{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T20:04:21Z","timestamp":1789329861469,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110143","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:04:15Z","timestamp":1781967855000},"page":"110143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Triazole-linked piperidinyl Glyoxamides with anticancer potential: Integrating synthesis, docking, MD simulation, pharmacokinetics and in vitro assays"],"prefix":"10.1016","volume":"180","author":[{"given":"Yogita","family":"Tonger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnima","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Takkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desu Gayathri","family":"Niharika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Amarendar Reddy M","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surekha","family":"Pinninti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Mor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Kumar","family":"Badampudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110143_bb0005","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"Ca"},{"key":"10.1016\/j.bioorg.2026.110143_bb0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s43556-025-00352-w","article-title":"Drug resistance in cancer: molecular mechanisms and emerging treatment strategies","volume":"6","author":"Li","year":"2025","journal-title":"Molecular Biomedicine"},{"key":"10.1016\/j.bioorg.2026.110143_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108405","article-title":"New alkanesulfonate-based quinazolinone-acetohydrazide scaffolds: rational design, synthesis, molecular docking, anticancer properties and potential EGFR and its T790M\/L858R mutants inhibitors","volume":"160","author":"Morsy","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110143_bb0020","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3390\/ph15091071","article-title":"Concept of hybrid drugs and recent advancements in anticancer hybrids","volume":"15","author":"Singh","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bioorg.2026.110143_bb0025","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1055\/s-0042-1751452","article-title":"Recent advancements in triazole-based click chemistry in cancer drug discovery and development","volume":"7","author":"Kumar","year":"2023","journal-title":"SynOpen"},{"key":"10.1016\/j.bioorg.2026.110143_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.126817","article-title":"[NN= NN]-linked fused triazoles with \u03c0-\u03c0 stacking and hydrogen bonds: towards thermally stable, insensitive, and highly energetic materials","volume":"406","author":"Li","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioorg.2026.110143_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2017.01.026","article-title":"Synthesis of C5-tethered indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors","volume":"128","author":"Guggilapu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110143_bb0040","first-page":"218","article-title":"Indole-3-glyoxylamide-an important scaffold for anticancer activity","volume":"8","author":"Buvana","year":"2020","journal-title":"Asian Journal of Pharmaceutical Research and Development"},{"key":"10.1016\/j.bioorg.2026.110143_bb0045","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.3390\/ijms24032937","article-title":"Piperidine derivatives: recent advances in synthesis and pharmacological applications","volume":"24","author":"Frolov","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110143_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28207092","article-title":"New 1, 2, 3-triazole\/1, 2, 4-triazole hybrids as aromatase inhibitors: design, synthesis, and apoptotic antiproliferative activity","volume":"28","author":"Maghraby","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110143_bb0055","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.3390\/cancers16132479","article-title":"Overcoming chemoresistance in Cancer: the promise of crizotinib","volume":"16","author":"Musa","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.bioorg.2026.110143_bb0060","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10637-009-9244-6","article-title":"Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors","volume":"28","author":"Oostendorp","year":"2010","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.bioorg.2026.110143_bb0065","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1016\/j.tetlet.2009.05.030","article-title":"A concise synthesis of indolic enamides: Coscinamide a, coscinamide B, and igzamide","volume":"50","author":"Ma","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2026.110143_bb0070","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.podrm.2022.11.004","article-title":"Vandetanib","volume":"48","author":"Al-Ghusn","year":"2023","journal-title":"Profiles of Drug Substances, Excipients and Related Methodology"},{"key":"10.1016\/j.bioorg.2026.110143_bb0075","first-page":"3147","article-title":"The story of MCF-7 breast cancer cell line: 40 years of experience in research","volume":"35","author":"Com\u015fa","year":"2015","journal-title":"Anticancer Res"},{"key":"10.1016\/j.bioorg.2026.110143_bb0080","doi-asserted-by":"crossref","first-page":"866","DOI":"10.2174\/0115733947308352240729162826","article-title":"Comprehensive review on cervical cancer: global health burden","volume":"21","author":"Aziz","year":"2025","journal-title":"Current Cancer Therapy Reviews"},{"key":"10.1016\/j.bioorg.2026.110143_bb0085","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/carcin\/23.12.2063","article-title":"Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate","volume":"23","author":"Crowley-Weber","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bioorg.2026.110143_bb0090","doi-asserted-by":"crossref","first-page":"40998","DOI":"10.1039\/D5RA03819G","article-title":"Current progress of 1, 2, 3-triazole hybrids as EGFR inhibitors for cancer therapy\u2013a literature review","volume":"15","author":"Khasawneh","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2026.110143_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106313","article-title":"Synthesis and cytotoxicity evaluation of DNA-interactive \u03b2-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and in silico modelling studies","volume":"131","author":"Soni","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110143_bb0100","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1021\/acsptsci.2c00118","article-title":"Synthesis of morpholine-, piperidine-, and N-substituted piperazine-coupled 2-(benzimidazol-2-yl)-3-arylquinoxalines as novel potent antitumor agents","volume":"5","author":"Mamedov","year":"2022","journal-title":"ACS Pharmacology & Translational Science"},{"key":"10.1016\/j.bioorg.2026.110143_bb0105","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s43094-025-00862-y","article-title":"Assessing molecular docking tools: understanding drug discovery and design","volume":"11","author":"Nivatya","year":"2025","journal-title":"future J. Pharm. Sci."},{"key":"10.1016\/j.bioorg.2026.110143_bb0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2165\/00003495-200060001-00002","article-title":"Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy","volume":"60","author":"Raymond","year":"2000","journal-title":"Drugs"},{"key":"10.1016\/j.bioorg.2026.110143_bb0115","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/BCJ20160583","article-title":"Topoisomerases as anticancer targets","volume":"475","author":"Delgado","year":"2018","journal-title":"Biochem. J."},{"key":"10.1016\/j.bioorg.2026.110143_bb0120","first-page":"1","article-title":"New anticancer agents: in vitro and in vivo evaluation","volume":"19","author":"Zips","year":"2005","journal-title":"In Vivo"},{"key":"10.1016\/j.bioorg.2026.110143_bb0125","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.3390\/molecules27072105","article-title":"Molecular dynamics simulations: advances and applications","volume":"27","author":"Filipe","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110143_bb0130","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13321-018-0283-x","article-title":"ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database","volume":"10","author":"Dong","year":"2018","journal-title":"J. Cheminform."},{"key":"10.1016\/j.bioorg.2026.110143_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.130941","article-title":"Identification of anti-mycobacterial agents against mmpL3: virtual screening, ADMET analysis and MD simulations","volume":"1244","author":"Bhakhar","year":"2021","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.110143_bb0140","doi-asserted-by":"crossref","first-page":"108882","DOI":"10.1016\/j.bioorg.2025.108882","article-title":"Development of novel 1, 4-dihydropyridine-tethered isatin scaffolds as potential candidates for the treatment of cancer and fungal infections","volume":"164","author":"Takkar","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110143_bb0145","series-title":"Brucella Melitensis","first-page":"133","article-title":"in Silico Validation and ADMET Analysis for the Best Lead Molecules","author":"Pradeepkiran","year":"2021"},{"key":"10.1016\/j.bioorg.2026.110143_bb0150","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead-and drug-like compounds: the rule-of-five revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.bioorg.2026.110143_bb0155","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1089\/cmb.2019.0323","article-title":"Analysis of the physicochemical properties of acaricides based on Lipinski's rule of five","volume":"27","author":"Chen","year":"2020","journal-title":"J. Comput. Biol."},{"key":"10.1016\/j.bioorg.2026.110143_bb0160","first-page":"171","article-title":"Lipinski's rule of five, famous extensions and famous exceptions","volume":"3","author":"Ivanovi\u0107","year":"2020","journal-title":"Popular Scientific Article"},{"key":"10.1016\/j.bioorg.2026.110143_bb0165","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1021\/jm0306529","article-title":"Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat","volume":"47","author":"Lu","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110143_bb0170","doi-asserted-by":"crossref","DOI":"10.1002\/minf.202300115","article-title":"Absorption matters: a closer look at popular oral bioavailability rules for drug approvals","volume":"42","author":"Caminero Gomes Soares","year":"2023","journal-title":"Mol. Inform."},{"key":"10.1016\/j.bioorg.2026.110143_bb0175","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004628","article-title":"Improving the in-silico assessment of proarrhythmia risk by combining hERG (human ether-\u00e0-go-go-related gene) channel\u2013drug binding kinetics and multichannel pharmacology","volume":"10","author":"Li","year":"2017","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.bioorg.2026.110143_bb0180","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s43094-021-00388-z","article-title":"In silico assessment of chronic toxicity of a combination drug namely \u2018Olmesartan medoxomil and hydrochlorothiazide\u2019, marketed in Bangladesh","volume":"7","author":"Roy","year":"2021","journal-title":"Future Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.bioorg.2026.110143_bb0185","first-page":"35","article-title":"In silico study by using ProTox-II webserver for oral acute toxicity, organ toxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor signalling and stress response pathways of synthetic pyrethroids","author":"Ghosh","year":"2019","journal-title":"World Sci. News"},{"key":"10.1016\/j.bioorg.2026.110143_bb0190","doi-asserted-by":"crossref","first-page":"34239","DOI":"10.1039\/D3RA06387A","article-title":"Design, synthesis and in silico evaluation of newer 1, 4-dihydropyridine based amlodipine bio-isosteres as promising antihypertensive agents","volume":"13","author":"Takkar","year":"2023","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2026.110143_bb0195","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A boiled-egg to predict gastrointestinal absorption and brain penetration of small molecules","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bioorg.2026.110143_bb0200","first-page":"67","article-title":"The role of structure-activity relationship (SAR) in drug discovery","author":"Vaishnav","year":"2025","journal-title":"Indian Journal of Pharmaceutical Chemistry and Analytical Techniques (IJPCAT)"},{"key":"10.1016\/j.bioorg.2026.110143_bb0205","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1039\/D5SC07348K","article-title":"Which halogen to choose? Comparing the effects of chlorine and fluorine as bioisosteric substituents in drug design","volume":"17","author":"Summerfield","year":"2026","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioorg.2026.110143_bb0210","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202400740","article-title":"Halogen-based quinazolin-4 (3H)-one derivatives as MCF-7 breast cancer inhibitors: current developments and structure\u2013activity relationship","volume":"358","author":"Upadhyay","year":"2025","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bioorg.2026.110143_bb0215","article-title":"Reaction of some substituted (un) substituted isatins with 1, \u03c9-alkanes and their products with sodium azide","volume":"8","author":"Tri","year":"2021","journal-title":"Chemistry Proceedings"},{"key":"10.1016\/j.bioorg.2026.110143_bb0220","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1007\/s11696-021-01697-6","article-title":"Study on synthesis of some substituted N-propargyl isatins by propargylation reaction of corresponding isatins using potassium carbonate as base under ultrasound-and microwave-assisted conditions","volume":"75","author":"Tri","year":"2021","journal-title":"Chem. Pap."},{"key":"10.1016\/j.bioorg.2026.110143_bb0225","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1140\/epjb\/s10051-024-00822-0","article-title":"Anthracenyl chalcone: a promising anticancer agent\u2014structural and molecular docking studies","volume":"97","author":"Zainuri","year":"2024","journal-title":"The European Physical Journal B"},{"key":"10.1016\/j.bioorg.2026.110143_bb0230","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.compbiolchem.2019.01.013","volume":"79","author":"Murugavel","year":"2019","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.bioorg.2026.110143_bb0235","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.2174\/138945008786949432","article-title":"Molecular docking algorithms","volume":"9","author":"Dias","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bioorg.2026.110143_bb0240","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1007\/s11030-024-11026-0","article-title":"Integrated computational approaches for identification of potent pyrazole-based glycogen synthase kinase-3\u03b2 (GSK-3\u03b2) inhibitors: 3D-QSAR, virtual screening, docking, MM\/GBSA, EC, MD simulation studies","volume":"29","author":"Niharika","year":"2025","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bioorg.2026.110143_bb0245","series-title":"Understanding Molecular Simulation: From Algorithms to Applications","author":"Frenkel","year":"2023"},{"key":"10.1016\/j.bioorg.2026.110143_bb0250","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.110143_bb0255","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1021\/ci500467k","article-title":"iLOGP: a simple, robust, and efficient description of n-octanol\/water partition coefficient for drug design using the GB\/SA approach","volume":"54","author":"Daina","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2026.110143_bb0260","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0: a webserver for the prediction of toxicity of chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2026.110143_bb0265","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s00280-008-0798-3","article-title":"A model-based approach to the in vitro evaluation of anticancer activity","volume":"63","author":"Del Bene","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110143_bb0270","doi-asserted-by":"crossref","unstructured":"P. Kumar, A. Nagarajan, P.D. Uchil, Analysis of cell viability by the MTT assay, Cold Spring Harb. Protoc. 2018 (2018) pdb-prot095505.","DOI":"10.1101\/pdb.prot095505"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T19:39:21Z","timestamp":1789328361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826006796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":54,"alternative-id":["S0045206826006796"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110143","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triazole-linked piperidinyl Glyoxamides with anticancer potential: Integrating synthesis, docking, MD simulation, pharmacokinetics and in vitro assays","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110143","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110143"}}