{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:27:03Z","timestamp":1789619223780,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010338","name":"Chongqing Normal University","doi-asserted-by":"publisher","award":["19XLB006"],"award-info":[{"award-number":["19XLB006"]}],"id":[{"id":"10.13039\/100010338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bioorg.2026.109801","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:35:43Z","timestamp":1774542943000},"page":"109801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Discovery of garlic-derived peptides as natural DPP4 inhibitors: An integrated computational, network pharmacology, and in situ evaluation approach"],"prefix":"10.1016","volume":"175","author":[{"given":"Luyao","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2023","key":"10.1016\/j.bioorg.2026.109801_bb0005","first-page":"203","article-title":"Diabetes collaborators, global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global burden of disease study 2021","volume":"402","author":"GBD","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2026.109801_bb0010","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.2337\/dbi16-0023","article-title":"DPP-4 inhibition and the known unknown","volume":"65","author":"Horowitz","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.bioorg.2026.109801_bb0015","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1007\/s00125-019-4963-5","article-title":"The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice","volume":"62","author":"Hutch","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.bioorg.2026.109801_bb0020","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.2147\/DDDT.S426870","article-title":"Levita, pharmacological and clinical studies of medicinal plants that inhibit dipeptidyl peptidase-IV","volume":"17","author":"Rohani","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bioorg.2026.109801_bb0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s13596-018-0347-5","article-title":"Bioactive extract of artemisia judaica causes in vitro inhibition of dipeptidyl peptidase IV and pancreatic\/intestinal enzymes of the carbohydrate absorption cascade: implication for anti-diabetic new molecular entities (NMEs)","volume":"19","author":"Bhat","year":"2019","journal-title":"Orient Pharm Exp Med"},{"key":"10.1016\/j.bioorg.2026.109801_bb0030","first-page":"190","article-title":"Dipeptidyl peptidase IV inhibitory activity of fraction from white tea ethanolic extract (camellia sinensis (L.) kuntze) ex vivo","volume":"10","author":"Ekayanti","year":"2017","journal-title":"Pharm. J."},{"key":"10.1016\/j.bioorg.2026.109801_bb0035","doi-asserted-by":"crossref","unstructured":"B. Elya, R. Handayani, R. Sauriasari, A., U.S. Hasyyati, I.T. Permana, Y.I. Permatasar, Antidiabetic activity and phytochemical screening of extracts from indonesian plants by inhibition of alpha amylase, alpha glucosidase and dipeptidyl peptidase IV, Pak. J. Biol. Sci. 18 (2015) 279\u2013284. Doi: https:\/\/doi.org\/10.3923\/pjbs.2015.279.284.","DOI":"10.3923\/pjbs.2015.279.284"},{"key":"10.1016\/j.bioorg.2026.109801_bb0040","doi-asserted-by":"crossref","unstructured":"Y. Purnomo, D.W. Soeatmadji, S.B. Sumitro, M.A. Widodo, Anti-diabetic potential of urena lobata leaf extract through inhibition of dipeptidyl peptidase IV activity, Asian Pac. J. Trop. Biomed. 5 (2015) 645\u2013649. Doi: https:\/\/doi.org\/10.1016\/j.apjtb.2015.05.014.","DOI":"10.1016\/j.apjtb.2015.05.014"},{"key":"10.1016\/j.bioorg.2026.109801_bb0045","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.3390\/su12072892","article-title":"Understanding global food surplus and food waste to tackle economic and environmental sustainability","volume":"12","author":"Huang","year":"2020","journal-title":"Sustainability"},{"key":"10.1016\/j.bioorg.2026.109801_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130647","article-title":"Sweet-flavored peptides with biological activities from mulberry seed protein treated by multifrequency countercurrent ultrasonic technology","volume":"367","author":"Bian","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0055","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s10989-018-9713-x","article-title":"Production and identification of biologically active peptides derived from by-product of hen egg-yolk phospholipid extraction","volume":"25","author":"Ewelina Eckert","year":"2019","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.bioorg.2026.109801_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134793","article-title":"Production and identification of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from discarded cowhide collagen","volume":"405","author":"He","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127096","article-title":"Production and identification of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from discarded sardine pilchardus protein","volume":"328","author":"Rivero-Pino","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0070","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.chroma.2015.07.032","article-title":"Identification by hydrophilic interaction and reversed-phase liquid chromatography-tandem mass spectrometry of peptides with antioxidant capacity in food residues","volume":"1428","author":"V\u00e1squez-Villanueva","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.bioorg.2026.109801_bb0075","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1039\/D3FO05423C","article-title":"Identification, rapid screening, docking mechanism and in vitro digestion stability of novel DPP-4 inhibitory peptides from wheat gluten with ginger protease","volume":"15","author":"Pu","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.bioorg.2026.109801_bb0080","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1021\/acs.jafc.5b05429","article-title":"Dipeptidyl peptidase IV-inhibitory peptides derived from silver carp (hypophthalmichthys molitrix val.) proteins","volume":"64","author":"Zhang","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocs.2020.101186","article-title":"Target recognition and network pharmacology for revealing anti-diabetes mechanisms of natural product","volume":"45","author":"Wang","year":"2020","journal-title":"J. Comput. Sci."},{"key":"10.1016\/j.bioorg.2026.109801_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.104036","article-title":"Exploration of novel DPP-IV inhibitory peptides from discarded eggshell membrane: an integrated in silico and in vitro study","volume":"59","author":"Zhu","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.bioorg.2026.109801_bb0095","first-page":"6206","article-title":"Separation and purification of antioxidant peptides from idesia polycarpa maxim. Cake meal and study of conformational relationship between them, food sci","volume":"12","author":"Dou","year":"2024","journal-title":"Nutr"},{"key":"10.1016\/j.bioorg.2026.109801_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137537","article-title":"Two novel angiotensin I-converting enzyme inhibitory peptides from garlic protein: in silico screening, stability, antihypertensive effects in vivo and underlying mechanisms","volume":"435","author":"Xiang","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0105","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.3390\/molecules28073098","article-title":"Structural characterization, cytotoxicity, and the antifungal mechanism of a novel peptide extracted from garlic (allium sativa L.)","volume":"28","author":"Li","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.109801_bb0110","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/cbdd.13831","article-title":"A novel peptide isolated from garlic shows anticancer effect against leukemic cell lines via interaction with bcl-2 family proteins","volume":"97","author":"Rasaratnam","year":"2021","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bioorg.2026.109801_bb0115","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1021\/acs.jafc.3c00603","article-title":"Identification of novel dipeptidyl peptidase-IV inhibitory peptides in chickpea protein hydrolysates","volume":"71","author":"Zan","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144530","article-title":"Preparation, identification, and molecular mechanism of novel DPP-IV inhibitory peptides from pumpkin seed: in silico screening and experimental validation","volume":"486","author":"Chen","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.104592","article-title":"Isolation and characterization of DPP-IV inhibitory peptide from rabbit meat hydrolysate: mechanism, gastrointestinal resistance, and hypoglycemic effects of leucyl-leucine (LL)","volume":"61","author":"Hu","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.bioorg.2026.109801_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2023.103374","article-title":"Identification of novel dipeptidyl peptidase-4 inhibitory peptides from pea proteins: a combined in silico and in vitro study","volume":"56","author":"Zhang","year":"2023","journal-title":"Food Biosci."},{"key":"10.1016\/j.bioorg.2026.109801_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2025.107233","article-title":"Characterization and efficient screening of natural DPP-IV inhibitory peptides from Huizhou dry-cured ham: in silico and in vitro studies","volume":"140","author":"Xu","year":"2025","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.bioorg.2026.109801_bb0140","doi-asserted-by":"crossref","first-page":"10020","DOI":"10.1021\/acs.jafc.7b04043","article-title":"High-throughput and rapid screening of novel ACE inhibitory peptides from sericin source and inhibition mechanism by using in silico and in vitro prescriptions","volume":"65","author":"Sun","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131070","article-title":"Screening and mechanisms of novel angiotensin-I-converting enzyme inhibitory peptides from rabbit meat proteins: a combined in silico and in vitro study","volume":"370","author":"Chen","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139297","article-title":"Identification and molecular mechanisms of novel antioxidant peptides from fermented broad bean paste: a combined in silico and in vitro study","volume":"450","author":"Lin","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2023.103374","article-title":"Identification of novel dipeptidyl peptidase-4 inhibitory peptides from pea proteins: a combined in silico and in vitro study","volume":"56","author":"Zhang","year":"2023","journal-title":"Food Biosci."},{"key":"10.1016\/j.bioorg.2026.109801_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2023.100446","article-title":"Antidiabetic effects of protein hydrolysates from trachinotus ovatus and identification and screening of peptides with \u03b1-amylase and DPP-IV inhibitory activities","volume":"6","author":"Wan","year":"2023","journal-title":"Curr Res Food Sci"},{"key":"10.1016\/j.bioorg.2026.109801_bb0165","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1093\/bib\/bby077","article-title":"Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods","volume":"20","author":"Li","year":"2019","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.bioorg.2026.109801_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112317","article-title":"Comparison of physicochemical and umami characterization of aqueous and ethanolic takifugu obscurus muscle extracts","volume":"154","author":"Wang","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bioorg.2026.109801_bb0175","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1039\/C5FO01324K","article-title":"In silico, in vitro and in vivo analyses of dipeptidyl peptidase IV inhibitory activity and the antidiabetic effect of sodium caseinate hydrolysate","volume":"7","author":"Hsieh","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.bioorg.2026.109801_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2021.122990","article-title":"Purification, identification and molecular mechanism of dipeptidyl peptidase IV inhibitory peptides from discarded shrimp (penaeus vannamei) head","volume":"1186","author":"Xiang","year":"2021","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bioorg.2026.109801_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109161","article-title":"Identification of novel DPP-IV inhibitory peptides from Atlantic salmon (salmo Salar) skin","volume":"133","author":"Jin","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.bioorg.2026.109801_bb0190","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1021\/acs.jafc.1c08225","article-title":"Exploration of dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides from silkworm pupae (bombyx mori) proteins based on in silico and in vitro assessments","volume":"70","author":"Luo","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0195","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1021\/acs.jafc.1c04484","article-title":"Analysis of the structure and activity of dipeptidyl peptidase IV (DPP-IV) inhibitory oligopeptides from sorghum kafirin","volume":"70","author":"Dai","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0200","article-title":"Preparation and identification of dipeptidyl peptidase IV inhibitory peptides from quinoa protein, food res","volume":"156","author":"You","year":"2022","journal-title":"Int. (Ott. Ont,)"},{"key":"10.1016\/j.bioorg.2026.109801_bb0205","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3390\/nu10081082","article-title":"Soybean- and lupin-derived peptides inhibit DPP-IV activity on in situ human intestinal caco-2 cells and ex vivo human serum","volume":"10","author":"Lammi","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.bioorg.2026.109801_bb0210","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.3390\/foods11223626","article-title":"Tenebrio molitor proteins-derived DPP-4 inhibitory peptides: preparation, identification, and molecular binding mechanism","volume":"11","author":"Tan","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.bioorg.2026.109801_bb0215","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nsb882","article-title":"Crystal structure of human dipeptidyl peptidase IV\/CD26 in complex with a substrate analog","volume":"10","author":"Rasmussen","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.bioorg.2026.109801_bb0220","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1110\/ps.03460604","article-title":"Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation","volume":"13","author":"Aertgeerts","year":"2004","journal-title":"Protein Sci."},{"key":"10.1016\/j.bioorg.2026.109801_bb0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev.biophys.36.040306.132550","article-title":"Calculation of protein-ligand binding affinities","volume":"36","author":"Gilson","year":"2007","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1016\/j.bioorg.2026.109801_bb0230","doi-asserted-by":"crossref","DOI":"10.1063\/1.1887165","article-title":"Substrate concentration dependence of the diffusion-controlled steady-state rate constant","volume":"122","author":"Dzubiella","year":"2005","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bioorg.2026.109801_bb0235","unstructured":"V. Vermeirssen, P. Augustijns, N. Morel, J.V. Camp, A. Opsomer, W. Verstraete, In vitro intestinal transport and antihypertensive activity of ACE inhibitory pea and whey digests, (n.d.) 0\u201316."},{"key":"10.1016\/j.bioorg.2026.109801_bb0240","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/jn\/137.4.953","article-title":"Angiotensin converting enzyme inhibitory peptides from a lactotripeptide-enriched milk beverage are absorbed intact into the Circulation1","volume":"137","author":"Foltz","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.bioorg.2026.109801_bb0245","doi-asserted-by":"crossref","DOI":"10.1111\/j.1750-3841.2011.02455.x","article-title":"Food protein-derived bioactive peptides: production, processing, and potential health benefits","volume":"77","author":"Udenigwe","year":"2012","journal-title":"J. Food Sci."},{"key":"10.1016\/j.bioorg.2026.109801_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2025.106030","article-title":"Evaluation of novel angiotensin I-converting enzyme and dipeptidyl peptidase IV inhibitory peptides derived from yak milk based on peptidomics and network pharmacology","volume":"67","author":"Lan","year":"2025","journal-title":"Food Biosci."},{"key":"10.1016\/j.bioorg.2026.109801_bb0255","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3390\/md22080361","article-title":"The discovery and characterization of a potent DPP-IV inhibitory peptide from oysters for the treatment of type 2 diabetes based on computational and experimental studies","volume":"22","author":"Chen","year":"2024","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bioorg.2026.109801_bb0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0240873","article-title":"Network pharmacology of bioactives from sorghum bicolor with targets related to diabetes mellitus","volume":"15","author":"Oh","year":"2020","journal-title":"PloS One"},{"key":"10.1016\/j.bioorg.2026.109801_bb0265","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1186\/s12859-018-2449-y","article-title":"Benchmarking of different molecular docking methods for protein-peptide docking","volume":"19","author":"Agrawal","year":"2019","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.bioorg.2026.109801_bb0270","doi-asserted-by":"crossref","unstructured":"L.G. Trabuco, S. Lise, E. Petsalaki, R.B. Russell, PepSite: Prediction of peptide-binding sites from protein surfaces, (n.d.). Doi: https:\/\/doi.org\/10.1093\/nar\/gks398.","DOI":"10.1093\/nar\/gks398"},{"key":"10.1016\/j.bioorg.2026.109801_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.105766","article-title":"Identification and molecular mechanism of a novel DPP-IV inhibitory tetrapeptide IPVK from rabbit meat proteins: insights from in silico study and experimental validation","volume":"63","author":"Hu","year":"2025","journal-title":"Food Biosci."},{"key":"10.1016\/j.bioorg.2026.109801_bb0280","article-title":"Influence of peptide characteristics on their stability, intestinal transport, and in vitro bioavailability: a review","volume":"43","author":"Wang","year":"2019","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0285","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.109801_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.143067","article-title":"Identification and characterization of two novel dipeptidyl peptidase-IV inhibitory peptides from the simulated gastrointestinal digestion of tartary buckwheat proteins","volume":"473","author":"Wu","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0295","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1021\/acs.jafc.3c00603","article-title":"Identification of novel dipeptidyl peptidase-IV inhibitory peptides in chickpea protein hydrolysates","volume":"71","author":"Zan","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.109801_bb0300","doi-asserted-by":"crossref","unstructured":"N. Shekoohi, P. Harnedy-Rothwell, S. Sharkey, R. Lafferty, N. Khatib, F. O' Harte, R.J. FitzGerald, Purification and characterization of multifunctional peptides with in situ insulinotropic and antioxidative activity from a blue whiting (micromesistius poutassou) protein hydrolysate, J. Funct. Foods 116 (2024) 106173. Doi: https:\/\/doi.org\/10.1016\/j.jff.2024.106173.","DOI":"10.1016\/j.jff.2024.106173"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826003378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826003378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:56:58Z","timestamp":1776121018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826003378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":60,"alternative-id":["S0045206826003378"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109801","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of garlic-derived peptides as natural DPP4 inhibitors: An integrated computational, network pharmacology, and in situ evaluation approach","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109801"}}