{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:36:32Z","timestamp":1790282192031,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003398","name":"Shanxi Scholarship Council of China","doi-asserted-by":"publisher","award":["2023-004 &amp; 2023-018"],"award-info":[{"award-number":["2023-004 &amp; 2023-018"]}],"id":[{"id":"10.13039\/501100003398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004480","name":"Shanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["202303021212361"],"award-info":[{"award-number":["202303021212361"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004480","name":"Shanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["202303021211017"],"award-info":[{"award-number":["202303021211017"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22475124"],"award-info":[{"award-number":["22475124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22573061"],"award-info":[{"award-number":["22573061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.109981","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:06:52Z","timestamp":1778627212000},"page":"109981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A thiosemicarbazone-based dinuclear copper(II) complex: potent antiproliferative activity, distinct cell-type-specific anticancer mechanisms and robust in vivo antitumor efficacy"],"prefix":"10.1016","volume":"179","author":[{"given":"Shufang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109981_bb0005","first-page":"56","article-title":"Global patterns and trends in cancer-related premature death and their impact on life expectancy across 185 countries: a population-based analysis","volume":"12","author":"Sun","year":"2025","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.bioorg.2026.109981_bb0010","doi-asserted-by":"crossref","first-page":"10821","DOI":"10.1039\/D2DT01875F","article-title":"A chemical perspective on the clinical use of platinum-based anticancer drugs","volume":"51","author":"Alassadi","year":"2022","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2026.109981_bb0015","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.3390\/molecules27196485","article-title":"Metallo-drugs in cancer therapy: past, present and future","volume":"27","author":"Lucaciu","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.109981_bb0020","doi-asserted-by":"crossref","first-page":"9263","DOI":"10.1038\/s41467-025-64295-0","article-title":"Leveraging platinum-protein interactions to overcome chemoresistance","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2026.109981_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.215791","article-title":"Gastrointestinal cancer cells with Pt-resistance and relationship with aberrant expression of long non-coding RNAs","volume":"509","author":"Ferretti","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109981_bb0030","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1039\/D0SC04082G","article-title":"Metallodrugs are unique: opportunities and challenges of discovery and development","volume":"12","author":"Anthony","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioorg.2026.109981_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2025.104522","article-title":"Advances in copper complexes incancertreatment","volume":"30","author":"Balsa","year":"2025","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bioorg.2026.109981_bb0040","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1093\/nar\/gkv467","article-title":"Intercalation processes of copper complexes in DNA","volume":"23","author":"Galindo-Murillo","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2026.109981_bb0045","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1039\/D1QI00233C","article-title":"Water-mediated reduction of [Cu(dmp)2(CH3CN)]2+: implications of the structure of a classical complex on its activity as an anticancer drug","volume":"8","author":"Lev\u00edn","year":"2021","journal-title":"Inorg. Chem. Front."},{"key":"10.1016\/j.bioorg.2026.109981_bb0050","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.3390\/ijms24087531","article-title":"Finding new molecular targets of two copper(II)-hydrazone complexes on triple-negative breast Cancer cells using mass-spectrometry-based quantitative proteomics","volume":"24","author":"Balsa","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109981_bb0055","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jinorgbio.2018.10.003","article-title":"Anticancer copper complex with nucleus, mitochondrion and cyclooxygenase-2 as multiple targets","volume":"190","author":"Shi","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2023.215579","article-title":"Riding the metal wave: A review of the latest developments in metal-based anticancer agents","volume":"501","author":"Abdolmaleki","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109981_bb0065","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10555-017-9701-1","article-title":"Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents","volume":"36","author":"Chen","year":"2017","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bioorg.2026.109981_bb0070","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1039\/C2CC16818A","article-title":"Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex","volume":"48","author":"Yuan","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioorg.2026.109981_bb0075","article-title":"Targeting ubiquitin\u2013proteasome system with copper complexes for cancer therapy","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bioorg.2026.109981_bb0080","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1039\/C9CC06972K","article-title":"Potent and selective PTP1B inhibition by a platinum(II) complex: possible implications for a new antitumor strategy","volume":"56","author":"Yuan","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioorg.2026.109981_bb0085","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3390\/ph16020234","article-title":"Potential of copper and copper compounds for anticancer applications","volume":"16","author":"Ji","year":"2023","journal-title":"PHARMACEUTICALS-BASE"},{"key":"10.1016\/j.bioorg.2026.109981_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117702","article-title":"Recent advances in the discovery of copper(II) complexes as potential anticancer drugs","volume":"292","author":"Rogalewicz","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0095","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.drudis.2021.01.015","article-title":"Biochemical pathways of copper complexes: progress over the past 5 years","volume":"26","author":"Zehra","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bioorg.2026.109981_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202200652","article-title":"Recent development of copper (II) complexes of polypyridyl ligands in chemotherapy and photodynamic therapy","volume":"18","author":"Rani","year":"2023","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bioorg.2026.109981_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2023.215156","article-title":"Cu-related agents for cancer therapies","volume":"487","author":"Wang","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109981_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202100520","article-title":"Anticancer activity and mechanism of action evaluation of an Acylhydrazone Cu(II) complex toward breast Cancer cells, spheroids, and mammospheres","volume":"17","author":"Balsa","year":"2022","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bioorg.2026.109981_bb0115","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1039\/D4DT03445G","article-title":"Antiproliferative activity of a series of copper(II) complexes derived from a furan-containing N-acylhydrazone: monomers, dimers, charge status, and cell mechanistic studies on triple negative breast cancer cells","volume":"54","author":"Espindola-Moreno","year":"2025","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2026.109981_bb0120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ica.2018.11.039","article-title":"Synthesis, crystal structure and cytotoxicity assays of a copper(II) nitrate complex with a tridentate ONO acylhydrazone ligand. Spectroscopic and theoretical studies of the complex and its ligand","volume":"487","author":"Burgos-Lopez","year":"2019","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.bioorg.2026.109981_bb0125","doi-asserted-by":"crossref","first-page":"16285","DOI":"10.1039\/D5DT01851J","article-title":"Biochemical assays for evaluating anticancer activity and validating mechanisms of action in coordination\/organometallic compounds: a review","volume":"54","author":"Alezi","year":"2025","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2026.109981_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.140511","article-title":"Versatile biological activities of thiosemicarbazones and their metal complexes","volume":"1322","author":"Zahra","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.109981_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2025.122861","article-title":"Recent advances in the synthesis, structure, property and application of copper(II) complexes of salicylaldehyde thiosemicarbazone derivatives","volume":"588","author":"Middya","year":"2025","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.bioorg.2026.109981_bb0140","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1021\/acs.jmedchem.3c02378","article-title":"Developing a copper(II) isopropyl 2-pyridyl ketone thiosemicarbazone compound based on the ib subdomain of human serum albumin\u2013indomethacin complex: inhibiting tumor growth by remodeling the tumor microenvironment","volume":"67","author":"Man","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116697","article-title":"Anticancer activity of new water-soluble sulfonated thiosemicarbazone copper(II) complexes targeting disulfide isomerase","volume":"276","author":"Miglioli","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0150","doi-asserted-by":"crossref","first-page":"6029","DOI":"10.1039\/D3DT00148B","article-title":"Development of a zinc(II) 2-pyridinecarboxaldehyde thiosemicarbazone complex with remarkable antitumor and antiangiogenic activities","volume":"52","author":"Jiang","year":"2023","journal-title":"Dalton T."},{"key":"10.1016\/j.bioorg.2026.109981_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139389","article-title":"In vitro and in vivo anticancer activities of Bi(III) 2-thiazolecarboxaldehyde thiosemicarbazone complex","volume":"1318","author":"Jia","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.109981_bb0160","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.saa.2008.10.030","article-title":"Preparation, magnetic and EPR spectral studies of copper(II) complexes of an anticancer drug analogue","volume":"72","author":"Manoj","year":"2009","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioorg.2026.109981_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112266","article-title":"In vitro and in vivo anticancer activity of tridentate thiosemicarbazone copper complexes: unravelling an unexplored pharmacological target","volume":"194","author":"Carcelli","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0170","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1021\/acs.jmedchem.2c01600","article-title":"Designing tailored thiosemicarbazones with bespoke properties: the styrene moiety imparts potent activity, inhibits heme center oxidation, and results in a novel \u201cstealth zinc(II) complex\u201d","volume":"66","author":"Dharmasivam","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111543","article-title":"Copper(II) complexes based on thiosemicarbazone ligand: preparation, crystal structure, Hirshfeld surface, energy framework, antiMycobacterium activity, in silico and molecular docking studies","volume":"223","author":"Souza","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0180","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1039\/D3CE00119A","article-title":"Perchlorate-induced structural diversity in thiosemicarbazone copper(II) complexes provides insights to understand the reactivity in acidic and basic media","volume":"25","author":"Gil-Garc\u00eda","year":"2023","journal-title":"CrystEngComm"},{"key":"10.1016\/j.bioorg.2026.109981_bb0185","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1016\/j.ica.2009.04.019","article-title":"Magnetic, spectroscopic and X-ray crystallographic structural studies on copper(II) complexes of tridentate NNS Schiff base ligands formed from 2-acetylpyrazine and S-methyl- and S-benzyldithiocarbazates","volume":"362","author":"Hamid","year":"2009","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.bioorg.2026.109981_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107422","article-title":"In vitro and in vivo antiproliferative activity on lung cancer of two acylhydrazone based zinc(II) complexes","volume":"147","author":"Chang","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2023.112293","article-title":"Multifunctional O-phenanthroline silver(I) complexes for antitumor activity against colorectal adenocarcinoma cells and antimicrobial properties by multiple mechanisms","volume":"246","author":"Niu","year":"2023","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0200","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1016\/j.bmcl.2018.05.038","article-title":"Synthesis and anti-proliferative activity of allogibberic acid derivatives containing 1,2,3-triazole pharmacophore","volume":"28","author":"Wu","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.109981_bb0205","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/molecules22030467","article-title":"Synthesis and evaluation of new pyrazoline derivatives as potential anticancer agents in HepG-2 cell line","volume":"22","author":"Xu","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.109981_bb0210","doi-asserted-by":"crossref","first-page":"8036","DOI":"10.1039\/C6DT00451B","article-title":"Four Cu(II) complexes based on antitumor chelators: synthesis, structure, DNA binding\/damage, HSA interaction and enhanced cytotoxicity","volume":"45","author":"Liu","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2026.109981_bb0215","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ica.2019.04.019","article-title":"Synthesis and characterisations of copper(II) complexes of 5-methoxyisatin thiosemicarbazones: effect of N-terminal substitution on DNA\/protein binding and biological activities","volume":"492","author":"Aneesrahman","year":"2019","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.bioorg.2026.109981_bb0220","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jinorgbio.2014.03.004","article-title":"Thiosemicarbazone Cu(II) and Zn(II) complexes as potential anticancer agents: syntheses, crystal structure, DNA cleavage, cytotoxicity and apoptosis induction activity","volume":"136","author":"Shao","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0225","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ejmech.2018.09.020","article-title":"Designing anticancer copper(II) complexes by optimizing 2-pyridine-thiosemicarbazone ligands","volume":"158","author":"Deng","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0230","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ejmech.2013.04.036","article-title":"Cytotoxic activity, albumin and DNA binding of new copper(II) complexes with chalcone-derived thiosemicarbazones","volume":"65","author":"Da Silva","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0235","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.abb.2016.07.009","article-title":"Human topoisomerase IB is a target of a thiosemicarbazone copper(II) complex","volume":"606","author":"Vutey","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bioorg.2026.109981_bb0240","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jinorgbio.2016.11.026","article-title":"Biophysical characterization and antineoplastic activity of new bis(thiosemicarbazonato) Cu(II) complexes","volume":"167","author":"Palma","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0245","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1021\/jm300938r","article-title":"In vitro and in vivo anticancer activity of copper bis(thiosemicarbazone) complexes","volume":"56","author":"Palanimuthu","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0250","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ica.2017.12.008","article-title":"Synthesis, spectral characterization and biological evaluation of some copper(II) complexes containing 4-oxo-4H-chromene-3-carbaldehyde-4(N)-substituted thiosemicarbazones","volume":"471","author":"Kalaiarasi","year":"2018","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.bioorg.2026.109981_bb0255","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ejmech.2016.05.021","article-title":"Four copper(II) compounds synthesized by anion regulation: structure, anticancer function and anticancer mechanism","volume":"121","author":"Zhang","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2019.111412","article-title":"New series of water-soluble thiosemicarbazones and their copper(II) complexes as potentially promising anticancer compounds","volume":"293","author":"Mirzaahmadi","year":"2019","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioorg.2026.109981_bb0265","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00775-023-02001-5","article-title":"A novel water-soluble thiosemicarbazone Schiff base ligand and its complexes as potential anticancer agents and cellular fluorescence imaging","volume":"28","author":"Feizpour","year":"2023","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0270","doi-asserted-by":"crossref","first-page":"7120","DOI":"10.1039\/C8NJ06274A","article-title":"Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene. Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells","volume":"43","author":"Rodr\u00edguez","year":"2019","journal-title":"New J. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111134","article-title":"Anticancer potency of copper(II) complexes of thiosemicarbazones","volume":"210","author":"Singh","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0280","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1039\/D3DT03806H","article-title":"Discovery of mitochondrion-targeting copper(II)-plumbagin and -bipyridine complexes as chemodynamic therapy agents with enhanced antitumor activity","volume":"53","author":"Zhang","year":"2024","journal-title":"Dalton T."},{"key":"10.1016\/j.bioorg.2026.109981_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2015.08.012","article-title":"Cytotoxic activity, DNA damage, cellular uptake, apoptosis and western blot analysis of ruthenium(II) polypyridyl complex against human lung decarcinoma A549 cell","volume":"152","author":"Lai","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0290","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.bcp.2003.10.031","article-title":"Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells","volume":"67","author":"Daniel","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109981_bb0295","first-page":"897","article-title":"Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells","volume":"7","author":"Daniel","year":"2005","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bioorg.2026.109981_bb0300","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.1021\/jm060712l","article-title":"Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells","volume":"49","author":"Adsule","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109981_bb0305","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jtbi.2018.11.023","article-title":"Critical roles of I\u03baB\u03b1 and RelA phosphorylation in transitional oscillation in NF-\u03baB signaling module","volume":"462","author":"Hatanaka","year":"2019","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.bioorg.2026.109981_bb0310","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.semcdb.2012.04.005","article-title":"Coordination of cell growth and division by the ubiquitin\u2013proteasome system","volume":"23","author":"Benanti","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bioorg.2026.109981_bb0315","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ng1963","article-title":"Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis","volume":"39","author":"Julien","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bioorg.2026.109981_bb0320","series-title":"Gaussian 16, Revision A. 03","author":"Frisch","year":"2016"},{"key":"10.1016\/j.bioorg.2026.109981_bb0325","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1021\/acsmedchemlett.9b00284","article-title":"Novel copper complexes that inhibit the proteasome and trigger apoptosis in triple-negative breast cancer cells","volume":"10","author":"Li","year":"2019","journal-title":"ACS Med. Chem. Lett."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826005171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826005171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:54:04Z","timestamp":1783058044000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826005171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":65,"alternative-id":["S0045206826005171"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109981","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A thiosemicarbazone-based dinuclear copper(II) complex: potent antiproliferative activity, distinct cell-type-specific anticancer mechanisms and robust in vivo antitumor efficacy","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109981","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109981"}}