{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:19:08Z","timestamp":1787678348311,"version":"build-2784847793"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012326","name":"International Science and Technology Cooperation Programme","doi-asserted-by":"publisher","award":["262102521004"],"award-info":[{"award-number":["262102521004"]}],"id":[{"id":"10.13039\/501100012326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Henan Province Natural Science Foundation","doi-asserted-by":"publisher","award":["252300421379"],"award-info":[{"award-number":["252300421379"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010950","name":"Department of Science and Technology of Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1704185"],"award-info":[{"award-number":["U1704185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110058","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:51:42Z","timestamp":1780069902000},"page":"110058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Structure-guided discovery of phenyl-carbamates as novel dual TRPV1 antagonists\/FAAH inhibitors"],"prefix":"10.1016","volume":"180","author":[{"given":"Yingda","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenqin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110058_bb0005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2165\/00002018-200629020-00002","article-title":"NSAID-associated adverse effects and acid control aids to prevent them -: a review of current treatment options","volume":"29","author":"N\u00e6sdall","year":"2006","journal-title":"Drug Saf."},{"key":"10.1016\/j.bioorg.2026.110058_bb0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejpain.2004.05.004","article-title":"Opioids in neuropathic pain: clues from animal studies","volume":"9","author":"Dickenson","year":"2005","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.bioorg.2026.110058_bb0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/jnr.24695","article-title":"Pain management with opioids in adults","volume":"100","author":"Montgomery","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bioorg.2026.110058_bb0020","doi-asserted-by":"crossref","first-page":"7963","DOI":"10.1021\/acs.jmedchem.1c00100","article-title":"Recent progress on tubulin inhibitors with dual targeting capabilities for cancer therapy","volume":"64","author":"Shuai","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0025","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1021\/acs.jmedchem.1c01714","article-title":"Development of dual inhibitors targeting epidermal growth factor receptor in cancer therapy","volume":"65","author":"Tan","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/13543776.2026.2619515","article-title":"Novel fatty acid amide hydrolase (FAAH) inhibitors: a patent review from 2015 to 2025","volume":"36","author":"Landolfi","year":"2026","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2026.110058_bb0035","first-page":"48","article-title":"Cannabinoid receptors: which cells, where, how, and why?","volume":"126","author":"Matsuda","year":"1992","journal-title":"NIDA Res. Monogr."},{"key":"10.1016\/j.bioorg.2026.110058_bb0040","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0006-2952(93)90486-G","article-title":"Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist","volume":"46","author":"Deutsch","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110058_bb0045","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1021\/jm031140x","article-title":"Cyclohexylcarbamic acid 3\u2032- or 4\u2032-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies","volume":"47","author":"Mor","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0050","first-page":"1247","article-title":"Fatty acid amide hydrolase inhibitors: a patent review (2009-2014)","volume":"25","author":"Lodola","year":"2015","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2026.110058_bb0055","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1080\/17460441.2020.1751118","article-title":"Advances in the discovery of fatty acid amide hydrolase inhibitors: what does the future hold?","volume":"15","author":"Fazio","year":"2020","journal-title":"Expert Opin. Drug Dis."},{"key":"10.1016\/j.bioorg.2026.110058_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111953","article-title":"A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents","volume":"188","author":"Tripathi","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0065","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jmb.2010.05.034","article-title":"Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation","volume":"400","author":"Mileni","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bioorg.2026.110058_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310942","article-title":"Weak hypotensive effect of chronic administration of the dual FAAH\/MAGL inhibitor JZL195 in spontaneously hypertensive rats as revealed by area under the curve analysis","volume":"24","author":"Toczek","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110058_bb0075","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.1016\/j.bmcl.2014.10.064","article-title":"Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates","volume":"24","author":"Rose","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110058_bb0080","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.phrs.2013.07.003","article-title":"Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as \"dual-target\" analgesics","volume":"76","author":"Maione","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioorg.2026.110058_bb0085","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.pain.2012.04.020","volume":"153","author":"Huggins","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.bioorg.2026.110058_bb0090","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.pain.2012.06.016","article-title":"Inhibitors of endocannabinoid breakdown for pain: not so FA(AH)cile, after all","volume":"153","author":"Di Marzo","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.bioorg.2026.110058_bb0095","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s40268-016-0127-y","article-title":"Safety, tolerability and pharmacokinetics of FAAH inhibitor V158866: a double-blind, randomised, placebo-controlled phase I study in healthy volunteers","volume":"16","author":"Pawsey","year":"2016","journal-title":"Drugs R&D"},{"key":"10.1016\/j.bioorg.2026.110058_bb0100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fmolb.2020.00144","article-title":"A closer look at anandamide interaction with TRPV1","volume":"7","author":"Muller","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bioorg.2026.110058_bb0105","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fmolb.2020.00144","article-title":"A closer look at anandamide interaction with TRPV1","volume":"7","author":"Muller","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bioorg.2026.110058_bb0110","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1021\/acs.jmedchem.5b00132","article-title":"Benzo[d]imidazole transient receptor potential vanilloid 1 antagonists for the treatment of pain: discovery of trans-2-(2-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1H-benz imidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)","volume":"58","author":"Parsons","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0115","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1021\/acs.jmedchem.8b00156","article-title":"Analyses of synthetic N-acyl dopamine derivatives revealing different structural requirements for their anti-inflammatory and transient-receptor-potential-channel-of-the-vanilloid-receptor-subfamily-subtype-1 (TRPV1)-activating properties","volume":"61","author":"Pallavi","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0120","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/med.21427","article-title":"Medicinal chemistry, pharmacology, and clinical implications of TRPV1 receptor antagonists","volume":"37","author":"Tabrizi","year":"2017","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bioorg.2026.110058_bb0125","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1021\/acs.jnatprod.5b00599","article-title":"Partial activation and inhibition of TRPV1 channels by evodiamine and rutaecarpine, two major components of the fruits of Evodia rutaecarpa","volume":"79","author":"Wang","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.110058_bb0130","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1021\/jm300780p","article-title":"2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-Trifluoromethylpyridin-3-ylmethyl) C-region","volume":"55","author":"Kim","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0135","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1016\/j.bmcl.2017.08.020","article-title":"Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists","volume":"27","author":"Lee","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110058_bb0140","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/13543776.2021.1854225","article-title":"A patent review of transient receptor potential vanilloid type 1 modulators (2014-present)","volume":"31","author":"Gao","year":"2021","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2026.110058_bb0145","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1177\/0269881117691567","article-title":"N-arachidonoyl-serotonin, a dual FAAH and TRPV1 blocker, inhibits the retrieval of contextual fear memory: role of the cannabinoid CB1 receptor in the dorsal hippocampus","volume":"31","author":"Gobira","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bioorg.2026.110058_bb0150","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1016\/j.bmcl.2009.09.033","article-title":"Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands","volume":"19","author":"Morera","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110058_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114191","article-title":"Discovery of (S)-N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl) pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist","volume":"233","author":"Qiao","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105229","article-title":"Novel piperazine urea derivatives as highly potent transient receptor potential vanilloid 1 (TRPV1) antagonists","volume":"115","author":"Hu","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112236","article-title":"Study on chemical modification and analgesic activity of N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl) piperazine-1-carboxamide","volume":"194","author":"Nie","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0170","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s13577-019-00238-4","article-title":"Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions","volume":"32","author":"Wu","year":"2019","journal-title":"Hum. Cell"},{"key":"10.1016\/j.bioorg.2026.110058_bb0175","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2147\/JPR.S228577","article-title":"Role of melatonin in the regulation of pain","volume":"13","author":"Xie","year":"2020","journal-title":"J. Pain Res."},{"key":"10.1016\/j.bioorg.2026.110058_bb0180","doi-asserted-by":"crossref","unstructured":"H. Dahlhaus, W. Hanekamp, M. Lehr, (Indolylalkyl) piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH), Medchemcomm 8(2017) 616\u2013620, Doi: https:\/\/doi.org\/10.1039\/c6md00683c.","DOI":"10.1039\/C6MD00683C"},{"key":"10.1016\/j.bioorg.2026.110058_bb0185","doi-asserted-by":"crossref","unstructured":"T. Terwege, H. Dahlhaus, W. Hanekamp, M. Lehr, \u03c9-Heteroarylalkylcarbamates as inhibitors of fatty acid amide hydrolase (FAAH), Medchemcomm 5(2014) 932\u2013936, Doi: https:\/\/doi.org\/10.1039\/c4md00181h.","DOI":"10.1039\/C4MD00181H"},{"key":"10.1016\/j.bioorg.2026.110058_bb0190","doi-asserted-by":"crossref","first-page":"7902","DOI":"10.1021\/acs.jmedchem.8b00893","article-title":"Identification of bivalent ligands with melatonin receptor agonist and fatty acid amide hydrolase (FAAH) inhibitory activity that exhibit ocular hypotensive effect in the rabbit","volume":"61","author":"Spadoni","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110058_bb0195","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.chembiol.2005.08.011","article-title":"Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes","volume":"12","author":"Alexander","year":"2005","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.110058_bb0200","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1038\/s41467-023-38162-9","article-title":"Human TRPV1 structure and inhibition by the analgesic SB-366791","volume":"14","author":"Neuberger","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2026.110058_bb0205","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1021\/ja110877y","article-title":"Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent \u03b1-ketoheterocycle inhibitor of fatty acid amide hydrolase","volume":"133","author":"Mileni","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2026.110058_bb0210","doi-asserted-by":"crossref","unstructured":"W. Andrew, B. Martino, B. Stefan, S. Gabriel, T. Gerardo, G. Rafal, F.T. Heer, B.T. A P de, R. Christine, B. Lorenza, SWISS-MODEL: homology modelling of protein structures and complexes, Nucleic Acids Res. 46(2018) W296-W303, Doi: https:\/\/doi.org\/10.1093\/nar\/gky427.","DOI":"10.1093\/nar\/gky427"},{"key":"10.1016\/j.bioorg.2026.110058_bb0215","doi-asserted-by":"crossref","unstructured":"M.J. Abrahama, T. Murtola, R. Schulz, S. P\u00e1ll, J.C. Smith, B. Hess, E. Lindahl E, GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers, SoftwareX 1\u20132 (2015) 19\u201325, Doi: https:\/\/doi.org\/10.1016\/j.softx.2015.06.001.","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"10.1016\/j.bioorg.2026.110058_bb0220","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van der Spoel","year":"2005","journal-title":"J. Comput. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826005948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826005948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:29:49Z","timestamp":1787675389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826005948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":44,"alternative-id":["S0045206826005948"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110058","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-guided discovery of phenyl-carbamates as novel dual TRPV1 antagonists\/FAAH inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110058"}}