{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T20:06:46Z","timestamp":1776110806872,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200109"],"award-info":[{"award-number":["82200109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016697","name":"Youth Innovation Technology Project of Higher School in Shandong Province","doi-asserted-by":"publisher","award":["2022KJ090"],"award-info":[{"award-number":["2022KJ090"]}],"id":[{"id":"10.13039\/100016697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2024QH133"],"award-info":[{"award-number":["ZR2024QH133"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2024MH170"],"award-info":[{"award-number":["ZR2024MH170"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bioorg.2026.109769","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:07:55Z","timestamp":1773828475000},"page":"109769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dimethyl bisphenolate inhibits ovarian cancer growth by regulating the PI3K\/AKT\/mTOR signaling pathway"],"prefix":"10.1016","volume":"174","author":[{"given":"Mengke","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyuan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runpeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huachang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingtao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruozhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiwu","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuling","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qizhi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Pt 1","key":"10.1016\/j.bioorg.2026.109769_bb0005","article-title":"The latest research progress: active components of traditional Chinese medicine as promising candidates for ovarian cancer therapy","volume":"337","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2026.109769_bb0010","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2147\/JIR.S503479","article-title":"Inflammation and immune escape in ovarian cancer: pathways and therapeutic opportunities","volume":"18","author":"Liu","year":"2025","journal-title":"J. Inflamm. Res."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109769_bb0015","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109769_bb0020","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12964-025-02056-8","article-title":"Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair","volume":"23","author":"Xiao","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bioorg.2026.109769_bb0025","article-title":"A novel mechanism of 6-methoxydihydroavicine in suppressing ovarian carcinoma by disrupting mitochondrial homeostasis and triggering ROS\/ MAPK mediated apoptosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.bioorg.2026.109769_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082362","article-title":"Magnolol: a neolignan from the Magnolia family for the prevention and treatment of cancer","volume":"19","author":"Ranaware","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bioorg.2026.109769_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/biom10020245","article-title":"Machilin D, a lignin derived from Saururus chinensis, suppresses breast cancer stem cells and inhibits NF-\u03baB signaling","volume":"10","author":"Zhen","year":"2020","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.bioorg.2026.109769_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054576","article-title":"Machilin D promotes apoptosis and autophagy, and inhibits necroptosis in human oral squamous cell carcinoma cells","volume":"24","author":"Yun","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.bioorg.2026.109769_bb0045","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.52586\/5013","article-title":"The killing effect of Tanshinol on breast cancer cells: insight into the reversion of TGF-\u03b21-mediated suppression of NK cell functions","volume":"26","author":"Yang","year":"2021","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"10.1016\/j.bioorg.2026.109769_bb0050","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2147\/OTT.S185997","article-title":"Tanshinol inhibits the growth, migration and invasion of hepatocellular carcinoma cells via regulating the PI3K-AKT signaling pathway","volume":"12","author":"Zhu","year":"2019","journal-title":"Onco. Targets Ther."},{"key":"10.1016\/j.bioorg.2026.109769_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115214","article-title":"Tanshinol suppresses osteosarcoma by specifically inducing apoptosis of U2-OS cells through p53-mediated mechanism","volume":"292","author":"Yu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109769_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010588","article-title":"Caffeic acid and diseases-mechanisms of action","volume":"24","author":"Pavl\u00edkov\u00e1","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109769_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2019.12.008","article-title":"Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: a novel therapeutic strategy","volume":"80","author":"Tewari","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"9","key":"10.1016\/j.bioorg.2026.109769_bb0070","doi-asserted-by":"crossref","first-page":"8391","DOI":"10.3390\/ijms24098391","article-title":"PI3K\/AKT\/mTOR dysregulation and reprogramming metabolic pathways in renal cancer: crosstalk with the VHL\/HIF axis","volume":"24","author":"Badoiu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109769_bb0075","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.semcancer.2019.05.012","article-title":"Role of the PI3K\/AKT\/mTOR signaling pathway in ovarian cancer: biological and therapeutic significance","volume":"59","author":"Ediriweera","year":"2019","journal-title":"Semin. Cancer Biol."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109769_bb0080","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/tox.23752","article-title":"A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR-1 mediated mitochondrial dysfunction and apoptosis","volume":"38","author":"Ma","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.bioorg.2026.109769_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107593","article-title":"Induction of programmed necrosis: a novel anti-cancer strategy for natural compounds","volume":"214","author":"Yu","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109769_bb0090","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.70014","article-title":"Exploring the effect of Gomisin a on non-small cell lung cancer with network pharmacology, molecular docking, in vitro and in vivo assays","volume":"104","author":"Liu","year":"2024","journal-title":"Chem. Biol. Drug Des."},{"issue":"17","key":"10.1016\/j.bioorg.2026.109769_bb0095","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.3390\/ijms21176357","article-title":"Arctigenin attenuates breast Cancer progression through decreasing GM-CSF\/TSLP\/STAT3\/\u03b2-catenin signaling","volume":"21","author":"Shi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109769_bb0100","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.bioorg.2026.109769_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031353","article-title":"Wnt and PI3K\/Akt\/mTOR survival pathways as therapeutic targets in glioblastoma","volume":"23","author":"Barzegar Behrooz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109769_bb0110","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/CAD.0000000000001031","article-title":"Sesamin induces cell cycle arrest and apoptosis through p38\/C-Jun N-terminal kinase mitogen-activated protein kinase pathways in human colorectal cancer cells","volume":"32","author":"Wang","year":"2021","journal-title":"Anti-Cancer Drugs"},{"issue":"6","key":"10.1016\/j.bioorg.2026.109769_bb0115","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1142\/S0192415X24500551","article-title":"Atractylodin: an alkyne compound with anticancer potential","volume":"52","author":"Zhong","year":"2024","journal-title":"Am. J. Chin. Med."},{"issue":"9","key":"10.1016\/j.bioorg.2026.109769_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092105","article-title":"Citrate-induced p85\u03b1\u2212PTEN complex formation causes G(2)\/M phase arrest in human pharyngeal squamous carcinoma cell lines","volume":"20","author":"Hung","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.bioorg.2026.109769_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/cells13110924","article-title":"Apoptosis, a metabolic \u201chead-to-head\u201d between tumor and T cells: implications for immunotherapy","volume":"13","author":"Franzese","year":"2024","journal-title":"Cells"},{"issue":"9\u201310","key":"10.1016\/j.bioorg.2026.109769_bb0130","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s10495-021-01687-9","article-title":"Mechanism of interaction between autophagy and apoptosis in cancer","volume":"26","author":"Das","year":"2021","journal-title":"Apoptosis"},{"key":"10.1016\/j.bioorg.2026.109769_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172477","article-title":"Anti-tumor efficacy of phellamurin in osteosarcoma cells: involvement of the PI3K\/AKT\/mTOR pathway","volume":"858","author":"Zhang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109769_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2024.01.023","article-title":"The neuroprotective effects of BMSC-derived exosomes against glutamate-induced HT22 cell cytotoxicity","volume":"542","author":"Rong","year":"2024","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109769_bb0145","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s12951-022-01576-6","article-title":"Biologically synthesized black ginger-selenium nanoparticle induces apoptosis and autophagy of AGS gastric cancer cells by suppressing the PI3K\/Akt\/mTOR signaling pathway","volume":"20","author":"Wang","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109769_bb0150","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/jcp.29160","article-title":"Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria","volume":"235","author":"Altinok","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"7\u20139","key":"10.1016\/j.bioorg.2026.109769_bb0155","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/ars.2023.0506","article-title":"Pleiotropic regulation of PGC-1\u03b1 in tumor initiation and progression","volume":"41","author":"Zhang","year":"2024","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109769_bb0160","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12964-021-00745-8","article-title":"Correction to: loss of PTEN expression is associated with PI3K pathway-dependent metabolic reprogramming in hepatocellular carcinoma","volume":"19","author":"Zhao","year":"2021","journal-title":"Cell Commun. Signal"},{"issue":"2","key":"10.1016\/j.bioorg.2026.109769_bb0165","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41568-019-0216-7","article-title":"The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism","volume":"20","author":"Hoxhaj","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109769_bb0170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2014.04.007","article-title":"Adenosine induces apoptosis in human liver cancer cells through ROS production and mitochondrial dysfunction","volume":"448","author":"Ma","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bioorg.2026.109769_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-05775-3","article-title":"TIPE3 represses head and neck squamous cell carcinoma progression via triggering PGAM5 mediated mitochondria dysfunction","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.bioorg.2026.109769_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/biom14060695","article-title":"Prostate Cancer-specific lysine 53 acetylation of cytochrome c drives metabolic reprogramming and protects from apoptosis in intact cells","volume":"14","author":"Morse","year":"2024","journal-title":"Biomolecules"},{"issue":"11","key":"10.1016\/j.bioorg.2026.109769_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27113513","article-title":"Natural products in preventing tumor drug resistance and related signaling pathways","volume":"27","author":"Yang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.109769_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154669","article-title":"Label-free-based quantitative proteomic analysis of the inhibition of cisplatin-resistant ovarian cancer cell proliferation by cucurbitacin B","volume":"111","author":"Yin","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.109769_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217116","article-title":"Natural products reverse cisplatin resistance in the hypoxic tumor microenvironment","volume":"598","author":"Yang","year":"2024","journal-title":"Cancer Lett."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826003056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826003056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:37:09Z","timestamp":1776105429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826003056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":39,"alternative-id":["S0045206826003056"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109769","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dimethyl bisphenolate inhibits ovarian cancer growth by regulating the PI3K\/AKT\/mTOR signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109769","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109769"}}