{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:06:32Z","timestamp":1780995992595,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.109997","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T22:15:23Z","timestamp":1778969723000},"page":"109997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma"],"prefix":"10.1016","volume":"179","author":[{"given":"Diego","family":"Olivieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Mari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Battistelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Burattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Carfagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Gianfanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Onesimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Bottegoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riham","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Annous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Salucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Versari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Faenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Micucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Retini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109997_bb0005","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/0284186X.2013.789139","article-title":"Gastric cancer: decreasing incidence but stable survival in the Netherlands","volume":"53","author":"Dassen","year":"2014","journal-title":"Acta Oncol. (Madr)"},{"key":"10.1016\/j.bioorg.2026.109997_bb0010","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10555-020-09925-3","article-title":"Gastric cancer: a comprehensive review of current and future treatment strategies","volume":"39","author":"Sexton","year":"2020","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bioorg.2026.109997_bb0015","article-title":"Gastric cancer\u2014epidemiology, modifiable and non-modifiable risk factors, challenges and opportunities: an updated review","volume":"41","author":"Mamun","year":"2024","journal-title":"Cancer Treat. Res. Commun."},{"key":"10.1016\/j.bioorg.2026.109997_bb0020","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.4251\/wjgo.v16.i9.3798","article-title":"Matching traditional Chinese medicine and Western medicine-based research: advanced nutraceutical development for proactive gastric cancer prevention","volume":"16","author":"Micucci","year":"2024","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.bioorg.2026.109997_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70350","article-title":"Food waste to wellness: a grape pomace blend in gastric Cancer prevention","volume":"13","author":"Micucci","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.bioorg.2026.109997_bb0030","series-title":"Molecular Mechanisms of Gastric Cancer Development","first-page":"25","article-title":"Clinical pathogenesis","author":"Wroblewski","year":"2023"},{"key":"10.1016\/j.bioorg.2026.109997_bb0035","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1159\/000518107","article-title":"Advanced gastric Cancer: current treatment landscape and a future outlook for sequential and personalized guide: Swiss expert statement article","volume":"44","author":"Siebenh\u00fcner","year":"2021","journal-title":"Oncol. Res. Treat."},{"key":"10.1016\/j.bioorg.2026.109997_bb0040","first-page":"264","article-title":"Current treatment and recent progress in gastric cancer","volume":"71","author":"Joshi","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bioorg.2026.109997_bb0045","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1200\/JCO.2017.74.2130","article-title":"Adjuvant chemoradiotherapy with Epirubicin, cisplatin, and fluorouracil compared with adjuvant chemoradiotherapy with fluorouracil and leucovorin after curative resection of gastric Cancer: results from CALGB 80101 (Alliance)","volume":"35","author":"Fuchs","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bioorg.2026.109997_bb0050","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/07357900600633924","article-title":"A phase II study of doxorubicin, cisplatin, and 5-fluorouracil in patients with advanced adenocarcinoma of the stomach or Esophagus","volume":"24","author":"Kulke","year":"2006","journal-title":"Cancer Investig."},{"key":"10.1016\/j.bioorg.2026.109997_bb0055","doi-asserted-by":"crossref","first-page":"23142","DOI":"10.1038\/s41598-021-02391-z","article-title":"Survival outcomes of management in metastatic gastric adenocarcinoma patients","volume":"11","author":"Hu","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.109997_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154761","article-title":"Unrevealing the vital role of ncRNAs in gastric Cancer chemoresistance","volume":"250","author":"Kazemi","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.bioorg.2026.109997_bb0065","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa2004413","article-title":"Trastuzumab Deruxtecan in previously treated HER2-positive gastric Cancer","volume":"382","author":"Shitara","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioorg.2026.109997_bb0070","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.2217\/fon-2021-0398","article-title":"Efficacy of trastuzumab and potential risk factors on survival in patients with HER2-positive metastatic gastric Cancer","volume":"17","author":"Topcu","year":"2021","journal-title":"Future Oncol."},{"key":"10.1016\/j.bioorg.2026.109997_bb0075","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(13)61719-5","article-title":"Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial","volume":"383","author":"Fuchs","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2026.109997_bb0080","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1080\/14737140.2016.1231576","article-title":"The safety and efficacy of ramucirumab in combination with paclitaxel for the treatment of advanced gastric or gastro-esophageal junction adenocarcinoma","volume":"16","author":"Garrido","year":"2016","journal-title":"Expert. Rev. Anticancer. Ther."},{"key":"10.1016\/j.bioorg.2026.109997_bb0085","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41419-025-07426-1","article-title":"Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment","volume":"16","author":"Varone","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.109997_bb0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.canlet.2006.05.015","article-title":"\u0391-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1\/2 and c-Jun N-terminal kinase in a biphasic manner","volume":"247","author":"Zhao","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.109997_bb0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.canlet.2010.04.002","article-title":"Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells","volume":"296","author":"Huang","year":"2010","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.109997_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.tetlet.2020.151923","article-title":"General synthesis of unnatural 4-, 5-, 6-, and 7-bromo-d-tryptophans by means of a regioselective indole alkylation","volume":"61","author":"Bartoccini","year":"2020","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2026.109997_bb0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.canlet.2017.02.007","article-title":"VCPA, a novel synthetic derivative of \u03b1-tocopheryl succinate, sensitizes human gastric cancer to doxorubicin-induced apoptosis via ROS-dependent mitochondrial dysfunction","volume":"393","author":"Wu","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.109997_bb0110","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3748\/wjg.v10.i8.1110","article-title":"C-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells","volume":"10","author":"Wu","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bioorg.2026.109997_bb0115","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3892\/or.2014.3282","article-title":"RRR-\u03b1-tocopheryl succinate induces apoptosis in human gastric cancer cells via the NF-\u03baB signaling pathway","volume":"32","author":"Sun","year":"2014","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bioorg.2026.109997_bb0120","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/adsc.201900918","article-title":"Bis-alkoxycarbonylation of acrylic esters and amides for the synthesis of 2-alkoxycarbonyl or 2-carbamoyl succinates","volume":"362","author":"Olivieri","year":"2020","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.bioorg.2026.109997_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/cctc.202101923","article-title":"Combined effect of palladium catalyst and the alcohol to promote the uncommon bis-Alkoxycarbonylation of allylic substrates","volume":"14","author":"Olivieri","year":"2022","journal-title":"ChemCatChem"},{"key":"10.1016\/j.bioorg.2026.109997_bb0130","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jcat.2023.03.008","article-title":"Regioselective one-step alkoxy-aryloxycarbonylation of alkenes","volume":"421","author":"Olivieri","year":"2023","journal-title":"J. Catal."},{"key":"10.1016\/j.bioorg.2026.109997_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcat.2024.115397","article-title":"Versatile stereoselective oxidative alkoxycarbonylation of styrenes at room-temperature","volume":"432","author":"Olivieri","year":"2024","journal-title":"J. Catal."},{"key":"10.1016\/j.bioorg.2026.109997_bb0140","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/adsc.201701597","article-title":"Diastereospecific bis-alkoxycarbonylation of 1,2-disubstituted olefins catalyzed by aryl \u03b1-diimine palladium(II) catalysts","volume":"360","author":"Olivieri","year":"2018","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.bioorg.2026.109997_bb0145","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/adsc.201400501","article-title":"Selective aryl \u03b1-Diimine\/palladium-catalyzed bis-alkoxy- carbonylation of olefins for the synthesis of substituted succinic diesters","volume":"357","author":"Fini","year":"2015","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.bioorg.2026.109997_bb0150","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3390\/ijms19030903","article-title":"Hydroquinone exhibits in vitro and in vivo anti-Cancer activity in Cancer cells and mice","volume":"19","author":"Byeon","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109997_bb0155","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/antiox11020343","article-title":"Antioxidant activity of natural Hydroquinones","volume":"11","author":"Giner","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.bioorg.2026.109997_bb0160","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1039\/D4RA00007B","article-title":"Design, synthesis, and inhibitory activity of hydroquinone ester derivatives against mushroom tyrosinase","volume":"14","author":"Xie","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2026.109997_bb0165","first-page":"0681","article-title":"Nitroalkanes and dimethyl maleate as source of 3-alkyl succinic anhydrides and (E)-3-alkylidene succinic anhydrides","volume":"5","author":"Ballini","year":"2002","journal-title":"Synthesis"},{"key":"10.1016\/j.bioorg.2026.109997_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112047","article-title":"Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign","volume":"189","author":"Linciano","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109997_bb0175","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1021\/cr9804644","article-title":"Late-metal catalysts for ethylene Homo- and copolymerization","volume":"100","author":"Ittel","year":"2000","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.109997_bb0180","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1021\/om400887x","article-title":"New aryl \u03b1-Diimine palladium(II) catalysts in Stereocontrolled CO\/vinyl Arene copolymerization","volume":"33","author":"Carfagna","year":"2014","journal-title":"Organometallics"},{"issue":"23","key":"10.1016\/j.bioorg.2026.109997_bb0185","doi-asserted-by":"crossref","first-page":"14425","DOI":"10.1021\/acs.jmedchem.0c01332","article-title":"Evolution of Novartis\u2019 small molecule screening deck design","volume":"63","author":"Schuffenhauer","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109997_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242116003","article-title":"Paradigm shift in gastric Cancer prevention: harnessing the potential of Aristolochia olivieri extract","volume":"24","author":"Micucci","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109997_bb0195","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3390\/ph15121576","article-title":"Antidiabetic potential of novel 1,3,5-Trisubstituted-2-Thioxoimidazloidin-4-one analogues: insights into \u03b1-glucosidase, \u03b1-amylase, and antioxidant activities","volume":"15","author":"Khirallah","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bioorg.2026.109997_bb0200","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.2147\/DDDT.S463626","article-title":"Trimetazidine alleviates bleomycin-induced pulmonary fibrosis by targeting the long noncoding RNA CBR3-AS1-mediated miRNA-29 and Resistin-like molecule alpha 1: deciphering a novel trifecta role of LncRNA CBR3-AS1\/miRNA-29\/FIZZ1 axis in lung fibrosis","volume":"18","author":"Alzahrani","year":"2024","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bioorg.2026.109997_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/biom14081018","article-title":"Novel insights into the antimicrobial and antibiofilm activity of pyrroloquinoline quinone (PQQ); in vitro, in silico, and shotgun proteomic studies","volume":"14","author":"Labib","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioorg.2026.109997_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1601501","article-title":"The intersection of helicobacter pylori and gastric cancer: signaling pathways and molecular mechanisms","volume":"15","author":"He","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109997_bb0215","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12957-025-03867-2","article-title":"Comparison among early-onset, late-onset, and conventional-onset adenocarcinoma of stomach and esophagogastric junction: a retrospective study","volume":"23","author":"Liang","year":"2025","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.bioorg.2026.109997_bb0220","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3724\/zdxbyxb-2023-0522","article-title":"Advances in targeted therapy for gastric cancer based on tumor driver genes","volume":"53","author":"Wu","year":"2024","journal-title":"J. Zhejiang Univ. (Med. Sci.)"},{"key":"10.1016\/j.bioorg.2026.109997_bb0225","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a004945","article-title":"RNA sequencing profiles and diagnostic signatures linked with response to ramucirumab in gastric cancer","volume":"6","author":"Sorokin","year":"2020","journal-title":"Molecular Case Studies"},{"key":"10.1016\/j.bioorg.2026.109997_bb0230","doi-asserted-by":"crossref","first-page":"23273","DOI":"10.1038\/s41598-025-06047-0","article-title":"Study on the regulation of gastric cancer cell apoptosis by LACTB through mitochondrial autophagy pathway","volume":"15","author":"Nie","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.109997_bb0235","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cdd.2010.191","article-title":"The Beclin 1 network regulates autophagy and apoptosis","volume":"18","author":"Kang","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioorg.2026.109997_bb0240","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1742-4658.2010.07965.x","article-title":"Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis","volume":"278","author":"Zhou","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.bioorg.2026.109997_bb0245","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.1074\/jbc.M109.038331","article-title":"The anti-apoptotic protein BCL2L1\/BCL-xL is neutralized by pro-apoptotic PMAIP1\/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of Prosurvival MCL1 expression","volume":"285","author":"Hagenbuchner","year":"2010","journal-title":"J. Biol. Chem."}],"updated-by":[{"DOI":"10.1016\/j.bioorg.2026.110024","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000}},{"DOI":"10.1016\/j.bioorg.2026.110024","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000}}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682600533X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682600533X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:17:22Z","timestamp":1780993042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520682600533X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":49,"alternative-id":["S004520682600533X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109997","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109997","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109997"}}