{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:25:52Z","timestamp":1777681552132,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2024MC135"],"award-info":[{"award-number":["ZR2024MC135"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2023MB046"],"award-info":[{"award-number":["ZR2023MB046"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22201165"],"award-info":[{"award-number":["22201165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204240"],"award-info":[{"award-number":["82204240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bioorg.2026.109865","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:26:44Z","timestamp":1776284804000},"page":"109865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Discovery of novel tert-butylhydroquinone derivatives as potential anti-endothelial injury agents: Synthesis, in vitro, and in vivo evaluation"],"prefix":"10.1016","volume":"176","author":[{"given":"Juan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Qi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Zhu","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-He","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kong-Kai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Shi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109865_bb0005","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41569-021-00668-4","volume":"19","author":"Engelen","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bioorg.2026.109865_bb0010","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/joim.12605","volume":"281","author":"Tesauro","year":"2017","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bioorg.2026.109865_bb0015","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1124\/pharmrev.120.000096","volume":"73","author":"Xu","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bioorg.2026.109865_bb0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12929-019-0551-8","volume":"26","author":"Lee","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bioorg.2026.109865_bb0025","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.toxrep.2022.04.027","volume":"9","author":"Khezerlou","year":"2022","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.bioorg.2026.109865_bb0030","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/502564","volume":"2010","author":"Jin","year":"2010","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bioorg.2026.109865_bb0035","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbalip.2013.09.004","volume":"1841","author":"Li","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bioorg.2026.109865_bb0040","volume":"2016","author":"Ye","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bioorg.2026.109865_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2017.08.018","volume":"281","author":"Bai","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bioorg.2026.109865_bb0050","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cbi.2017.05.021","volume":"273","author":"Xu","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bioorg.2026.109865_bb0055","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bcp.2010.03.004","volume":"80","author":"Yan","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109865_bb0060","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.freeradbiomed.2019.01.016","volume":"134","author":"Schmidlin","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioorg.2026.109865_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102793","volume":"64","author":"Sun","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioorg.2026.109865_bb0070","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1046\/j.1365-2443.2003.00640.x","volume":"8","author":"Itoh","year":"2003","journal-title":"Genes Cells"},{"key":"10.1016\/j.bioorg.2026.109865_bb0075","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev-pharmtox-052220-104025","volume":"62","author":"Torrente","year":"2022","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bioorg.2026.109865_bb0080","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.redox.2017.03.029","volume":"12","author":"Silva-Palacios","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioorg.2026.109865_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113117","volume":"152","author":"Dai","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2026.109865_bb0090","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1302\/2046-3758.1011.BJR-2020-0242.R4","volume":"10","author":"Zhang","year":"2021","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.bioorg.2026.109865_bb0095","volume":"2020","author":"Zhou","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109865_bb0100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/10641963.2016.1259322","volume":"39","author":"Zhou","year":"2017","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.bioorg.2026.109865_bb0105","volume":"1007","author":"Yuan","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109865_bb0110","volume":"2022","author":"Saito","year":"2022","journal-title":"Eur. J. Org. Chem."},{"issue":"20","key":"10.1016\/j.bioorg.2026.109865_bb0115","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1016\/j.bmcl.2017.09.013","volume":"27","author":"Song","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"23","key":"10.1016\/j.bioorg.2026.109865_bb0120","doi-asserted-by":"crossref","first-page":"17123","DOI":"10.1021\/acs.jmedchem.1c01157","volume":"64","author":"Machulkin","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109865_bb0125","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.steroids.2016.01.011","volume":"108","author":"Lei","year":"2016","journal-title":"Steroids"},{"key":"10.1016\/j.bioorg.2026.109865_bb0130","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.109865_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105606","volume":"120","author":"Xie","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109865_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155097","volume":"121","author":"Xue","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.109865_bb0145","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1089\/adt.2020.1007","volume":"19","author":"Tsui","year":"2021","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.bioorg.2026.109865_bb0150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pdpdt.2017.05.005","volume":"19","author":"Kawczyk-Krupka","year":"2017","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.bioorg.2026.109865_bb0155","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/10623329909078498","volume":"6","author":"Manduteanu","year":"1999","journal-title":"Endothelium"},{"key":"10.1016\/j.bioorg.2026.109865_bb0160","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1161\/01.ATV.18.5.842","volume":"18","author":"Nakashima","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bioorg.2026.109865_bb0165","doi-asserted-by":"crossref","first-page":"105","DOI":"10.31083\/j.fbl2703105","volume":"27","author":"Aaa Shaito","year":"2022","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.bioorg.2026.109865_bb0170","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.freeradbiomed.2020.07.026","volume":"160","author":"Bai","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioorg.2026.109865_bb0175","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/s41419-021-04054-3","volume":"12","author":"Ouyang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.109865_bb0180","volume":"2020","author":"Ma","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bioorg.2026.109865_bb0185","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1248\/bpb.32.1359","volume":"32","author":"Tan","year":"2009","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109865_bb0190","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s11658-021-00294-5","volume":"26","author":"Deng","year":"2021","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bioorg.2026.109865_bb0195","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.109865_bb0200","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2026.109865_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103066","volume":"70","author":"Zhang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioorg.2026.109865_bb0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.freeradbiomed.2019.06.001","volume":"141","author":"Li","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioorg.2026.109865_bb0215","doi-asserted-by":"crossref","first-page":"E4676","DOI":"10.1073\/pnas.1614943114","volume":"114","author":"Quinti","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioorg.2026.109865_bb0220","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1021\/jm4017174","volume":"57","author":"Zhuang","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109865_bb0225","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1038\/nprot.2007.321","volume":"2","author":"Niesen","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bioorg.2026.109865_bb0230","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/14756366.2018.1461856","volume":"33","author":"Jiang","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109865_bb0235","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1021\/jm5000529","volume":"57","author":"Jiang","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109865_bb0240","author":"Zhang","year":"2025","journal-title":"Mol. Divers."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826004013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826004013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:40:15Z","timestamp":1777452015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826004013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":48,"alternative-id":["S0045206826004013"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109865","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel tert-butylhydroquinone derivatives as potential anti-endothelial injury agents: Synthesis, in vitro, and in vivo evaluation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109865","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109865"}}