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(Seoul)"},{"key":"10.1016\/j.bioorg.2026.110429_bb0400","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev-genom-090711-163739","article-title":"Enzyme replacement therapy for lysosomal diseases: lessons from 20 years of experience and remaining challenges","volume":"13","author":"Desnick","year":"2012","journal-title":"Annu. Rev. Genomics Hum. 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C"},{"key":"10.1016\/j.bioorg.2026.110429_bb0565","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/26\/35\/355703","article-title":"pH-sensitive polymer assisted self-aggregation of bis(pyrene) in living cells in situ with turn-on fluorescence","volume":"26","author":"Duan","year":"2015","journal-title":"Nanotechnology"},{"issue":"38","key":"10.1016\/j.bioorg.2026.110429_bb0570","doi-asserted-by":"crossref","first-page":"12519","DOI":"10.1002\/anie.201807373","article-title":"Supramolecular assemblies with near-infrared emission mediated in two stages by cucurbituril and amphiphilic calixarene for lysosome-targeted cell imaging","volume":"57","author":"Chen","year":"2018","journal-title":"Angew. 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