{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:51:19Z","timestamp":1791409879444,"version":"4.3.3"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1802000"],"award-info":[{"award-number":["2023YFA1802000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110388","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T06:05:04Z","timestamp":1786773904000},"page":"110388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Novel VHL ligand-based PROTACs targeting JNK1: design, synthesis, and biological evaluation with potent anti-EMT activity"],"prefix":"10.1016","volume":"181","author":[{"given":"Shuhua","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiabin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bioorg.2026.110388_bb0005","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41580-024-00733-z","article-title":"Epithelial-mesenchymal transition in tissue repair and degeneration","volume":"25","author":"Youssef","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110388_bb0010","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000512218","article-title":"Epithelial-mesenchymal transition (EMT) as a therapeutic target","volume":"211","author":"Jonckheere","year":"2022","journal-title":"Cells Tissues Organs"},{"issue":"2","key":"10.1016\/j.bioorg.2026.110388_bb0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer","volume":"20","author":"Dongre","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.110388_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.737570","article-title":"Epithelial-to-mesenchymal transition in fibrosis: concepts and targeting strategies","volume":"12","author":"Lovisa","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110388_bb0025","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bbrc.2019.02.049","article-title":"JNK1\/\u03b2-catenin axis regulates H\u2082O\u2082-induced epithelial-to-mesenchymal transition in human lens epithelial cells","volume":"511","author":"Li","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110388_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032009","article-title":"A crosstalk between the Smad and JNK signaling in the TGF-\u03b2-induced epithelial-mesenchymal transition in rat peritoneal mesothelioma cells","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bioorg.2026.110388_bb0035","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jare.2024.09.029","article-title":"The role of JNK signaling pathway in organ fibrosis","volume":"74","author":"Hao","year":"2025","journal-title":"J. Adv. Res."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110388_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057329","article-title":"KIF4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8)","volume":"8","author":"Tiwari","year":"2013","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.bioorg.2026.110388_bb0045","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1128\/MCB.01122-10","article-title":"Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation","volume":"31","author":"Celluare","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bioorg.2026.110388_bb0050","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-13-180","article-title":"JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermal carcinoma K8 cells through snail and twist1","volume":"13","author":"Zhan","year":"2013","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.bioorg.2026.110388_bb0055","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/jcm5070063","article-title":"Mechanisms of TGF\u03b2-induced epithelial-mesenchymal transition","volume":"5","author":"Moustakas","year":"2016","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bioorg.2026.110388_bb0060","article-title":"Resistance is futile: overcoming resistance to targeted therapies in lung adenocarcinoma","volume":"1","author":"Neel","year":"2017","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.bioorg.2026.110388_bb0065","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41573-021-00252-y","article-title":"Trends in kinase drug discovery: targets, indications and inhibitor design","volume":"20","author":"Attwood","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.bioorg.2026.110388_bb0070","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41580-024-00729-9","article-title":"Targeted protein degradation: from mechanisms to clinic","volume":"25","author":"Tsai","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2026.110388_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117212","article-title":"Recent advances in developing targeted protein degraders","volume":"284","author":"Cheng","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"15","key":"10.1016\/j.bioorg.2026.110388_bb0080","doi-asserted-by":"crossref","first-page":"8554","DOI":"10.1073\/pnas.141230798","article-title":"Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation","volume":"98","author":"Sakamoto","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110388_bb0085","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.chembiol.2017.09.010","article-title":"Lessons in PROTAC design from selective degradation with a promiscuous warhead","volume":"25","author":"Bondeson","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.110388_bb0090","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41589-021-00742-5","article-title":"Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy","volume":"17","author":"Wang","year":"2021","journal-title":"Nat. Chem. Biol."},{"issue":"19","key":"10.1016\/j.bioorg.2026.110388_bb0095","doi-asserted-by":"crossref","first-page":"17713","DOI":"10.1021\/acs.jmedchem.4c01764","article-title":"Structure optimization of c-Jun N-terminal kinase 1 inhibitors for treating idiopathic pulmonary fibrosis","volume":"67","author":"Huang","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110388_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.130044","article-title":"Discovery of a selective and potent inhibitor of c-Jun N-terminal kinase 1 with anti-pulmonary fibrosis effect","volume":"116","author":"Ren","year":"2025","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110388_bb0105","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1021\/acs.jmedchem.4c01904","article-title":"Discovery of SMD-3236: a potent, highly selective and efficacious SMARCA2 degrader for the treatment of SMARC4-deficient human cancers","volume":"68","author":"Yang","year":"2025","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110388_bb0110","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1021\/ja209924v","article-title":"Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL\/HIF-1\u03b1 interaction","volume":"134","author":"Buckley","year":"2012","journal-title":"J. Am. Chem. Soc."},{"issue":"20","key":"10.1016\/j.bioorg.2026.110388_bb0115","doi-asserted-by":"crossref","first-page":"8657","DOI":"10.1021\/jm5011258","article-title":"Structure-guided design and optimization of small molecules targeting the protein\u2013protein interaction between the von Hippel\u2013Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities","volume":"57","author":"Galdeano","year":"2014","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:08:19Z","timestamp":1791407299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826009247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":23,"alternative-id":["S0045206826009247"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110388","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel VHL ligand-based PROTACs targeting JNK1: design, synthesis, and biological evaluation with potent anti-EMT activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110388","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110388"}}