{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:37:27Z","timestamp":1792831047966,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["110\\u20132320-B-002-010-MY2"],"award-info":[{"award-number":["110\\u20132320-B-002-010-MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bioorg.2026.110558","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:16:07Z","timestamp":1790205367000},"page":"110558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Discovery of first histone deacetylase 10 fluorescent probe"],"prefix":"10.1016","volume":"183","author":[{"given":"Ching","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian-Siou","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Ju","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit Dhananjay","family":"Jagtap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Hsia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Wu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.bioorg.2026.110558_bb0005","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41568-022-00473-2","article-title":"Polyamines in cancer: integrating organismal metabolism and antitumour immunity","volume":"22","author":"Holbert","year":"2022","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.bioorg.2026.110558_bb0010","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00726-009-0396-7","article-title":"Polyamines: fundamental characters in chemistry and biology","volume":"38","author":"Agostinelli","year":"2010","journal-title":"Amino Acids"},{"issue":"18","key":"10.1016\/j.bioorg.2026.110558_bb0015","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1016\/j.ejca.2004.07.025","article-title":"Amplification remains prognostically strong 20 years after its \u201cclinical debut\u201d","volume":"40","author":"Cohn","year":"2004","journal-title":"Eur. J. Cancer"},{"issue":"6","key":"10.1016\/j.bioorg.2026.110558_bb0020","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrc3526","article-title":"Neuroblastoma: developmental biology, cancer genomics and immunotherapy","volume":"13","author":"Cheung","year":"2013","journal-title":"Nat. Rev. Cancer"},{"issue":"23","key":"10.1016\/j.bioorg.2026.110558_bb0025","doi-asserted-by":"crossref","first-page":"9735","DOI":"10.1158\/0008-5472.CAN-07-6866","article-title":"Is a critical determinant of oncogenesis and a therapeutic target in neuroblastoma","volume":"68","author":"Hogarty","year":"2008","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110558_bb0030","first-page":"457","article-title":"Polyamine deprivation, malnutrition and tumor-growth","volume":"12","author":"Sarhan","year":"1992","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110558_bb0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0022-3565(25)20122-7","article-title":"The potential of a novel polyamine transport inhibitor in cancer chemotherapy","volume":"278","author":"Aziz","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bioorg.2026.110558_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32659-w","article-title":"Maintenance DFMO increases survival in high risk neuroblastoma","volume":"8","author":"Sholler","year":"2018","journal-title":"Sci. Rep."},{"issue":"477","key":"10.1016\/j.bioorg.2026.110558_bb0045","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau1099","article-title":"Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma","volume":"11","author":"Gamble","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110558_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102407","article-title":"Histone deacetylase-10 liberates spermidine to support polyamine homeostasis and tumor cell growth","volume":"298","author":"Stewart","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2026.110558_bb0055","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15368","article-title":"Histone deacetylase 10 structure and molecular function as a polyamine deacetylase","volume":"8","author":"Hai","year":"2017","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110558_bb0060","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/ijc.28139","article-title":"AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport","volume":"133","author":"Samal","year":"2013","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110558_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-20896-z","article-title":"Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas","volume":"12","author":"Khan","year":"2021","journal-title":"Nat. Commun."},{"issue":"28","key":"10.1016\/j.bioorg.2026.110558_bb0070","doi-asserted-by":"crossref","first-page":"E2592","DOI":"10.1073\/pnas.1300113110","article-title":"Histone deacetylase 10 promotes autophagy-mediated cell survival","volume":"110","author":"Oehme","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioorg.2026.110558_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28265-5","article-title":"Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance","volume":"8","author":"Ridinger","year":"2018","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.bioorg.2026.110558_bb0080","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nrm2531","article-title":"Fluorescent probes for super-resolution imaging in living cells","volume":"9","author":"Fern\u00e1ndez-Su\u00e1rez","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"41","key":"10.1016\/j.bioorg.2026.110558_bb0085","doi-asserted-by":"crossref","first-page":"18861","DOI":"10.1021\/jacs.2c05030","article-title":"Aza-SAHA derivatives are selective histone deacetylase 10 chemical probes that inhibit polyamine deacetylation and Phenocopy HDAC10 knockout","volume":"144","author":"Steimbach","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"42","key":"10.1016\/j.bioorg.2026.110558_bb0090","doi-asserted-by":"crossref","DOI":"10.1039\/C8OB00966J","article-title":"A highly HDAC6-selective inhibitor acts as a fluorescent probe","volume":"16","author":"Ho","year":"2018","journal-title":"Org. Biomol. Chem."},{"issue":"31","key":"10.1016\/j.bioorg.2026.110558_bb0095","doi-asserted-by":"crossref","first-page":"10842","DOI":"10.1021\/ja102758v","article-title":"Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, Tubastatin a","volume":"132","author":"Butler","year":"2010","journal-title":"J. Am. Chem. Soc."},{"issue":"39","key":"10.1016\/j.bioorg.2026.110558_bb0100","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.1039\/D0TC03681A","article-title":"1,8-Naphthalimide-based fluorescent chemosensors: recent advances and perspectives","volume":"8","author":"Dong","year":"2020","journal-title":"J. Mater. Chem. C"},{"issue":"41","key":"10.1016\/j.bioorg.2026.110558_bb0105","doi-asserted-by":"crossref","first-page":"18861","DOI":"10.1021\/jacs.2c05030","article-title":"Aza-SAHA derivatives are selective histone deacetylase 10 chemical probes that inhibit polyamine deacetylation and Phenocopy HDAC10 knockout br","volume":"144","author":"Steimbach","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"16","key":"10.1016\/j.bioorg.2026.110558_bb0110","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1002\/anie.199517281","article-title":"New fluorescent model compounds for the study of Photoinduced Electron-transfer - the influence of a molecular electric-field in the excited-state","volume":"34","author":"De Silva","year":"1995","journal-title":"Angew. Chem. Int. Edit."},{"issue":"27\u201328","key":"10.1016\/j.bioorg.2026.110558_bb0115","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1016\/j.tet.2012.04.110","article-title":"Naphthalimide-based fluorescent off\/on probes for the detection of thiols","volume":"68","author":"Sun","year":"2012","journal-title":"Tetrahedron"},{"issue":"50","key":"10.1016\/j.bioorg.2026.110558_bb0120","doi-asserted-by":"crossref","first-page":"6866","DOI":"10.1039\/D0CC01251C","article-title":"Mixed alkoxy\/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity","volume":"56","author":"Rudebeck","year":"2020","journal-title":"Chem. Commun."},{"issue":"7","key":"10.1016\/j.bioorg.2026.110558_bb0125","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1021\/acs.jcim.1c00075","article-title":"MolGpka: a web server for small molecule pKa prediction using a graph-convolutional neural network","volume":"61","author":"Pan","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"12","key":"10.1016\/j.bioorg.2026.110558_bb0130","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1351\/PAC-REP-10-09-31","article-title":"Standards for photoluminescence quantum yield measurements in solution (IUPAC technical report)","volume":"83","author":"Brouwer","year":"2011","journal-title":"Pure Appl. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826010941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826010941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:06:17Z","timestamp":1792829177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826010941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":26,"alternative-id":["S0045206826010941"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110558","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of first histone deacetylase 10 fluorescent probe","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110558","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110558"}}