{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:27:23Z","timestamp":1793896043445,"version":"4.8.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ANRF\/PAIR\/2025\/000029\/PAIR"],"award-info":[{"award-number":["ANRF\/PAIR\/2025\/000029\/PAIR"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110103","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:33:46Z","timestamp":1781541226000},"page":"110103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Design, synthesis, in vitro and in silico evaluation of novel 5-(1-benzyl-1H-indol-3-yl)-3-phenyl-4,5-dihydroisoxazole derivatives against ER-positive breast cancer"],"prefix":"10.1016","volume":"180","author":[{"given":"Agnidipta","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Midha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Mayank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamalpreet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somesh","family":"Baranwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Jaitak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110103_bb0005","series-title":"Cancer statistics, 2026, CA: a cancer Journal for clinicians","first-page":"e70043","volume":"76(1)","author":"Rebecca","year":"2026"},{"key":"10.1016\/j.bioorg.2026.110103_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2025.1622954","article-title":"Global burden and projections of breast cancer incidence and mortality to 2050: a comprehensive analysis of GLOBOCAN data","volume":"13","author":"Freihat","year":"2025","journal-title":"Front. Public Health"},{"key":"10.1016\/j.bioorg.2026.110103_bb0015","author":"Mazloomi"},{"issue":"6","key":"10.1016\/j.bioorg.2026.110103_bb0020","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/his.15557","article-title":"Emad a Rakha, outcome prediction of oestrogen receptor-positive breast cancer based on a panel of oestrogen receptor-regulated genes","volume":"87","author":"Makhlouf","year":"2025","journal-title":"Histopathology"},{"issue":"10","key":"10.1016\/j.bioorg.2026.110103_bb0025","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1039\/D5MD00297D","article-title":"Design, synthesis and biological evaluation of novel bis (indolyl)-tetrazine derivatives as anti-breast cancer agents","volume":"16","author":"Kaur","year":"2025","journal-title":"RSC Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110103_bb0030","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1039\/D3MD00730H","article-title":"Design, synthesis, in vitro and in silico evaluation of indole-based tetrazole derivatives as putative anti-breast cancer agents","volume":"15","author":"Kaur","year":"2024","journal-title":"RSC Med. Chem."},{"issue":"29","key":"10.1016\/j.bioorg.2026.110103_bb0035","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.2174\/0929867329666221006110528","article-title":"Kanamarlapudi J Lavanya, Nandini, Kamalpreet Kaur, Vikas Jaitak, effectiveness of selective estrogen receptor modulators in breast cancer therapy: an update","volume":"30","author":"Das","year":"2023","journal-title":"Curr. Med. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2026.110103_bb0040","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.1021\/acsomega.2c07793","article-title":"Mai E Shoman, taha FS Ali, Eman AM Beshr, Mahmoud Mohamed, Eman Alaaeldin, Ahmed M Shawky, vanillin-based indolin-2-one derivative bearing a pyridyl moiety as a promising anti-breast cancer agent via anti-estrogenic activity","volume":"8","author":"Bender","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.bioorg.2026.110103_bb0045","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.fct.2014.01.040","article-title":"\u03b1-Mangostin-induced apoptosis is mediated by estrogen receptor \u03b1 in human breast cancer cells","volume":"66","author":"Won","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110103_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011011","article-title":"Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression","volume":"5","author":"Dalvai","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2026.110103_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107341","article-title":"Design, synthesis, in silico and biological evaluation of new indole based oxadiazole derivatives targeting estrogen receptor alpha","volume":"147","author":"Kaur","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110103_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.70206","article-title":"Kalyan Kumar Sethi, selective Estrogen receptor modulators (SERMs): advances, challenges, and future prospects in ER+ breast Cancer therapy","volume":"359","author":"Saini","year":"2026","journal-title":"Arch. Pharm."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110103_bb0065","first-page":"773","article-title":"Design, synthesis, molecular docking and molecular dynamics studies of some 3-methoxy flavone derivatives as an anti-breast cancer agent, discover","volume":"16","author":"Fegade","year":"2025","journal-title":"Oncology"},{"key":"10.1016\/j.bioorg.2026.110103_bb0070","article-title":"Progress in heterocyclic hybrids for breast Cancer therapy: emerging trends, hybridization techniques, mechanistic pathways and SAR insights","author":"Gangwar","year":"2025","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110103_bb0075","doi-asserted-by":"crossref","first-page":"34","DOI":"10.46796\/ijpc.v6i4.763","article-title":"Indole as a biological scaffold: a comprehensive review","author":"Seepana","year":"2025","journal-title":"Int. J. Pharmacogn. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110103_bb0080","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jnutbio.2005.10.012","article-title":"Matthew J Milner, John a Milner, young S Kim, Estrogen receptor \u03b1 as a target for indole-3-carbinol","volume":"17","author":"Wang","year":"2006","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bioorg.2026.110103_bb0085","article-title":"Kamalpreet Kaur, Vikas Jaitak, isoxazole derivatives as anticancer agent: a review on synthetic strategies, mechanism of action and SAR studies","volume":"221","author":"Girish Chandra Arya","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2026.110103_bb0090","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.3390\/molecules25081909","article-title":"Kranthi Kumar Gangu, Sreekantha B Jonnalagadda, a review on recent advances in nitrogen-containing molecules and their biological applications","volume":"25","author":"Kerru","year":"2020","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.bioorg.2026.110103_bb0095","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2174\/1573409913666170406144642","article-title":"Multitargeted molecular docking study of natural-derived alkaloids on breast cancer pathway components","volume":"13","author":"Singla","year":"2017","journal-title":"Curr. Comput. Aided Drug Des."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110103_bb0100","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cbi.2010.05.015","article-title":"1-benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells","volume":"186","author":"Nguyen","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bioorg.2026.110103_bb0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejmech.2018.01.051","article-title":"Kunj Bihari Gupta, Shishir Upadhyay, Monisha Dhiman, Vikas Jaitak, design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-\u03b1)","volume":"146","author":"Singla","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110103_bb0110","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bmc.2017.11.040","article-title":"Kunj Bihari Gupta, Shishir Upadhyay, Monisha Dhiman, Vikas Jaitak, design, synthesis and biological evaluation of novel indole-xanthendione hybrids as selective estrogen receptor modulators","volume":"26","author":"Singla","year":"2018","journal-title":"Bioorg. Med. Chem."},{"issue":"20","key":"10.1016\/j.bioorg.2026.110103_bb0115","doi-asserted-by":"crossref","first-page":"8128","DOI":"10.1021\/acs.jmedchem.5b00984","volume":"58","author":"De Savi","year":"2015","journal-title":"J. Med. Chem."},{"issue":"11","key":"10.1016\/j.bioorg.2026.110103_bb0120","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1016\/j.bmcl.2005.03.111","article-title":"Benzothieno [3, 2-b] indole derivatives as potent selective estrogen receptor modulators","volume":"15","author":"Ji","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"11","key":"10.1016\/j.bioorg.2026.110103_bb0125","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1007\/s11696-021-01775-9","article-title":"The inhibitory potency of isoxazole-curcumin analogue for the management of breast cancer: a comparative in vitro and molecular modeling investigation","volume":"75","author":"Rodrigues","year":"2021","journal-title":"Chem. Pap."},{"issue":"18","key":"10.1016\/j.bioorg.2026.110103_bb0130","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1016\/j.bmcl.2017.08.033","article-title":"Synthesis of novel forskolin isoxazole derivatives with potent anti-cancer activity against breast cancer cell lines","volume":"27","author":"Burra","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110103_bb0135","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11010-016-2777-z","article-title":"Induction of apoptosis and downregulation of ER\u03b1 in DMBA-induced mammary gland tumors in Sprague\u2013Dawley rats by synthetic 3, 5-disubstituted isoxazole derivatives","volume":"420","author":"Ananda","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bioorg.2026.110103_bb0140","first-page":"1","article-title":"Vishakha, Tushar Midha, Mayank, Somesh Baranwal, Bhim Singh, Akhilesh Gangwar, Vikas Jaitak, design, synthesis, in silico and in vitro anti-breast cancer evaluation of novel indole-isoxazole\/isoxazoline hybrids as ER\u03b1 inhibitors","author":"Das","year":"2026","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bioorg.2026.110103_bb0145","article-title":"Discovery of C-9 boronated berberine derivatives with enhanced selectivity against breast cancer","author":"Liao","year":"2026","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110103_bb0150","first-page":"1","article-title":"Lan Lan Liu, Fei Chen, bin Zeng, human embryonic kidney 293 cells: a vehicle for biopharmaceutical manufacturing, Structural Biology, and Electrophysiology: state of the art and future perspectives","volume":"205","author":"Jianwen","year":"2018","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.bioorg.2026.110103_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128668","volume":"64","author":"Ejaz","year":"2022","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110103_bb0160","series-title":"Alexandru Almasan, Apoptosis assays, Cardiovascular disease","first-page":"279","author":"Oancea","year":"2006"},{"key":"10.1016\/j.bioorg.2026.110103_bb0165","series-title":"Bioavailability, The ADME Encyclopedia: A Comprehensive Guide on Biopharmacy and Pharmacokinetics","first-page":"107","author":"Quiroga","year":"2022"},{"key":"10.1016\/j.bioorg.2026.110103_bb0170","series-title":"Molecular Dynamics Simulation of Protein and Protein\u2013Ligand Complexes","first-page":"133","author":"Shukla","year":"2020"},{"issue":"5","key":"10.1016\/j.bioorg.2026.110103_bb0175","doi-asserted-by":"crossref","first-page":"640","DOI":"10.2174\/0115734099263650230926053750","article-title":"Synthesis, and in-silico studies of indole-chalcone derivatives targeting estrogen receptor alpha (ER-\u03b1) for breast cancer","volume":"20","author":"Choudhari","year":"2024","journal-title":"Curr. Comput. Aided Drug Des."},{"issue":"8","key":"10.1016\/j.bioorg.2026.110103_bb0180","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1007\/s00044-012-0385-3","article-title":"Synthesis, antitubercular activity, and QSAR analysis of substituted nitroaryl analogs: chalcone, pyrazole, isoxazole, and pyrimidines","volume":"22","author":"Gupta","year":"2013","journal-title":"Med. Chem. Res."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110103_bb0185","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3390\/pharmaceutics17020247","volume":"17","author":"S\u00e1nchez-D\u00edez","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioorg.2026.110103_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117954","article-title":"Isorhamnetin exerts anti-proliferative effect on cancer-associated fibroblasts by inducing cell cycle arrest","volume":"185","author":"Ganbold","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2026.110103_bb0195","volume":"1267","author":"Ashish Ranjan Dwivedi","year":"2022","journal-title":"J. Mol. Struct."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110103_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2025.104144","article-title":"Protocol for predicting \u03b3-tocotrienol and \u03b4-tocotrienol binding to colorectal cancer-related proteins using Schr\u00f6dinger\u2019s maestro and glide","volume":"6","author":"Khalid","year":"2025","journal-title":"STAR Protocols"},{"issue":"2","key":"10.1016\/j.bioorg.2026.110103_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202503946","article-title":"Identification of 1, 5-benzothiazepine derivatives as potent Estrogen receptor \u03b1 inhibitors via integrated De novo fragment-based designing and pharmacophore Modeling","volume":"11","author":"Pareek","year":"2026","journal-title":"ChemistrySelect"},{"issue":"2","key":"10.1016\/j.bioorg.2026.110103_bb0210","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2174\/138920006775541552","article-title":"Preclinical pharmacokinetics: an approach towards safer and efficacious drugs","volume":"7","author":"Singh","year":"2006","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.bioorg.2026.110103_bb0215","article-title":"Vikas Jaitak, in silico approaches for the identification of novel FGFR1 inhibitor in cancer: a fragment-based De novo drug designing guided virtual screening approach","author":"Bala","year":"2025","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.bioorg.2026.110103_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.crstbi.2024.100124","article-title":"Identification of coumarin derivatives targeting acetylcholinesterase for Alzheimer's disease by field-based 3D-QSAR, pharmacophore model-based virtual screening, molecular docking, MM\/GBSA, ADME and MD Simulation study","volume":"7","author":"Saha","year":"2024","journal-title":"Curr. Res. Struct. Biol."},{"issue":"19","key":"10.1016\/j.bioorg.2026.110103_bb0225","doi-asserted-by":"crossref","first-page":"10323","DOI":"10.1080\/07391102.2023.2256876","volume":"42","author":"Das","year":"2024","journal-title":"J. Biomol. Struct. Dyn."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:03:31Z","timestamp":1793894611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826006395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":45,"alternative-id":["S0045206826006395"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110103","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, in vitro and in silico evaluation of novel 5-(1-benzyl-1H-indol-3-yl)-3-phenyl-4,5-dihydroisoxazole derivatives against ER-positive breast cancer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110103","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110103"}}