{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T15:47:41Z","timestamp":1776181661573,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903449"],"award-info":[{"award-number":["81903449"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bioorg.2026.109814","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T20:19:57Z","timestamp":1774815597000},"page":"109814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development of membrane-targeting honokiol derivatives as antibacterial agents against gram-positive bacteria"],"prefix":"10.1016","volume":"175","author":[{"given":"Jinqian","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yandong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinhu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6474","key":"10.1016\/j.bioorg.2026.109814_bb0005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.aay3041","article-title":"Effect of tolerance on the evolution of antibiotic resistance under drug combinations","volume":"367","author":"Liu","year":"2020","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.bioorg.2026.109814_bb0010","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41575-021-00449-x","article-title":"Helicobacter pylori infection and antibiotic resistance - from biology to clinical implications","volume":"18","author":"Tshibangu-Kabamba","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bioorg.2026.109814_bb0015","article-title":"The 2024 political declaration on antimicrobial resistance needs bold targets","volume":"386","author":"Tangcharoensathien","year":"2024","journal-title":"Bmj"},{"key":"10.1016\/j.bioorg.2026.109814_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101143","article-title":"Revolutionising infection control: building the next generation of phage banks","volume":"77","author":"Wahid","year":"2024","journal-title":"Drug Resist. Updat."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109814_bb0025","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cmi.2022.10.018","article-title":"Antibiotic heteroresistance in ESKAPE pathogens, from bench to bedside","volume":"29","author":"Roch","year":"2023","journal-title":"Clin. Microbiol. Infect."},{"issue":"8056","key":"10.1016\/j.bioorg.2026.109814_bb0030","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/s41586-025-08608-9","article-title":"Clonal candida auris and ESKAPE pathogens on the skin of residents of nursing homes","volume":"639","author":"Proctor","year":"2025","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bioorg.2026.109814_bb0035","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.jiph.2021.10.020","article-title":"Antibiotic resistance in microbes: history, mechanisms, therapeutic strategies and future prospects","volume":"14","author":"Uddin","year":"2021","journal-title":"J. Infect. Public Health"},{"issue":"10","key":"10.1016\/j.bioorg.2026.109814_bb0040","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00203-024-04133-x","article-title":"Antimicrobial peptide-based strategies to overcome antimicrobial resistance","volume":"206","author":"Girdhar","year":"2024","journal-title":"Arch. Microbiol."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109814_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanmic.2024.100992","article-title":"Addressing urgent priorities in antibiotic development: insights from WHO 2023 antibacterial clinical pipeline analyses","volume":"6","author":"Melchiorri","year":"2025","journal-title":"Lancet. Microbe."},{"issue":"19","key":"10.1016\/j.bioorg.2026.109814_bb0050","doi-asserted-by":"crossref","first-page":"20081","DOI":"10.1021\/acs.jmedchem.5c00922","article-title":"Fluorinated modification as a simple strategy that effectively enhances the stability and activity of antimicrobial peptides","volume":"68","author":"Ouyang","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109814_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116072","article-title":"Antimicrobial peptides: An alternative to traditional antibiotics","volume":"265","author":"Ji","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"11","key":"10.1016\/j.bioorg.2026.109814_bb0060","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41579-025-01200-y","article-title":"Antimicrobial peptides: structure, functions and translational applications","volume":"23","author":"Oliveira J\u00fanior","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"issue":"11","key":"10.1016\/j.bioorg.2026.109814_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24119451","article-title":"Creation of new antimicrobial peptides","volume":"24","author":"Galzitskaya","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.bioorg.2026.109814_bb0070","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1039\/D4TB00260A","article-title":"Antimicrobial therapy based on self-assembling peptides","volume":"12","author":"Wang","year":"2024","journal-title":"J. Mater. Chem. B"},{"issue":"24","key":"10.1016\/j.bioorg.2026.109814_bb0075","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.4155\/fmc-2022-0160","article-title":"Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review","volume":"14","author":"Hellewell","year":"2022","journal-title":"Future Med. Chem."},{"issue":"45","key":"10.1016\/j.bioorg.2026.109814_bb0080","doi-asserted-by":"crossref","first-page":"41800","DOI":"10.1021\/jacs.5c14236","article-title":"Bacterial phospholipid-inducible Helix-transformable antimicrobial polypeptides","volume":"147","author":"Zhang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"20","key":"10.1016\/j.bioorg.2026.109814_bb0085","doi-asserted-by":"crossref","first-page":"21318","DOI":"10.1021\/acs.jmedchem.5c01188","article-title":"Effects of halogen substitution on the antibiotic characteristics of conjugated oligoelectrolytes","volume":"68","author":"Limwongyut","year":"2025","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.bioorg.2026.109814_bb0090","doi-asserted-by":"crossref","first-page":"22484","DOI":"10.1021\/acs.jmedchem.5c01462","article-title":"Beyond the \"2 + 2 pharmacophore\" electronic and hydrophobic effects control the activity of cationic amphiphilic antimicrobial 2,5-Diketopiperazines","volume":"68","author":"Siu","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109814_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116969","article-title":"Development of membrane-targeting chalcone derivatives as antibacterial agents against multidrug-resistant bacteria","volume":"280","author":"Yang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2026.109814_bb0100","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1021\/acs.jmedchem.4c03167","article-title":"Development of membrane-targeting osthole derivatives containing pyridinium quaternary ammonium moieties with potent anti-methicillin-resistant staphylococcus aureus properties","volume":"68","author":"Xu","year":"2025","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.bioorg.2026.109814_bb0105","doi-asserted-by":"crossref","first-page":"22047","DOI":"10.1021\/acs.jmedchem.5c02054","article-title":"Cheap, fast, safe, sustainable, and positively irresistible: the future of cationic amphiphilic disinfectant development","volume":"68","author":"Hedges","year":"2025","journal-title":"J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2026.109814_bb0110","article-title":"Development of Xanthoangelol-derived compounds with membrane-disrupting effects against gram-positive bacteria","volume":"13","author":"Yang","year":"2024","journal-title":"Antibiotics (Basel)"},{"issue":"10","key":"10.1016\/j.bioorg.2026.109814_bb0115","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1021\/ar700270t","article-title":"Ceragenins: Cholic acid-based mimics of antimicrobial peptides","volume":"41","author":"Lai","year":"2008","journal-title":"Acc. Chem. Res."},{"issue":"6","key":"10.1016\/j.bioorg.2026.109814_bb0120","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.copbio.2008.10.013","article-title":"De novo designed synthetic mimics of antimicrobial peptides","volume":"19","author":"Scott","year":"2008","journal-title":"Curr. Opin. Biotechnol."},{"issue":"4","key":"10.1016\/j.bioorg.2026.109814_bb0125","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1021\/jm401680a","article-title":"Small molecular antibacterial peptoid mimics: the simpler the better!","volume":"57","author":"Ghosh","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109814_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114593","article-title":"Design, synthesis, and biological evaluation of membrane-active honokiol derivatives as potent antibacterial agents","volume":"240","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109814_bb0135","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.biopha.2018.08.054","article-title":"Honokiol: An anticancer lignan","volume":"107","author":"Rauf","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2026.109814_bb0140","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jneuroim.2018.07.013","article-title":"Anti-inflammatory properties of honokiol in activated primary microglia and astrocytes","volume":"323","author":"Rickert","year":"2018","journal-title":"J. Neuroimmunol."},{"issue":"4","key":"10.1016\/j.bioorg.2026.109814_bb0145","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.pharep.2018.01.003","article-title":"Protective and therapeutic activity of honokiol in reversing motor deficits and neuronal degeneration in the mouse model of parkinson's disease","volume":"70","author":"Chen","year":"2018","journal-title":"Pharmacol. Rep."},{"issue":"18","key":"10.1016\/j.bioorg.2026.109814_bb0150","doi-asserted-by":"crossref","first-page":"16858","DOI":"10.1021\/acs.jmedchem.4c01860","article-title":"Membrane-targeting amphiphilic honokiol derivatives containing an oxazole moiety as potential antibacterials against methicillin-resistant staphylococcus aureus","volume":"67","author":"Yang","year":"2024","journal-title":"J. Med. Chem."},{"issue":"17","key":"10.1016\/j.bioorg.2026.109814_bb0155","doi-asserted-by":"crossref","first-page":"12903","DOI":"10.1021\/acs.jmedchem.1c01073","article-title":"Development of membrane-active Honokiol\/Magnolol amphiphiles as potent antibacterial agents against methicillin-resistant staphylococcus aureus (MRSA)","volume":"64","author":"Guo","year":"2021","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2026.109814_bb0160","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.bmcl.2017.06.022","article-title":"Design, synthesis and antibacterial evaluation of honokiol derivatives","volume":"28","author":"Wu","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109814_bb0165","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/acsinfecdis.9b00190","article-title":"A bisphenolic honokiol analog outcompetes oral antimicrobial agent cetylpyridinium chloride via a membrane-associated mechanism","volume":"6","author":"Ochoa","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bioorg.2026.109814_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.129949","article-title":"Design, synthesis, and evaluation of pyranochromene derivatives as membrane targeting antibacterials against gram-positive bacteria","volume":"113","author":"Wang","year":"2024","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"14","key":"10.1016\/j.bioorg.2026.109814_bb0175","doi-asserted-by":"crossref","first-page":"9894","DOI":"10.1021\/acs.jmedchem.1c00312","article-title":"Modular design of membrane-active antibiotics: from macromolecular antimicrobials to small scorpionlike peptidomimetics","volume":"64","author":"Wang","year":"2021","journal-title":"J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2026.109814_bb0180","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1007\/s00253-019-09698-y","article-title":"Melittin: from honeybees to superbugs","volume":"103","author":"Memariani","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bioorg.2026.109814_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116784","article-title":"Design, synthesis and biological evaluation of amphiphilic benzopyran derivatives as potent antibacterial agents against multidrug-resistant bacteria","volume":"277","author":"Liu","year":"2024","journal-title":"Eur. J. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826003500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826003500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:51:01Z","timestamp":1776178261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826003500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":37,"alternative-id":["S0045206826003500"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109814","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of membrane-targeting honokiol derivatives as antibacterial agents against gram-positive bacteria","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109814"}}