{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:24:42Z","timestamp":1790432682873,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81001669"],"award-info":[{"award-number":["81001669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560391"],"award-info":[{"award-number":["81560391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104388"],"award-info":[{"award-number":["82104388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009103","name":"Education Department of Shaanxi Province","doi-asserted-by":"publisher","award":["25JK0422"],"award-info":[{"award-number":["25JK0422"]}],"id":[{"id":"10.13039\/501100009103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110043","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:09:16Z","timestamp":1779811756000},"page":"110043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A novel lysosome-targeting fluorescent probe for intracellular HClO imaging and aqueous environment detection based on smartphone-assisted quantification"],"prefix":"10.1016","volume":"180","author":[{"given":"Jiayi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashuang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglu","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiran","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110043_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137265","article-title":"Development of non-modified long-wavelength fluorescent-emission carbon dots for the imaging of intracellular hypochlorous acid (ClO-) during ferroptosis","volume":"428","author":"Bian","year":"2025","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.bioorg.2026.110043_bb0010","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1039\/D3AY00338H","article-title":"In vivo bioimaging and detection of endogenous hypochlorous acid in lysosome using a near-infrared fluorescent probe","volume":"15","author":"Jiang","year":"2023","journal-title":"Anal. Methods"},{"key":"10.1016\/j.bioorg.2026.110043_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116836","article-title":"Probing the toxic hypochlorous acid in natural waters and biosystem by a coumarin-based fluorescence probe","volume":"282","author":"Ma","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bioorg.2026.110043_bb0020","doi-asserted-by":"crossref","first-page":"7237","DOI":"10.3390\/molecules27217237","article-title":"A hydroxytricyanopyrrole-based fluorescent probe for sensitive and selective detection of hypochlorous acid","volume":"27","author":"Zeng","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110043_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2026.127676","article-title":"Illuminating epilepsy: A deep NIR-I fluorogenic sensor reports peroxynitrite dynamics in vivo","volume":"355","author":"Han","year":"2026","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioorg.2026.110043_bb0030","article-title":"Fluorescent probe for the detection of hypochlorous acid in water samples and cell models","author":"Hu","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2026.110043_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.121986","article-title":"A naphthalimide-based and golgi-targetable fluorescence probe for quantifying hypochlorous acid","volume":"286","author":"Liu","year":"2023","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioorg.2026.110043_bb0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3164\/jcbn.24-152","article-title":"LC\/MS\/MS detection of uric acid oxidation metabolites to evaluate reactive oxygen and nitrogen species in vivo with application to pseudo-inflammation","volume":"76","author":"Yokozawa","year":"2025","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.bioorg.2026.110043_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/or.2021.8022","article-title":"Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells","volume":"45","author":"Freund","year":"2021","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bioorg.2026.110043_bb0050","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1021\/acssensors.1c00930","article-title":"Ratiometric detection of hypochlorous acid in brain tissues of neuroinflammation and maternal immune activation models with a deep-red\/near-infrared emitting probe","volume":"6","author":"Kim","year":"2021","journal-title":"ACS Sens."},{"key":"10.1016\/j.bioorg.2026.110043_bb0055","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1039\/D1AN02178H","article-title":"A benzocoumarin-based fluorescent probe for ultra-sensitive and fast detection of endogenous\/exogenous hypochlorous acid and its applications","volume":"147","author":"Liu","year":"2022","journal-title":"Analyst"},{"key":"10.1016\/j.bioorg.2026.110043_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342993","article-title":"A dual-functional NIR fluorescence probe for detecting hypochlorous acid and bisulfite in biosystem","volume":"1320","author":"Ma","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bioorg.2026.110043_bb0065","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1002\/asia.201901041","article-title":"A reaction-based fluorescent probe for imaging of native hypochlorous acid","volume":"14","author":"Wang","year":"2019","journal-title":"Chem. Asian J."},{"key":"10.1016\/j.bioorg.2026.110043_bb0070","doi-asserted-by":"crossref","first-page":"11881","DOI":"10.1021\/acs.analchem.2c02431","article-title":"Mitochondria-targeted ratiometric chemdosimeter to detect hypochlorite acid for monitoring the drug-damaged liver and kidney","volume":"94","author":"Shangguan","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.110043_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127874","article-title":"A specifically triggered turn-on fluorescent probe platform and its visual imaging of HClO in cells, arthritis and tumors","volume":"427","author":"Wang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.bioorg.2026.110043_bb0080","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1039\/D1CS01097B","article-title":"Photoinduced electron transfer (PeT) based fluorescent probes for cellular imaging and disease therapy","volume":"52","author":"Niu","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2026.110043_bb0085","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/bios11020030","article-title":"Detection technologies for reactive oxygen species: fluorescence and electrochemical methods and their applications","volume":"11","author":"Duanghathaipornsuk","year":"2021","journal-title":"Biosensors"},{"key":"10.1016\/j.bioorg.2026.110043_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.141345","article-title":"A rapid and highly selective purine-based fluorescent probe for hypochlorite detection with cellular applications","volume":"1328","author":"Alam","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.110043_bb0095","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1021\/acs.accounts.9b00302","article-title":"Reaction-based fluorescent probes for the detection and imaging of reactive oxygen, nitrogen, and sulfur species","volume":"52","author":"Wu","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bioorg.2026.110043_bb0100","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1002\/asia.201900672","article-title":"Imaging of hypochlorous acid by fluorescence and applications in biological systems","volume":"14","author":"Yudhistira","year":"2019","journal-title":"Chem. Asian J."},{"key":"10.1016\/j.bioorg.2026.110043_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2026.127459","article-title":"Imaging alkaline phosphatase activity in alcoholic liver disease via a rational-designed NIR fluorogenic probe","volume":"350","author":"Ding","year":"2026","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioorg.2026.110043_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.127097","article-title":"ONOO\u2212-activated deep NIR-I fluorescent probe for visualization of non-alcoholic fatty liver disease","volume":"348","author":"Tuo","year":"2026","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioorg.2026.110043_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.128118","article-title":"Design of a naphthalimide-based probe for acrolein detection in foods and cells","volume":"426","author":"Jiang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.bioorg.2026.110043_bb0120","doi-asserted-by":"crossref","first-page":"14304","DOI":"10.1021\/acs.jafc.2c05659","article-title":"Naphthalimide-based fluorescent probe for profiling of aldehydes during oxidation of unsaturated lipids","volume":"70","author":"Lin","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.110043_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/bio.4699","article-title":"Naphthalimide-based fluorescent probe for Hg2 detection and imaging in living cells and zebrafish","volume":"39","author":"Wang","year":"2024","journal-title":"Luminescence"},{"key":"10.1016\/j.bioorg.2026.110043_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.127866","article-title":"A lysosomal-targeted switchable fluorescent probe for the detection of peroxynitrite in living tumor cells and in vivo","volume":"291","author":"Jiang","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.bioorg.2026.110043_bb0135","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jconrel.2025.01.079","article-title":"A novel prostate cancer-specific fluorescent probe based on extracellular vesicles targeting STEAP1 applied in fluorescence guided surgery","volume":"380","author":"Sun","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioorg.2026.110043_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108266","article-title":"A near-infrared fluorescent probe toward \u03b2-gal with dual-targeting potential of hepatocytes and lysosomes: Design, synthesis, and evaluation","volume":"157","author":"Yi","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110043_bb0145","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.snb.2019.01.134","article-title":"Imaging of lysosomal activity using naphthalimide-benzimidazole based fluorescent probe in living cells","volume":"286","author":"Sharma","year":"2019","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.bioorg.2026.110043_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.122365","article-title":"A 1,8-naphthalimide-based lysosome-targeting dual-analyte fluorescent probe for the detection of pH and palladium in biological samples","volume":"231","author":"Xie","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.bioorg.2026.110043_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136517","article-title":"Chitosan-naphthalimide probes for dual channel recognition of HClO and H2S in cells and their application in photodynamic therapy","volume":"281","author":"Zhao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2026.110043_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2019.120549","article-title":"Two-photon fluorescence visualization of lysosomal pH changes during mitophagy and cell apoptosis","volume":"209","author":"Dong","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.bioorg.2026.110043_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.122011","article-title":"A fluorescent probe based on triphenylamine with AIE and ICT characteristics for hydrazine detection","volume":"286","author":"Huang","year":"2023","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioorg.2026.110043_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.121768","article-title":"Sensitive fluorescent detection and micromechanism of mn-doped CuS probe for oxytetracycline hydrochloride","volume":"284","author":"Zhang","year":"2023","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826005791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826005791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:44:03Z","timestamp":1787676243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826005791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":34,"alternative-id":["S0045206826005791"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110043","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel lysosome-targeting fluorescent probe for intracellular HClO imaging and aqueous environment detection based on smartphone-assisted quantification","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110043"}}