{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:20:53Z","timestamp":1787678453231,"version":"build-2784847793"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110111","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:28:58Z","timestamp":1781566138000},"page":"110111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Precision imaging of Pantetheinase activity in a collagen-induced arthritis model via a Ratiometric fluorescent probe"],"prefix":"10.1016","volume":"180","author":[{"given":"Dongjin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bioorg.2026.110111_bb0005","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.bioorg.2026.110111_bb0010","first-page":"1707","article-title":"Pathogenesis of rheumatoid arthritis: one year in review 2024","volume":"42","author":"D\u2019Orazio","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.bioorg.2026.110111_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102425","article-title":"Insights into the treatment of rheumatoid arthritis: a paradigm in medicine","volume":"110","author":"Smolen","year":"2020","journal-title":"J. Autoimmun."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110111_bb0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMra2103726","article-title":"Rheumatoid arthritis - common origins, Divergent Mechanisms","volume":"388","author":"Gravallese","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"10086","key":"10.1016\/j.bioorg.2026.110111_bb0025","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/S0140-6736(17)31472-1","article-title":"Pathogenetic insights from the treatment of rheumatoid arthritis","volume":"389","author":"McInnes","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.bioorg.2026.110111_bb0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.immuni.2017.02.006","article-title":"Immunopathogenesis of rheumatoid arthritis","volume":"46","author":"Firestein","year":"2017","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110111_bb0035","first-page":"31","article-title":"Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis","volume":"10","author":"Luo","year":"2023","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.bioorg.2026.110111_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125532","article-title":"Treatment evaluation of rheumatoid arthritis by in situ fluorescence imaging of the Golgi cysteine","volume":"270","author":"Wang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.bioorg.2026.110111_bb0045","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/978-1-0716-4306-8_18","article-title":"Models of rheumatoid arthritis","volume":"2885","author":"Gr\u00f6tsch","year":"2025","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bioorg.2026.110111_bb0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-0716-3682-4_1","article-title":"Collagen-induced arthritis models","volume":"2766","author":"Miyoshi","year":"2024","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bioorg.2026.110111_bb0055","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/978-1-4939-8997-3_14","article-title":"In vivo models of rheumatoid arthritis","volume":"1914","author":"Gr\u00f6tsch","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110111_bb0060","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1042\/BST20140092","article-title":"Role of the Vnn1 pantetheinase in tissue tolerance to stress","volume":"42","author":"Naquet","year":"2014","journal-title":"Biochem. Soc. Trans."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110111_bb0065","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.exppara.2010.02.009","article-title":"Cysteamine, the natural metabolite of pantetheinase, shows specific activity against plasmodium","volume":"125","author":"Min-Oo","year":"2010","journal-title":"Exp. Parasitol."},{"issue":"16","key":"10.1016\/j.bioorg.2026.110111_bb0070","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.1128\/MCB.24.16.7214-7224.2004","article-title":"Vanin-1(\u2212\/\u2212) mice exhibit a glutathione-mediated tissue resistance to oxidative stress","volume":"24","author":"Berruyer","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"13","key":"10.1016\/j.bioorg.2026.110111_bb0075","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1084\/jem.20061640","article-title":"Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity","volume":"203","author":"Berruyer","year":"2006","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110111_bb0080","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1021\/acs.analchem.4c05982","article-title":"Vanin-1-activated fluorescent probe for real-time in vivo imaging of inflammatory responses across multiple tissue types","volume":"97","author":"Dai","year":"2025","journal-title":"Anal. Chem."},{"issue":"39","key":"10.1016\/j.bioorg.2026.110111_bb0085","doi-asserted-by":"crossref","first-page":"14754","DOI":"10.1021\/acs.analchem.3c02875","article-title":"Vanin-1-activated chemiluminescent probe: help to early diagnosis of acute kidney injury with high signal-to-noise ratio through urinalysis","volume":"95","author":"Feng","year":"2023","journal-title":"Anal. Chem."},{"issue":"20","key":"10.1016\/j.bioorg.2026.110111_bb0090","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.1021\/acs.analchem.7b03303","article-title":"Ratiometric fluorescent probe for imaging of Pantetheinase in living cells","volume":"89","author":"Hu","year":"2017","journal-title":"Anal. Chem."},{"issue":"47","key":"10.1016\/j.bioorg.2026.110111_bb0095","doi-asserted-by":"crossref","first-page":"18635","DOI":"10.1021\/acs.analchem.4c02545","article-title":"Dual-locked chemiluminescent probe enables precise imaging and timely diagnosis of colitis via chymotrypsin\/Vanin-1 Cascade activation","volume":"96","author":"Jin","year":"2024","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2026.110111_bb0100","article-title":"Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo","volume":"401","author":"Jing","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"15","key":"10.1016\/j.bioorg.2026.110111_bb0105","doi-asserted-by":"crossref","first-page":"9545","DOI":"10.1021\/acs.analchem.8b02266","article-title":"Bioluminescent probe for detection of starvation-induced Pantetheinase upregulation","volume":"90","author":"Lin","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.110111_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135538","article-title":"A highly specific two-photon fluorescent probe for pantetheinase and its biological applications","volume":"408","author":"Lin","year":"2024","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.bioorg.2026.110111_bb0115","doi-asserted-by":"crossref","first-page":"10378","DOI":"10.1021\/acs.analchem.1c02386","article-title":"Near-infrared fluorescent probe for imaging and evaluating the role of Vanin-1 in chemotherapy","volume":"93","author":"Lu","year":"2021","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2026.110111_bb0120","article-title":"Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo","volume":"401","author":"Qian","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.bioorg.2026.110111_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.138330","article-title":"A pantetheinase\u2013viscosity dual-responsive cascade fluorescent probe for real-time imaging of chemotherapy-induced intestinal mucositis","volume":"444","author":"Qu","year":"2025","journal-title":"Sens. Actuators B"},{"issue":"47","key":"10.1016\/j.bioorg.2026.110111_bb0130","doi-asserted-by":"crossref","first-page":"12802","DOI":"10.1039\/D0SC04537C","article-title":"A near-infrared fluorescence probe for imaging of pantetheinase in cells and mice in vivo","volume":"11","author":"Yang","year":"2020","journal-title":"Chem. Sci."},{"issue":"22","key":"10.1016\/j.bioorg.2026.110111_bb0135","doi-asserted-by":"crossref","first-page":"12319","DOI":"10.1021\/acs.analchem.7b03332","article-title":"Near-infrared fluorescent probe with remarkable large stokes shift and Favorable water solubility for real-time tracking leucine aminopeptidase in living cells and in vivo","volume":"89","author":"Zhang","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.110111_bb0140","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.apsb.2021.06.004","article-title":"A NIR fluorescent probe for Vanin-1 and its applications in imaging kidney injury diagnosis and the development of inhibitor","volume":"12","author":"Zhenhao","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"5","key":"10.1016\/j.bioorg.2026.110111_bb0145","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nprot.2007.173","article-title":"Collagen-induced arthritis","volume":"2","author":"Brand","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bioorg.2026.110111_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.138416","article-title":"Photoinduced electron transfer-driven dual-ligand MOF fluorescence sensor for highly selective and sensitive detection of periodate in complex water samples","volume":"444","author":"Jiang","year":"2025","journal-title":"Sens. Actuators B"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110111_bb0155","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1432-1033.1985.tb09279.x","article-title":"Copper ions as inhibitors of protein C of soluble methane monooxygenase of Methylococcus capsulatus (Bath)","volume":"153","author":"Green","year":"1985","journal-title":"Eur. J. Biochem."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110111_bb0160","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.it.2023.08.008","article-title":"pH sensing at the intersection of tissue homeostasis and inflammation","volume":"44","author":"Hajjar","year":"2023","journal-title":"Trends Immunol."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:30:37Z","timestamp":1787675437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826006474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":32,"alternative-id":["S0045206826006474"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110111","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Precision imaging of Pantetheinase activity in a collagen-induced arthritis model via a Ratiometric fluorescent probe","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110111","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110111"}}