{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:51:21Z","timestamp":1791409881643,"version":"4.3.3"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110267","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:50:43Z","timestamp":1784533843000},"page":"110267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synthesis, fungicidal activity, and DFT calculation of novel amide derivatives based on the metabolite of cyprodinil"],"prefix":"10.1016","volume":"181","author":[{"given":"Shengqiang","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"51","key":"10.1016\/j.bioorg.2026.110267_bb0005","doi-asserted-by":"crossref","first-page":"32460","DOI":"10.1021\/acs.jafc.5c11544","article-title":"Green pesticide research and development integrating molecular targets, mechanisms, resistance, and innovation in theory and technology","volume":"73","author":"Wang","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110267_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/fes3.293","article-title":"Future direction of agrochemical development for plant disease in China","volume":"10","author":"Guo","year":"2021","journal-title":"Food Energy Secur."},{"issue":"21","key":"10.1016\/j.bioorg.2026.110267_bb0015","doi-asserted-by":"crossref","first-page":"14417","DOI":"10.3390\/su142114417","article-title":"The potential and green chemistry attributes of biopesticides for sustainable agriculture","volume":"14","author":"Fenibo","year":"2022","journal-title":"Sustainability"},{"key":"10.1016\/j.bioorg.2026.110267_bb0020","series-title":"Hayes' handbook of pesticide toxicology","first-page":"1903","article-title":"Cyprodinil: a fungicide of the anilinopyrimidine class","author":"Waechter","year":"2010"},{"key":"10.1016\/j.bioorg.2026.110267_bb0025","series-title":"Modern crop protection compounds","first-page":"869","article-title":"Fungicides acting on amino acids and protein synthesis: anilinopyrimidines\u2013assumed methionine biosynthesis inhibitors","volume":"2","author":"Gisi","year":"2026"},{"issue":"3","key":"10.1016\/j.bioorg.2026.110267_bb0030","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ps.2780420304","article-title":"Possible methionine biosynthesis inhibition by pyrimidinamine fungicides","volume":"42","author":"Masner","year":"1994","journal-title":"Pestic. Sci."},{"issue":"7","key":"10.1016\/j.bioorg.2026.110267_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/su14074056","article-title":"Particularities of fungicides and factors affecting their fate and removal efficacy: a review","volume":"14","author":"Gikas","year":"2022","journal-title":"Sustainability"},{"issue":"2","key":"10.1016\/j.bioorg.2026.110267_bb0040","article-title":"Peer review of the pesticide risk assessment of the active substance cyprodinil","volume":"23","author":"E.F.S. Authority","year":"2025","journal-title":"EFSA J."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110267_bb0045","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1094\/PDIS-06-12-0539-RE","article-title":"Resistance to cyprodinil and lack of fludioxonil resistance in Botrytis cinerea isolates from strawberry in north and South Carolina","volume":"97","author":"Fern\u00e1ndez-Ortu\u00f1o","year":"2013","journal-title":"Plant Dis."},{"key":"10.1016\/j.bioorg.2026.110267_bb0050","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/ps.7179","article-title":"Conversion of fungicide cyprodinil to salts with organic acids: preparation, characterization, advantages","volume":"79","author":"Wang","year":"2023","journal-title":"Pest Manag. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110267_bb0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11306-010-0231-x","article-title":"Metabolomics in pesticide research and development: review and future perspectives","volume":"7","author":"Aliferis","year":"2011","journal-title":"Metabolomics"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110267_bb0060","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3390\/molecules22060958","article-title":"Ovicidal and insecticidal activities of pyriproxyfen derivatives with an oxime ester group","volume":"22","author":"Sun","year":"2017","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.bioorg.2026.110267_bb0065","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.dyepig.2010.08.012","article-title":"On the 75th anniversary of Prontosil","volume":"88","author":"Wainwright","year":"2011","journal-title":"Dyes Pigments"},{"issue":"3","key":"10.1016\/j.bioorg.2026.110267_bb0070","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0048-3575(91)90084-Y","article-title":"Influence of fenchlorazole-ethyl on the metabolism of fenoxaprop-ethyl in wheat, barley, and crabgrass","volume":"41","author":"Yaacoby","year":"1991","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.bioorg.2026.110267_bb0075","first-page":"247","article-title":"Inhibition of AChE by single and simultaneous exposure to malathion and its degradation products","volume":"26","author":"Krsti\u0107","year":"2007","journal-title":"Gen. Physiol. Biophys."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110267_bb0080","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/etc.3536","article-title":"Comparative chronic toxicity of imidacloprid, clothianidin, and thiamethoxam to Chironomus dilutus and estimation of toxic equivalency factors","volume":"36","author":"Cavallaro","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"issue":"48","key":"10.1016\/j.bioorg.2026.110267_bb0085","doi-asserted-by":"crossref","first-page":"30582","DOI":"10.1021\/acs.jafc.5c09296","article-title":"Comprehensive overview of pyrazole amide derivatives as novel pesticides for crop protection and Pest management","volume":"73","author":"Luo","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"14","key":"10.1016\/j.bioorg.2026.110267_bb0090","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1021\/cr4005605","article-title":"Application of the intermediate derivatization approach in agrochemical discovery","volume":"114","author":"Guan","year":"2014","journal-title":"Chem. Rev."},{"issue":"47","key":"10.1016\/j.bioorg.2026.110267_bb0095","doi-asserted-by":"crossref","first-page":"26027","DOI":"10.1021\/acs.jafc.4c05854","article-title":"Comprehensive overview of the amide linker modification in the succinate dehydrogenase inhibitors","volume":"72","author":"Zeng","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"19","key":"10.1016\/j.bioorg.2026.110267_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197144","article-title":"Review on structures of pesticide targets","volume":"21","author":"Li","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110267_bb0105","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.chemosphere.2016.05.036","article-title":"Identification of photoproducts of fungicide cyprodinil and elucidation of transformation mechanism in water using LC-IT-TOF-MS\/MS technique","volume":"160","author":"Chen","year":"2016","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.bioorg.2026.110267_bb0110","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/hlca.200390137","article-title":"Helicity-encoded molecular strands: efficient access by the hydrazone route and structural features","volume":"86","author":"Schmitt","year":"2003","journal-title":"Helv. Chim. Acta"},{"issue":"15","key":"10.1016\/j.bioorg.2026.110267_bb0115","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.tetlet.2016.02.106","article-title":"Novel multi-component syntheses of pyrimidines using \u03b2-CD in aqueous medium","volume":"57","author":"Rakhi","year":"2016","journal-title":"Tetrahedron Lett."},{"issue":"9","key":"10.1016\/j.bioorg.2026.110267_bb0120","first-page":"24","article-title":"Synthesis of pyrimethanil","volume":"26","author":"Zhou","year":"2005","journal-title":"Pest. Sci. Admin."},{"issue":"11","key":"10.1016\/j.bioorg.2026.110267_bb0125","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1021\/acs.jafc.5c00044","article-title":"New isoxazoline cyclopropyl-picolinamide derivatives as potential insecticides","volume":"73","author":"Song","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110267_bb0130","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/jlcr.1657","article-title":"Unusual base-catalyzed exchange in the synthesis of deuterated PF-2413873 a","volume":"52","author":"Rozze","year":"2009","journal-title":"J. Labelled. Compd. Rad."},{"key":"10.1016\/j.bioorg.2026.110267_bb0135","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bioorg.2018.06.030","article-title":"Design, synthesis, biological activities and DFT calculation of novel 1, 2, 4-triazole Schiff base derivatives","volume":"80","author":"Jin","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110267_bb0140","series-title":"Laboratory manual of experimental microbiology","author":"Atlas","year":"1995"},{"key":"10.1016\/j.bioorg.2026.110267_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.141278","article-title":"Synthesis, biological assessment, and in silico binding mode interaction analyses and DFT studies of biphenylsulfonamide-based potent MMP-2 inhibitors effective against chronic myeloid leukemia","volume":"1328","author":"Baidya","year":"2025","journal-title":"J. Mol. Struct."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826008035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826008035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:09:00Z","timestamp":1791407340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826008035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"alternative-id":["S0045206826008035"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110267","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, fungicidal activity, and DFT calculation of novel amide derivatives based on the metabolite of cyprodinil","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110267"}}