{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:21:55Z","timestamp":1791289315075,"version":"4.3.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3501600"],"award-info":[{"award-number":["2022YFC3501600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110089","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:03:46Z","timestamp":1781222626000},"page":"110089","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Millepurpan from Astragali Radix binds condensin SMC2 to reverse microglial cell cycle arrest and metabolic reprogramming in neuroinflammation"],"prefix":"10.1016","volume":"180","author":[{"given":"Yue","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Fei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui-Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Zheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Xiao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Zhe","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Wei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Wu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Fei","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110089_bb0005","series-title":"Neuroinflammation in Alzheimer\u2019s disease: current progress in molecular signaling and therapeutics","first-page":"1","volume":"46(1)","author":"Thakur","year":"2023"},{"key":"10.1016\/j.bioorg.2026.110089_bb0010","series-title":"Neuroinflammation in Alzheimer\u2019s disease","first-page":"388","volume":"14(4)","author":"Heneka","year":"2015"},{"key":"10.1016\/j.bioorg.2026.110089_bb0015","series-title":"MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson\u2019s disease","first-page":"13","volume":"15(1)","author":"Yao","year":"2018"},{"key":"10.1016\/j.bioorg.2026.110089_bb0020","series-title":"Anti-neuroinflammatory potential of natural products in the treatment of Alzheimer\u2019s disease","first-page":"1486","volume":"28(3)","author":"Deng","year":"2023"},{"key":"10.1016\/j.bioorg.2026.110089_bb0025","series-title":"Effect of hemoadsorption during cardiopulmonary bypass surgery\u2013a blinded, randomized, controlled pilot study using a novel adsorbent","first-page":"96","volume":"20(1)","author":"Bernardi","year":"2016"},{"key":"10.1016\/j.bioorg.2026.110089_bb0030","series-title":"Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation","first-page":"7313","volume":"68(18)","author":"Yang","year":"2008"},{"key":"10.1016\/j.bioorg.2026.110089_bb0035","series-title":"Europium-doped cerium oxide nanoparticles for microglial amyloid beta clearance and homeostasis","first-page":"1232","volume":"13(8)","author":"Machhi","year":"2022"},{"key":"10.1016\/j.bioorg.2026.110089_bb0040","series-title":"Astragali radix (Huangqi): a time-honored nourishing herbal medicine","first-page":"119","volume":"19(1)","author":"Zhang","year":"2024"},{"key":"10.1016\/j.bioorg.2026.110089_bb0045","series-title":"Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application","first-page":"165","volume":"47(3)","author":"Liu","year":"2024"},{"key":"10.1016\/j.bioorg.2026.110089_bb0050","article-title":"Astragaloside IV: A promising natural neuroprotective agent for neurological disorders","volume":"159","author":"Yao","year":"2023","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.bioorg.2026.110089_bb0055","series-title":"Pharmaceutical values of calycosin: one type of flavonoid isolated from astragalus","first-page":"9952578","volume":"2021(1)","author":"Gong","year":"2021"},{"key":"10.1016\/j.bioorg.2026.110089_bb0060","series-title":"A critical review of Astragalus polysaccharides: from therapeutic mechanisms to pharmaceutics","first-page":"112654","volume":"147","author":"Du","year":"2022"},{"key":"10.1016\/j.bioorg.2026.110089_bb0065","doi-asserted-by":"crossref","first-page":"113249","DOI":"10.1016\/j.phytochem.2022.113249","article-title":"Bioactive pterocarpans from the root of Astragalus membranaceus var. mongholicus","volume":"200","author":"Bao","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2026.110089_bb0070","series-title":"Astramalabaricosides A\u2013T, highly oxygenated malabaricane triterpenoids with migratory inhibitory activity from Astragalus membranaceus var. mongholicus","first-page":"2312","volume":"85(10)","author":"Luo","year":"2022"},{"issue":"18","key":"10.1016\/j.bioorg.2026.110089_bb0075","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1080\/14786419.2021.2012771","article-title":"New cytotoxic chalcone derivatives from Astragalus ponticus Pall","volume":"36","author":"Koldas","year":"2021","journal-title":"Nat. Prod. Res."},{"issue":"13","key":"10.1016\/j.bioorg.2026.110089_bb0080","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.phymed.2015.09.005","article-title":"Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells","volume":"22","author":"Gatouillat","year":"2015","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.110089_bb0085","doi-asserted-by":"crossref","first-page":"108833","DOI":"10.1016\/j.pharmthera.2025.108833","article-title":"Recent advances in target identification technology of natural products","volume":"269","author":"Liu","year":"2025","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bioorg.2026.110089_bb0090","series-title":"Structural basis of an asymmetric condensin ATPase cycle","first-page":"1175","volume":"74(6)","author":"Hassler","year":"2019"},{"key":"10.1016\/j.bioorg.2026.110089_bb0095","series-title":"Condensin Smc2-Smc4 dimers are flexible and dynamic","first-page":"1813","volume":"14(8)","author":"Eeftens","year":"2016"},{"issue":"45","key":"10.1016\/j.bioorg.2026.110089_bb0100","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1021\/acs.biochem.1c00473","article-title":"Ycs4 Subunit of Saccharomyces cerevisiae Condensin Binds DNA and Modulates the Enzyme Turnover","volume":"60","author":"Sarkar","year":"2021","journal-title":"Biochemistry"},{"key":"10.1016\/j.bioorg.2026.110089_bb0105","series-title":"Invited review: Architectures and mechanisms of ATP binding cassette proteins","first-page":"492","volume":"105(8)","author":"Hopfner","year":"2016"},{"key":"10.1016\/j.bioorg.2026.110089_bb0110","series-title":"Early glycolytic reprogramming controls microglial inflammatory activation","first-page":"129","volume":"18(1)","author":"Cheng","year":"2021"},{"issue":"4","key":"10.1016\/j.bioorg.2026.110089_bb0115","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nprot.2009.21","article-title":"Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics","volume":"4","author":"Boersema","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bioorg.2026.110089_bb0120","series-title":"Total glucosides of Picrorhizae Rhizome alleviate non-alcoholic steatohepatitis (NASH) by specifically targeting acyl-CoA oxidase 1","volume":"10(21)","author":"Zhuo","year":"2024"},{"issue":"W1","key":"10.1016\/j.bioorg.2026.110089_bb0125","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx407","article-title":"HDOCK: a web server for protein\u2013protein and protein\u2013DNA\/RNA docking based on a hybrid strategy","volume":"45","author":"Yan","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2026.110089_bb0130","series-title":"Gaussian 16 rev. c. 01, wallingford, ct","author":"Frisch","year":"2016"},{"key":"10.1016\/j.bioorg.2026.110089_bb0135","series-title":"Protective effect of quercetin in LPS-induced murine acute lung injury mediated by cAMP-Epac pathway","first-page":"1093","volume":"41(3)","author":"Wang","year":"2018"},{"key":"10.1016\/j.bioorg.2026.110089_bb0140","series-title":"Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a\/\u03b2-Catenin and Akt\/NF-\u03baB signaling pathways","first-page":"154933","volume":"118","author":"Wang","year":"2023"},{"key":"10.1016\/j.bioorg.2026.110089_bb0145","series-title":"Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer\u2019s disease pathology","first-page":"4365","volume":"186(20)","author":"Mathys","year":"2023"},{"key":"10.1016\/j.bioorg.2026.110089_bb0150","series-title":"A single-cell RNA sequencing study reveals cellular and molecular dynamics of the hippocampal neurogenic niche","first-page":"3271","volume":"21(11)","author":"Artegiani","year":"2017"},{"key":"10.1016\/j.bioorg.2026.110089_bb0155","series-title":"Single-cell RNA sequencing reveals the evolution of the immune landscape during perihematomal edema progression after intracerebral hemorrhage","first-page":"140","volume":"21(1)","author":"Zhang","year":"2024"},{"key":"10.1016\/j.bioorg.2026.110089_bb0160","series-title":"MAFG-driven astrocytes promote CNS inflammation","first-page":"593","volume":"578(7796)","author":"Wheeler","year":"2020"},{"key":"10.1016\/j.bioorg.2026.110089_bb0165","series-title":"Single-cell analysis reveals T cell infiltration in old neurogenic niches","first-page":"205","volume":"571(7764)","author":"Dulken","year":"2019"},{"key":"10.1016\/j.bioorg.2026.110089_bb0170","series-title":"A simplified thermal proteome profiling approach to screen protein targets of a ligand","author":"Zhang","year":"2020"},{"key":"10.1016\/j.bioorg.2026.110089_bb0175","series-title":"Condensin Smc4 promotes inflammatory innate immune response by epigenetically enhancing NEMO transcription","first-page":"67","volume":"92","author":"Wang","year":"2018"},{"key":"10.1016\/j.bioorg.2026.110089_bb0180","series-title":"Preclinical translational platform of neuroinflammatory disease biology relevant to neurodegenerative disease","first-page":"37","volume":"21(1)","author":"Larson","year":"2024"},{"key":"10.1016\/j.bioorg.2026.110089_bb0185","series-title":"Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1\/NLRP3\/Caspase-1 pathway","first-page":"3882","volume":"12(8)","author":"Wang","year":"2022"},{"key":"10.1016\/j.bioorg.2026.110089_bb0190","series-title":"Sepiapterin reductase inhibition leading to selective reduction of inflammatory joint pain in mice and increased urinary sepiapterin levels in humans and mice","first-page":"57","volume":"72(1)","author":"Fujita","year":"2020"},{"key":"10.1016\/j.bioorg.2026.110089_bb0195","series-title":"Chromosome cohesion, condensation, and separation","first-page":"115","volume":"69(1)","author":"Hirano","year":"2000"},{"key":"10.1016\/j.bioorg.2026.110089_bb0200","series-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","first-page":"84","volume":"341(6141)","author":"Molina","year":"2013"},{"key":"10.1016\/j.bioorg.2026.110089_bb0205","series-title":"Target identification using drug affinity responsive target stability (DARTS)","first-page":"21984","volume":"106(51)","author":"Lomenick","year":"2009"},{"key":"10.1016\/j.bioorg.2026.110089_bb0210","series-title":"Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases","first-page":"1","volume":"3(2):reviews3003","author":"Harvey","year":"2002"},{"issue":"10","key":"10.1016\/j.bioorg.2026.110089_bb0215","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1093\/nar\/gkq038","article-title":"Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins","volume":"38","author":"Griese","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2026.110089_bb0220","series-title":"The condensin complex is a mechanochemical motor that translocates along DNA","first-page":"672","volume":"358(6363)","author":"Terakawa","year":"2017"},{"key":"10.1016\/j.bioorg.2026.110089_bb0225","series-title":"Cell Painting: a decade of discovery and innovation in cellular imaging","first-page":"254","volume":"22(2)","author":"Seal","year":"2025"},{"key":"10.1016\/j.bioorg.2026.110089_bb0230","doi-asserted-by":"crossref","first-page":"176600","DOI":"10.1016\/j.ejphar.2024.176600","article-title":"Dabrafenib mitigates the neuroinflammation caused by ferroptosis in experimental autoimmune encephalomyelitis by up regulating Axl receptor","volume":"973","author":"Liu","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110089_bb0235","series-title":"Gastrodin attenuates proliferation and inflammatory responses in activated microglia through Wnt\/\u03b2-catenin signaling pathway","first-page":"190","volume":"1717","author":"Yao","year":"2019"},{"key":"10.1016\/j.bioorg.2026.110089_bb0240","series-title":"Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent","first-page":"434","volume":"10(3)","author":"Feng","year":"2020"},{"key":"10.1016\/j.bioorg.2026.110089_bb0245","series-title":"Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism","first-page":"743","volume":"27(8)","author":"Lee","year":"2020"},{"key":"10.1016\/j.bioorg.2026.110089_bb0250","series-title":"Chromosome dynamics during mitosis","first-page":"a015792","volume":"7(6)","author":"Hirano TJCSHpib.","year":"2015"},{"issue":"4","key":"10.1016\/j.bioorg.2026.110089_bb0255","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bph.13139","article-title":"Microglial M1\/M2 polarization and metabolic states","volume":"173","author":"Orihuela","year":"2016","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110089_bb0260","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41422-020-0372-z","article-title":"Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle","volume":"31","author":"Liu","year":"2021","journal-title":"Cell Res."},{"issue":"14","key":"10.1016\/j.bioorg.2026.110089_bb0265","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1128\/MCB.02074-05","article-title":"Cyclin D1 determines mitochondrial function invivo","volume":"26","author":"Sakamaki","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bioorg.2026.110089_bb0270","series-title":"Methods in enzymology","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/B978-0-12-801415-8.00016-3","article-title":"Analysis and interpretation of microplate-based oxygen consumption and pH data","volume":"547","author":"Divakaruni","year":"2014"},{"key":"10.1016\/j.bioorg.2026.110089_bb0275","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.freeradbiomed.2020.02.030","article-title":"Medicine. Semisynthetic quercetin-quinone mitigates BV-2 microglia activation through modulation of Nrf2 pathway","volume":"152","author":"\u0160kand\u00edk","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioorg.2026.110089_bb0280","series-title":"Decoding NLRP3 Inflammasome activation in Alzheimer\u2019s disease: a focus on receptor Dynamics","first-page":"1","author":"Maurya","year":"2025"},{"issue":"2","key":"10.1016\/j.bioorg.2026.110089_bb0285","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1039\/D0NR05958G","article-title":"Dendrimer\u2013tesaglitazar conjugate induces a phenotype shift of microglia and enhances \u03b2-amyloid phagocytosis","volume":"13","author":"DeRidder","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.bioorg.2026.110089_bb0290","doi-asserted-by":"crossref","first-page":"576293","DOI":"10.3389\/fphar.2020.576293","article-title":"Designing clinical trials for anti-inflammatory therapies in cystic fibrosis","volume":"11","author":"Perrem","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110089_bb0295","series-title":"Applications. Cyclin\/Forkhead-mediated coordination of cyclin waves: an autonomous oscillator rationalizing the quantitative model of Cdk control for budding yeast","first-page":"48","volume":"7(1)","author":"Barberis","year":"2021"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110089_bb0300","doi-asserted-by":"crossref","first-page":"21675","DOI":"10.1038\/s41598-025-96654-8","article-title":"Prognostic and immunotherapeutic significance of NCAPD2 in pan-cancer and its role in hepatocellular carcinoma progression via the AKT\/GSK-3\u03b2 signaling pathway","volume":"15","author":"Ma","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.110089_bb0305","series-title":"Structural maintenance of chromosome protein 4 promotes the progression of cardia adenocarcinoma via regulation of the Wnt\/\u03b2-catenin signaling pathway","first-page":"611","volume":"27(4)","author":"Zhu","year":"2024"},{"issue":"9","key":"10.1016\/j.bioorg.2026.110089_bb0310","first-page":"1240","article-title":"Functions of SMC2 in the development of zebrafish","volume":"9","author":"Li","year":"2021","journal-title":"Liver"},{"issue":"12","key":"10.1016\/j.bioorg.2026.110089_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004847","article-title":"Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions","volume":"10","author":"Nishide","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bioorg.2026.110089_bb0320","series-title":"cGAS-STING signalling regulates microglial chemotaxis in genome instability","first-page":"1188","volume":"52(3)","author":"Talbot","year":"2024"},{"issue":"3","key":"10.1016\/j.bioorg.2026.110089_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103875","article-title":"Sex disparities in DNA damage response pathways: Novel determinants in cancer formation and therapy","volume":"25","author":"Cardano","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.bioorg.2026.110089_bb0330","series-title":"NCAPG confers trastuzumab resistance via activating SRC\/STAT3 signaling pathway in HER2-positive breast cancer","first-page":"547","volume":"11(7)","author":"Jiang","year":"2020"},{"key":"10.1016\/j.bioorg.2026.110089_bb0335","series-title":"SMC Complexes: Methods and Protocols","first-page":"197","article-title":"A protocol for assaying the ATPase activity of recombinant cohesin holocomplexes","author":"Voulgaris","year":"2019"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:34:03Z","timestamp":1787675643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826006255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":67,"alternative-id":["S0045206826006255"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110089","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Millepurpan from Astragali Radix binds condensin SMC2 to reverse microglial cell cycle arrest and metabolic reprogramming in neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110089"}}