{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:20:03Z","timestamp":1787678403310,"version":"build-2784847793"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110109","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:13:37Z","timestamp":1781651617000},"page":"110109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Discovery of furan-trimethoxyphenyl hybrids as novel colchicine-binding site inhibitors that induce mitotic catastrophe with potent anti-acute myeloid leukemia effect"],"prefix":"10.1016","volume":"180","author":[{"given":"Peng","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongdong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110109_bb0005","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood.2022016867","article-title":"Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN","volume":"140","author":"D\u00f6hner","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.bioorg.2026.110109_bb0010","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bioorg.2026.110109_bb0015","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1056\/NEJMoa2012971","article-title":"Azacitidine and venetoclax in previously untreated acute myeloid Leukemia","volume":"383","author":"DiNardo","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioorg.2026.110109_bb0020","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1056\/NEJMoa1902688","article-title":"Gilteritinib or chemotherapy for relapsed or refractory FLT3-mutated AML","volume":"381","author":"Perl","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioorg.2026.110109_bb0025","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022608","article-title":"Microtubules and microtubule-associated proteins","volume":"10","author":"Goodson","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bioorg.2026.110109_bb0030","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/bjh.12196","article-title":"Mesenchymal stromal cells primed with paclitaxel attract and kill leukaemia cells, inhibit angiogenesis and improve survival of leukaemia-bearing mice","volume":"160","author":"Pessina","year":"2013","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bioorg.2026.110109_bb0035","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jconrel.2022.01.010","article-title":"Emerging nanomedicines of paclitaxel for cancer treatment","volume":"342","author":"Chen","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioorg.2026.110109_bb0040","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejca.2015.12.022","article-title":"Is there a role of nab-paclitaxel in the treatment of advanced non-small cell lung cancer? The data suggest yes","volume":"56","author":"Villaruz","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bioorg.2026.110109_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/biom9120789","article-title":"Paclitaxel's mechanistic and clinical effects on breast Cancer","volume":"9","author":"Abu Samaan","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioorg.2026.110109_bb0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10120-009-0505-z","article-title":"Paclitaxel chemotherapy for the treatment of gastric cancer","volume":"12","author":"Sakamoto","year":"2009","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.bioorg.2026.110109_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188777","article-title":"Combination of microtubule targeting agents with other antineoplastics for cancer treatment","volume":"1877","author":"Liang","year":"2022","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.bioorg.2026.110109_bb0060","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ejmech.2018.04.011","article-title":"Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site","volume":"151","author":"Li","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110109_bb0065","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.4155\/fmc-2017-0100","article-title":"Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures","volume":"9","author":"Li","year":"2017","journal-title":"Fut. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110109_bb0070","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40659-019-0241-8","article-title":"Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells","volume":"52","author":"Wang","year":"2019","journal-title":"Biol. Res."},{"key":"10.1016\/j.bioorg.2026.110109_bb0075","article-title":"Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer","volume":"28","author":"Ding","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110109_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202100327","article-title":"Antitumor and multikinase inhibition activities of some synthesized coumarin and benzofuran derivatives","volume":"355","author":"Ahmed","year":"2022","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bioorg.2026.110109_bb0085","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1021\/jf104498p","article-title":"Citrus limonin and its glucoside inhibit Colon adenocarcinoma cell proliferation through apoptosis","volume":"59","author":"Chidambara Murthy","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.110109_bb0090","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.2147\/DDDT.S215895","article-title":"Glucoside derivatives of podophyllotoxin: synthesis, physicochemical properties, and cytotoxicity","volume":"13","author":"Zi","year":"2019","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bioorg.2026.110109_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111697","article-title":"Potent combretastatin A-4 analogs containing 1,2,4-triazole: synthesis, antiproliferative, anti-tubulin activity, and docking study","volume":"183","author":"Mustafa","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110109_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116497","article-title":"Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 cells","volume":"272","author":"Zhang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110109_bb0105","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1039\/D2MD00144F","article-title":"An organometallic analogue of combretastatin A-4 and its apoptosis-inducing effects on lymphoma, leukemia and other tumor cells in vitro","volume":"13","author":"Abodo Onambele","year":"2022","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110109_bb0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1158\/0008-5472.CAN-17-0577","article-title":"Metabolically stable tubulin inhibitor targets the colchicine binding site and overcomes taxane resistance","volume":"78","author":"Arnst","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2026.110109_bb0115","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.ejmech.2017.11.062","article-title":"Recent advances in microtubule-stabilizing agents","volume":"143","author":"Cao","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110109_bb0120","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cclet.2019.04.045","article-title":"Synthesis and biological evaluation of piperidyl benzimidazole carboxamide derivatives as potent PARP-1 inhibitors and antitumor agents","volume":"31","author":"Zhang","year":"2020","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110109_bb0125","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.cclet.2018.09.020","article-title":"Naphthalimides and analogues as antitumor agents: a review on molecular design, bioactivity and mechanism of action","volume":"29","author":"Chen","year":"2018","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110109_bb0130","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cclet.2015.03.015","article-title":"Novel hybrids from N-hydroxyarylamide and indole ring through click chemistry as histone deacetylase inhibitors with potent antitumor activities","volume":"26","author":"Cai","year":"2015","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110109_bb0135","article-title":"N-benzyl arylamide derivatives as novel and potent tubulin polymerization inhibitors against gastric cancers: design, structure\u2013activity relationships and biological evaluations","author":"Song","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110109_bb0140","first-page":"407","article-title":"Deficient TSC1\/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex","volume":"26","author":"Jin","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bioorg.2026.110109_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174802","article-title":"IMB5476, a novel microtubule inhibitor, induces mitotic catastrophe and overcomes multidrug resistance in tumors","volume":"919","author":"Zheng","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110109_bb0150","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1038\/s41467-019-11584-0","article-title":"Mild replication stress causes chromosome mis-segregation via premature centriole disengagement","volume":"10","author":"Wilhelm","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2026.110109_bb0155","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.108","article-title":"Mitotic catastrophe and cell death induced by depletion of centrosomal proteins","volume":"4","author":"Kimura","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.110109_bb0160","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tcb.2012.11.005","article-title":"Histone modifications and mitosis: countermarks, landmarks, and bookmarks","volume":"23","author":"Wang","year":"2013","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bioorg.2026.110109_bb0165","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13062-021-00313-7","article-title":"A link between mitotic defects and mitotic catastrophe: detection and cell fate","volume":"16","author":"Sazonova","year":"2021","journal-title":"Biol. Direct"},{"key":"10.1016\/j.bioorg.2026.110109_bb0170","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cub.2005.01.038","article-title":"The Mad1\/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint","volume":"15","author":"De Antoni","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bioorg.2026.110109_bb0175","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrm3115","article-title":"Mitotic catastrophe: a mechanism for avoiding genomic instability","volume":"12","author":"Vitale","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.110109_bb0180","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1158\/1078-0432.CCR-21-0464","article-title":"Pharmacologic targeting of mcl-1 induces mitochondrial dysfunction and apoptosis in B-cell lymphoma cells in a TP53- and BAX-dependent manner","volume":"27","author":"Liu","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bioorg.2026.110109_bb0185","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.110109_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.109233","article-title":"Discovery of novel aniline-pyrimidine analogues as orally bioavailable dual VEGFR-2\/tubulin inhibitors with potent antitumor and anti-angiogenesis efficacy","volume":"167","author":"Chu","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110109_bb0195","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejpb.2023.09.014","article-title":"Liposomal nanostructures for gemcitabine and paclitaxel delivery in pancreatic cancer","volume":"192","author":"Silli","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioorg.2026.110109_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2020.100742","article-title":"Taxanes in cancer treatment: activity, chemoresistance and its overcoming","volume":"54","author":"Mosca","year":"2021","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bioorg.2026.110109_bb0205","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ygyno.2020.01.005","article-title":"Pazopanib and Fosbretabulin in recurrent ovarian cancer (PAZOFOS): a multi-Centre, phase 1b and open-label, randomised phase 2 trial","volume":"156","author":"Morgan","year":"2020","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bioorg.2026.110109_bb0210","first-page":"531","article-title":"Ombrabulin plus cisplatin versus placebo plus cisplatin in patients with advanced soft-tissue sarcomas after failure of anthracycline and ifosfamide chemotherapy: a randomised, double-blind, placebo-controlled, phase 3 trial, the lancet","volume":"16","author":"Blay","year":"2015","journal-title":"Oncology"},{"key":"10.1016\/j.bioorg.2026.110109_bb0215","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S2213-2600(24)00178-4","article-title":"Plinabulin plus docetaxel versus docetaxel in patients with non-small-cell lung cancer after disease progression on platinum-based regimen (DUBLIN-3): a phase 3, international, multicentre, single-blind, parallel group, randomised controlled trial","volume":"12","author":"Han","year":"2024","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.bioorg.2026.110109_bb0220","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/35024000","article-title":"Microtubule motors in mitosis","volume":"407","author":"Sharp","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2026.110109_bb0225","doi-asserted-by":"crossref","first-page":"23490","DOI":"10.1038\/s41598-021-02503-9","article-title":"The effect of paclitaxel on apoptosis, autophagy and mitotic catastrophe in AGS cells","volume":"11","author":"Khing","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.110109_bb0230","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrm2163","article-title":"The spindle-assembly checkpoint in space and time","volume":"8","author":"Musacchio","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.110109_bb0235","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.148","article-title":"Mitosis-targeted anti-cancer therapies: where they stand","volume":"3","author":"Chan","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.110109_bb0240","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bioorg.2026.110109_bb0245","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.canlet.2014.12.023","article-title":"Polo-like kinase 1 inhibitor BI2536 causes mitotic catastrophe following activation of the spindle assembly checkpoint in non-small cell lung cancer cells","volume":"357","author":"Choi","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.110109_bb0250","doi-asserted-by":"crossref","first-page":"R787","DOI":"10.1016\/j.cub.2004.09.020","article-title":"APC\/C and SCF: controlling each other and the cell cycle","volume":"14","author":"Vodermaier","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bioorg.2026.110109_bb0255","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1038\/s41467-022-35461-5","article-title":"CENP-F-dependent DRP1 function regulates APC\/C activity during oocyte meiosis I","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2026.110109_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105184","article-title":"Thiazolidinone-linked1,2,3-triazoles with monoterpenic skeleton as new potential anticancer agents: design, synthesis and molecular docking studies","volume":"115","author":"Oubella","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110109_bb0265","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41419-018-0408-1","article-title":"Cytochrome c speeds up caspase cascade activation by blocking 14-3-3epsilon-dependent Apaf-1 inhibition","volume":"9","author":"Elena-Real","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.110109_bb0270","doi-asserted-by":"crossref","first-page":"14571","DOI":"10.1038\/s41598-017-14901-z","article-title":"Involvement of autophagy in the outcome of mitotic catastrophe","volume":"7","author":"Sorokina","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:40:06Z","timestamp":1787676006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826006450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":54,"alternative-id":["S0045206826006450"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110109","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of furan-trimethoxyphenyl hybrids as novel colchicine-binding site inhibitors that induce mitotic catastrophe with potent anti-acute myeloid leukemia effect","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110109"}}