{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:15:35Z","timestamp":1788221735160,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008048","name":"Nanjing University","doi-asserted-by":"publisher","award":["SKLCC2506"],"award-info":[{"award-number":["SKLCC2506"]}],"id":[{"id":"10.13039\/501100008048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["25B150034"],"award-info":[{"award-number":["25B150034"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["262102230097"],"award-info":[{"award-number":["262102230097"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011245","name":"State Key Laboratory of Coordination Chemistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22107050"],"award-info":[{"award-number":["22107050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bioorg.2026.109781","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T15:52:09Z","timestamp":1774108329000},"page":"109781","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Cyclic peptide-decorated PtIV-DCA prodrug triggers ferroptosis in glioblastoma via the disruption of energy metabolism"],"prefix":"10.1016","volume":"175","author":[{"given":"Haisheng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoshui","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyue","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109781_bb0005","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41571-020-00447-z","article-title":"EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood","volume":"18","author":"Weller","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioorg.2026.109781_bb0010","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1124\/pr.117.014944","article-title":"Current challenges and opportunities in treating glioblastoma","volume":"70","author":"Shergalis","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bioorg.2026.109781_bb0015","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.apsb.2021.12.019","article-title":"Therapeutic strategies of glioblastoma (GBM): the current advances in the molecular targets and bioactive small molecule compounds","volume":"12","author":"Liu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2026.109781_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2019.101896","article-title":"Molecular targeted therapy of glioblastoma","volume":"80","author":"Le Rhun","year":"2019","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.bioorg.2026.109781_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2024.100985","article-title":"Advancing glioblastoma treatment by targeting metabolism","volume":"51","author":"Zhao","year":"2024","journal-title":"Neoplasia"},{"key":"10.1016\/j.bioorg.2026.109781_bb0030","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1476-4598-12-152","article-title":"Tumor glycolysis as a target for cancer therapy: progress and prospects","volume":"12","author":"Ganapathy-Kanniappan","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bioorg.2026.109781_bb0035","doi-asserted-by":"crossref","first-page":"1522392","DOI":"10.3389\/fimmu.2024.1522392","article-title":"Targeting glycolysis: exploring a new frontier in glioblastoma therapy","volume":"15","author":"Yang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioorg.2026.109781_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217156","article-title":"Glycolysis, the sweet appetite of the tumor microenvironment","volume":"600","author":"Kooshan","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.109781_bb0045","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.semcancer.2022.09.007","article-title":"Tumor glycolysis, an essential sweet tooth of tumor cells","volume":"86","author":"Paul","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bioorg.2026.109781_bb0050","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejmech.2016.04.003","article-title":"Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: another tools to fight glioblastoma","volume":"118","author":"Sestito","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109781_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104511","article-title":"Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy","volume":"150","author":"Abdel-Wahab","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioorg.2026.109781_bb0060","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13046-015-0183-0","article-title":"Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways","volume":"34","author":"Pan","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bioorg.2026.109781_bb0065","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/s41556-024-01429-4","article-title":"Mitochondria and cell death","volume":"26","author":"Glover","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.109781_bb0070","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41568-018-0038-z","article-title":"Every step of the way: integrins in cancer progression and metastasis","volume":"18","author":"Hamidi","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bioorg.2026.109781_bb0075","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1021\/acs.jmedchem.1c00350","article-title":"New Thyrointegrin \u03b1v\u03b23 antagonist with a scalable synthesis, brain penetration, and potent activity against glioblastoma Multiforme","volume":"64","author":"Hay","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109781_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106694","article-title":"The challenges and opportunities of \u03b1v\u03b23-based therapeutics in cancer: from bench to clinical trials","volume":"189","author":"Gu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioorg.2026.109781_bb0085","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ccr.2017.11.014","article-title":"Platinum coordination compounds with potent anticancer activity","volume":"375","author":"Deo","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109781_bb0090","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","article-title":"The next generation of platinum drugs: targeted Pt(II) agents, nanoparticle delivery, and Pt(IV) prodrugs","volume":"116","author":"Johnstone","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109781_bb0095","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1021\/acs.chemrev.8b00209","article-title":"Stimuli-responsive therapeutic Metallodrugs","volume":"119","author":"Wang","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109781_bb0100","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.3390\/ijms22105111","article-title":"Revisiting platinum-based anticancer drugs to overcome gliomas","volume":"22","author":"Jeon","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109781_bb0105","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1039\/C5SC04049C","article-title":"Glutathione boosting the cytotoxicity of a magnetic platinum(IV) nano-prodrug in tumor cells","volume":"7","author":"Zhu","year":"2016","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioorg.2026.109781_bb0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41568-020-00308-y","article-title":"The rediscovery of platinum-based cancer therapy","volume":"21","author":"Rottenberg","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bioorg.2026.109781_bb0115","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1021\/acs.inorgchem.9b00708","article-title":"Targeting energy metabolism by a platinum(IV) prodrug as an alternative pathway for cancer suppression","volume":"58","author":"Jin","year":"2019","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109781_bb0120","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioorg.2026.109781_bb0125","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1021\/acscentsci.4c01941","article-title":"Cellular discrepancy of platinum complexes in interfering with mitochondrial DNA","volume":"11","author":"Jin","year":"2025","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.bioorg.2026.109781_bb0130","first-page":"941","article-title":"mtDNA mutations help support Cancer cells","volume":"1","author":"Prag","year":"2020","journal-title":"Nat. Can."},{"key":"10.1016\/j.bioorg.2026.109781_bb0135","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.cmet.2024.07.011","article-title":"Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma","volume":"36","author":"Li","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.bioorg.2026.109781_bb0140","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/cac2.12549","article-title":"The regulatory roles and clinical significance of glycolysis in tumor","volume":"44","author":"Qiao","year":"2024","journal-title":"Cancer Commun."},{"key":"10.1016\/j.bioorg.2026.109781_bb0145","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioorg.2026.109781_bb0150","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.109781_bb0155","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioorg.2026.109781_bb0160","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/8464817","article-title":"Capsaicin enhances temozolomide-resistant glioblastoma cells'chemosensitivity and ferroptosis through FHOD1\/IRF2 downregulation","volume":"2024","author":"Hacioglu","year":"2024","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.bioorg.2026.109781_bb0165","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.bioorg.2026.109781_bb0170","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41419-023-06045-y","article-title":"The diversified role of mitochondria in ferroptosis in cancer","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.109781_bb0175","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s11011-025-01729-0","article-title":"Ferroptosis-inducing effects of cromolyn in microglia through NCOA4-mediated ferritinophagy","volume":"40","author":"Kilic","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bioorg.2026.109781_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108767","article-title":"PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis","volume":"34","author":"Song","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.bioorg.2026.109781_bb0185","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70529","article-title":"Boric acid suppresses glioblastoma cellular survival by regulating ferroptosis via SOX10\/GPx4\/ACSL4 signalling and iron metabolism","volume":"29","author":"Kilic","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioorg.2026.109781_bb0190","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10555-021-09987-x","article-title":"Multiprong control of glioblastoma multiforme invasiveness: blockade of pro-inflammatory signaling, anti-angiogenesis, and homeostasis restoration","volume":"40","author":"Bazan","year":"2021","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bioorg.2026.109781_bb0195","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70578","article-title":"Boric acid induces oxidative damage and apoptosis through SEMA3A\/PLXNA1\/NRP1 signalling pathway in U251 glioblastoma cell","volume":"29","author":"Kar","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioorg.2026.109781_bb0200","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12929-024-01060-3","article-title":"Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage","volume":"31","author":"Kotani","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bioorg.2026.109781_bb0205","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70474","article-title":"Notch1 and major vault proteins modulate temozolomide resistance in glioblastoma","volume":"29","author":"Tuncer","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioorg.2026.109781_bb0210","doi-asserted-by":"crossref","first-page":"8327","DOI":"10.1039\/D3SC01874A","article-title":"Regulating tumor glycometabolism and the immune microenvironment by inhibiting lactate dehydrogenase with platinum(IV) complexes","volume":"14","author":"Jin","year":"2023","journal-title":"Chem. Sci."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826003172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826003172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:55:40Z","timestamp":1786020940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826003172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":42,"alternative-id":["S0045206826003172"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109781","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclic peptide-decorated PtIV-DCA prodrug triggers ferroptosis in glioblastoma via the disruption of energy metabolism","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109781","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109781"}}