{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:21:39Z","timestamp":1787678499756,"version":"build-2784847793"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002657","name":"Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002657","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004006","name":"Istanbul University Scientific Research Projects Unit","doi-asserted-by":"publisher","award":["TSA-2024-40304"],"award-info":[{"award-number":["TSA-2024-40304"]}],"id":[{"id":"10.13039\/501100004006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110066","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:55:36Z","timestamp":1780329336000},"page":"110066","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Discovery of novel imidazo[2,1-b]thiazole-hydrazone hybrids as multi-target anticancer agents: Dual PARP-1\/COX-2 inhibition and MetAP-2 modulation"],"prefix":"10.1016","volume":"180","author":[{"given":"Merve","family":"Camci Eren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Abudayyak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efe Do\u011fukan","family":"Dincel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl","family":"\u00d6zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuray","family":"Ulusoy-G\u00fczeldemirci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110066_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104558","article-title":"Design, synthesis, biological evaluation and molecular docking of new 1, 3, 4-oxadiazole homonucleosides and their double-headed analogs as antitumor agents","volume":"108","author":"Mansouri","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0010","series-title":"National Cancer Institute","year":"2026"},{"key":"10.1016\/j.bioorg.2026.110066_bb0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejmech.2017.05.016","article-title":"Designing multi-targeted agents: an emerging anticancer drug discovery paradigm","volume":"136","author":"Fu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202301950","article-title":"Development of novel indazolyl-acyl hydrazones as antioxidant and anticancer agents that target VEGFR-2 in human breast cancer cells","volume":"21","author":"Parameshwaraiah","year":"2024","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bioorg.2026.110066_bb0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12964-023-01302-1","article-title":"Unveiling the mechanisms and challenges of cancer drug resistance","volume":"22","author":"Khan","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bioorg.2026.110066_bb0030","article-title":"Synthesis and biological evaluation of novel benzohydrazide derivatives of substituted quinazoline-2, 4 (1H,3H)-diones as selective PARP-1 inhibitors with promising anti-proliferative activity","volume":"1349","author":"Tawfik","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.110066_bb0035","article-title":"Discovery of novel thiosemicarbazone dimers as effective inhibitors of poly (ADP-ribose) polymerase-1 (PARP-1) for use in cancer therapy","volume":"302","author":"Wang","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108761","article-title":"From bench to bedside: synthetic strategies and clinical application of PARP inhibitors","volume":"163","author":"Man","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.637504","article-title":"Cyclooxygenase-2 inhibitor: a potential combination strategy with immunotherapy in cancer","volume":"11","author":"Pu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bioorg.2026.110066_bb0050","first-page":"1288","article-title":"Design, synthesis and biological evaluation of new Imidazo [2, 1-B] thiazole derivatives as selective COX-2 inhibitors","volume":"17","author":"Shahrasbi","year":"2018","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.bioorg.2026.110066_bb0055","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1002\/jcp.27411","article-title":"Cyclooxygenase-2 in cancer: a review","volume":"234","author":"Hashemi Goradel","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bioorg.2026.110066_bb0060","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.3390\/ijms23031432","article-title":"NSAIDs and cancer resolution: new paradigms beyond cyclooxygenase","volume":"23","author":"Kolawole","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110066_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136910","article-title":"Discovery of anti-tumor agent targeted MetAP-2 using a special turn-on fluorescent probe","volume":"424","author":"Li","year":"2025","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0070","doi-asserted-by":"crossref","first-page":"11119","DOI":"10.1021\/acs.jmedchem.9b01070","article-title":"Identification of methionine aminopeptidase-2 (MetAP-2) inhibitor M8891: a clinical compound for the treatment of cancer","volume":"62","author":"Heinrich","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0075","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1021\/acs.jmedchem.9b00041","article-title":"Discovery and structure-based optimization of next-generation reversible methionine aminopeptidase-2 (MetAP-2) inhibitors","volume":"62","author":"Heinrich","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0080","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2174\/092986712799320709","article-title":"The development of MetAP-2 inhibitors in cancer treatment","volume":"19","author":"Yin","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2026.110066_bb0085","article-title":"Novel levamisole derivative induces extrinsic pathway of apoptosis in Cancer cells and inhibits tumor progression in mice","volume":"7","author":"Hedge","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2026.110066_bb0090","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/07391102.2023.2280756","article-title":"Chalcone-based imidazo [2, 1-b] thiazole derivatives: synthesis, crystal structure, potent anticancer activity, and computational studies","volume":"43","author":"Dadou","year":"2025","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.bioorg.2026.110066_bb0095","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1080\/17568919.2025.2552637","article-title":"Recent progress in the synthetic and medicinal perspective of imidazo [2, 1-b] thiazole derivatives","volume":"17","author":"Amrutkar","year":"2025","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0100","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s11030-019-09974-z","article-title":"Synthesis, molecular docking and evaluation of novel sulfonyl hydrazones as anticancer agents and COX-2 inhibitors","volume":"24","author":"\u015eenkarde\u015f","year":"2020","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bioorg.2026.110066_bb0105","doi-asserted-by":"crossref","first-page":"2300426","DOI":"10.1002\/ardp.202300426","article-title":"Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition","volume":"357","author":"\u0106ur\u010di\u0107","year":"2024","journal-title":"Arch. Pharm. (Weinheim)."},{"key":"10.1016\/j.bioorg.2026.110066_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2025.127637","article-title":"Cytotoxic activity, caspase-3 mediated apoptosis, and PARP-1 inhibition targeted molecular modeling studies of novel imidazole-fused hydrazones","volume":"429","author":"Tapera","year":"2025","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioorg.2026.110066_bb0115","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1002\/cmdc.201402310","article-title":"Design and synthesis of imidazo [2, 1-b] thiazole\u2013chalcone conjugates: microtubule-destabilizing agents","volume":"9","author":"Kamal","year":"2014","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bioorg.2026.110066_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116698","article-title":"Design, synthesis and biological evaluation of a new series of imidazothiazole-hydrazone hybrids as dual EGFR and Akt inhibitors for NSCLC therapy","volume":"276","author":"Alt\u0131ntop","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0125","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0223-5234(94)90101-5","article-title":"Imidazo [2, 1-b] thiazole derivatives. XI. Modulation of the CD2-receptor of human T trypsinized lymphocytes by several imidazo [2, 1-b] thiazoles","volume":"29","author":"Harraga","year":"1994","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0130","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3389\/fonc.2020.00371","article-title":"Targeting the DNA damage response for the treatment of high risk neuroblastoma","volume":"10","author":"Southgate","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bioorg.2026.110066_bb0135","doi-asserted-by":"crossref","first-page":"djx062","DOI":"10.1093\/jnci\/djx062","article-title":"Loss of DNA damage response in neuroblastoma and utility of a PARP inhibitor","volume":"109","author":"Takagi","year":"2017","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"10.1016\/j.bioorg.2026.110066_bb0140","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1186\/s12885-016-2656-8","article-title":"An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma","volume":"16","author":"Nile","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bioorg.2026.110066_bb0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.canlet.2005.01.049","article-title":"Prospects for therapeutic inhibition of neuroblastoma angiogenesis","volume":"228","author":"Shusterman","year":"2005","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.110066_bb0150","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1158\/1078-0432.CCR-04-1917","article-title":"Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models","volume":"11","author":"Morowitz","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bioorg.2026.110066_bb0155","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/782020","article-title":"Targeting angiogenesis for controlling neuroblastoma","volume":"2012","author":"Roy Choudhury","year":"2012","journal-title":"J. Oncol."},{"key":"10.1016\/j.bioorg.2026.110066_bb0160","doi-asserted-by":"crossref","first-page":"7210","DOI":"10.1158\/0008-5472.CAN-04-1795","article-title":"Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo","volume":"64","author":"Johnsen","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2026.110066_bb0165","doi-asserted-by":"crossref","first-page":"2400562","DOI":"10.1002\/ardp.202400562","article-title":"Novel hydrazide-hydrazone containing 1, 2, 4-triazole as potent inhibitors of antiapoptotic protein Bcl-xL: synthesis, biological evaluation, and docking studies","volume":"357","author":"Kuran","year":"2024","journal-title":"Arch. Pharm. (Weinheim)."},{"key":"10.1016\/j.bioorg.2026.110066_bb0170","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202405876","article-title":"Discovery of dual-inhibitor acyl Hydrazones for acetylcholinesterase and carbonic anhydrase I\/II: a mechanistic insight into Alzheimer\u2019s disease","volume":"10","author":"Dincel","year":"2025","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bioorg.2026.110066_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.132673","article-title":"Design, synthesis, biological evaluation, molecular docking, and dynamic simulation study of novel imidazo [2, 1-b] thiazole derivatives as potent antioxidant agents","volume":"1258","author":"Dincel","year":"2022","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.110066_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202405534","article-title":"New imidazo [2, 1-b] thiazole linked hydrazide\u2013hydrazones as potent \u03b1-glucosidase inhibitors: synthesis, biological evaluation, and docking insights","volume":"10","author":"Durmaz","year":"2025","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bioorg.2026.110066_bb0185","doi-asserted-by":"crossref","first-page":"183","DOI":"10.26650\/IstanbulJPharm.2025.1600357","article-title":"Design and synthesis of novel Imidazo [2, 1-b] thiazole-based 4-Thiazolidinone derivatives as potent \u03b1-glucosidase inhibitors","volume":"55","author":"Dincel","year":"2025","journal-title":"\u0130stanbul J. Pharm."},{"key":"10.1016\/j.bioorg.2026.110066_bb0190","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.2174\/0118715206356980250113074705","article-title":"Preliminary investigations on acyl Hydrazones bearing sulfonamides as inhibitors of the human carbonic anhydrase isoforms I, II, IX, and XII","volume":"25","author":"Dincel","year":"2025","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0195","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/10426507.2024.2320672","article-title":"Synthesis and in vitro carbonic anhydrase and acetylcholinesterase inhibitory activities of novel hydrazide\u2013hydrazone compounds containing 1, 2, 4-triazole ring","volume":"199","author":"Dincel","year":"2024","journal-title":"Phosphorus Sulfur Silicon Relat. Elem."},{"key":"10.1016\/j.bioorg.2026.110066_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202500630","article-title":"Novel Imidazo [2,1-b] thiazole based 4-Thiazolidinones: molecular dynamics guided design, synthesis, and \u03b1-glucosidase inhibitory evaluation","volume":"10","author":"Hasbal-Celikok","year":"2025","journal-title":"ChemistrySelect"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:47:19Z","timestamp":1787676439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826006024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":40,"alternative-id":["S0045206826006024"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110066","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel imidazo[2,1-b]thiazole-hydrazone hybrids as multi-target anticancer agents: Dual PARP-1\/COX-2 inhibition and MetAP-2 modulation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110066"}}