{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:53:40Z","timestamp":1791262420314,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003398","name":"Shanxi Scholarship Council of China","doi-asserted-by":"publisher","award":["20250052"],"award-info":[{"award-number":["20250052"]}],"id":[{"id":"10.13039\/501100003398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014988","name":"Program for the Scientific Activities of Selected Returned Overseas Professionals in Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014988","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370091"],"award-info":[{"award-number":["82370091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110498","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:06:47Z","timestamp":1789085207000},"page":"110498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mechanistic insights into di(2-ethylhexyl) phthalate exposure in obstructive sleep apnea: network toxicology and in vitro validation"],"prefix":"10.1016","volume":"182","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shudan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limantian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bioorg.2026.110498_bb0005","article-title":"The global burden of obstructive sleep apnea","volume":"15","author":"Iannella","year":"2025","journal-title":"Diagnostics (Basel)"},{"issue":"12","key":"10.1016\/j.bioorg.2026.110498_bb0010","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/S2213-2600(25)00243-7","article-title":"Projecting the 30-year burden of obstructive sleep apnoea in the USA: a prospective modelling study","volume":"13","author":"Boers","year":"2025","journal-title":"Lancet Respir. Med."},{"issue":"17","key":"10.1016\/j.bioorg.2026.110498_bb0015","article-title":"The global socioeconomic burden of obstructive sleep apnea: a comprehensive review","volume":"13","author":"Zappala","year":"2025","journal-title":"Healthcare (Basel)"},{"issue":"15","key":"10.1016\/j.bioorg.2026.110498_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/jcm14155574","article-title":"Obstructive sleep apnea and type 2 diabetes: an update","volume":"14","author":"Gentile","year":"2025","journal-title":"J. Clin. Med."},{"issue":"11","key":"10.1016\/j.bioorg.2026.110498_bb0025","article-title":"Association between obstructive sleep apnea and cardiovascular risk: a systematic review and meta-analysis of prospective cohort studies","volume":"61","author":"Craciun","year":"2025","journal-title":"Medicina (Kaunas)"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110498_bb0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40885-024-00276-7","article-title":"Obstructive sleep apnea and hypertension; critical overview","volume":"30","author":"Kwon","year":"2024","journal-title":"Clin. Hypertens."},{"key":"10.1016\/j.bioorg.2026.110498_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2025.103221","article-title":"The relationship between obesity and obstructive sleep apnea in four community-based cohorts: an individual participant data meta-analysis of 12,860 adults","volume":"83","author":"Esmaeili","year":"2025","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.bioorg.2026.110498_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2025.108348","article-title":"Unmasking obstructive sleep apnea: estimated prevalence and impact in the United States","volume":"248","author":"Sonmez","year":"2025","journal-title":"Respir. Med."},{"issue":"9","key":"10.1016\/j.bioorg.2026.110498_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/nu16091291","article-title":"Vitamin D deficiency exacerbates poor sleep outcomes with endocrine-disrupting chemicals exposure: a large American population study","volume":"16","author":"Zhou","year":"2024","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.bioorg.2026.110498_bb0050","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1007\/s11010-024-05165-z","article-title":"Adipose tissue as target of environmental toxicants: focus on mitochondrial dysfunction and oxidative inflammation in metabolic dysfunction-associated steatotic liver disease","volume":"480","author":"Lolescu","year":"2025","journal-title":"Mol. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110498_bb0055","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an Endocrine Society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bioorg.2026.110498_bb0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.reprotox.2016.10.001","article-title":"Metabolism disrupting chemicals and metabolic disorders","volume":"68","author":"Heindel","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.bioorg.2026.110498_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109829","article-title":"Hallmarks of EDCs among children in Southern China in Relation with obstructive sleep apnea","volume":"204","author":"Zhou","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.bioorg.2026.110498_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118106","article-title":"Phthalate metabolites: characterization, toxicities, global distribution, and exposure assessment","volume":"291","author":"Zhang","year":"2021","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110498_bb0075","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/1097-0274(200101)39:1<100::AID-AJIM10>3.0.CO;2-Q","article-title":"Health risks posed by use of Di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review","volume":"39","author":"Tickner","year":"2001","journal-title":"Am. J. Ind. Med."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110498_bb0080","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1539-6924.2006.00770.x","article-title":"What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?","volume":"26","author":"Wormuth","year":"2006","journal-title":"Risk Anal."},{"issue":"1526","key":"10.1016\/j.bioorg.2026.110498_bb0085","first-page":"2063","article-title":"Human body burdens of chemicals used in plastic manufacture","volume":"364","author":"Koch","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110498_bb0090","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1289\/ehp.6723","article-title":"Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000","volume":"112","author":"Silva","year":"2004","journal-title":"Environ. Health Perspect."},{"issue":"9","key":"10.1016\/j.bioorg.2026.110498_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11090742","article-title":"Lutein modulates oxidative stress, inflammatory and apoptotic biomarkers related to di-(2-ethylhexyl) phthalate (DEHP) hepato-nephrotoxicity in male rats: role of nuclear factor kappa B","volume":"11","author":"Gad El-Karim","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.bioorg.2026.110498_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116103","article-title":"Mitochondrial dysfunction mediated by thioredoxin-interacting protein: a crucial determinant in di(2-ethylhexyl) phthalate-induced liver failure","volume":"272","author":"Xu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bioorg.2026.110498_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112818","article-title":"DEHP-induced mitophagy and mitochondrial damage in the heart are associated with dysregulated mitochondrial biogenesis","volume":"161","author":"Zhang","year":"2022","journal-title":"Food Chem. Toxicol."},{"issue":"7086","key":"10.1016\/j.bioorg.2026.110498_bb0110","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","author":"Houstis","year":"2006","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110498_bb0115","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1161\/01.ATV.0000150649.39934.13","article-title":"Oxidative stress and vascular disease","volume":"25","author":"Madamanchi","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bioorg.2026.110498_bb0120","article-title":"Oxidative stress: the nexus of obesity and cognitive dysfunction in diabetes","volume":"14","author":"Li","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"10","key":"10.1016\/j.bioorg.2026.110498_bb0125","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s41569-025-01142-1","article-title":"Mitochondrial quality control in cardiomyocytes: safeguarding the heart against disease and ageing","volume":"22","author":"Ravindran","year":"2025","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bioorg.2026.110498_bb0130","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.freeradbiomed.2021.01.053","article-title":"Chronic intermittent hypoxia-induced mitochondrial dysfunction mediates endothelial injury via the TXNIP\/NLRP3\/IL-1beta signaling pathway","volume":"165","author":"Yan","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110498_bb0135","doi-asserted-by":"crossref","first-page":"490","DOI":"10.7555\/JBR.30.20160110","article-title":"Chronic intermittent hypoxia induces cardiac inflammation and dysfunction in a rat obstructive sleep apnea model","volume":"30","author":"Wei","year":"2016","journal-title":"J. Biomed. Res."},{"key":"10.1016\/j.bioorg.2026.110498_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113968","article-title":"Association between Di-2-ethylhexyl phthalate and nonalcoholic fatty liver disease among US adults: mediation analysis of body mass index and waist circumference in the NHANES","volume":"179","author":"He","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bioorg.2026.110498_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116216","article-title":"Association of phthalate exposure with type 2 diabetes and the mediating effect of oxidative stress: a case-control and computational toxicology study","volume":"274","author":"Tan","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110498_bb0150","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1476-069X-13-6","article-title":"Gender and racial\/ethnic differences in the associations of urinary phthalate metabolites with markers of diabetes risk: National Health and Nutrition Examination Survey 2001-2008","volume":"13","author":"Huang","year":"2014","journal-title":"Environ. Health"},{"issue":"Pt 2","key":"10.1016\/j.bioorg.2026.110498_bb0155","article-title":"Urinary phthalate concentrations and mortality risk: a population-based study","volume":"214","author":"Beyer","year":"2022","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110498_bb0160","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"issue":"12","key":"10.1016\/j.bioorg.2026.110498_bb0165","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1164\/rccm.200402-193OC","article-title":"Increased levels and activity of matrix metalloproteinase-9 in obstructive sleep apnea syndrome","volume":"170","author":"Tazaki","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.bioorg.2026.110498_bb0170","doi-asserted-by":"crossref","first-page":"28800","DOI":"10.3390\/ijms161226131","article-title":"Possible mechanisms of di(2-ethylhexyl) phthalate-induced MMP-2 and MMP-9 expression in A7r5 rat vascular smooth muscle cells","volume":"16","author":"Shih","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110498_bb0175","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/toxres\/tfad022","article-title":"Di(2-ethylhexyl) phthalate mediates oxidative stress and activates p38MAPK\/NF-kB to exacerbate diabetes-induced kidney injury in vitro and in vivo models","volume":"12","author":"Ding","year":"2023","journal-title":"Toxicol. Res. (Camb)."},{"key":"10.1016\/j.bioorg.2026.110498_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118689","article-title":"Mechanistic insight into plasticizer di-(2-ethylhexyl) phthalate as an environmental hazard for abdominal aortic aneurysm: evidence from in vitro and in vivo studies","volume":"302","author":"Wang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bioorg.2026.110498_bb0185","article-title":"Di (2-ethylhexyl) phthalate and polystyrene microplastics co-exposure caused oxidative stress to activate NF-kappaB\/NLRP3 pathway aggravated pyroptosis and inflammation in mouse kidney","volume":"926","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.bioorg.2026.110498_bb0190","doi-asserted-by":"crossref","first-page":"1390777","DOI":"10.3389\/fphys.2024.1390777","article-title":"Sex hormone supplementation improves breathing and restores respiratory neuroplasticity following C2 hemisection in rats","volume":"15","author":"Barok","year":"2024","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bioorg.2026.110498_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129689","article-title":"Phthalate-induced testosterone\/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene","volume":"439","author":"Zhao","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110498_bb0200","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.tiv.2012.04.003","article-title":"Mono-(2-ethylhexyl) phthalate affects the steroidogenesis in rat Leydig cells through provoking ROS perturbation","volume":"26","author":"Zhao","year":"2012","journal-title":"Toxicol. in Vitro"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110498_bb0205","first-page":"3","article-title":"Androgen receptor structure, function and biology: from bench to bedside","volume":"37","author":"Davey","year":"2016","journal-title":"Clin. Biochem. Rev."},{"issue":"9","key":"10.1016\/j.bioorg.2026.110498_bb0210","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/j.1349-7006.2007.00535.x","article-title":"Protein kinase C-delta regulates the stability of hypoxia-inducible factor-1 alpha under hypoxia","volume":"98","author":"Lee","year":"2007","journal-title":"Cancer Sci."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110498_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061498","article-title":"The role of tyrosine phosphorylation of protein kinase C Delta in infection and inflammation","volume":"20","author":"Yang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.bioorg.2026.110498_bb0220","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.freeradbiomed.2011.08.027","article-title":"Regulation of skin inflammation and angiogenesis by EC-SOD via HIF-1alpha and NF-kappaB pathways","volume":"51","author":"Kim","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110498_bb0225","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1074-7613(00)80249-6","article-title":"Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading","volume":"4","author":"Riese","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.bioorg.2026.110498_bb0230","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.sleep.2023.11.028","article-title":"Renal sympathetic denervation ameliorates the activated inflammatory response through JAK-STAT pathway in a chronic obstructive sleep apnea animal model","volume":"113","author":"Hsiao","year":"2024","journal-title":"Sleep Med."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110498_bb0235","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12931-022-02092-9","article-title":"Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea","volume":"23","author":"Marin-Oto","year":"2022","journal-title":"Respir. Res."},{"key":"10.1016\/j.bioorg.2026.110498_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114500","article-title":"Blockage of calcium-sensing receptor improves chronic intermittent hypoxia-induced cognitive impairment by PERK-ATF4-CHOP pathway","volume":"368","author":"You","year":"2023","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110498_bb0245","first-page":"743","article-title":"Sheng-Mai-San attenuates contractile dysfunction and structural damage induced by chronic intermittent hypoxia in mice","volume":"13","author":"Mo","year":"2015","journal-title":"Chin. J. Nat. Med."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110498_bb0250","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1039\/C8TX00263K","article-title":"Di-(2-ethylhexyl) phthalate (DEHP) inhibits steroidogenesis and induces mitochondria-ROS mediated apoptosis in rat ovarian granulosa cells","volume":"8","author":"Tripathi","year":"2019","journal-title":"Toxicol. Res. (Camb.)"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826010345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826010345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:25:17Z","timestamp":1791260717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826010345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":50,"alternative-id":["S0045206826010345"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110498","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic insights into di(2-ethylhexyl) phthalate exposure in obstructive sleep apnea: network toxicology and in vitro validation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110498","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110498"}}