{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:05:00Z","timestamp":1788185100472,"version":"build-2803163510"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110160","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T22:59:24Z","timestamp":1782601164000},"page":"110160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Targeting quorum sensing in Pseudomonas aeruginosa: Novel benzo[d]imidazole-based LasR inhibitors with tunable head, \u03b1,\u03b2-unsaturated linker, and tail segments."],"prefix":"10.1016","volume":"180","author":[{"given":"Esraa Z.","family":"Mohammed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidy H.","family":"El-Zoheiry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab H.","family":"Abd El-Aleam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourhan G.","family":"Naga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona E.M.","family":"Mabrouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed B.M.","family":"Mehany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem A.","family":"Abdel-Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha M.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110160_bb0005","series-title":"Global Antibiotic Resistance Surveillance Report 2025","author":"World Health Organization","year":"2025"},{"key":"10.1016\/j.bioorg.2026.110160_bb0010","series-title":"WHO\u2019s 2025 GLASS report: Progress, Patterns and Persistent Gaps","author":"London School of Hygiene \\& Tropical Medicine","year":"2025"},{"key":"10.1016\/j.bioorg.2026.110160_bb0015","article-title":"Exploring the impact of antibiotic resistance: spread and implications","volume":"14","author":"Workman","year":"2025","journal-title":"J. Microbiol. Biotechnol. Food Sci."},{"key":"10.1016\/j.bioorg.2026.110160_bb0020","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3390\/toxins8080236","article-title":"Cellular effects of pyocyanin, a secreted virulence factor of Pseudomonas aeruginosa","volume":"8","author":"Hall","year":"2016","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.bioorg.2026.110160_bb0025","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1469-0691.2007.01681.x","article-title":"Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium","volume":"13","author":"Mesaros","year":"2007","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.bioorg.2026.110160_bb0030","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.medmal.2005.10.007","article-title":"Targeting mechanisms of Pseudomonas aeruginosa pathogenesis","volume":"36","author":"Kipnis","year":"2006","journal-title":"Med. Mal. Infect."},{"key":"10.1016\/j.bioorg.2026.110160_bb0035","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s13213-011-0273-y","article-title":"Contribution of an arsenal of virulence factors to pathogenesis of Pseudomonas aeruginosa infections","volume":"61","author":"Strateva","year":"2011","journal-title":"Ann. Microbiol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0040","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nchembio.2007.24","article-title":"Targeting virulence: a new paradigm for antimicrobial therapy","volume":"3","author":"Clatworthy","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0045","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.mib.2009.06.012","article-title":"Productive steps toward an antimicrobial targeting virulence","volume":"12","author":"Barczak","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202501173","article-title":"Exploring the anticancer properties of quinoxaline-based molecules: a systematic review","volume":"22","author":"Abdelall","year":"2025","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bioorg.2026.110160_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2026.109561","article-title":"Design, regioselective, time gated synthesis of novel benzo[d]imidazole analogues as potential quorum sensing inhibitors targeting LasR in Pseudomonas aeruginosa","volume":"171","author":"Mohammed","year":"2026","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2024.1350391","article-title":"Inhibitory effect of natural compounds on quorum sensing system in Pseudomonas aeruginosa: a helpful promise for managing biofilm community","volume":"15","author":"Shariati","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0065","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.3390\/ijms25052655","article-title":"Molecular aspects of the functioning of pathogenic bacteria biofilm based on quorum sensing (QS) signal-response system and innovative non-antibiotic strategies for their elimination","volume":"25","author":"Juszczuk-Kubiak","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110160_bb0070","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/cbic.200700551","article-title":"Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing","volume":"9","author":"Geske","year":"2008","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bioorg.2026.110160_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/PMC.S13209","article-title":"Interfering with bacterial quorum sensing","volume":"8","author":"Reuter","year":"2016","journal-title":"Perspect. Medicin. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0080","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/acschembio.8b00971","article-title":"An autoinducer analogue reveals an alternative mode of ligand binding for the LasR quorum-sensing receptor","volume":"14","author":"Paczkowski","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0085","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1128\/JB.182.10.2811-2822.2000","article-title":"LuxR- and acyl-homoserine-lactone-controlled non-lux genes define a quorum-sensing regulon in Vibrio fischeri","volume":"182","author":"Callahan","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0090","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1016\/j.bmc.2011.06.072","article-title":"Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing","volume":"19","author":"McInnis","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115972","article-title":"Novel ligustilide derivatives target quorum sensing system LasR\/LasB and relieve inflammatory response against Pseudomonas aeruginosa infection","volume":"263","author":"Liu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0100","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1007\/s00253-019-09618-0","article-title":"Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors","volume":"103","author":"Ahmed","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0105","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s11274-024-03889-0","article-title":"A biomedical perspective of pyocyanin from Pseudomonas aeruginosa: its applications and challenges","volume":"40","author":"Balaji","year":"2024","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0110","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/1120009X.2025.2510093","article-title":"PqsR-specific quorum sensing inhibitors targeting Pseudomonas aeruginosa: current advances and future directions","volume":"38","author":"Aziz","year":"2025","journal-title":"J. Chemother."},{"key":"10.1016\/j.bioorg.2026.110160_bb0115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s44371-025-00121-2","article-title":"Disrupting quorum sensing by exploring conformational dynamics and active site flexibility of LasR protein in Pseudomonas aeruginosa","volume":"2","author":"Manu","year":"2025","journal-title":"Discov. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0120","article-title":"A comprehensive review of the pathogenic mechanisms of Pseudomonas aeruginosa: synergistic effects of virulence factors, quorum sensing, and biofilm formation","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0125","doi-asserted-by":"crossref","first-page":"36459","DOI":"10.1039\/D1RA06238G","article-title":"Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance","volume":"11","author":"Abd El-Aleam","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2026.110160_bb0130","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.chembiol.2018.06.007","article-title":"Structural and biochemical studies of non-native agonists of the LasR quorum-sensing receptor reveal an L3 loop \u201cout\u201d conformation for LasR","volume":"25","author":"O\u2019Reilly","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0135","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.chembiol.2009.09.001","article-title":"Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor","volume":"16","author":"Zou","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0140","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1016\/j.bmcl.2007.11.095","article-title":"Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa","volume":"18","author":"Mattmann","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110160_bb0145","article-title":"Design and synthesis of 5-substituted-2-iminothiazolidin-4-one derivatives as quorum sensing inhibitors against Pseudomonas aeruginosa virulence factors: an integrated study of molecular docking, dynamics, and biological assays","volume":"1346","author":"Abd El-Aleam","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.110160_bb0150","doi-asserted-by":"crossref","first-page":"29273","DOI":"10.1039\/C9RA05059K","article-title":"Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in Pseudomonas aeruginosa","volume":"9","author":"Srinivasarao","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2026.110160_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116880","article-title":"Design, synthesis, and molecular dynamic simulations of some novel benzo[d]thiazoles with anti-virulence activity against Pseudomonas aeruginosa","volume":"279","author":"Mohammed","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0160","article-title":"Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: evidence from comprehensive molecular dynamics simulation and in vitro investigation","volume":"241","author":"El-Aleam","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134856","article-title":"New benzimidazole derivatives targeting LasR with antibiofilm efficacy against Pseudomonas aeruginosa: an integrated in vitro and molecular dynamics simulation- based investigation","volume":"1277","author":"El-Aleam","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.110160_bb0170","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1248\/cpb.c17-00922","article-title":"Synthesis of novel thiophene, thiazole and coumarin derivatives based on benzimidazole nucleus and their cytotoxicity and toxicity evaluations","volume":"66","author":"Mohareb","year":"2018","journal-title":"Chem. Pharm. Bull. (Tokyo)."},{"key":"10.1016\/j.bioorg.2026.110160_bb0175","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/j.ejmech.2011.02.033","article-title":"Synthesis and biological activity of novel barbituric and thiobarbituric acid derivatives against non-alcoholic fatty liver disease","volume":"46","author":"Ma","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.109444","article-title":"Pyrazole derivatives as dual COX-2\/ EGFR inhibitors with anticancer potential: optimization of difenamizole analogs","volume":"170","author":"Farag","year":"2026","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0185","first-page":"112","article-title":"Green and conventional synthetic strategies for quinoxaline derivatives: toward a sustainable future","volume":"2","author":"Abdelaziz","year":"2025","journal-title":"J. Pharm. Sci. Drug Manuf."},{"key":"10.1016\/j.bioorg.2026.110160_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ddr.70168","article-title":"Design, synthesis, and 2D QSAR analysis of some novel pyrazolo[1,5-a]pyrimidine derivatives as Pim-1 kinase inhibitors for the treatment of MCF-7 breast cancer","volume":"86","author":"Mohammed","year":"2025","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.bioorg.2026.110160_bb0195","doi-asserted-by":"crossref","first-page":"30624","DOI":"10.1021\/acsomega.5c12128","article-title":"Khellin-derived benzofuran\u2013pyrazoline hybrids as kinase-targeted anticancer agents","volume":"11","author":"Al-Qadhi","year":"2026","journal-title":"ACS Omega"},{"key":"10.1016\/j.bioorg.2026.110160_bb0200","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1107\/S205698901500047X","article-title":"Crystal structure of the chalcone (E)-3-(furan-2-yl)-1-phenylprop-2-en-1-one","volume":"71","author":"V\u00e1zquez-Vuelvas","year":"2015","journal-title":"Acta Crystallogr. Sect. E Crystallogr. Commun."},{"key":"10.1016\/j.bioorg.2026.110160_bb0205","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1107\/S2056989018017450","article-title":"Crystal structure and hirshfeld surface analysis of a chalcone derivative: (E)-3-(4-fluoro-phen-yl)-1-(4-nitro-phen-yl)prop-2-en-1-one","volume":"75","author":"Wong","year":"2019","journal-title":"Acta Crystallogr. Sect. E Crystallogr. Commun."},{"key":"10.1016\/j.bioorg.2026.110160_bb0210","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/j.ejmech.2010.02.022","article-title":"Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a]quinolines and fluorenes: synthesis, antitumor evaluation in vitro and crystal structure determination","volume":"45","author":"Hranjec","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0215","doi-asserted-by":"crossref","first-page":"12707","DOI":"10.3390\/molecules181012707","article-title":"Heteroaryl Chalcones: design, synthesis, X-ray crystal structures and biological evaluation","volume":"18","author":"Kumar","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110160_bb0220","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3390\/molecules25051162","article-title":"Design, synthesis, and biological evaluation of aromatic amide-substituted benzimidazole-derived chalcones. The effect of upregulating TP53 protein expression","volume":"25","author":"Wu","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110160_bb0225","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.3390\/molecules24183259","article-title":"Design and synthesis of Benzimidazole-Chalcone derivatives as potential anticancer agents","volume":"24","author":"Hsieh","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110160_bb0230","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.3390\/molecules26061620","article-title":"Assessing the molecular targets and mode of action of Furanone C-30 on Pseudomonas aeruginosa quorum sensing","volume":"26","author":"Markus","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110160_bb0235","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s00253-024-13247-7","article-title":"Effect of L-HSL on biofilm and motility of Pseudomonas aeruginosa and its mechanism","volume":"108","author":"Tang","year":"2024","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0240","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.micro.56.012302.160938","article-title":"Type IV pili and twitching motility","volume":"56","author":"Mattick","year":"2002","journal-title":"Ann. Rev. Microbiol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0245","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.1128\/JB.182.21.5990-5996.2000","article-title":"Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili","volume":"182","author":"K\u00f6hler","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/biom13111573","article-title":"Norlobaridone inhibits quorum sensing-dependent biofilm formation and some virulence factors in Pseudomonas aeruginosa by disrupting its transcriptional activator protein LasR dimerization","volume":"13","author":"Soltane","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioorg.2026.110160_bb0255","doi-asserted-by":"crossref","first-page":"17981","DOI":"10.1073\/pnas.1316981110","article-title":"A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation","volume":"110","author":"O\u2019Loughlin","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bioorg.2026.110160_bb0260","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0265","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/j.1460-2075.1996.tb00329.x","article-title":"Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus","volume":"15","author":"Behrens","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.bioorg.2026.110160_bb0270","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and AutoDock\/Vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.bioorg.2026.110160_bb0275","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0280","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ejmech.2016.12.014","article-title":"Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors","volume":"126","author":"Akhtar","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.128194","article-title":"Low cytotoxic quinoline-4-carboxylic acids derived from vanillin precursors as potential human dihydroorotate dehydrogenase inhibitors","volume":"46","author":"Petrovi\u0107","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110160_bb0290","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2025.2580515","article-title":"In vitro \u03b1-glucosidase inhibition, molecular dynamics and docking study of phenyl carbamoyl methoxy thiosemicarbazone derivatives as potential anti-diabetic agents","volume":"40","author":"Valadbeigi","year":"2025","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0295","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.3390\/molecules29143387","article-title":"Design, synthesis, and characterization of novel thiazolidine-2,4-dione-acridine hybrids as antitumor agents","volume":"29","author":"Garberov\u00e1","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110160_bb0300","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1248\/cpb.58.953","article-title":"Synthesis and antimicrobial activity of some novel 4-(1H-benz[d]imidazol-2yl)-1,3-thiazol-2-amines","volume":"58","author":"Malla Reddy","year":"2010","journal-title":"Chem. Pharm. Bull. (Tokyo)."},{"key":"10.1016\/j.bioorg.2026.110160_bb0305","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s11030-022-10494-6","article-title":"Identification of bicyclic compounds that act as dual inhibitors of Bcl-2 and Mcl-1","volume":"27","author":"Uthale","year":"2023","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bioorg.2026.110160_bb0310","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1080\/00397911.2020.1784436","article-title":"Investigation of the reactivity of (1-H -benzo[d]imidazol-2-yl)acetonitrile and (benzo[d]thiazol-2-yl)acetonitrile as precursors for novel bis(benzo[4,5]imidazo[1,2- a]pyridines) and bis(benzo[4,5]thiazolo[3,2-a]pyridines)","volume":"50","author":"Darweesh","year":"2020","journal-title":"Synth. Commun."},{"key":"10.1016\/j.bioorg.2026.110160_bb0315","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/j.bmc.2016.03.036","article-title":"Design, synthesis and biological evaluation of 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones as inhibitors of protein kinase FGFR1","volume":"24","author":"Gryshchenko","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113003","article-title":"N-substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: synthesis, biological activity and computational analysis","volume":"211","author":"Perin","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103972","article-title":"Antimicrobial evaluation and docking study of some new substituted benzimidazole-2yl derivatives","volume":"101","author":"Abdel-Motaal","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0330","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/jhet.3407","article-title":"Synthesis of some Benzimidazole-based heterocycles and their application as copper corrosion inhibitors: Benzimidazole derivatives as corrosion inhibitors","volume":"56","author":"Eldebss","year":"2019","journal-title":"J. Heterocyclic Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0335","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.bmc.2008.12.059","article-title":"Synthesis and antiprotozoal activity of novel 1-methylbenzimidazole derivatives","volume":"17","author":"Valdez-Padilla","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0340","doi-asserted-by":"crossref","DOI":"10.1038\/s41538-025-00606-5","article-title":"Comparison of metabolic profiles, regulatory pathways, and quorum sensing inhibition activity of brown mustard seeds (Brassica juncea L.) post germination and roasting treatments","volume":"9","author":"Ghallab","year":"2025","journal-title":"npj Sci. Food"},{"key":"10.1016\/j.bioorg.2026.110160_bb0345","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpha.2015.11.005","article-title":"Methods for in vitro evaluating antimicrobial activity: a review","volume":"6","author":"Balouiri","year":"2016","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.bioorg.2026.110160_bb0350","series-title":"Performance Standards for Antimicrobial Susceptibility Testing: 24th Informational Supplement","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2014"},{"key":"10.1016\/j.bioorg.2026.110160_bb0355","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1038\/s41598-025-87609-0","article-title":"Innovative application of ceftriaxone as a quorum sensing inhibitor in Pseudomonas aeruginosa","volume":"15","author":"Naga","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.110160_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114021","article-title":"Design and synthesis of ciprofloxacin-sulfonamide hybrids to manipulate ciprofloxacin pharmacological qualities: potency and side effects","volume":"228","author":"Ibrahim","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0365","doi-asserted-by":"crossref","first-page":"17942","DOI":"10.1038\/s41598-023-44063-0","article-title":"Inhibition of Pseudomonas aeruginosa quorum sensing by methyl gallate from Mangifera indica","volume":"13","author":"Naga","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.110160_bb0370","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11274-022-03337-x","article-title":"Methoxyisoflavan derivative from Trigonella stellata inhibited quorum sensing and virulence factors of Pseudomonas aeruginosa","volume":"38","author":"Naga","year":"2022","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0375","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4314\/ahs.v17i1.25","article-title":"Quorum sensing inhibitory activity of sub-inhibitory concentrations of \u03b2-lactams","volume":"17","author":"El-Mowafy","year":"2017","journal-title":"Afr. Health Sci."},{"key":"10.1016\/j.bioorg.2026.110160_bb0380","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.716789","article-title":"Quorum sensing inhibiting activity of cefoperazone and its metallic derivatives on Pseudomonas aeruginosa","volume":"11","author":"Naga","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0385","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/1471-2180-8-189","article-title":"Involvement of a phospholipase C in the hemolytic activity of a clinical strain of Pseudomonas fluorescens","volume":"8","author":"Rossignol","year":"2008","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0390","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s10126-007-9036-y","article-title":"Quorum sensing antagonism from marine organisms","volume":"10","author":"Skindersoe","year":"2008","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0395","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.micpath.2014.07.008","article-title":"Aspirin is an efficient inhibitor of quorum sensing, virulence and toxins in Pseudomonas aeruginosa","volume":"74","author":"El-Mowafy","year":"2014","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bioorg.2026.110160_bb0400","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1128\/AAC.00612-07","article-title":"Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by South Florida plant extracts","volume":"52","author":"Adonizio","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2026.110160_bb0405","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1073\/pnas.060030097","article-title":"Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa","volume":"97","author":"Rashid","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bioorg.2026.110160_bb0410","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1128\/JB.181.13.4133-4136.1999","article-title":"Swarming by pseudomonas syringae B728a requires gacS (lemA) and gacA but not the acyl-homoserine lactone biosynthetic gene ahlI","volume":"181","author":"Kinscherf","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bioorg.2026.110160_bb0415","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","article-title":"Scalable molecular dynamics with NAMD","volume":"26","author":"Phillips","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0420","doi-asserted-by":"crossref","first-page":"673A","DOI":"10.1016\/j.bpj.2017.11.3632","article-title":"QwikMD-gateway for easy simulation with VMD and NAMD","volume":"114","author":"Ribeiro","year":"2018","journal-title":"Biophys. J."},{"key":"10.1016\/j.bioorg.2026.110160_bb0425","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"key":"10.1016\/j.bioorg.2026.110160_bb0430","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1021\/ct300418h","article-title":"MMPBSA.Py: an efficient program for end-state free energy calculations","volume":"8","author":"Miller","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.bioorg.2026.110160_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.109116","article-title":"Novel quinoxaline derivatives as promising cytotoxic agents: structure-based design, in silico studies, VEGFR-2 inhibition, and PI3K\/AKT\/mTOR pathway modulation","volume":"166","author":"Abdelall","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110160_bb0440","doi-asserted-by":"crossref","first-page":"W271","DOI":"10.1093\/nar\/gku339","article-title":"iMODS: internal coordinates normal mode analysis server","volume":"42","author":"L\u00f3pez-Blanco","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2026.110160_bb0445","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1093\/bioinformatics\/btr497","article-title":"iMod: multipurpose normal mode analysis in internal coordinates","volume":"27","author":"L\u00f3pez-Blanco","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bioorg.2026.110160_bb0450","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/prot.20151","article-title":"Predictions of protein flexibility: first order measures","volume":"56","author":"Kovacs","year":"2004","journal-title":"Proteins Struct. Funct. Bioinforma."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826006966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:49:52Z","timestamp":1787676592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826006966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":90,"alternative-id":["S0045206826006966"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110160","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting quorum sensing in Pseudomonas aeruginosa: Novel benzo[d]imidazole-based LasR inhibitors with tunable head, \u03b1,\u03b2-unsaturated linker, and tail segments.","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110160"}}