{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:27:23Z","timestamp":1793896043399,"version":"4.8.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477114"],"award-info":[{"award-number":["22477114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108030"],"award-info":[{"award-number":["82020108030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["241111312500"],"award-info":[{"award-number":["241111312500"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["252300421352"],"award-info":[{"award-number":["252300421352"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110067","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T15:46:40Z","timestamp":1780933600000},"page":"110067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A homologous cell membrane-coated peptide-based USP7 degrader enhances degradation efficiency and anti-tumor activity in gastric Cancer"],"prefix":"10.1016","volume":"180","author":[{"given":"Cong-Cong","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nin-Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Ge","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Bing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Liang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Nan-Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110067_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188903","article-title":"USP7 - a crucial regulator of cancer hallmarks","volume":"1878","author":"Saha","year":"2023","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.bioorg.2026.110067_bb0010","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/path.1931","article-title":"The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways","volume":"208","author":"Masuya","year":"2006","journal-title":"J. Pathol."},{"key":"10.1016\/j.bioorg.2026.110067_bb0015","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nature07290","article-title":"The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network","volume":"455","author":"Song","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2026.110067_bb0020","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1172\/JCI120518","article-title":"Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis","volume":"128","author":"Su","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioorg.2026.110067_bb0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/jmcb\/mjw049","article-title":"Modulation of the p53\/MDM2 interplay by HAUSP inhibitors","volume":"9","author":"Tavana","year":"2017","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.110067_bb0030","doi-asserted-by":"crossref","first-page":"e867","DOI":"10.1038\/cddis.2013.400","article-title":"USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis","volume":"4","author":"Fan","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.110067_bb0035","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1158\/1535-7163.MCT-09-0097","article-title":"Small-molecule inhibitor of USP7\/HAUSP ubiquitin protease stabilizes and activates p53 in cells","volume":"8","author":"Colland","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bioorg.2026.110067_bb0040","doi-asserted-by":"crossref","first-page":"10056","DOI":"10.1021\/acs.jmedchem.7b01293","article-title":"Discovery of small-molecule inhibitors of ubiquitin specific protease 7 (USP7) using integrated NMR and in silico techniques","volume":"60","author":"Di Lello","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110067_bb0045","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nchembio.2528","article-title":"Discovery and characterization of highly potent and selective allosteric USP7 inhibitors","volume":"14","author":"Gavory","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.110067_bb0050","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature24006","article-title":"USP7 small-molecule inhibitors interfere with ubiquitin binding","volume":"550","author":"Kategaya","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2026.110067_bb0055","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.chembiol.2017.09.003","article-title":"Structure-guided development of a potent and selective non-covalent active-site inhibitor of USP7","volume":"24","author":"Lamberto","year":"2017","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.bioorg.2026.110067_bb0060","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1021\/acs.jmedchem.0c00245","article-title":"Discovery of potent, selective, and orally bioavailable inhibitors of USP7 with in vivo antitumor activity","volume":"63","author":"Leger","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110067_bb0065","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1021\/acsmedchemlett.7b00512","article-title":"Identification and structure-guided development of pyrimidinone based USP7 inhibitors","volume":"9","author":"O\u2019Dowd","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110067_bb0070","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1038\/s41598-020-62076-x","article-title":"Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism","volume":"10","author":"Schauer","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.110067_bb0075","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature24451","article-title":"Molecular basis of USP7 inhibition by selective small-molecule inhibitors","volume":"550","author":"Turnbull","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2026.110067_bb0080","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41573-021-00371-6","article-title":"PROTAC targeted protein degraders: the past is prologue","volume":"21","author":"Bekes","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2026.110067_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.103395","article-title":"PROTAC technology: a new drug design for chemical biology with many challenges in drug discovery","volume":"28","author":"Guedeney","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bioorg.2026.110067_bb0090","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-020-00885-3","article-title":"Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy","volume":"13","author":"Li","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bioorg.2026.110067_bb0095","doi-asserted-by":"crossref","first-page":"8858","DOI":"10.1039\/D2CC02094G","article-title":"Targeting the deubiquitinase USP7 for degradation with PROTACs","volume":"58","author":"Murgai","year":"2022","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.bioorg.2026.110067_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202204395","article-title":"Discovery of a potent and selective degrader for USP7","volume":"61","author":"Pei","year":"2022","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.bioorg.2026.110067_bb0105","doi-asserted-by":"crossref","first-page":"13197","DOI":"10.1021\/acs.jmedchem.4c01134","article-title":"Discovery of a highly potent, selective and efficacious USP7 degrader for the treatment of acute lymphoblastic Leukemia","volume":"67","author":"Xu","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110067_bb0110","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1038\/s41418-023-01180-7","article-title":"Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1","volume":"30","author":"Yi","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioorg.2026.110067_bb0115","doi-asserted-by":"crossref","first-page":"10141","DOI":"10.7150\/thno.46985","article-title":"The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination","volume":"10","author":"Jin","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bioorg.2026.110067_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.129945","article-title":"Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3","volume":"112","author":"Yang","year":"2024","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110067_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105212","article-title":"Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy","volume":"105","author":"Zhang","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bioorg.2026.110067_bb0130","doi-asserted-by":"crossref","first-page":"8554","DOI":"10.1073\/pnas.141230798","article-title":"Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation","volume":"98","author":"Sakamoto","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioorg.2026.110067_bb0135","article-title":"A comprehensive review on current advances in peptide drug development and design","volume":"20","author":"Lee","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110067_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201701741","article-title":"Encapsulation of hydrophilic and hydrophobic peptides into hollow mesoporous silica nanoparticles for enhancement of antitumor immune response","volume":"13","author":"Xie","year":"2017","journal-title":"Small"},{"key":"10.1016\/j.bioorg.2026.110067_bb0145","doi-asserted-by":"crossref","unstructured":"N. H. Lee, S. You, A. Taghizadeh, M. Taghizadeh and H. S. Kim, Cell membrane-cloaked nanotherapeutics for targeted drug delivery, Int. J. Mol. Sci., 2022, 23.","DOI":"10.3390\/ijms23042223"},{"key":"10.1016\/j.bioorg.2026.110067_bb0150","doi-asserted-by":"crossref","first-page":"55840","DOI":"10.1021\/acsami.1c16543","article-title":"Neural cell membrane-coated nanoparticles for targeted and enhanced uptake by central nervous system cells","volume":"13","author":"Zhang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioorg.2026.110067_bb0155","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jconrel.2024.01.055","article-title":"SiATG5-loaded cancer cell membrane-fused liposomes induced increased uptake of albumin-bound chemotherapeutics by pancreatic cancer cells","volume":"367","author":"Yan","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioorg.2026.110067_bb0160","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ebiom.2016.10.018","article-title":"Ubiquitin-specific Protease-7 inhibition impairs Tip60-dependent Foxp3+ T-regulatory cell function and promotes antitumor immunity","volume":"13","author":"Wang","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bioorg.2026.110067_bb0165","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.apsb.2020.11.005","article-title":"Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2026.110067_bb0170","doi-asserted-by":"crossref","unstructured":"M. Alsaadawe, B. A. Radman, J. Long, M. Alsaadawi, W. Fang and X. Lyu, Epstein Barr virus: a cellular hijacker in cancer, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2024, 1879, 189218.","DOI":"10.1016\/j.bbcan.2024.189218"},{"key":"10.1016\/j.bioorg.2026.110067_bb0175","doi-asserted-by":"crossref","first-page":"47753","DOI":"10.1074\/jbc.M307200200","article-title":"Protein interaction domains of the ubiquitin-specific protease, USP7\/HAUSP","volume":"278","author":"Holowaty","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2026.110067_bb0180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.molcel.2005.02.029","article-title":"Structure of the p53 binding domain of HAUSP\/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization","volume":"18","author":"Saridakis","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bioorg.2026.110067_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0040027","article-title":"Structural basis of competitive recognition of p53 and MDM2 by HAUSP\/USP7: implications for the regulation of the p53-MDM2 pathway","volume":"4","author":"Hu","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bioorg.2026.110067_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-05375-7","article-title":"High-potency PD-1\/PD-L1 degradation induced by peptide-PROTAC in human cancer cells","volume":"13","author":"Dai","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.110067_bb0195","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejmech.2018.01.063","article-title":"Discovery of a Keap1-dependent peptide PROTAC to knockdown tau by ubiquitination-proteasome degradation pathway","volume":"146","author":"Lu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110067_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.chembiol.2023.07.006","article-title":"Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, beta-catenin, and FoxP3","volume":"30","author":"Roth","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.110067_bb0205","article-title":"De novo Design of an Androgen Receptor DNA binding domain-targeted peptide PROTAC for prostate Cancer therapy","volume":"9","author":"Ma","year":"2022","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.bioorg.2026.110067_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14225539","article-title":"USP7 Inhibitors in Cancer Immunotherapy: Current Status and Perspective","volume":"14","author":"Korenev","year":"2022","journal-title":"Cancers (Basel)"}],"updated-by":[{"DOI":"10.1016\/j.bioorg.2026.110308","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000}},{"DOI":"10.1016\/j.bioorg.2026.110308","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000}}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:03:42Z","timestamp":1793894622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826006036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":42,"alternative-id":["S0045206826006036"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110067","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A homologous cell membrane-coated peptide-based USP7 degrader enhances degradation efficiency and anti-tumor activity in gastric Cancer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110067"}}