{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:54:35Z","timestamp":1789768475497,"version":"4.0.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024-MSBA-30"],"award-info":[{"award-number":["2024-MSBA-30"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.109999","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:31:43Z","timestamp":1779305503000},"page":"109999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["New hybrid iridoid glycoside oligomers from Scabiosa comosa with anti-cholestasis potential"],"prefix":"10.1016","volume":"179","author":[{"given":"Shaoqiang","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqing","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueshi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109999_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116594","article-title":"Molecular insights into experimental models and therapeutics for cholestasis","volume":"174","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2026.109999_bb0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mam.2017.06.001","article-title":"Mechanisms of bile acid mediated inflammation in the liver","volume":"56","author":"Li","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bioorg.2026.109999_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118804","article-title":"Si-Ni-San ameliorates cholestatic liver injury by favoring P. goldsteinii colonization","volume":"337","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.bioorg.2026.109999_bb0020","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41575-021-00566-7","article-title":"Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology","volume":"19","author":"Fuchs","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"11","key":"10.1016\/j.bioorg.2026.109999_bb0025","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut-liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109999_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118956","article-title":"Swertia cincta and its main active ingredients regulate the PPAR-\u03b1 pathway in anti-cholestatic liver injury","volume":"337","author":"Feng","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.bioorg.2026.109999_bb0035","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/hep.29569","article-title":"A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis","volume":"67","author":"Kowdley","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.bioorg.2026.109999_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2017.06.020","article-title":"Primary biliary cholangitis: old and novel therapy","volume":"47","author":"Floreani","year":"2018","journal-title":"Eur. J. Intern. Med."},{"issue":"6","key":"10.1016\/j.bioorg.2026.109999_bb0045","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/ptr.6621","article-title":"Natural products for the prevention and treatment of cholestasis: a review","volume":"34","author":"Ma","year":"2020","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.bioorg.2026.109999_bb0050","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/medicines5040110","article-title":"Scabiosa genus: a rich source of bioactive metabolites","volume":"5","author":"Pinto","year":"2018","journal-title":"Medicines"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109999_bb0055","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1038\/s41598-021-81399-x","article-title":"Systematic profiling of the effective ingredients and mechanism of Scabiosa comosa and S. tschilliensis against hepatic fibrosis combined with network pharmacology","volume":"11","author":"Chen","year":"2021","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bioorg.2026.109999_bb0060","doi-asserted-by":"crossref","first-page":"272","DOI":"10.21037\/apm.2020.02.29","article-title":"Anti-liver fibrosis effect of total flavonoids from Scabiosa comosa Fisch. ex Roem. et Schult. on liver fibrosis in rat models and its proteomics analysis","volume":"9","author":"Menggensilimu","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.bioorg.2026.109999_bb0065","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.biopha.2018.06.118","article-title":"Flavonoid-rich Scabiosa comosa inflorescence extract attenuates CCl4-induced hepatic fibrosis by modulating TGF-\u03b2-induced Smad3 phosphorylation","volume":"106","author":"Ma","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.bioorg.2026.109999_bb0070","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1021\/acs.jnatprod.9b00490","article-title":"Glucoconjugated monoterpene indole alkaloids from Uncaria rhynchophylla","volume":"82","author":"Guo","year":"2019","journal-title":"J. Nat. Prod."},{"issue":"10","key":"10.1016\/j.bioorg.2026.109999_bb0075","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/S0031-9422(00)83036-8","article-title":"Abeliosides A and B, secoiridoid glucosides from Abelia grandiflora","volume":"24","author":"Murai","year":"1985","journal-title":"Phytochemistry"},{"issue":"9","key":"10.1016\/j.bioorg.2026.109999_bb0080","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1021\/acs.orglett.5c00317","article-title":"Triangesinenolides A-C: trimeric phthalides with anti-renal fibrosis potential from Angelica sinensis","volume":"27","author":"Lv","year":"2025","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2026.109999_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2024.114339","article-title":"Characterization and anti-inflammatory investigation of sesquiterpene lactones from Ixeris chinensis","volume":"231","author":"Fan","year":"2025","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2026.109999_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155124","article-title":"Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-\u03baB\/NRF2 axis to reduce bile acid accumulation and its subsequent inflammation and oxidative stress","volume":"122","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.109999_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120453","article-title":"Structure and hepatoprotective activity of Usp10\/NF-\u03baB\/Nrf2 pathway-related Morchella esculenta polysaccharide","volume":"303","author":"Teng","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109999_bb0100","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2300847","article-title":"Bifidobacterium alleviate metabolic disorders via converting methionine to 5\u2032-methylthioadenosine","volume":"16","author":"Lyu","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bioorg.2026.109999_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.109424","article-title":"Intricate polycyclic dimeric phthalides derived from Angelica sinensis with potential to attenuate renal fibrosis","volume":"169","author":"Lv","year":"2026","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109999_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117136","article-title":"Phenolipid JE from Syzygium cumini attenuated obesity via modulating NF-\u03baB\/NLRP3 signaling pathway and gut microbiota-bile acid-FXR axis in high-fat diet-fed mice","volume":"241","author":"Wang","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.bioorg.2026.109999_bb0115","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1021\/acs.chemrestox.9b00148","article-title":"Industrial, biocide, and cosmetic chemical inducers of cholestasis","volume":"32","author":"Vilas-Boas","year":"2019","journal-title":"Chem. Res. Toxicol."},{"issue":"Pt 1","key":"10.1016\/j.bioorg.2026.109999_bb0120","article-title":"Gardenia extract protects against intrahepatic cholestasis by regulating bile acid enterohepatic circulation","volume":"319","author":"Qin","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2026.109999_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156164","article-title":"Chidan Tuihuang granule modulates gut microbiota to influence NOD1\/RIPK2 pathway in cholestatic liver injury recovery","volume":"135","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.109999_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1485035","article-title":"Integrated multi-omics analyses combined with western blotting discovered that cis-TSG alleviated liver injury via modulating lipid metabolism","volume":"15","author":"Teka","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.109999_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112672","article-title":"Yinchenzhufu decoction protects against alpha-naphthylisothiocyanate-induced acute cholestatic liver injury in mice by ameliorating disordered bile acid homeostasis and inhibiting inflammatory responses","volume":"254","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2026.109999_bb0140","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jpba.2019.04.009","article-title":"A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice","volume":"171","author":"Lin","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109999_bb0145","doi-asserted-by":"crossref","first-page":"32911","DOI":"10.1038\/s41598-025-17560-7","article-title":"Conjugated bile acids in serum reflect disease severity and predict survival in chronic liver disease of humans and rats","volume":"15","author":"Eguchi","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.109999_bb0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jare.2018.03.005","article-title":"Synopsis of arachidonic acid metabolism: a review","volume":"11","author":"Hanna","year":"2018","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109999_bb0155","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41392-024-01811-6","article-title":"Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets","volume":"9","author":"Fleishman","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109999_bb0160","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.bioorg.2026.109999_bb0165","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1097\/HEP.0000000000001438","article-title":"Benefits and challenges to therapeutic targeting of bile acid circulation in cholestatic liver disease","volume":"82","author":"Trauner","year":"2025","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.bioorg.2026.109999_bb0170","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1142\/S0192415X16500397","article-title":"Geniposide inhibits alpha-naphthylisothiocyanate-induced intrahepatic cholestasis: the downregulation of STAT3 and NF-\u03baB signaling plays an important role","volume":"44","author":"Tan","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.bioorg.2026.109999_bb0175","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jep.2016.12.022","article-title":"Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats","volume":"196","author":"Wang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2026.109999_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107942","article-title":"Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity","volume":"220","author":"Nie","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109999_bb0185","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s12072-023-10621-x","article-title":"FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease","volume":"18","author":"Li","year":"2024","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.bioorg.2026.109999_bb0190","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ebiom.2018.10.028","article-title":"Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis","volume":"37","author":"Wang","year":"2018","journal-title":"EBioMedicine"},{"issue":"9","key":"10.1016\/j.bioorg.2026.109999_bb0195","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.tet.2004.01.001","article-title":"Total synthesis of apigenin 7,4\u2032-di-O-\u03b2-glucopyranoside, a component of blue flower pigment of Salvia patens, and seven chiral analogues","volume":"60","author":"Oyama","year":"2004","journal-title":"Tetrahedron"},{"issue":"6","key":"10.1016\/j.bioorg.2026.109999_bb0200","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0031-9422(00)86881-8","article-title":"Iridoids of Rauwolfia grandiflora","volume":"35","author":"Bianco","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2026.109999_bb0205","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1038\/ncomms4606","article-title":"The seco-iridoid pathway from Catharanthus roseus","volume":"5","author":"Miettinen","year":"2014","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bioorg.2026.109999_bb0210","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/BF02977002","article-title":"Tissue factor inhibitory flavonoids from the fruits of Chaenomeles sinensis","volume":"25","author":"Lee","year":"2002","journal-title":"Arch. Pharm. Res."},{"issue":"6","key":"10.1016\/j.bioorg.2026.109999_bb0215","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1021\/np50048a041","article-title":"De Mello, Constituents of Guettarda platypoda","volume":"49","author":"Ferrari","year":"1986","journal-title":"J. Nat. Prod."},{"issue":"3","key":"10.1016\/j.bioorg.2026.109999_bb0220","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0031-9422(02)00541-1","article-title":"Two chromone-secoiridoid glycosides and three indole alkaloid glycosides from Neonauclea sessilifolia","volume":"62","author":"Itoh","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2026.109999_bb0225","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.fitote.2019.04.015","article-title":"Absolute structure assignment of an iridoid-monoterpenoid indole alkaloid hybrid from Dipsacus asper","volume":"135","author":"Yu","year":"2019","journal-title":"Fitoterapia"},{"issue":"2","key":"10.1016\/j.bioorg.2026.109999_bb0230","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0031-9422(79)80069-2","article-title":"Novel bis-iridoid glucosides from Dipsacus sylvestris","volume":"18","author":"Jensen","year":"1979","journal-title":"Phytochemistry"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109999_bb0235","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.toxlet.2013.09.019","article-title":"Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in sandwich-cultured rat hepatocytes","volume":"224","author":"Guo","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bioorg.2026.109999_bb0240","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.tox.2016.09.020","article-title":"Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes","volume":"370","author":"Li","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.bioorg.2026.109999_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153153","article-title":"Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor","volume":"68","author":"Li","year":"2020","journal-title":"Phytomedicine"},{"issue":"19","key":"10.1016\/j.bioorg.2026.109999_bb0250","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.3390\/nu14193938","article-title":"Ginsenosides restore lipid and redox homeostasis in mice with intrahepatic cholestasis through SIRT1\/AMPK pathways","volume":"14","author":"Li","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bioorg.2026.109999_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154529","article-title":"NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury","volume":"108","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.109999_bb0260","doi-asserted-by":"crossref","first-page":"117060","DOI":"10.1016\/j.jep.2023.117060","article-title":"Identifying hepatoprotective mechanism and effective components of Yinchenzhufu decoction in chronic cholestatic liver injury using a comprehensive strategy based on metabolomics, molecular biology, pharmacokinetics, and cytology","volume":"319","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2026.109999_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156021","article-title":"Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway","volume":"134","author":"Ma","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.109999_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2025.106020","article-title":"\u03b2-Sitosterol protects against ANIT-induced hepatotoxicity and cholestasis via FXR activation","volume":"104","author":"Yan","year":"2025","journal-title":"Toxicol. In Vitro"},{"issue":"5","key":"10.1016\/j.bioorg.2026.109999_bb0275","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/j.apsb.2024.02.017","article-title":"A combined nanotherapeutic approach targeting farnesoid X receptor, ferroptosis, and fibrosis for nonalcoholic steatohepatitis treatment","volume":"14","author":"Fu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.bioorg.2026.109999_bb0280","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41420-021-00660-4","article-title":"Ferroptosis in liver disease: new insights into disease mechanisms","volume":"7","author":"Wu","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bioorg.2026.109999_bb0285","article-title":"Dysregulated bile acid metabolism drives lipid peroxidation and ferroptosis in NAFLD: therapeutic potential for traditional Chinese medicine","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.109999_bb0290","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.1038\/s41467-023-42702-8","article-title":"Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis","volume":"14","author":"Tschuck","year":"2023","journal-title":"Nat. Commun."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826005353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826005353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:39:44Z","timestamp":1783150784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826005353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":58,"alternative-id":["S0045206826005353"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109999","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New hybrid iridoid glycoside oligomers from Scabiosa comosa with anti-cholestasis potential","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109999","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109999"}}