{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:55:13Z","timestamp":1791262513450,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110544","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:46:39Z","timestamp":1789602399000},"page":"110544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Total synthesis and biological evaluation of catenulobactin B as neuroprotective agent"],"prefix":"10.1016","volume":"182","author":[{"given":"Min","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Qin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Lei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110544_bb0005","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2026.110544_bb0010","doi-asserted-by":"crossref","first-page":"13693","DOI":"10.1021\/acs.chemrev.3c00479","article-title":"Parkinson\u2019s disease: advances in treatment and the syntheses of various classes of pharmaceutical drug substances","volume":"123","author":"Hill","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.110544_bb0015","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"123","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.bioorg.2026.110544_bb0020","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41582-024-01034-x","article-title":"Parkinson disease therapy: current strategies and future research priorities","volume":"20","author":"Stocchi","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bioorg.2026.110544_bb0025","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s43088-025-00675-1","article-title":"Huperzine a: a natural acetylcholinesterase inhibitor with multifunctional neuroprotective effects","volume":"14","author":"Singh","year":"2025","journal-title":"Beni-Suef Univ. J. Basic Appl. Sci."},{"key":"10.1016\/j.bioorg.2026.110544_bb0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0163-7258(95)02002-0","article-title":"The pharmacology of galanthamine and its analogues","volume":"68","author":"Harvey","year":"1995","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.bioorg.2026.110544_bb0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0006-3223(00)01101-X","article-title":"Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer\u2019s disease","volume":"49","author":"Coyle","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bioorg.2026.110544_bb0040","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejphar.2014.11.038","article-title":"The adenosine a 2A receptor antagonist, istradefylline enhances the anti-parkinsonian activity of low doses of dopamine agonists in MPTP-treated common marmosets","volume":"747","author":"Uchida","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110544_bb0045","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1021\/acs.jcim.7b00722","article-title":"Structural investigation of the Dopamine-2 receptor agonist bromocriptine binding to dimeric D2HighR and D2LowR states","volume":"58","author":"Salmas","year":"2018","journal-title":"J. Chem. In. Model."},{"key":"10.1016\/j.bioorg.2026.110544_bb0050","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1021\/mp060012c","article-title":"Apomorphine in dopaminergic therapy","volume":"3","author":"Subramony","year":"2006","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioorg.2026.110544_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117534","article-title":"Amino acid- and peptide-conjugated heterocyclic compounds: a comprehensive review of synthesis strategies and biological activities","volume":"290","author":"Sylvianingsih","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110544_bb0060","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1021\/acs.jnatprod.8b00261","article-title":"Catenulobactins a and B, heterocyclic peptides from culturing Catenuloplanes sp. with a mycolic acid-containing bacterium","volume":"81","author":"Hoshino","year":"2018","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.110544_bb0065","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/adsc.200600550","article-title":"Dehydrative cyclization catalyzed by the combination of molybdenum(VI) oxides and benzoic acids: first synthesis of the antitumour substance BE-70016","volume":"349","author":"Sakakura","year":"2007","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.bioorg.2026.110544_bb0070","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1021\/ol050543j","article-title":"Molybdenum oxides as highly effective dehydrative cyclization catalysts for the synthesis of Oxazolines and Thiazolines","volume":"7","author":"Akira Sakakura","year":"2005","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2026.110544_bb0075","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1039\/D2OB00166G","article-title":"Synthetic studies towards naturally occurring \u03b3-(Z)\/(E)-alkylidenebutenolides through bimetallic cascade cyclization and an adventitious photoisomerization method","volume":"20","author":"Chatterjee","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2026.110544_bb0080","doi-asserted-by":"crossref","first-page":"7584","DOI":"10.1039\/c2ob26077h","article-title":"Syntheses of mycobactin analogs as potent and selective inhibitors of mycobacterium tuberculosis","volume":"10","author":"Ju\u00e1rez-Hern\u00e1ndez","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2026.110544_bb0085","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1021\/acs.orglett.8b02832","article-title":"Total synthesis of the proposed structure of mycobactin","volume":"20","author":"Ghosh","year":"2018","journal-title":"J. Org. Lett."},{"key":"10.1016\/j.bioorg.2026.110544_bb0090","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1021\/jo00083a001","article-title":"Effect of tertiary bases on O-Benzotriazolyluronium salt-induced peptide segment coupling","volume":"59","author":"Carpino","year":"1994","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.bioorg.2026.110544_bb0095","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1021\/ja00063a082","article-title":"1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive","volume":"115","author":"Carpino","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2026.110544_bb0100","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1021\/jo00116a054","article-title":"Efficiency in peptide coupling: 1-Hydroxy-7-azabenzotriazole vs 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine","volume":"60","author":"Carpino","year":"1995","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.bioorg.2026.110544_bb0105","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.ccr.2012.03.013","article-title":"Copper, zinc and iron in neurodegenerative diseases (Alzheimer\u2019s, Parkinson\u2019s and prion diseases)","volume":"256","author":"Kozlowski","year":"2012","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2026.110544_bb0110","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neulet.2007.06.052","article-title":"Copper- and iron-induced differential fibril formation in a-synuclein: TEM study","volume":"424","author":"Bharathi Indi","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bioorg.2026.110544_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000027","article-title":"Elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging","volume":"4","author":"van Ham","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bioorg.2026.110544_bb0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fnana.2014.00155","article-title":"Parkinson\u2019s disease: animal models and dopaminergic cell vulnerability","volume":"8","author":"Blesa","year":"2014","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.bioorg.2026.110544_bb0125","article-title":"Expanding automated gene summaries for Caenorhabditis and parasitic nematode species in WormBase","author":"Kishore","year":"2024","journal-title":"Micropubl. Biol."},{"key":"10.1016\/j.bioorg.2026.110544_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007792","article-title":"DMT1 orthologues regulate and are regulated differentially by manganese levels in C. Elegans","volume":"4","author":"Au","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2026.110544_bb0135","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fphar.2014.00113","article-title":"Mechanisms of iron metabolism in Caenorhabditis elegans","volume":"5","author":"Anderson","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110544_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2025.112826","article-title":"Exploring age-related iron dysregulation: effects on longevity, body size, and behavior in C. Elegans","volume":"208","author":"Zeidan","year":"2025","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bioorg.2026.110544_bb0145","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1038\/s41467-022-32500-z","article-title":"Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons","volume":"13","author":"Pekec","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826010801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826010801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:32:19Z","timestamp":1791261139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826010801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"alternative-id":["S0045206826010801"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110544","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Total synthesis and biological evaluation of catenulobactin B as neuroprotective agent","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110544","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110544"}}