{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:50:27Z","timestamp":1790801427843,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114\\u20132113-M-002-016"],"award-info":[{"award-number":["NSTC 114\\u20132113-M-002-016"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112\\u20132320-B-A49\\u2013032"],"award-info":[{"award-number":["NSTC 112\\u20132320-B-A49\\u2013032"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113\\u20132320-B-A49\\u2013030-MY3"],"award-info":[{"award-number":["NSTC 113\\u20132320-B-A49\\u2013030-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bioorg.2026.109946","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:53:35Z","timestamp":1777942415000},"page":"109946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Design, synthesis, and evaluation of novel andrographolide derivatives as anti-pancreatic cancer therapeutics"],"prefix":"10.1016","volume":"178","author":[{"given":"Yun-Ruei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Yu","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin-Yu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Hsiung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-1690","authenticated-orcid":false,"given":"Lee-Chiang","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ling","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109946_bb0005","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bioorg.2026.109946_bb0010","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2026.109946_bb0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-023-01347-1","article-title":"Targeting p53 pathways: mechanisms, structures, and advances in therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioorg.2026.109946_bb0020","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/s41419-022-05408-1","article-title":"Mutant p53 in cancer: from molecular mechanism to therapeutic modulation","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.109946_bb0025","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/1947601911408889","article-title":"Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis","volume":"2","author":"Rivlin","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.bioorg.2026.109946_bb0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-023-01253-7","article-title":"Targeting p53 gain-of-function activity in cancer therapy: a cautionary tale","volume":"31","author":"Attardi","year":"2024","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioorg.2026.109946_bb0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbamcr.2014.10.003","article-title":"Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine","volume":"1853","author":"Fiorini","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bioorg.2026.109946_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113710","article-title":"Andrographolide and its derivatives: current achievements and future perspectives","volume":"224","author":"Zhang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109946_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155860","article-title":"Andrographolide suppresses the malignancy of pancreatic cancer via alleviating DNMT3B-dependent repression of tumor suppressor gene ZNF382","volume":"132","author":"Zhuang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.109946_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117438","article-title":"The therapeutic potential of andrographolide in cancer treatment","volume":"180","author":"Hu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2026.109946_bb0055","first-page":"761","article-title":"Andrographolide induces degradation of mutant p53 via activation of Hsp70","volume":"53","author":"Sato","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bioorg.2026.109946_bb0060","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1039\/c2np20012k","article-title":"Electrophilic natural products and their biological targets","volume":"29","author":"Gersch","year":"2012","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bioorg.2026.109946_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152770","article-title":"Development of a bifunctional Andrographolide-based chemical probe for pharmacological study","volume":"11","author":"Hsu","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.bioorg.2026.109946_bb0070","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbrc.2020.08.086","article-title":"Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage","volume":"533","author":"Shi","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bioorg.2026.109946_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117582","article-title":"Design, synthesis, and anti-cancer evaluation of C-14 arylcarbamate derivatives of andrographolide","volume":"98","author":"Yang","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109946_bb0080","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1002\/anie.201915744","article-title":"A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents","volume":"59","author":"Hoelzel","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2026.109946_bb0085","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1246\/bcsj.52.1989","article-title":"A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization","volume":"52","author":"Junji Inanaga","year":"1979","journal-title":"Bulletin of the Chemical Society of Japan"},{"key":"10.1016\/j.bioorg.2026.109946_bb0090","doi-asserted-by":"crossref","first-page":"81s","DOI":"10.18433\/J3T886","article-title":"Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond","volume":"11","author":"Rao","year":"2008","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.bioorg.2026.109946_bb0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00001813-200202000-00003","article-title":"COX-2 inhibitors in cancer treatment and prevention, a recent development","volume":"13","author":"Xu","year":"2002","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.bioorg.2026.109946_bb0100","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1039\/C8CS00395E","article-title":"Click and release: bioorthogonal approaches to \"on-demand\" activation of prodrugs","volume":"48","author":"Ji","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2026.109946_bb0105","doi-asserted-by":"crossref","first-page":"10818","DOI":"10.1039\/D4TB01413H","article-title":"Bioorthogonal chemistry-based prodrug strategies for enhanced biosafety in tumor treatments: current progress and challenges","volume":"12","author":"Yao","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioorg.2026.109946_bb0110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bmcl.2011.11.085","article-title":"New substituted C-19-andrographolide analogues with potent cytotoxic activities","volume":"22","author":"Sirion","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.109946_bb0115","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.4049\/jimmunol.173.6.4207","article-title":"Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50","volume":"173","author":"Xia","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioorg.2026.109946_bb0120","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/onc.2015.216","article-title":"MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies","volume":"35","author":"Hessmann","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.bioorg.2026.109946_bb0125","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1158\/1535-7163.MCT-16-0050","article-title":"Concepts to target MYC in pancreatic Cancer","volume":"15","author":"Wirth","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bioorg.2026.109946_bb0130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbcan.2016.11.003","article-title":"Molecular interplay between mutant p53 proteins and autophagy in cancer cells","volume":"1867","author":"Cordani","year":"2017","journal-title":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"},{"key":"10.1016\/j.bioorg.2026.109946_bb0135","article-title":"Targeting mutant p53 stabilization for cancer therapy","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109946_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101203","article-title":"The dialogue between the ubiquitin-proteasome system and autophagy: implications in ageing","volume":"64","author":"Sun-Wang","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bioorg.2026.109946_bb0145","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ncb3380","article-title":"Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer","volume":"18","author":"Walerych","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.109946_bb0150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41392-024-01800-9","article-title":"Protein neddylation and its role in health and diseases","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioorg.2026.109946_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102146","article-title":"Stress-induced NEDDylation promotes cytosolic protein aggregation through HDAC6 in a p62-dependent manner","volume":"24","author":"Kim","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.bioorg.2026.109946_bb0160","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41573-022-00571-8","article-title":"Drugging p53 in cancer: one protein, many targets","volume":"22","author":"Hassin","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2026.109946_bb0165","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1021\/acs.jmedchem.4c02415","article-title":"Development of potent and selective CK1alpha molecular glue degraders","volume":"68","author":"Geng","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109946_bb0170","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1021\/jacsau.4c00762","article-title":"Development of Oral, potent, and selective CK1alpha degraders for AML therapy","volume":"4","author":"Huang","year":"2024","journal-title":"JACS Au"},{"key":"10.1016\/j.bioorg.2026.109946_bb0175","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature14430","article-title":"Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment","volume":"523","author":"Alexandrova","year":"2015","journal-title":"Nature"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826004827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826004827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:52:31Z","timestamp":1783180351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826004827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"alternative-id":["S0045206826004827"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109946","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and evaluation of novel andrographolide derivatives as anti-pancreatic cancer therapeutics","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109946"}}