{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:55:06Z","timestamp":1791262506667,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110458","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:48:04Z","timestamp":1788619684000},"page":"110458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mycosubtilin suppresses HepG2 proliferation, binds p38\u03b1 in vitro, and engages ER stress\u2013associated MAPK signaling"],"prefix":"10.1016","volume":"182","author":[{"given":"Jun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifa","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110458_bb0005","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/516S1a","article-title":"Liver cancer","volume":"516","author":"Gravitz","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2026.110458_bb0010","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/s41571-023-00825-3","article-title":"Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy","volume":"20","author":"Singal","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.canlet.2015.07.018","article-title":"Heterogeneity of liver cancer and personalized therapy","volume":"379","author":"Li","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.110458_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217472","article-title":"Drug resistance in TKI therapy for hepatocellular carcinoma: mechanisms and strategies","volume":"613","author":"Jiang","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.110458_bb0025","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","article-title":"Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma","volume":"382","author":"Finn","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioorg.2026.110458_bb0030","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1007\/s00253-022-12046-2","article-title":"Indispensable role of microbes in anticancer drugs and discovery trends","volume":"106","author":"Kapoor","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0035","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/mnfr.201000419","article-title":"Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells","volume":"55","author":"Dia","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bioorg.2026.110458_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/md20110704","article-title":"Laminaria japonica peptides suppress liver cancer by inducing apoptosis: possible signaling pathways and mechanism","volume":"20","author":"Wu","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bioorg.2026.110458_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103311","article-title":"The antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo","volume":"93","author":"Gao","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110458_bb0050","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/CAD.0000000000000688","article-title":"Bacillomycin D-C16 triggers apoptosis of gastric cancer cells through the PI3K\/Akt and FoxO3a signaling pathways","volume":"30","author":"Lin","year":"2019","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.bioorg.2026.110458_bb0055","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s12013-013-9676-7","article-title":"Surfactin-induced apoptosis through ROS-ERS-Ca2+-ERK pathways in HepG2 cells","volume":"67","author":"Wang","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bioorg.2026.110458_bb0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13568-018-0606-3","article-title":"Potential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells","volume":"8","author":"Zhao","year":"2018","journal-title":"AMB Express"},{"key":"10.1016\/j.bioorg.2026.110458_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.104206","article-title":"Peptides as innovative strategies to combat drug resistance in cancer therapy","volume":"29","author":"Lamb","year":"2024","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bioorg.2026.110458_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137264","article-title":"Biological activity of natural and synthetic peptides as anticancer agents","volume":"25","author":"Bauso","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110458_bb0075","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/s12602-023-10181-4","article-title":"The secondary metabolites of Bacillus subtilis strain Z15 induce apoptosis in hepatocellular carcinoma cells","volume":"17","author":"Aimaier","year":"2025","journal-title":"Probiot. Antimicrob. Proteins"},{"key":"10.1016\/j.bioorg.2026.110458_bb0080","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s12864-023-09313-5","article-title":"Effect of bacillus subtilis strain Z15 secondary metabolites on immune function in mice","volume":"24","author":"Cao","year":"2023","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bioorg.2026.110458_bb0085","article-title":"Isolation and characterization of a mycosubtilin homologue antagonizing verticillium dahliae produced by Bacillus subtilis strain Z15","volume":"17","author":"Lin","year":"2022","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bioorg.2026.110458_bb0090","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s12602-025-10534-1","article-title":"Mycosubtilin induces G1 phase block and autophagy in cervical cancer HeLa cells","volume":"18","author":"Li","year":"2026","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.bioorg.2026.110458_bb0095","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13045-022-01392-3","article-title":"Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research","volume":"15","author":"Tong","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0100","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.110458_bb0105","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1529\/biophysj.107.114090","article-title":"Effect of fengycin, a lipopeptide produced by Bacillus subtilis, on model biomembranes","volume":"94","author":"Deleu","year":"2008","journal-title":"Biophys. J."},{"key":"10.1016\/j.bioorg.2026.110458_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17091142","article-title":"State of the art of cyclic lipopeptide-membrane interactions: pore formation and bilayer permeability","volume":"17","author":"Zakharova","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioorg.2026.110458_bb0115","article-title":"Inhibitory effects of mycosubtilin on proliferation of colon cancer SW480 cells","volume":"21","author":"Yang","year":"2026","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bioorg.2026.110458_bb0120","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.7150\/ijbs.35284","article-title":"Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2","volume":"15","author":"Zhou","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bioorg.2026.110458_bb0125","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3389\/fphar.2019.00651","article-title":"Lycorine induces mitochondria-dependent apoptosis in hepatoblastoma HepG2 cells through ROCK1 activation","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0130","first-page":"1013","article-title":"Neferine isolated from Nelumbo nucifera enhances anti-cancer activities in Hep3B cells: molecular mechanisms of cell cycle arrest, ER stress induced apoptosis and anti-angiogenic response","volume":"20","author":"Yoon","year":"2013","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.bioorg.2026.110458_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/cells11172627","article-title":"Nicotinamide adenine dinucleotide (NAD) metabolism as a relevant target in cancer","volume":"11","author":"Navas","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bioorg.2026.110458_bb0140","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ccell.2018.05.010","article-title":"ROS promotes Cancer cell survival through calcium Signaling","volume":"33","author":"Reczek","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bioorg.2026.110458_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2025.101426","article-title":"Membrane remodeling, ion channels, ca(2+) signaling, and stress pathways as molecular links between type 2 diabetes and cancer","volume":"106","author":"Ferreira","year":"2025","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bioorg.2026.110458_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103288","article-title":"Redox-active vitamin C suppresses human osteosarcoma growth by triggering intracellular ROS-iron-calcium signaling crosstalk and mitochondrial dysfunction","volume":"75","author":"Vaishampayan","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0155","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.colsurfb.2010.01.034","article-title":"Interactions of the natural antimicrobial mycosubtilin with phospholipid membrane models","volume":"78","author":"Nasir","year":"2010","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioorg.2026.110458_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2021.183730","article-title":"Surfactin cyclic lipopeptides change the plasma membrane composition and lateral organization in mammalian cells","volume":"1863","author":"W\u00f3jtowicz","year":"2021","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bioorg.2026.110458_bb0165","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1128\/IAI.00579-13","article-title":"The p38 MAPK and JNK pathways protect host cells against Clostridium perfringens beta-toxin","volume":"81","author":"Nagahama","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bioorg.2026.110458_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/srep39303","article-title":"Surfactin inducing mitochondria-dependent ROS to activate MAPKs, NF-\u03baB and inflammasomes in macrophages for adjuvant activity","volume":"6","author":"Gan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.110458_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103537","article-title":"Gp93 safeguards tissue homeostasis by preventing ROS-JNK-mediated apoptosis","volume":"81","author":"Xu","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404027","article-title":"A three-in-one Heptamethine cyanine dye induces endoplasmic reticulum stress and apoptosis in colorectal Cancer","volume":"14","author":"Park","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioorg.2026.110458_bb0185","doi-asserted-by":"crossref","DOI":"10.1007\/s11030-025-11291-7","article-title":"Advances in targeting p38 MAPK for cancer therapy: insights from molecular pharmacology and medicinal chemistry","author":"Bhole","year":"2025","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bioorg.2026.110458_bb0190","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-5793(95)00357-F","article-title":"SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1","volume":"364","author":"Cuenda","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bioorg.2026.110458_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.143413","article-title":"Interaction of vernodalin with p38 mitogen-activated protein kinase (p38 MAPK) and subsequent effects in lung cancer cell model","volume":"311","author":"Zhou","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0200","doi-asserted-by":"crossref","first-page":"594","DOI":"10.5483\/BMBRep.2013.46.12.092","article-title":"Binding model for eriodictyol to Jun-N terminal kinase and its anti-inflammatory signaling pathway","volume":"46","author":"Lee","year":"2013","journal-title":"BMB Rep."},{"key":"10.1016\/j.bioorg.2026.110458_bb0205","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijbiomac.2017.08.178","article-title":"Sulfated polysaccharide of Sepiella Maindroni ink inhibits the migration, invasion and matrix metalloproteinase-2 expression through suppressing EGFR-mediated p38\/MAPK and PI3K\/Akt\/mTOR signaling pathways in SKOV-3 cells","volume":"107","author":"Jiang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115463","article-title":"Isoliensinine suppresses bone loss by targeted inhibition of RANKL-RANK binding","volume":"210","author":"Deng","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0215","doi-asserted-by":"crossref","DOI":"10.1172\/JCI177142","article-title":"Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers","volume":"134","author":"Miao","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioorg.2026.110458_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115800","article-title":"Up-regulation of PUMA caused the activation of p53 phosphorylation and acetylation, enhancing the interaction between PUMA and Bcl-X and mediating arsenic-induced apoptosis","volume":"434","author":"Zhou","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0225","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1158\/0008-5472.CAN-22-3032","article-title":"The mTOR Signaling pathway interacts with the ER stress response and the unfolded protein response in Cancer","volume":"83","author":"Mafi","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2026.110458_bb0230","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.semcancer.2021.04.004","article-title":"Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis","volume":"76","author":"Wadgaonkar","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bioorg.2026.110458_bb0235","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1002\/jcsm.13288","article-title":"Corylifol a ameliorates muscle atrophy by inhibiting TAOK1\/p38-MAPK\/FoxO3 pathway in cancer cachexia","volume":"14","author":"Zhang","year":"2023","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bioorg.2026.110458_bb0240","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1476-4598-12-35","article-title":"Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to ad-eIF5A1 in A549 lung cancer cells","volume":"12","author":"Taylor","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bioorg.2026.110458_bb0245","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.canlet.2021.10.014","article-title":"(125)I seeds inhibit proliferation and promote apoptosis in cholangiocarcinoma cells by regulating the AGR2-mediated p38 MAPK pathway","volume":"524","author":"Zhou","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.110458_bb0250","doi-asserted-by":"crossref","first-page":"11702","DOI":"10.1021\/acs.jafc.0c02476","article-title":"Peptides from extruded lupin (Lupinus albus L.) regulate inflammatory activity via the p38 MAPK signal transduction pathway in RAW 264.7 cells","volume":"68","author":"Gao","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2026.110458_bb0255","article-title":"PD-1 suppresses human CD38(+) circulating Tfr cells and regulates humoral immunity","volume":"13","author":"Zhang","year":"2025","journal-title":"J. Immunother. Cancer"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826009946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:32:35Z","timestamp":1791261155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826009946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":51,"alternative-id":["S0045206826009946"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110458","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mycosubtilin suppresses HepG2 proliferation, binds p38\u03b1 in vitro, and engages ER stress\u2013associated MAPK signaling","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110458"}}