{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:41:22Z","timestamp":1788496882797,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960777"],"award-info":[{"award-number":["81960777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007846","name":"Yunnan Province Department of Education","doi-asserted-by":"publisher","award":["2026Y0633"],"award-info":[{"award-number":["2026Y0633"]}],"id":[{"id":"10.13039\/501100007846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202101AZ070001-055"],"award-info":[{"award-number":["202101AZ070001-055"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202101AZ070001-326"],"award-info":[{"award-number":["202101AZ070001-326"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2019FF002-005"],"award-info":[{"award-number":["2019FF002-005"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2025SS2507"],"award-info":[{"award-number":["2025SS2507"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bioorg.2026.109910","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:01:59Z","timestamp":1777305719000},"page":"109910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Exploration of novel costunolide derivatives bearing indole\/indoline as anti-ulcerative colitis agents by targeting JAK2-STAT3 pathways"],"prefix":"10.1016","volume":"178","author":[{"given":"Hengli","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109910_bb0005","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2026.109910_bb0010","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3390\/jcm11020400","article-title":"The role of innate and adaptive immune cells in the pathogenesis and development of the inflammatory response in ulcerative colitis","volume":"11","author":"Ka\u0142u\u017cna","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bioorg.2026.109910_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.immuni.2008.12.010","article-title":"Interleukin-17A and interleukin-17F: a tale of two cytokines","volume":"30","author":"Dubin","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.bioorg.2026.109910_bb0020","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.coi.2011.07.006","article-title":"Recent advances in the IL-17 cytokine family","volume":"23","author":"Gaffen","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bioorg.2026.109910_bb0025","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13075-018-1582-3","article-title":"IL-17A induces osteoblast differentiation by activating JAK2\/STAT3 in ankylosing spondylitis","volume":"20","author":"Jo","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bioorg.2026.109910_bb0030","article-title":"Integrating immunologic signaling networks: the JAK\/STAT pathway in colitis and colitis-associated cancer","volume":"4","author":"Zundler","year":"2016","journal-title":"Vaccines (Basel)."},{"key":"10.1016\/j.bioorg.2026.109910_bb0035","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.3748\/wjg.v26.i28.4055","article-title":"Differential regulation of JAK\/STAT-signaling in patients with ulcerative colitis and crohns disease","volume":"26","author":"Cordes","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bioorg.2026.109910_bb0040","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1002\/ptr.8271","article-title":"Magnoflorine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibiting JAK2\/STAT3 signaling pathway","volume":"38","author":"Wen","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bioorg.2026.109910_bb0045","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3390\/ph16020316","article-title":"Therapeutic effect of costunolide in autoimmune hepatitis: network pharmacology and experimental validation","volume":"16","author":"Huang","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bioorg.2026.109910_bb0050","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cbi.2016.03.003","article-title":"Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation","volume":"250","author":"Zheng","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bioorg.2026.109910_bb0055","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1039\/D2FO02545K","article-title":"Potential skin health promoting benefits of costunolide: a therapeutic strategy to improve skin inflammation in imiquimod-induced psoriasis","volume":"14","author":"Zhan","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.bioorg.2026.109910_bb0060","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.apsb.2022.09.014","article-title":"Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases","volume":"13","author":"Xu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2026.109910_bb0065","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1016\/j.bmcl.2006.05.083","article-title":"Synthesis of 13-amino costunolide derivatives as anticancer agents","volume":"16","author":"Srivastava","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.109910_bb0070","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/10286020.2016.1193012","article-title":"\u201cClick\u201d reaction mediated synthesis of costunolide and dehydrocostuslactone derivatives and evaluation of their cytotoxic activity","volume":"18","author":"Kumar","year":"2016","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2026.109910_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.107054","article-title":"Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK\/NF-\u03baB pathways","volume":"143","author":"Lu","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109910_bb0080","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1039\/D2QO00534D","article-title":"The indole nucleus as a selective COX-2 inhibitor and anti-inflammatory agent (2011\u22122022)","volume":"9","author":"Nisha","year":"2022","journal-title":"Org. Chem. Front."},{"key":"10.1016\/j.bioorg.2026.109910_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107931","article-title":"Indole-based COX-2 inhibitors: a decade of advances in inflammation, cancer, and alzheimer\u2019s therapy","volume":"153","author":"Shah","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109910_bb0090","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1039\/D4MD00021H","article-title":"New azole derivatives linked to indole\/indoline moieties combined with FLC against drug-resistant candida albicans","volume":"15","author":"Shen","year":"2024","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109910_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128826","article-title":"Discovery of novel indole and indoline derivatives against candida albicans as potent antifungal agents","volume":"71","author":"Ma","year":"2022","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.109910_bb0100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.molimm.2017.01.007","article-title":"Anti-inflammatory effects of ononin on lipopolysaccharide-stimulated RAW 264.7 cells","volume":"83","author":"Dong","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bioorg.2026.109910_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.107054","article-title":"Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK\/NF-\u03baB pathways","volume":"143","author":"Lu","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109910_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27217432","article-title":"Anti-inflammatory, antioxidative, and nitric oxide-scavenging activities of a quercetin nanosuspension with polyethylene glycol in LPS-induced RAW 264.7 macrophages","volume":"27","author":"Kang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.109910_bb0115","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.3390\/cells14242020","article-title":"Ameliorative effects of vitamin e and lutein on hydrogen peroxide-triggered oxidative cytotoxicity via combined transcriptome and metabolome analysis","volume":"14","author":"Lv","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.bioorg.2026.109910_bb0120","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bioorg.2026.109910_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116689","article-title":"Jing-Fang n-butanol extract and its isolated JFNE-C inhibit ferroptosis and inflammation in LPS induced RAW264.7 macrophages via STAT3\/p53\/SLC7A11 signaling pathway","volume":"316","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2026.109910_bb0130","doi-asserted-by":"crossref","first-page":"9344","DOI":"10.3390\/ijms23169344","article-title":"Inflammatory bowel disease: a review of pre-clinical murine models of human disease","volume":"23","author":"Katsandegwaza","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109910_bb0135","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/exd.13115","article-title":"IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin","volume":"26","author":"Takagi","year":"2017","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bioorg.2026.109910_bb0140","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231425","article-title":"CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17","volume":"221","author":"Cavagnero","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bioorg.2026.109910_bb0145","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/jcp.29080","article-title":"Glycochenodeoxycholate promotes the metastasis of gallbladder cancer cells by inducing epithelial to mesenchymal transition via activation of SOCS3\/JAK2\/STAT3 signaling pathway","volume":"235","author":"Wang","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bioorg.2026.109910_bb0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12020-019-01880-6","article-title":"Mechanism of the JAK2\/STAT3-CAV-1-NR2B signaling pathway in painful diabetic neuropathy","volume":"64","author":"Li","year":"2019","journal-title":"Endocrine"},{"key":"10.1016\/j.bioorg.2026.109910_bb0155","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cels.2019.01.003","article-title":"Quantifying drug combination synergy along potency and efficacy axes","volume":"8","author":"Meyer","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.bioorg.2026.109910_bb0160","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1038\/s41598-023-32321-0","article-title":"Targeting the NF-\u03baB pathway enhances responsiveness of mammary tumors to JAK inhibitors","volume":"13","author":"Bapat","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.109910_bb0165","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioorg.2026.109910_bb0170","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1111\/j.1582-4934.2011.01483.x","article-title":"Inhibition of JAK2\/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway","volume":"16","author":"Du","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioorg.2026.109910_bb0175","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/cr.2009.80","article-title":"Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2\/Stat3","volume":"19","author":"Lanuti","year":"2009","journal-title":"Cell Res."},{"key":"10.1016\/j.bioorg.2026.109910_bb0180","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bioorg.2026.109910_bb0185","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1007\/BF01303184","article-title":"Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin","volume":"38","author":"Murthy","year":"1993","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bioorg.2026.109910_bb0190","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/s41590-024-01846-5","article-title":"Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus","volume":"25","author":"Al-Azab","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bioorg.2026.109910_bb0195","doi-asserted-by":"crossref","first-page":"7755","DOI":"10.3390\/ijms25147755","article-title":"Quercetin attenuates KLF4-mediated phenotypic switch of VSMCs to macrophage-like cells in atherosclerosis: a critical role for the JAK2\/STAT3 pathway","volume":"25","author":"Xiang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109910_bb0200","doi-asserted-by":"crossref","unstructured":"Y. Hu, Y. Hu, A. Yin, Y. Lv, J. Li, J. Fan, B. Qian, J. Song, Y. Zhang, IP-10 acts early in CV-A16 infection to induce BBB destruction and promote virus entry into the CNS by increasing TNF-\u03b1 expression, Front. Immunol. 15 (20241104) 1374447. doi:https:\/\/doi.org\/10.3389\/fimmu.2024.1374447.","DOI":"10.3389\/fimmu.2024.1374447"},{"key":"10.1016\/j.bioorg.2026.109910_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119778","article-title":"Demethylenetetrahydroberberine alleviates nonalcoholic fatty liver disease by inhibiting the NLRP3 inflammasome and oxidative stress in mice","volume":"281","author":"Zhang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bioorg.2026.109910_bb0210","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.7150\/thno.72471","article-title":"DDX56 transcriptionally activates MIST1 to facilitate tumorigenesis of HCC through PTEN-AKT signaling","volume":"12","author":"Zhou","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bioorg.2026.109910_bb0215","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826004463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826004463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:01:42Z","timestamp":1783141302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826004463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":43,"alternative-id":["S0045206826004463"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109910","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploration of novel costunolide derivatives bearing indole\/indoline as anti-ulcerative colitis agents by targeting JAK2-STAT3 pathways","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109910"}}