{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:52:43Z","timestamp":1791262363595,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX25_ 1549"],"award-info":[{"award-number":["SJCX25_ 1549"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20231165"],"award-info":[{"award-number":["BK20231165"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110449","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:18:36Z","timestamp":1787930316000},"page":"110449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A light-gated \u201cmembrane-to-mitochondria\u201d sequentially targeted AIE photosensitizer for potentiated photodynamic therapy and imaging of breast cancer"],"prefix":"10.1016","volume":"182","author":[{"given":"Tonghui","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangying","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110449_bb0005","article-title":"Cancer statistics, 2026","volume":"76","author":"Siegel","year":"2026","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bioorg.2026.110449_bb0010","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jnci\/90.12.889","article-title":"Photodynamic therapy","volume":"90","author":"Dougherty","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bioorg.2026.110449_bb0015","first-page":"250","article-title":"Photodynamic therapy of cancer: an update","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bioorg.2026.110449_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122108","article-title":"A hypochlorite-activated strategy for realizing fluorescence turn-on, type I and type II ROS-combined photodynamic tumor ablation","volume":"297","author":"Huang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioorg.2026.110449_bb0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1039\/cs9952400019","article-title":"Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy","volume":"24","author":"Bonnett","year":"1995","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2026.110449_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/bio.4655","article-title":"Reviewing the evolutive ACQ-to-AIE transformation of photosensitizers for phototheranostics","volume":"39","author":"Zhu","year":"2024","journal-title":"Luminescence"},{"key":"10.1016\/j.bioorg.2026.110449_bb0035","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1021\/acs.jmedchem.9b02014","article-title":"Aggregation-induced emission photosensitizers: from molecular design to photodynamic therapy: miniperspective","volume":"63","author":"Dai","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110449_bb0040","doi-asserted-by":"crossref","first-page":"1801350","DOI":"10.1002\/adma.201801350","article-title":"Photosensitizers with aggregation-induced emission: materials and biomedical applications","volume":"30","author":"Hu","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioorg.2026.110449_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.215756","article-title":"Design strategies for aggregation-induced emission photosensitizers with enhanced safety in photodynamic therapy","volume":"507","author":"Gao","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.110449_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.160692","article-title":"Recent process of NIR-type AIE-active fluorescent materials for biomedical applications of fluorescent imaging and phototherapeutics","volume":"507","author":"Xie","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioorg.2026.110449_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.137035","article-title":"Multifunctional molecular theranostic agent for fluorescence-magnetic resonance dual-modal imaging and photodynamic-chemodynamic synergistic therapy","volume":"426","author":"Kuang","year":"2025","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.bioorg.2026.110449_bb0060","doi-asserted-by":"crossref","first-page":"19543","DOI":"10.1021\/acsami.1c02019","article-title":"Organelle-targeted photosensitizers for precision photodynamic therapy","volume":"13","author":"Wang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioorg.2026.110449_bb0065","doi-asserted-by":"crossref","first-page":"7205","DOI":"10.1021\/acs.jmedchem.2c01653","article-title":"Discovery of subcellular-targeted Aza-BODIPY photosensitizers for efficient photodynamic antitumor therapy","volume":"66","author":"Liu","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110449_bb0070","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.bbabio.2014.02.005","article-title":"Reactive oxygen species: re-evaluation of generation, monitoring and role in stress-signaling in phototrophic organisms","volume":"1837","author":"Schmitt","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bioorg.2026.110449_bb0075","doi-asserted-by":"crossref","first-page":"1606167","DOI":"10.1002\/adma.201606167","article-title":"Mitochondrion-anchoring photosensitizer with aggregation-induced emission characteristics synergistically boosts the radiosensitivity of cancer cells to ionizing radiation","volume":"29","author":"Yu","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioorg.2026.110449_bb0080","doi-asserted-by":"crossref","first-page":"8145","DOI":"10.1021\/acsnano.8b03138","article-title":"Bright near-infrared aggregation-induced emission luminogens with strong two-photon absorption, excellent organelle specificity, and efficient photodynamic therapy potential","volume":"12","author":"Zheng","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioorg.2026.110449_bb0085","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1002\/anie.202016399","article-title":"Activation of pyroptosis by membrane-anchoring AIE photosensitizer design: new prospect for photodynamic cancer cell ablation","volume":"60","author":"Wu","year":"2021","journal-title":"Angew. Chem.-Int. Edit."},{"key":"10.1016\/j.bioorg.2026.110449_bb0090","doi-asserted-by":"crossref","first-page":"9610","DOI":"10.1002\/anie.202000740","article-title":"Three-pronged attack by homologous far-red\/NIR AIEgens to achieve 1+1+1>3 synergistic enhanced photodynamic therapy","volume":"59","author":"Xu","year":"2020","journal-title":"Angew. Chem.-Int. Edit."},{"key":"10.1016\/j.bioorg.2026.110449_bb0095","doi-asserted-by":"crossref","first-page":"2403954","DOI":"10.1002\/adhm.202403954","article-title":"A microneedle patch delivers mitochondria- and lysosomes- dual targeting prodrug-like photosensitizers with regulated photoactivity for precise photodynamic therapy","volume":"14","author":"Liu","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioorg.2026.110449_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202423348","article-title":"Activatable photosensitizers: from fundamental principles to advanced designs","volume":"64","author":"Kwon","year":"2025","journal-title":"Angew. Chem.-Int. Edit."},{"key":"10.1016\/j.bioorg.2026.110449_bb0105","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1039\/D5SC08201C","article-title":"Intramolecular exciton coupling modulates the convergent singlet-triplet energy gap toward NIR-emissive heavy-atom-free oligo-BODIPY photosensitizers","volume":"17","author":"Pan","year":"2026","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioorg.2026.110449_bb0110","doi-asserted-by":"crossref","first-page":"15189","DOI":"10.1002\/anie.201810326","article-title":"Strategies to enhance the photosensitization: polymerization and the donor-acceptor even-odd effect","volume":"57","author":"Liu","year":"2018","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.bioorg.2026.110449_bb0115","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1039\/D1TB02598H","article-title":"Synthesis of tetraphenylethene-based D-A conjugated molecules with near-infrared AIE features, and their application in photodynamic therapy","volume":"10","author":"Li","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioorg.2026.110449_bb0120","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1039\/D2TB01224C","article-title":"Tuning intramolecular charge transfer and spin-orbit coupling of AIE-active type-I photosensitizers for photodynamic therapy","volume":"10","author":"Singh","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioorg.2026.110449_bb0125","article-title":"Triphenylamine-AIEgens photoactive materials for cancer theranostics","volume":"35","author":"Wang","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110449_bb0130","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.3390\/ijms20082002","article-title":"Rational design of modified oxobacteriochlorins as potential photodynamic therapy photosensitizers","volume":"20","author":"Alberto","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110449_bb0135","doi-asserted-by":"crossref","first-page":"2101056","DOI":"10.1002\/adhm.202101056","article-title":"Mitochondrion-anchored photosensitizer with near infrared-I aggregation-induced emission for near infrared-II two-photon photodynamic therapy","volume":"10","author":"He","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioorg.2026.110449_bb0140","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1039\/C5TC03299G","article-title":"Triphenylamine-functionalized tetraphenylpyrazine: facile preparation and multifaceted functionalities","volume":"4","author":"Chen","year":"2016","journal-title":"J. Mater. Chem. C"},{"key":"10.1016\/j.bioorg.2026.110449_bb0145","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/adfm.201102191","article-title":"Biocompatible nanoparticles with aggregation-induced emission characteristics as far-red\/near-infrared fluorescent bioprobes for in vitro and in vivo imaging applications","volume":"22","author":"Qin","year":"2012","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioorg.2026.110449_bb0150","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.7150\/thno.16358","article-title":"Targeting negative surface charges of cancer cells by multifunctional nanoprobes","volume":"6","author":"Chen","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.bioorg.2026.110449_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114012","article-title":"Reactive oxygen species produced by photodynamic therapy enhance docosahexaenoic acid lipid peroxidation and induce the death of breast cancer cells","volume":"241","author":"Bai","year":"2024","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioorg.2026.110449_bb0160","doi-asserted-by":"crossref","first-page":"5080843","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bioorg.2026.110449_bb0165","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1021\/acs.chemrev.8b00626","article-title":"Reactive oxygen species (ROS)-based nanomedicine","volume":"119","author":"Yang","year":"2019","journal-title":"Chem. Rev."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:18:44Z","timestamp":1791260324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826009855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":33,"alternative-id":["S0045206826009855"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110449","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A light-gated \u201cmembrane-to-mitochondria\u201d sequentially targeted AIE photosensitizer for potentiated photodynamic therapy and imaging of breast cancer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110449","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110449"}}