fused 20 (S)-protopanaxadiol derivatives as potent antiosteoporosis agents","volume":"66","author":"Wang","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109768_bb0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41413-019-0066-7","article-title":"Bench-to-bedside strategies for osteoporotic fracture: from osteoimmunology to mechanosensation","volume":"7","author":"Xie","year":"2019","journal-title":"Bone Res."},{"key":"10.1016\/j.bioorg.2026.109768_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1063899","article-title":"Kidney tonifying traditional Chinese medicine: potential implications for the prevention and treatment of osteoporosis","volume":"13","author":"Duan","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109768_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116641","article-title":"Methanolic extract of O.Umbellata L. exhibits anti-osteoporotic effect via promoting osteoblast proliferation in MG-63 cells and inhibiting osteoclastogenesis in RANKL-stimulated RAW 264.7 cells","volume":"315","author":"Paramasivam","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2026.109768_bb0025","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3390\/ijms21010349","article-title":"Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells","volume":"21","author":"Qadir","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109768_bb0030","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00018-016-2425-5","article-title":"Wnt signaling and cellular metabolism in osteoblasts","volume":"74","author":"Karner","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bioorg.2026.109768_bb0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jfutfo.2023.07.001","article-title":"A review: the mechanism of plant-derived polysaccharides on osteoblasts and osteoclasts","volume":"4","author":"Ren","year":"2024","journal-title":"J. Future Foods"},{"key":"10.1016\/j.bioorg.2026.109768_bb0040","doi-asserted-by":"crossref","first-page":"15738","DOI":"10.1021\/acs.jmedchem.4c01377","article-title":"Discovery of novel neo-clerodane derivatives as potent dual-functional antiosteoporosis agents through targeting peroxisome proliferator-activated receptor-\u03b3","volume":"67","author":"Peng","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109768_bb0045","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1039\/D3NP00013C","article-title":"Natural ten-membered lactones: sources, structural diversity, biological activity, and intriguing future","volume":"41","author":"Dubovik","year":"2024","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bioorg.2026.109768_bb0050","first-page":"2279","article-title":"ChemInform abstract: fifteen years of biological and synthetic studies of decarestrictine family","volume":"64","author":"Riatto","year":"2008","journal-title":"ChemInform"},{"key":"10.1016\/j.bioorg.2026.109768_bb0055","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1021\/cr050045o","article-title":"Total synthesis of natural 8- and 9-membered lactones: recent advancements in medium-sized ring formation","volume":"107","author":"Shiina","year":"2007","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109768_bb0060","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1039\/D2NP00025C","article-title":"Fungal bioactive macrolides","volume":"39","author":"Evidente","year":"2022","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bioorg.2026.109768_bb0065","first-page":"2755","article-title":"The structure of thiobiscephalosporolide A, a dimeric pentaketide macrolide from Cephalosporium aphidicola","volume":"16","author":"Ackland","year":"1985","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"10.1016\/j.bioorg.2026.109768_bb0070","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1021\/acs.orglett.2c03432","article-title":"Cordycicadins A\u2013D, antifeedant polyketides from the entomopathogenic fungus Cordyceps cicadae JXCH1","volume":"24","author":"Li","year":"2022","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2026.109768_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202300773","article-title":"Tricrilactones A\u2013H, potent antiosteoporosis macrolides with distinctive ring skeletons from Trichocladium crispatum, an alpine moss-associated fungus","volume":"62","author":"Han","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2026.109768_bb0080","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acs.orglett.9b04099","article-title":"Herpotrichones A and B, two intermolecular [4 + 2] adducts with anti-neuroinflammatory activity from a Herpotrichia species","volume":"22","author":"Han","year":"2020","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2026.109768_bb0085","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1021\/cr300402y","article-title":"Azaphilones: chemistry and biology","volume":"113","author":"Gao","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109768_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108757","article-title":"Ganoderma calidophilum-derived highly oxygenated lanostane triterpenoids: multitarget neuroprotection through AMPK\/mTOR\/SIRT1 axis modulation and gut-brain axis crosstalk","volume":"163","author":"Guo","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109768_bb0095","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1021\/acs.jnatprod.5c01149","article-title":"Cyathstrines A\u2013K, structurally diverse polycyclic polyoxygenated cyathane diterpenoid xylosides with antibacterial and neuroprotective activities from the fungus Cyathus striatus","volume":"88","author":"Zhao","year":"2025","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.109768_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202300566","article-title":"Two decarestrictine analogs from the soil-derived fungus Penicillium sp. YUD18003 associated with Gastrodia elata","volume":"20","author":"Xie","year":"2023","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bioorg.2026.109768_bb0105","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1021\/jo00391a009","article-title":"Asymmetric microbial reduction of prochiral 2,2-disubstituted cycloalkanediones","volume":"52","author":"Brooks","year":"1987","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2026.109768_bb0110","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/jmre.1996.1016","article-title":"HECADE: HMQC- and HSQC-based 2D NMR experiments for accurate and sensitive determination of heteronuclear coupling constants from E.COSY-type cross peaks","volume":"124","author":"Ko\u017ami\u0144ski","year":"1997","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.bioorg.2026.109768_bb0115","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1021\/cr030733c","article-title":"Determination of relative configuration in organic compounds by NMR spectroscopy and computational methods","volume":"107","author":"Bifulco","year":"2007","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109768_bb0120","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.7164\/antibiotics.45.1176","article-title":"Secondary metabolites by chemical screening. 20. Decarestrictines, a new family of inhibitors of cholesterol biosynthesis from Penicillium: III. Decarestrictines E to M","volume":"45","author":"Grabley","year":"1992","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2026.109768_bb0125","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1021\/np400873v","article-title":"Anti-inflammatory diterpenoids from the roots of Euphorbia ebracteolata","volume":"77","author":"Liu","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.109768_bb0130","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1021\/np070610d","article-title":"Botryolides A\u2013E, decarestrictine analogues from a fungicolous Botryotrichum sp. (NRRL 38180)","volume":"71","author":"Sy","year":"2008","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.109768_bb0135","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s10020-024-00957-x","article-title":"Wnt\/\u03b2-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis","volume":"30","author":"Wang","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.bioorg.2026.109768_bb0140","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3390\/biom13030483","article-title":"Progress of Wnt signaling pathway in osteoporosis","volume":"13","author":"Gao","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioorg.2026.109768_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.112850","article-title":"Novel antiosteoporotic peptides purified from protein hydrolysates of taihe black-boned silky fowl: by larval zebrafish model and molecular docking","volume":"169","author":"Qiu","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.bioorg.2026.109768_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172794","article-title":"Icariin promotes osteogenic differentiation by suppressing notch signaling","volume":"865","author":"Xu","year":"2019","journal-title":"Eur. J. Pharmacol."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826003044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826003044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:31:31Z","timestamp":1776108691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826003044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":30,"alternative-id":["S0045206826003044"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109768","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel ten-membered lactones as osteoblastogenesis agents targeting Wnt\/\u03b2-catenin signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109768"}}