{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:56Z","timestamp":1791262616019,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2025JYJ014"],"award-info":[{"award-number":["2025JYJ014"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032767","name":"Sichuan Medical Association","doi-asserted-by":"publisher","award":["Q20250004"],"award-info":[{"award-number":["Q20250004"]}],"id":[{"id":"10.13039\/100032767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2026NSFSC0577"],"award-info":[{"award-number":["2026NSFSC0577"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2024ZD0531300"],"award-info":[{"award-number":["2024ZD0531300"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110542","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:51:26Z","timestamp":1789721486000},"page":"110542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development and evaluation of 68Ga-DOTA-EP-1: A novel PET tracer targeting EpCAM for malignant tumor diagnosis"],"prefix":"10.1016","volume":"182","author":[{"given":"Shijie","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanggang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiheng","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110542_bb0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.5230\/jgc.2024.24.e32","article-title":"Clinicopathologic characteristics of trop family proteins (trop-2 and EpCAM) in gastric carcinoma","volume":"24","author":"Kim","year":"2024","journal-title":"J. Gastric Cancer"},{"key":"10.1016\/j.bioorg.2026.110542_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114443","article-title":"Targeted EpCAM-binding for the development of potent and effective anticancer proteins","volume":"161","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2026.110542_bb0015","doi-asserted-by":"crossref","first-page":"165","DOI":"10.15698\/cst2019.06.188","article-title":"Biology and clinical relevance of EpCAM","volume":"3","author":"Keller","year":"2019","journal-title":"Cell Stress"},{"key":"10.1016\/j.bioorg.2026.110542_bb0020","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3390\/biomedicines12051129","article-title":"Regulation of the function and expression of EpCAM","volume":"12","author":"Xiao","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bioorg.2026.110542_bb0025","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.3390\/cells9092128","article-title":"EpCAM as modulator of tissue plasticity","volume":"9","author":"Fagotto","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bioorg.2026.110542_bb0030","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/S0002-9440(10)63570-5","article-title":"The epithelial cell adhesion molecule (ep-CAM) as a morphoregulatory molecule is a tool in surgical pathology","volume":"163","author":"Winter","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bioorg.2026.110542_bb0035","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3390\/biom11070956","article-title":"Functional implications of the dynamic regulation of EpCAM during epithelial-to-mesenchymal transition","volume":"11","author":"Brown","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioorg.2026.110542_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011109","article-title":"Characterization of EpCAM-positive and EpCAM-negative tumor cells in early-stage breast cancer","volume":"25","author":"Perelmuter","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110542_bb0045","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1021\/acs.molpharmaceut.9b00185","article-title":"Identification of tumor specific peptide as EpCAM ligand and its potential diagnostic and therapeutic clinical application","volume":"16","author":"Ma","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioorg.2026.110542_bb0050","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.3390\/cancers13143589","article-title":"Influence of the position and composition of radiometals and radioiodine labels on imaging of epcam expression in prostate cancer model using the DARPin Ec1","volume":"13","author":"Deyev","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bioorg.2026.110542_bb0055","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.3390\/cancers16162818","article-title":"Detection of hepatocellular carcinoma in an orthotopic patient-derived xenograft with an epithelial cell adhesion molecule-specific peptide","volume":"16","author":"Wu","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.bioorg.2026.110542_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.138310","article-title":"A novel peptide multimer for enhanced imaging and multivalent detection of hepatocellular carcinoma","volume":"444","author":"Feng","year":"2025","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.bioorg.2026.110542_bb0065","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1021\/cbmi.4c00030","article-title":"Peptide PET imaging: a review of recent developments and a look at the future of radiometal-labeled peptides in medicine","volume":"2","author":"Shabsigh","year":"2024","journal-title":"Chem. Biomed. Imaging"},{"key":"10.1016\/j.bioorg.2026.110542_bb0070","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1021\/acs.chemrev.9b00738","article-title":"ImmunoPET: concept, design, and applications","volume":"120","author":"Wei","year":"2020","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.110542_bb0075","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1158\/2326-6066.CIR-21-0062","article-title":"Bispecific CAR T cells against EpCAM and inducible ICAM-1 overcome antigen heterogeneity and generate superior antitumor responses","volume":"9","author":"Yang","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.bioorg.2026.110542_bb0080","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4263520","article-title":"Combination therapy with EpCAM-CAR-NK-92 cells and regorafenib against human colorectal cancer models","volume":"2018","author":"Zhang","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.bioorg.2026.110542_bb0085","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s41181-025-00347-6","article-title":"Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression","volume":"10","author":"Vorobyeva","year":"2025","journal-title":"EJNMMI Radiopharm. Chem."},{"key":"10.1016\/j.bioorg.2026.110542_bb0090","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.3390\/cancers16162815","article-title":"Phase I clinical evaluation of designed ankyrin repeat protein [99mTc]Tc(CO)3-(HE)3-Ec1 for visualization of EpCAM-expressing lung cancer","volume":"16","author":"Zelchan","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.bioorg.2026.110542_bb0095","doi-asserted-by":"crossref","first-page":"10815","DOI":"10.2147\/IJN.S539010","article-title":"Emerging applications of EpCAM-targeted nuclear medicine probes: current research and future perspectives","volume":"20","author":"Huang","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bioorg.2026.110542_bb0100","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s00259-024-06910-8","article-title":"ImmunoPET imaging of EpCAM in solid tumours with nanobody tracers: a preclinical study","volume":"52","author":"Xu","year":"2025","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.bioorg.2026.110542_bb0105","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1021\/acs.bioconjchem.1c00188","article-title":"EpCAM-targeting aptamer radiotracer for tumor-specific PET imaging","volume":"32","author":"Li","year":"2021","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.bioorg.2026.110542_bb0110","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1002\/adhm.201500724","article-title":"Discovering of tumor-targeting peptides using bi-functional microarray","volume":"4","author":"Wang","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioorg.2026.110542_bb0115","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s00259-023-06407-w","article-title":"Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer","volume":"51","author":"Houvast","year":"2024","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.bioorg.2026.110542_bb0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/antib11020041","article-title":"Development of a novel anti-EpCAM monoclonal antibody for various applications","volume":"11","author":"Li","year":"2022","journal-title":"Antibodies"},{"key":"10.1016\/j.bioorg.2026.110542_bb0125","doi-asserted-by":"crossref","first-page":"812","DOI":"10.2967\/jnumed.115.168153","article-title":"Biodistribution and PET imaging of labeled bispecific T cell-engaging antibody targeting EpCAM","volume":"57","author":"Warnders","year":"2016","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.bioorg.2026.110542_bb0130","doi-asserted-by":"crossref","first-page":"47407","DOI":"10.1021\/acsomega.5c06875","article-title":"Dynamic PET imaging of EpCAM-positive colorectal cancer using radiolabeled DTN-SYL3C aptamer conjugates","volume":"10","author":"Huang","year":"2025","journal-title":"ACS Omega"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826010783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826010783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:37:54Z","timestamp":1791261474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826010783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":26,"alternative-id":["S0045206826010783"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110542","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and evaluation of 68Ga-DOTA-EP-1: A novel PET tracer targeting EpCAM for malignant tumor diagnosis","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110542","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110542"}}