{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:49:55Z","timestamp":1791409795406,"version":"4.3.3"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["LHGJ20250415"],"award-info":[{"award-number":["LHGJ20250415"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["242102311210"],"award-info":[{"award-number":["242102311210"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017634","name":"Henan University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110425","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:54:33Z","timestamp":1787327673000},"page":"110425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Carbon monoxide activatable near-infrared fluorescent probe to explore drug-induced liver injury and protective effect of TCMs components"],"prefix":"10.1016","volume":"181","author":[{"given":"Yilei","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manman","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfa","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110425_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/17562848231163410","article-title":"Drug-induced liver injury: a comprehensive review","volume":"16","author":"Hosack","year":"2023","journal-title":"Ther. Adv. Gastroenterol."},{"key":"10.1016\/j.bioorg.2026.110425_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155142","article-title":"Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective","volume":"122","author":"Rani","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.110425_bb0015","first-page":"611","article-title":"Drug-induced liver injury: diagnosis of exclusion","volume":"95","author":"Maev","year":"2023","journal-title":"Ter. Arkh."},{"key":"10.1016\/j.bioorg.2026.110425_bb0020","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3390\/metabo12060564","article-title":"The potential role of metabolomics in drug-induced liver injury (DILI) assessment","volume":"12","author":"Moreno-Torres","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.bioorg.2026.110425_bb0025","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000018322","article-title":"Novel biomarkers for potential risk stratification of drug induced liver injury (DILI): a narrative perspective on current trends","volume":"98","author":"Danjuma","year":"2019","journal-title":"Medicine"},{"key":"10.1016\/j.bioorg.2026.110425_bb0030","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.3390\/ijms23116049","article-title":"Challenges and future of drug-induced liver injury research-laboratory tests","volume":"23","author":"Weber","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110425_bb0035","doi-asserted-by":"crossref","first-page":"S291","DOI":"10.33549\/physiolres.933441","article-title":"Cardiovascular effects of gasotransmitter donors","volume":"65","author":"Cebov\u00e1","year":"2016","journal-title":"Physiol. Res."},{"key":"10.1016\/j.bioorg.2026.110425_bb0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/2045-9912-2-32","article-title":"Neuroprotective, neurotherapeutic, and neurometabolic effects of carbon monoxide","volume":"2","author":"Mahan","year":"2012","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.bioorg.2026.110425_bb0045","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2121-12-10","article-title":"Carbon monoxide prevents hepatic mitochondrial membrane permeabilization","volume":"12","author":"Queiroga","year":"2011","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.bioorg.2026.110425_bb0050","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/pr.57.4.3","article-title":"Carbon monoxide: endogenous production, physiological functions, and pharmacological applications","volume":"57","author":"Wu","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bioorg.2026.110425_bb0055","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3390\/biom11040589","article-title":"Heme Oxygenase-1 signaling and redox homeostasis in physiopathological conditions","volume":"11","author":"Consoli","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioorg.2026.110425_bb0060","doi-asserted-by":"crossref","first-page":"5083876","DOI":"10.1155\/2020\/5083876","article-title":"Carbon monoxide being hydrogen sulfide and nitric oxide molecular sibling, as endogenous and exogenous modulator of oxidative stress and antioxidative mechanisms in the digestive system","volume":"2020","author":"Korbut","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bioorg.2026.110425_bb0065","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jconrel.2021.01.025","article-title":"Nano-designed carbon monoxide donor SMA\/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration","volume":"331","author":"Song","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioorg.2026.110425_bb0070","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1039\/D3AN01631E","article-title":"Activatable fluorescent probes for early diagnosis and evaluation of liver injury","volume":"149","author":"Lin","year":"2024","journal-title":"Analyst"},{"key":"10.1016\/j.bioorg.2026.110425_bb0075","article-title":"Recent advances in fluorescent nanomaterials designed for biomarker detection and imaging","volume":"32","author":"Sun","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioorg.2026.110425_bb0080","doi-asserted-by":"crossref","first-page":"11639","DOI":"10.1021\/acs.chemrev.4c00552","article-title":"Introduction: fluorescent probes in biology","volume":"124","author":"Chang","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.110425_bb0085","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1021\/acs.chemrev.3c00776","article-title":"Fluorescent probes for disease diagnosis","volume":"124","author":"Wang","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.110425_bb0090","doi-asserted-by":"crossref","first-page":"22267","DOI":"10.1039\/D5RA03102H","article-title":"An update on recent advances in fluorescent materials for fluorescence molecular imaging: a review","volume":"15","author":"Nkune","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2026.110425_bb0095","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1186\/s12951-022-01648-7","article-title":"In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications","volume":"20","author":"Refaat","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioorg.2026.110425_bb0100","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1039\/D2CS00650B","article-title":"Fluorescent probes for the detection of chemical warfare agents","volume":"52","author":"Meng","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2026.110425_bb0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s41061-022-00376-8","article-title":"Development and challenge of fluorescent probes for bioimaging applications: from visualization to diagnosis","volume":"380","author":"Li","year":"2022","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.bioorg.2026.110425_bb0110","doi-asserted-by":"crossref","first-page":"6345","DOI":"10.1039\/D3CS00124E","article-title":"Fluorescent small molecule donors","volume":"53","author":"Chen","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2026.110425_bb0115","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1080\/10408347.2022.2042670","article-title":"A critical review on organic small fluorescent probes for monitoring carbon monoxide in biology","volume":"53","author":"Yan","year":"2023","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.110425_bb0120","doi-asserted-by":"crossref","first-page":"11298","DOI":"10.1021\/acs.analchem.2c01948","article-title":"Strategy for detecting carbon monoxide: Cu2+-assisted fluorescent probe and its applications in biological imaging","volume":"94","author":"Bai","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.110425_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.344528","article-title":"A ratiometric fluorescent probe for the specific detection of carbon monoxide released from CORM-3 and induced by heme in living cells","volume":"1374","author":"Zhang","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bioorg.2026.110425_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126734","article-title":"A novel BN aromatic module modified near-infrared fluorescent probe for monitoring carbon monoxide-releasing molecule CORM-3 in living cells and animals","volume":"280","author":"Yao","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.bioorg.2026.110425_bb0135","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1039\/D1AY00704A","article-title":"A novel red emission fluorescent probe for monitoring carbon monoxide in living cells and zebrafish","volume":"13","author":"Chen","year":"2021","journal-title":"Anal. Methods"},{"key":"10.1016\/j.bioorg.2026.110425_bb0140","doi-asserted-by":"crossref","first-page":"21558","DOI":"10.1021\/acs.analchem.5c03963","article-title":"Rational design of a novel dual-functional fluorescent probe for simultaneous monitoring and imaging of mitochondrial CO and ATP fluctuations during drug-induced liver injury without spectral crosstalk","volume":"97","author":"Zhou","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.110425_bb0145","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1039\/D3TB00263B","article-title":"A novel red AIE fluorescent probe for ratiometric detection of carbon monoxide in vitro and in vivo","volume":"11","author":"Huang","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioorg.2026.110425_bb0150","article-title":"NIR imaging-guided carbon monoxide nanomedicine: design strategies, stimuli-responsive release, and multimodal synergistic therapies for precision disease treatment","volume":"36","author":"Li","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioorg.2026.110425_bb0155","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1039\/D3AY01886E","article-title":"A long-wavelength mitochondria-targeted CO fluorescent probe for living cells and zebrafish imaging","volume":"16","author":"Rong","year":"2024","journal-title":"Anal. Methods"},{"key":"10.1016\/j.bioorg.2026.110425_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122419","article-title":"Endogenous CO imaging in bacterial pneumonia with a NIR fluorescent probe","volume":"304","author":"Zhu","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioorg.2026.110425_bb0165","doi-asserted-by":"crossref","first-page":"1419169","DOI":"10.3389\/fcvm.2024.1419169","article-title":"Traditional Chinese medicine for cardiovascular disease: efficacy and safety","volume":"11","author":"Lin","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.bioorg.2026.110425_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102803","article-title":"Traditional Chinese herbal medicines for the treatment of ischemic stroke in China","volume":"110","author":"Dong","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bioorg.2026.110425_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121753","article-title":"Immunomodulatory effect of traditional Chinese medicine in infectious diseases","volume":"367","author":"Rao","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2026.110425_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9956248","article-title":"Combined therapy with traditional Chinese medicine and antiplatelet drugs for ischemic heart disease: mechanism, efficacy, and safety","volume":"2021","author":"Yu","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.bioorg.2026.110425_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153942","article-title":"Comparative effectiveness of glycyrrhizic acid preparations aimed at preventing and treating anti-tuberculosis drug-induced liver injury: a network meta-analysis of 97 randomized controlled trials","volume":"98","author":"Gong","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.110425_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.11.020","article-title":"Schisandra fruits for the management of drug-induced liver injury in China: a review","volume":"59","author":"Zhu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.110425_bb0195","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.3390\/biom15121743","article-title":"Integrating network pharmacology, molecular docking, and experimental validation: andrographolide attenuates acute liver injury via the NLRP3\/Caspase-1\/GSDMD-mediated Pyroptosis pathway","volume":"15","author":"Zhang","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioorg.2026.110425_bb0200","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3389\/fphar.2020.00531","article-title":"Paeoniflorin, a natural product with multiple targets in liver diseases-a Mini review","volume":"11","author":"Ma","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110425_bb0205","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwac206","article-title":"Natural products and drug discovery","volume":"9","author":"Newman","year":"2022","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.bioorg.2026.110425_bb0210","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/bcpt.14109","article-title":"BCPT perspectives on studies involving natural products, traditional Chinese medicine and systems pharmacology","volume":"135","author":"Tveden-Nyborg","year":"2024","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.bioorg.2026.110425_bb0215","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/01.RES.0000084381.86567.08","article-title":"Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule","volume":"93","author":"Clark","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioorg.2026.110425_bb0220","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/CCM.0b013e31822f0d64","article-title":"CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke","volume":"40","author":"Yabluchanskiy","year":"2012","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bioorg.2026.110425_bb0225","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3390\/molecules29091993","article-title":"A red-emission fluorescent probe with large stokes shift for detection of viscosity in living cells and tumor-bearing mice","volume":"29","author":"Wang","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110425_bb0230","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/bio.4265","article-title":"A novel fluorescent probe with large stokes shift for the detection of viscosity changes and its imaging in living cells","volume":"37","author":"Guo","year":"2022","journal-title":"Luminescence"},{"key":"10.1016\/j.bioorg.2026.110425_bb0235","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/17425255.2023.2223959","article-title":"Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease","volume":"19","author":"Chidiac","year":"2023","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.bioorg.2026.110425_bb0240","doi-asserted-by":"crossref","first-page":"1122632","DOI":"10.3389\/fphar.2023.1122632","article-title":"Acetaminophen-induced liver injury: molecular mechanism and treatments from natural products","volume":"14","author":"Liao","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110425_bb0245","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-pathmechdis-051122-094016","article-title":"Acetaminophen hepatotoxicity: paradigm for understanding mechanisms of drug-induced liver injury","volume":"19","author":"Jaeschke","year":"2024","journal-title":"Annu. Rev. Pathol."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:59:09Z","timestamp":1791406749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826009612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":49,"alternative-id":["S0045206826009612"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110425","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbon monoxide activatable near-infrared fluorescent probe to explore drug-induced liver injury and protective effect of TCMs components","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110425","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110425"}}