{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:51:23Z","timestamp":1791409883391,"version":"4.3.3"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504678"],"award-info":[{"award-number":["82504678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2025J08265"],"award-info":[{"award-number":["2025J08265"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J011065"],"award-info":[{"award-number":["2024J011065"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110416","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:21:53Z","timestamp":1787095313000},"page":"110416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["FRET-based hypoxia-responsive self-quenching BODIPY nanoparticles enhance lung cancer efficacy while avoiding skin toxicity"],"prefix":"10.1016","volume":"181","author":[{"given":"Chen","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangmei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bioorg.2026.110416_bb0005","doi-asserted-by":"crossref","first-page":"7979","DOI":"10.1021\/acsnano.3c00891","article-title":"Photodynamic and photothermal therapies: synergy opportunities for nanomedicine","volume":"17","author":"Overchuk","year":"2023","journal-title":"ACS Nano"},{"issue":"14","key":"10.1016\/j.bioorg.2026.110416_bb0010","doi-asserted-by":"crossref","first-page":"7918","DOI":"10.1021\/jacs.2c13189","article-title":"Apoptosis-amplified assembly of porphyrin nanofiber enhances photodynamic therapy of oral tumor","volume":"145","author":"Liu","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"36","key":"10.1016\/j.bioorg.2026.110416_bb0015","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.2174\/1381612826666200826140448","article-title":"Nanocarrier based topical drug delivery- a promising strategy for treatment of skin cancer","volume":"26","author":"Jain","year":"2020","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110416_bb0020","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3390\/pharmaceutics15010109","article-title":"Multifunctional photoactive nanomaterials for photodynamic therapy against tumor: recent advancements and perspectives","volume":"15","author":"Jain","year":"2023","journal-title":"Pharmaceutics"},{"issue":"20","key":"10.1016\/j.bioorg.2026.110416_bb0025","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.3390\/cancers15205043","article-title":"Photodynamic therapy combined with ferroptosis is a synergistic antitumor therapy strategy","volume":"15","author":"Huang","year":"2023","journal-title":"Cancers"},{"issue":"48","key":"10.1016\/j.bioorg.2026.110416_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202501623","article-title":"Harnessing photo-energy conversion in nanomaterials for precision theranostics","volume":"37","author":"Shi","year":"2025","journal-title":"Adv. Mater."},{"issue":"23","key":"10.1016\/j.bioorg.2026.110416_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14235762","article-title":"A non-invasive deep photoablation technique to inhibit DCIS progression and induce antitumor immunity","volume":"14","author":"Kaneko","year":"2022","journal-title":"Cancers"},{"issue":"11","key":"10.1016\/j.bioorg.2026.110416_bb0040","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3390\/cancers11111760","article-title":"Verteporfin-loaded lipid nanoparticles improve ovarian cancer photodynamic therapy in vitro and in vivo","volume":"11","author":"Michy","year":"2019","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110416_bb0045","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-025-03408-5","article-title":"Light-activatable manganese carbonate nanocubes elicit robust immunotherapy by amplifying endoplasmic reticulum stress-meditated pyroptotic cell death","volume":"44","author":"Wu","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110416_bb0050","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.apsb.2023.10.006","article-title":"Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy","volume":"14","author":"He","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2026.110416_bb0055","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canlet.2020.05.032","article-title":"Hypoxia-responsive nanoparticles for tumor-targeted drug delivery","volume":"490","author":"Li","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.110416_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114199","article-title":"Small-molecule probes for fluorescent detection of cellular hypoxia-related nitroreductase","volume":"203","author":"Qiao","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"15","key":"10.1016\/j.bioorg.2026.110416_bb0065","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1021\/acs.chemrev.7b00042","article-title":"Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications","volume":"117","author":"Zielonka","year":"2017","journal-title":"Chem. Rev."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110416_bb0070","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrc1367","article-title":"Exploiting tumour hypoxia in cancer treatment","volume":"4","author":"Brown","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bioorg.2026.110416_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.131129","article-title":"A high-performance enzyme-activated near-infrared probe for the sensing and tracking of tumor-related NQO1 in cells and in vivo","volume":"354","author":"Zhang","year":"2022","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.bioorg.2026.110416_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.131860","article-title":"Supramolecular fluorescence nanoprobe loaded with azobenzene for the detection of azoreductase: selective light-up of hypoxic cells","volume":"363","author":"Li","year":"2022","journal-title":"Sens. Actuators B"},{"issue":"5","key":"10.1016\/j.bioorg.2026.110416_bb0085","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0006-2952(91)90284-C","article-title":"High levels of expression of the NAD(P)H:Quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin","volume":"42","author":"Cresteil","year":"1991","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110416_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2024.109957","article-title":"Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: alleviating, exploiting and disregarding","volume":"36","author":"Jia","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110416_bb0095","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jconrel.2023.07.026","article-title":"FRET-based analysis on the structural stability of polymeric micelles: another key attribute beyond PEG coverage and particle size affecting the blood clearance","volume":"360","author":"Guo","year":"2023","journal-title":"J. Control. Release"},{"issue":"15","key":"10.1016\/j.bioorg.2026.110416_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202423348","article-title":"Activatable photosensitizers: from fundamental principles to advanced designs","volume":"64","author":"Kwon","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2026.110416_bb0105","doi-asserted-by":"crossref","first-page":"0101","DOI":"10.34133\/bmr.0101","article-title":"Hybrid homodimeric prodrug nanoassemblies for low-toxicity and synergistic chemophotodynamic therapy of melanoma","volume":"28","author":"Xu","year":"2024","journal-title":"Biomater. Res."},{"key":"10.1016\/j.bioorg.2026.110416_bb0110","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jconrel.2023.02.026","article-title":"An \"IgG-hitchhiking\" approach for rapid tumor accumulation and clearance of photosensitizers","volume":"356","author":"Lin","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioorg.2026.110416_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123740","article-title":"Tumor microenvironment-responsive nanoshield for precision photodynamic and photothermal synergistic cancer therapy with mitigated skin phototoxicity","volume":"327","author":"Zhang","year":"2026","journal-title":"Biomaterials"},{"issue":"19","key":"10.1016\/j.bioorg.2026.110416_bb0120","doi-asserted-by":"crossref","first-page":"16335","DOI":"10.1021\/acsami.8b04710","article-title":"Tumor-activated water-soluble photosensitizers for near-infrared photodynamic cancer therapy","volume":"10","author":"Xiong","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"22","key":"10.1016\/j.bioorg.2026.110416_bb0125","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1002\/chem.201706128","article-title":"Disulfide-linked dendritic oligomeric phthalocyanines as glutathione-responsive photosensitizers for photodynamic therapy","volume":"24","author":"Chow","year":"2018","journal-title":"Chem. Eur. J."},{"issue":"36","key":"10.1016\/j.bioorg.2026.110416_bb0130","doi-asserted-by":"crossref","first-page":"40546","DOI":"10.1021\/acsami.2c09071","article-title":"A hypoxia-activated prodrug conjugated with a BODIPY-based photothermal agent for imaging-guided chemo-photothermal combination therapy","volume":"14","author":"Yang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioorg.2026.110416_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114749","article-title":"A promising strategy for synergistic cancer therapy by integrating a photosensitizer into a hypoxia-activated prodrug","volume":"243","author":"Yang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110416_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135976","article-title":"Hypoxia-activated prodrug combining site-specific chemotherapy and light-driven photothermal therapy","volume":"415","author":"Weng","year":"2024","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.bioorg.2026.110416_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2022.110217","article-title":"A switchable phototherapeutic strategy based on a hypoxia-responsive photosensitizer for heterogeneous tumor ablation","volume":"201","author":"Lin","year":"2022","journal-title":"Dyes Pigments"},{"issue":"9","key":"10.1016\/j.bioorg.2026.110416_bb0150","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1021\/acs.molpharmaceut.5c00646","article-title":"Hypoxia-responsive nano-photosensitizer anchored by PEGylated BODIPY: a single-laser-driven platform for photo-enhanced synergistic chemo\/photodynamic\/photothermal cancer therapy","volume":"22","author":"Yang","year":"2025","journal-title":"Mol. Pharm."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110416_bb0155","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.7150\/jca.51537","article-title":"An update in clinical utilization of photodynamic therapy for lung cancer","volume":"12","author":"Wang","year":"2021","journal-title":"J. Cancer"},{"key":"10.1016\/j.bioorg.2026.110416_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2026.105398","article-title":"Transbronchial photodynamic therapy for peripheral lung cancer \u2013 a pilot study","volume":"58","author":"Chiu","year":"2026","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.bioorg.2026.110416_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102225","article-title":"Enhanced antibiofilm photodynamic therapy: leveraging the slow photon effect for maximized efficacy with minimal photosensitizer and light doses","volume":"56","author":"Zhou","year":"2024","journal-title":"Nano Today"},{"issue":"46","key":"10.1016\/j.bioorg.2026.110416_bb0170","doi-asserted-by":"crossref","first-page":"63041","DOI":"10.1021\/acsami.5c15795","article-title":"Mitochondria-targeted HA-coated nanosystem for ROS\/CO generation and metabolic reprogramming to enhance tumoricidal macrophage polarization","volume":"17","author":"Peng","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"45","key":"10.1016\/j.bioorg.2026.110416_bb0175","doi-asserted-by":"crossref","first-page":"41829","DOI":"10.1021\/acsami.9b09560","article-title":"Chlorin-based photoactivable galectin-3-inhibitor nanoliposome for enhanced photodynamic therapy and NK cell-related immunity in melanoma","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:09:32Z","timestamp":1791407372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826009521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"alternative-id":["S0045206826009521"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110416","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FRET-based hypoxia-responsive self-quenching BODIPY nanoparticles enhance lung cancer efficacy while avoiding skin toxicity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110416"}}