{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:17:03Z","timestamp":1783109823729,"version":"3.54.6"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372576"],"award-info":[{"award-number":["32372576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110028","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T23:30:27Z","timestamp":1779492627000},"page":"110028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synthesis and Mosquitocidal activity of Phenylpyrazole derivatives bearing Schiff Base moiety for reduced acute aquatic toxicity"],"prefix":"10.1016","volume":"179","author":[{"given":"Hetong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"33","key":"10.1016\/j.bioorg.2026.110028_bb0005","doi-asserted-by":"crossref","first-page":"852","DOI":"10.46234\/ccdcw2024.183","article-title":"A review of the latest control strategies for mosquito-borne diseases","volume":"6","author":"Ni","year":"2024","journal-title":"China CDC Wkly"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110028_bb0010","article-title":"Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes","volume":"15","author":"Sun","year":"2024","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110028_bb0015","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s10340-022-01557-6","article-title":"CRISPR\/Cas9-mediated f1534s substitution in the voltage-gated sodium channel reveals its necessity and sufficiency for deltamethrin resistance in Aedes albopictus","volume":"96","author":"Guo","year":"2022","journal-title":"J. Pestic. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110028_bb0020","article-title":"Syncytial and congregative effects of dengue and zika viruses on the Aedes albopictus cell line differ among viral strains","volume":"3","author":"Liu","year":"2023","journal-title":"Zoonoses (Burlington, Mass.)"},{"key":"10.1016\/j.bioorg.2026.110028_bb0025","article-title":"Advances in research on arboviral acquisition from hosts to mosquitoes","volume":"61","author":"Zhu","year":"2024","journal-title":"Curr. Opin. Insect Sci."},{"issue":"8","key":"10.1016\/j.bioorg.2026.110028_bb0030","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1140\/epjp\/s13360-020-00654-8","article-title":"Dynamical behavior and control strategy of a dengue epidemic model","volume":"135","author":"Khatua","year":"2020","journal-title":"The European Physical Journal Plus"},{"key":"10.1016\/j.bioorg.2026.110028_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112013","article-title":"Novel effective mosquito larvicide dl-methionine: lack of toxicity to non-target aquatic organisms","volume":"213","author":"Weeks","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bioorg.2026.110028_bb0040","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ibmb.2013.11.009","article-title":"The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod gamma-aminobutyric acid- and l-glutamate-gated chloride channels and insecticidal\/acaricidal activity","volume":"45","author":"Gassel","year":"2014","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110028_bb0045","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1584\/jpestics.D20-201","article-title":"Development of novel pesticides in the 21st century","volume":"45","author":"Umetsu","year":"2020","journal-title":"J. Pestic. Sci."},{"issue":"6127","key":"10.1016\/j.bioorg.2026.110028_bb0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/328221a0","article-title":"Sequence and functional expression of the Gabaa receptor shows a ligand-gated receptor super-family","volume":"328","author":"Schofield","year":"1987","journal-title":"Nature (London)"},{"issue":"3","key":"10.1016\/j.bioorg.2026.110028_bb0055","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pestbp.2009.07.012","article-title":"A new derivative of fipronil: effect of adding a glycinyl group to the 5-amine of pyrazole on phloem mobility and insecticidal activity","volume":"95","author":"Jiang","year":"2009","journal-title":"Pest. Biochem. Physiol."},{"issue":"12","key":"10.1016\/j.bioorg.2026.110028_bb0060","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1021\/tx980157t","article-title":"Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproduct","volume":"11","author":"Hainzl","year":"1998","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110028_bb0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1021\/acs.jafc.1c05694","article-title":"Human exposure of fipronil insecticide and the associated health risk","volume":"70","author":"Chen","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.110028_bb0070","series-title":"advances in insect physiology","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/B978-0-12-394389-7.00004-1","article-title":"Chapter four - \u03b3-aminobutyrate- and glutamate-gated chloride channels as targets of insecticides","volume":"44","author":"Ozoe","year":"2013"},{"issue":"48","key":"10.1016\/j.bioorg.2026.110028_bb0075","doi-asserted-by":"crossref","first-page":"40232","DOI":"10.1074\/jbc.R112.406280","article-title":"Glutamate-gated chloride channels *","volume":"287","author":"Wolstenholme","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110028_bb0080","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/bbb\/zbab202","article-title":"Ligand-gated ion channels as targets of neuroactive insecticides","volume":"86","author":"Ihara","year":"2021","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110028_bb0085","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1124\/jpet.104.065516","article-title":"Fipronil is a potent open channel blocker of glutamate-activated chloride channels in cockroach neurons","volume":"310","author":"Zhao","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bioorg.2026.110028_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123389","article-title":"A novel v263i mutation in the glutamate-gated chloride channel of plutella xylostella (l.) confers a high level of resistance to abamectin","volume":"230","author":"Sun","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110028_bb0095","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/pest.1993.1035","article-title":"Action of phenylpyrazole insecticides at the gaba-gated chloride channel","volume":"46","author":"Cole","year":"1993","journal-title":"Pest. Biochem. Physiol."},{"issue":"7","key":"10.1016\/j.bioorg.2026.110028_bb0100","doi-asserted-by":"crossref","first-page":"580","DOI":"10.3390\/insects14070580","article-title":"Characterization of glutamate-gated chloride channel in tribolium castaneum","volume":"14","author":"Qian","year":"2023","journal-title":"Insects"},{"key":"10.1016\/j.bioorg.2026.110028_bb0105","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ecoenv.2016.10.027","article-title":"Biochemical effects of fipronil and its metabolites on lipid peroxidation and enzymatic antioxidant defense in tadpoles (eupemphix nattereri: leiuperidae)","volume":"136","author":"Gripp","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bioorg.2026.110028_bb0110","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.aquatox.2017.02.027","article-title":"The effects of fipronil and the photodegradation product fipronil desulfinyl on growth and gene expression in juvenile blue crabs, callinectes sapidus, at different salinities","volume":"186","author":"Goff","year":"2017","journal-title":"Aquat. Toxicol."},{"issue":"8","key":"10.1016\/j.bioorg.2026.110028_bb0115","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/ps.4498","article-title":"Cross-resistance to three phenylpyrazole insecticides and a2\u2019n mutation detection of gaba receptor subunit in fipronil-resistant laodelphax striatellus (hemiptera: delphacidae)","volume":"73","author":"Wei","year":"2017","journal-title":"Pest Manag. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110028_bb0120","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/ps.3980","article-title":"Field-evolved resistance to imidacloprid and ethiprole in populations of brown planthopper nilaparvata lugens collected from across south and east asia","volume":"72","author":"Garrood","year":"2015","journal-title":"Pest Manag. Sci."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110028_bb0125","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.bmcl.2018.04.022","article-title":"Thioether-bridged arylalkyl-linked n-phenylpyrazole derivatives: design, synthesis, insecticidal activities, structure-activity relationship and molecular-modeling studies","volume":"28","author":"Fei","year":"2018","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.bioorg.2026.110028_bb0130","series-title":"Sulfur Chemistry","first-page":"35","article-title":"Sulfur-containing agrochemicals","author":"Devendar","year":"2019"},{"issue":"3","key":"10.1016\/j.bioorg.2026.110028_bb0135","first-page":"215","article-title":"Synthesis, characterization and bioactivity of fipronil derivatives as a lead for new insecticide","volume":"17","author":"Zheng","year":"2010","journal-title":"Indian J. Chem. Technol."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110028_bb0140","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/acs.jafc.3c04767","article-title":"Design, synthesis, and biological evaluation of pyrido [1,2-\u03b1] pyrimidinone mesoionic derivatives bearing propenylbenzene as the vector control insecticide","volume":"72","author":"Chen","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.110028_bb0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jhazmat.2015.12.055","article-title":"Toxic effects of thifluzamide on zebrafish (danio rerio)","volume":"307","author":"Yang","year":"2016","journal-title":"J. Hazard. Mater."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110028_bb0150","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jee\/18.2.265a","article-title":"A method of computing the effectiveness of an insecticide","volume":"18","author":"Abbott","year":"1925","journal-title":"J. Econ. Entomol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110028_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157489307779314320","article-title":"Molecular modeling databases: a new way in the search of protein targets for drug development","volume":"2","author":"Silveira","year":"2007","journal-title":"Curr. Bioinforma."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110028_bb0160","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1006\/jmbi.1996.0477","article-title":"A fast flexible docking method using an incremental construction algorithm","volume":"261","author":"Rarey","year":"1996","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110028_bb0165","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10822-012-9626-2","article-title":"A consistent description of hydrogen bond and dehydration energies in protein\u2013ligand complexes: methods behind the hyde scoring function","volume":"27","author":"Schneider","year":"2012","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110028_bb0170","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1584\/jpestics.J15-01","article-title":"Study on the structure and insecticide sensitivity of the rdl gaba receptor#","volume":"40","author":"Nakao","year":"2015","journal-title":"J. Pestic. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110028_bb0175","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pestbp.2006.09.001","article-title":"The a302s mutation in rdl that confers resistance to cyclodienes and limited cross-resistance to fipronil is undetectable in field populations of house flies from the Usa","volume":"88","author":"Gao","year":"2007","journal-title":"Pest. Biochem. Physiol."},{"key":"10.1016\/j.bioorg.2026.110028_bb0180","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ibmb.2014.08.008","article-title":"The role of rdl in resistance to phenylpyrazoles in drosophila melanogaster","volume":"54","author":"Remnant","year":"2014","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"W1","key":"10.1016\/j.bioorg.2026.110028_bb0185","doi-asserted-by":"crossref","first-page":"W530","DOI":"10.1093\/nar\/gkab294","article-title":"Plip 2021: expanding the scope of the protein\u2013ligand interaction profiler to dna and rna","volume":"49","author":"Adasme","year":"2021","journal-title":"Nucleic Acids Res."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682600564X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682600564X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:25:31Z","timestamp":1783106731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520682600564X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":37,"alternative-id":["S004520682600564X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110028","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and Mosquitocidal activity of Phenylpyrazole derivatives bearing Schiff Base moiety for reduced acute aquatic toxicity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110028"}}