{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:00:01Z","timestamp":1780995601513,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.109965","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T23:06:08Z","timestamp":1778367968000},"page":"109965","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Viscosity-responsive AIEgen with mitochondrial\/endoplasmic reticulum dual targeting for fatty liver fluorescence imaging and tumor photodynamic therapy"],"prefix":"10.1016","volume":"179","author":[{"given":"Chaolin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjian","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bioorg.2026.109965_bb0005","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41580-024-00820-1","article-title":"The roles of mitochondria in global and local intracellular calcium signalling","volume":"26","author":"Cartes-Saavedra","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109965_bb0010","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2016.07.002","article-title":"Mitochondria and Cancer","volume":"166","author":"Vyas","year":"2016","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109965_bb0015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"9","key":"10.1016\/j.bioorg.2026.109965_bb0020","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41568-025-00836-5","article-title":"Endoplasmic reticulum stress responses in anticancer immunity","volume":"25","author":"Hwang","year":"2025","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.bioorg.2026.109965_bb0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10930-025-10264-x","article-title":"Endoplasmic reticulum stress: implications in diseases","volume":"44","author":"Walter","year":"2025","journal-title":"Protein J."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109965_bb0030","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1038\/s41467-025-57408-2","article-title":"The pathways of secretory cargo export at the endoplasmic reticulum","volume":"16","author":"Malhotra","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109965_bb0035","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41420-024-02110-3","article-title":"Endoplasmic reticulum stress\u2014a key guardian in cancer","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Death Discovery"},{"issue":"6","key":"10.1016\/j.bioorg.2026.109965_bb0040","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrclinonc.2016.212","article-title":"Beyond the margins: real-time detection of cancer using targeted fluorophores","volume":"14","author":"Zhang","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"21","key":"10.1016\/j.bioorg.2026.109965_bb0045","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.7150\/thno.27679","article-title":"Dual-modality ImmunoPET\/fluorescence imaging of prostate Cancer with an anti-PSCA Cys-Minibody","volume":"8","author":"Tsai","year":"2018","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109965_bb0050","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41392-025-02140-y","article-title":"Phototherapy in cancer treatment: strategies and challenges","volume":"10","author":"Cai","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"21","key":"10.1016\/j.bioorg.2026.109965_bb0055","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1021\/cr400532z","article-title":"Functional nanomaterials for phototherapies of cancer","volume":"114","author":"Cheng","year":"2014","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109965_bb0060","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1186\/s12951-024-02853-2","article-title":"Double-camouflaged tellurium nanoparticles for enhanced photothermal immunotherapy of tumor","volume":"22","author":"Li","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"21","key":"10.1016\/j.bioorg.2026.109965_bb0065","doi-asserted-by":"crossref","first-page":"13454","DOI":"10.1021\/acs.chemrev.1c00381","article-title":"Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy","volume":"121","author":"Pham","year":"2021","journal-title":"Chem. Rev."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109965_bb0070","volume":"38","author":"Hou","year":"2026","journal-title":"The rise of AIE-peptide systems: design principles, multifunctional applications, and future Perspectives"},{"key":"10.1016\/j.bioorg.2026.109965_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.160692","article-title":"Recent process of NIR-type AIE-active fluorescent materials for biomedical applications of fluorescent imaging and phototherapeutics","volume":"507","author":"Xie","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioorg.2026.109965_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116802","article-title":"Recent advances of lipid droplet-targeted AIE-active materials for imaging, diagnosis and therapy","volume":"267","author":"Yuan","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109965_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202514187","article-title":"Molecular engineering of AIE-active ionic photosensitizer for dual-organelle targeted NIR-II phototheranostics","volume":"36","author":"Huang","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioorg.2026.109965_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123213","article-title":"An AIE-active near-infrared molecular probe for migrasome labeling","volume":"319","author":"Cui","year":"2025","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.bioorg.2026.109965_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202403937","article-title":"Molecular engineering of AIE-active photosensitizers with high biosafety for effect extracellular antibacteria","volume":"21","author":"Ma","year":"2025","journal-title":"Small"},{"issue":"15","key":"10.1016\/j.bioorg.2026.109965_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202410816","article-title":"Atomic engineering and aggregation effect to regulate synergistically type I reactive oxygen species of AIE-active deep red\/near infrared red photosensitizer","volume":"21","author":"Zheng","year":"2025","journal-title":"Small"},{"issue":"5","key":"10.1016\/j.bioorg.2026.109965_bb0105","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcc.22885","article-title":"Multiwfn: a multifunctional wavefunction analyzer","volume":"33","author":"Lu","year":"2012","journal-title":"J. Comput. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2026.109965_bb0110","doi-asserted-by":"crossref","DOI":"10.1063\/5.0216272","article-title":"A comprehensive electron wavefunction analysis toolbox for chemists, Multiwfn","volume":"161","author":"Lu","year":"2024","journal-title":"J. Chem. Phys."},{"issue":"36","key":"10.1016\/j.bioorg.2026.109965_bb0115","doi-asserted-by":"crossref","first-page":"20323","DOI":"10.1039\/D1CP02805G","article-title":"Efficient evaluation of electrostatic potential with computerized optimized code","volume":"23","author":"Zhang","year":"2021","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bioorg.2026.109965_bb0120","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jmgm.2012.07.004","article-title":"Quantitative analysis of molecular surface based on improved marching Tetrahedra algorithm","volume":"38","author":"Lu","year":"2012","journal-title":"J. Mol. Graph. Model."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109965_bb0125","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s11224-014-0430-6","article-title":"Wavefunction and reactivity study of benzo[a]pyrene diol epoxide and its enantiomeric forms","volume":"25","author":"Lu","year":"2014","journal-title":"Struct. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2026.109965_bb0130","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/poc.3111","article-title":"The geometry and electronic structure of Aristolochic acid: possible implications for a frozen resonance","volume":"26","author":"Manzetti","year":"2013","journal-title":"J. Phys. Org. Chem."},{"key":"10.1016\/j.bioorg.2026.109965_bb0135","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1-2","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109965_bb0140","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826005018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826005018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:12:31Z","timestamp":1780992751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826005018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":28,"alternative-id":["S0045206826005018"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109965","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Viscosity-responsive AIEgen with mitochondrial\/endoplasmic reticulum dual targeting for fatty liver fluorescence imaging and tumor photodynamic therapy","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109965","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109965"}}