{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:26:32Z","timestamp":1793895992425,"version":"4.8.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017242","name":"NIFDC","doi-asserted-by":"publisher","award":["2025SKLDRS0332"],"award-info":[{"award-number":["2025SKLDRS0332"]}],"id":[{"id":"10.13039\/100017242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bioorg.2026.110186","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T14:17:45Z","timestamp":1782656265000},"page":"110186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synthesis and biological evaluation of C6-modified Celastrol derivatives as anti-inflammatory agents targeting the NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"180","author":[{"given":"Hao-Ran","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Long","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Fu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110186_bb0005","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bioorg.2026.110186_bb0010","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1521-6896(03)00116-2","article-title":"Mechanisms of the inflammatory response","volume":"18","author":"Sherwood","year":"2004","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"10.1016\/j.bioorg.2026.110186_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/cells14070488","article-title":"The role of inflammation in cancer: mechanisms of tumor initiation, progression, and metastasis","volume":"14","author":"Nishida","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.bioorg.2026.110186_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/pore.2021.1610136","article-title":"Inflammation in focus: the beginning and the end","volume":"27","author":"Kiss","year":"2022","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.bioorg.2026.110186_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/nu18030404","article-title":"Diet, inflammation, and metabolic complications","volume":"18","author":"Puthanveetil","year":"2026","journal-title":"Nutrients"},{"key":"10.1016\/j.bioorg.2026.110186_bb0030","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41423-025-01310-w","article-title":"NF-\u03baB in inflammation and cancer","volume":"22","author":"Mao","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bioorg.2026.110186_bb0035","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","article-title":"NF-\u03baB: blending metabolism, immunity, and inflammation","volume":"43","author":"Capece","year":"2022","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bioorg.2026.110186_bb0040","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.fct.2018.06.040","article-title":"NF-\u03baB-iNOS-COX2-TNF \u03b1 inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats","volume":"118","author":"Natarajan","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bioorg.2026.110186_bb0045","doi-asserted-by":"crossref","DOI":"10.1007\/s00011-024-01983-5","article-title":"The role of celastrol in inflammation and diseases","volume":"74","author":"Lei","year":"2025","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bioorg.2026.110186_bb0050","doi-asserted-by":"crossref","first-page":"172","DOI":"10.5483\/BMBRep.2015.48.3.147","article-title":"Celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses by suppressing NF-\u03baB activation in RINm5F beta cells","volume":"48","author":"Ju","year":"2015","journal-title":"BMB Rep."},{"key":"10.1016\/j.bioorg.2026.110186_bb0055","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/emm.2007.78","article-title":"Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells","volume":"39","author":"Jung","year":"2007","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bioorg.2026.110186_bb0060","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2174\/138955706777934937","article-title":"Naturally occurring NF-kappaB inhibitors","volume":"6","author":"Nam","year":"2006","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110186_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112081","article-title":"Celastrol: progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology","volume":"189","author":"Hou","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110186_bb0070","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1021\/acs.jnatprod.0c00067","article-title":"Synthesis and biological evaluation of celastrol derivatives as potential immunosuppressive agents","volume":"83","author":"He","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.110186_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29020538","article-title":"Celastrol pyrazine derivative alleviates silicosis progression via inducing ROS-mediated apoptosis in activated fibroblasts","volume":"29","author":"Bai","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110186_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157110","article-title":"Celastrol derivatives ameliorate arthritis in AIA rats via modulating calcium signaling","volume":"146","author":"Huang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.110186_bb0085","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1158\/0008-5472.CAN-05-4529","article-title":"Celastrol, a triterpene extracted from the Chinese \u201cThunder of God Vine,\u201d is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice","volume":"66","author":"Yang","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2026.110186_bb0090","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bioorg.2026.110186_bb0095","first-page":"161","article-title":"Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa)","volume":"9","author":"Wu","year":"2023","journal-title":"J. Altern. Complement. Med."},{"key":"10.1016\/j.bioorg.2026.110186_bb0100","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3390\/nutraceuticals4040031","article-title":"Potential applications of the anti-inflammatory, antithrombotic and antioxidant health-promoting properties of curcumin: a critical review","volume":"4","author":"Rapti","year":"2024","journal-title":"Nutraceuticals"},{"key":"10.1016\/j.bioorg.2026.110186_bb0105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.pharmtox.43.100901.140223","article-title":"Hormesis: the dose-response revolution","volume":"43","author":"Calabrese","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bioorg.2026.110186_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41514-024-00155-3","article-title":"Current advances and future trends of hormesis in disease","volume":"10","author":"Wan","year":"2024","journal-title":"NPJ Aging"},{"key":"10.1016\/j.bioorg.2026.110186_bb0115","first-page":"23","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat. Rev."},{"key":"10.1016\/j.bioorg.2026.110186_bb0120","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bioorg.2026.110186_bb0125","first-page":"723","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev."},{"key":"10.1016\/j.bioorg.2026.110186_bb0130","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/cr.2011.13","article-title":"NF-\u03baB in immunobiology","volume":"21","author":"Hayden","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.bioorg.2026.110186_bb0135","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2026.110186_bb0140","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanak","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bioorg.2026.110186_bb0145","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/embr.201337983","article-title":"The I\u03baB kinase complex in NF-\u03baB regulation and beyond","volume":"15","author":"Hinz","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bioorg.2026.110186_bb0150","doi-asserted-by":"crossref","first-page":"W422","DOI":"10.1093\/nar\/gkae236","article-title":"ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support","volume":"52","author":"Fu","year":"2024","journal-title":"Nucleic Acids Res."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826007224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826007224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T15:50:51Z","timestamp":1793893851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826007224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"alternative-id":["S0045206826007224"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110186","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of C6-modified Celastrol derivatives as anti-inflammatory agents targeting the NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110186","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110186"}}