{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:50:15Z","timestamp":1791409815137,"version":"4.3.3"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110383","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T21:57:01Z","timestamp":1786917421000},"page":"110383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Selective anticancer activity of a multinuclear Cu(II) complex through apoptosis induction in ovarian cancer cells"],"prefix":"10.1016","volume":"181","author":[{"given":"Li","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Heidari Majd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Reza","family":"Ghaffari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bioorg.2026.110383_bb0005","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110383_bb0010","article-title":"Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries","volume":"76","author":"Sung","year":"2026","journal-title":"CA Cancer J. Clin."},{"issue":"7","key":"10.1016\/j.bioorg.2026.110383_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17070931","article-title":"Preclinical trials of cancer stem cells targeted by metal-based coordination complexes: a systematic review","volume":"17","author":"Bezerra","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioorg.2026.110383_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.216477","article-title":"Bridging the gap between theory and treatment: transition metal complexes as successful candidates in medicine","volume":"531","author":"Abdolmaleki","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.110383_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117702","article-title":"Recent advances in the discovery of copper(II) complexes as potential anticancer drugs","volume":"292","author":"Rogalewicz","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2026.110383_bb0030","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.7150\/thno.69424","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bioorg.2026.110383_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.216327","article-title":"Recent advances of Schiff base metal complexes as potential anticancer agents","volume":"525","author":"Lv","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.110383_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134683","article-title":"Synthesis, characterization, and anticancer activity of mononuclear Schiff-base metal complexes","volume":"1275","author":"Yin","year":"2023","journal-title":"J. Mol. Struct."},{"issue":"Pt 1","key":"10.1016\/j.bioorg.2026.110383_bb0045","article-title":"Integrated experimental and computational study of oxime-based derivatives: antiproliferative evaluation, gene expression, DNA minor groove binding, detailed DFT, docking, and molecular dynamics analyses","volume":"124","author":"Feizi-Dehnayebi","year":"2026","journal-title":"Comput. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110383_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12102863","article-title":"Copper complexes as anticancer agents targeting topoisomerases I and II","volume":"12","author":"Molinaro","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110383_bb0055","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s12964-024-01726-3","article-title":"The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm","volume":"22","author":"Vo","year":"2024","journal-title":"Cell Communication and Signaling"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110383_bb0060","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12967-025-06121-1","article-title":"Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications","volume":"23","author":"Cong","year":"2025","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110383_bb0065","article-title":"Cuproptosis: a copper-mediated programmed cell death, chemistry","volume":"20","author":"Meena","year":"2025","journal-title":"An Asian Journal"},{"issue":"7","key":"10.1016\/j.bioorg.2026.110383_bb0070","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.trechm.2021.03.006","article-title":"Metal complexes for therapeutic applications","volume":"3","author":"Karges","year":"2021","journal-title":"Trends Chem"},{"key":"10.1016\/j.bioorg.2026.110383_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2025.122730","article-title":"Investigating DNA-interaction and anticancer activity of new cu+2 complex coordinated with dipicolinic acid. Experimental and computational studies","volume":"584","author":"Heidari","year":"2025","journal-title":"Inorg. Chim. Acta"},{"issue":"3","key":"10.1016\/j.bioorg.2026.110383_bb0080","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2174\/0929867325666181031114306","article-title":"Current development of metal complexes with diamine ligands as potential anticancer agents","volume":"27","author":"Misirlic-Dencic","year":"2020","journal-title":"Curr. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110383_bb0085","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s10870-014-0515-5","article-title":"Two conformational isomers in a crystal of trans-Dibromobis(2,2-dimethyl-1,3-propanediamine)chromium(III) bromide","volume":"44","author":"Moon","year":"2014","journal-title":"J. Chem. Crystallogr."},{"key":"10.1016\/j.bioorg.2026.110383_bb0090","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.poly.2019.03.059","article-title":"Synthesis of monosubstituted dipicolinic acid hydrazide derivative and structural characterization of novel co(III) and Cr(III) complexes","volume":"166","author":"Garin","year":"2019","journal-title":"Polyhedron"},{"issue":"13","key":"10.1016\/j.bioorg.2026.110383_bb0095","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1021\/acs.jmedchem.3c00255","article-title":"In vitro and in vivo biological activities of dipicolinate oxovanadium(IV) complexes","volume":"66","author":"Choroba","year":"2023","journal-title":"J. Med. Chem."},{"issue":"15","key":"10.1016\/j.bioorg.2026.110383_bb0100","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1007\/s00018-016-2130-4","article-title":"The DNA damage-induced cell death response: a roadmap to kill cancer cells","volume":"73","author":"Matt","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"7","key":"10.1016\/j.bioorg.2026.110383_bb0105","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/jhet.4278","article-title":"Investigation and comparison of biological effects of regioselectively synthesized thiazole derivatives","volume":"58","author":"Moghaddam-manesh","year":"2021","journal-title":"J. Heterocyclic Chem."},{"key":"10.1016\/j.bioorg.2026.110383_bb0110","first-page":"1","article-title":"Unveiling the distinct effects of a two-dimensional copper\/sodium complex: oxidative stress on erythrocytes and cytotoxicity, apoptosis, drug resistance, and inflammation in lung cancer cells","volume":"25","author":"Li","year":"2025","journal-title":"Anti-Cancer Agents Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110383_bb0115","first-page":"6","article-title":"Increasing apoptosis induction and minimizing side effects of biosynthesized silver nanoparticles by utilizing halloysite nanotubes containing folic acid, Cancer","volume":"16","author":"Heidari Majd","year":"2025","journal-title":"Nanotechnology"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110383_bb0120","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1134\/S1607672921050148","article-title":"Evaluation of induced apoptosis by biosynthesized zinc oxide nanoparticles in MCF-7 breast Cancer cells using Bak1 and Bclx expression","volume":"500","author":"Yan","year":"2021","journal-title":"Dokl. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110383_bb0125","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3390\/solids3030027","article-title":"Synthesis, structural characterization, conformational and topological classification of different salts in the 2,2-Dimethylpropane-1,3-diamine\/HCl\/H2O-system","volume":"3","author":"Heimgert","year":"2022","journal-title":"Solids"},{"key":"10.1016\/j.bioorg.2026.110383_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.138836","article-title":"Synthesis and anti-cancer investigations of copper(II) complexes based on adenine","volume":"1315","author":"Zhai","year":"2024","journal-title":"J. Mol. Struct."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110383_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30102104","article-title":"Innovative approaches in the synthesis and optimization of copper complexes for antitumor therapies: a comprehensive review","volume":"30","author":"Silva","year":"2025","journal-title":"Molecules"},{"issue":"24","key":"10.1016\/j.bioorg.2026.110383_bb0140","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2404668121","article-title":"Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis","volume":"121","author":"Huang","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioorg.2026.110383_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2023.112432","article-title":"Copper(II) complexes with plumbagin and bipyridines target mitochondria for enhanced chemodynamic cancer therapy","volume":"251","author":"Zhang","year":"2024","journal-title":"J. Inorg. Biochem."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110383_bb0150","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/nar\/30.2.419","article-title":"Polyamine-nucleic acid interactions and the effects on structure in oriented DNA fibers","volume":"30","author":"van Dam","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2026.110383_bb0155","doi-asserted-by":"crossref","first-page":"1236063","DOI":"10.3389\/fimmu.2023.1236063","article-title":"Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations","volume":"14","author":"Gao","year":"2023","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.bioorg.2026.110383_bb0160","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1044-0305(00)00128-8","article-title":"Fragmentation chemistry of [M + cu]+ peptide ions containing an N-terminal arginine","volume":"11","author":"Shields","year":"2000","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.bioorg.2026.110383_bb0165","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.actbio.2025.01.014","article-title":"Copper-based biomaterials for anti-tumor therapy: recent advances and perspectives","volume":"193","author":"Zhang","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioorg.2026.110383_bb0170","article-title":"Biological properties of copper: antibacterial, osteogenesis of biomaterials","volume":"44","author":"Rahimi","year":"2025","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.bioorg.2026.110383_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107988","article-title":"Copper homeostasis and cuproptosis represent emerging targets for therapeutic intervention in inflammatory diseases","volume":"221","author":"Yang","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110383_bb0180","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12943-025-02434-3","article-title":"Epigenetic modification of cuproptosis by non-coding RNAs in cancer drug resistance","volume":"24","author":"Du","year":"2025","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110383_bb0185","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s12964-024-01726-3","article-title":"The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm","volume":"22","author":"Vo","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bioorg.2026.110383_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.841814","article-title":"Selective targeting of Cancer cells by copper ionophores: an overview","volume":"9","author":"Oliveri","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"18","key":"10.1016\/j.bioorg.2026.110383_bb0195","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1158\/1078-0432.CCR-12-0697","article-title":"Copper chelation enhances antitumor efficacy and systemic delivery of oncolytic HSV","volume":"18","author":"Yoo","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bioorg.2026.110383_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118422","article-title":"Cuproptosis: current insights into its multifaceted role in disease, cancer, and translational\/therapeutic opportunities","volume":"190","author":"Boaru","year":"2025","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110383_bb0205","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s10534-025-00676-8","article-title":"Apoptotic cell death induced by copper (II), manganese (II) and silver (I) complexes containing bridging dicarboxylate and 1,10-phenanthroline ligands: one of the multi-modes of anticancer activity?","volume":"38","author":"O\u2019Sullivan","year":"2025","journal-title":"BioMetals"},{"issue":"11","key":"10.1016\/j.bioorg.2026.110383_bb0210","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1101\/gad.1304105","article-title":"Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins","volume":"19","author":"Willis","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.bioorg.2026.110383_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fceld.2025.1628470","article-title":"Copper-induced cell death mechanisms and their role in the tumor microenvironment","volume":"4","author":"Jiao","year":"2025","journal-title":"Frontiers in Cell Death"},{"key":"10.1016\/j.bioorg.2026.110383_bb0220","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1038\/ncomms3726","article-title":"Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization","volume":"4","author":"Chen","year":"2013","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bioorg.2026.110383_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14070846","article-title":"Hydnocarpin, a natural flavonolignan, induces the ROS-mediated apoptosis of ovarian cancer cells and reprograms tumor-associated immune cells","volume":"14","author":"Kim","year":"2025","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.bioorg.2026.110383_bb0230","first-page":"675","article-title":"PI3K inhibition sensitize the cisplatin-resistant human ovarian Cancer cell OVCAR3 by induction of oxidative stress, rep biochem","volume":"10","author":"Baghal-Sadriforoush","year":"2022","journal-title":"Mol. Biol."},{"key":"10.1016\/j.bioorg.2026.110383_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2026.146098","article-title":"In situ synthesis and antitumor activity of novel planar salicylaldehyde Schiff base copper(II) complexes","volume":"1366","author":"Pan","year":"2026","journal-title":"J. Mol. Struct."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:01:08Z","timestamp":1791406868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826009193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":47,"alternative-id":["S0045206826009193"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110383","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective anticancer activity of a multinuclear Cu(II) complex through apoptosis induction in ovarian cancer cells","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110383","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110383"}}