{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:52:41Z","timestamp":1791262361247,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015375","name":"The Affiliated Hospital of Southwest Medical University","doi-asserted-by":"publisher","award":["24237"],"award-info":[{"award-number":["24237"]}],"id":[{"id":"10.13039\/501100015375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2024LZXNYDJ109"],"award-info":[{"award-number":["2024LZXNYDJ109"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2025JC034"],"award-info":[{"award-number":["2025JC034"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioorg.2026.110563","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:08:58Z","timestamp":1789830538000},"page":"110563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rhoifolin attenuates atopic dermatitis-like symptoms in mice by regulating PPAR\u03b1-mediated NF-\u03baB\/NLRP3 inflammation and pyroptosis processes"],"prefix":"10.1016","volume":"182","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengli","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110563_bb0005","first-page":"35","article-title":"Atopic dermatitis: an overview","volume":"86","author":"Berke","year":"2012","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.bioorg.2026.110563_bb0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/ACI.0000000000000837","article-title":"Clinical phenotypes of adult atopic dermatitis and related therapies","volume":"22","author":"Patruno","year":"2022","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0015","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/08923973.2021.1889583","article-title":"Atopic dermatitis: new insight into the etiology, pathogenesis, diagnosis and novel treatment strategies","volume":"43","author":"Mandlik","year":"2021","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154346","article-title":"Anti-atopic dermatitis effect of a modified Huang-Lian-Jie-Du decoction and its active fraction on 2,4-dinitrobenzene and MC903-induced mouse models","volume":"104","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.110563_bb0025","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.jaci.2017.01.011","article-title":"The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies","volume":"139","author":"Brunner","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0030","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/cei.13575","article-title":"Keratinocytes: innate immune cells in atopic dermatitis","volume":"204","author":"Chieosilapatham","year":"2021","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0035","doi-asserted-by":"crossref","first-page":"486","DOI":"10.12932\/AP-200122-1309","article-title":"Oleuropein attenuates inflammation and regulates immune responses in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model","volume":"43","author":"Huang","year":"2025","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0040","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12016-014-8415-1","article-title":"Molecular biology of atopic dermatitis","volume":"47","author":"Mu","year":"2014","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.bioorg.2026.110563_bb0045","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3390\/ijms24010781","article-title":"Immunopathogenesis of atopic dermatitis: focus on interleukins as disease drivers and therapeutic targets for novel treatments","volume":"24","author":"Makowska","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110563_bb0050","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3892\/mmr.2021.12148","article-title":"3,4,5-Trihydroxycinnamic acid exerts anti-inflammatory effects on TNF-\u03b1\/IFN-\u03b3-stimulated HaCaT cells","volume":"24","author":"Park","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bioorg.2026.110563_bb0055","doi-asserted-by":"crossref","first-page":"8237","DOI":"10.3390\/ijms22158237","article-title":"Effect of Neferine on DNCB-induced atopic dermatitis in HaCaT cells and BALB\/c mice","volume":"22","author":"Yang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110563_bb0060","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1194\/jlr.R800001-JLR200","article-title":"Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology","volume":"49","author":"Schmuth","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bioorg.2026.110563_bb0065","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/exd.12208","volume":"22","author":"Adachi","year":"2013","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113696","article-title":"Preventing NLRP3 inflammasome activation: therapeutic atrategy and challenges in atopic dermatitis","volume":"144","author":"Sun","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0075","doi-asserted-by":"crossref","first-page":"8009","DOI":"10.2147\/JIR.S484919","article-title":"Arctiin alleviates atopic dermatitis against inflammation and pyroptosis through suppressing TLR4\/MyD88\/NF-\u03baB and NLRP3\/Caspase-1\/GSDMD signaling pathways","volume":"17","author":"Li","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bioorg.2026.110563_bb0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.livres.2026.05.003","article-title":"PPAR\u03b1 activation alleviates lithocholic acid-induced liver injury by inhibiting pyroptosis","volume":"10","author":"Liang","year":"2026","journal-title":"Liver. Res."},{"key":"10.1016\/j.bioorg.2026.110563_bb0085","doi-asserted-by":"crossref","first-page":"43233","DOI":"10.1021\/acsomega.4c07915","article-title":"Rhoifolin attenuates concanavalin A-induced autoimmune hepatitis in mice via JAKs\/STATs mediated immune and apoptotic processes","volume":"9","author":"Zhao","year":"2024","journal-title":"ACS. Omega"},{"key":"10.1016\/j.bioorg.2026.110563_bb0090","doi-asserted-by":"crossref","first-page":"11109","DOI":"10.2147\/JIR.S515002","article-title":"Rhoifolin attenuates DSS-induced colitis in mice by modulating gut microbiota and restoring Th17\/Treg balance","volume":"18","author":"Xu","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bioorg.2026.110563_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.158095","article-title":"Rhoifolin inhibits ferroptosis and alleviates pulmonary arterial hypertension via the TNF-\u03b1\/TNF-R1\/CASP8\/CASP3 pathway","volume":"155","author":"Deng","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.110563_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157621","article-title":"Rhoifolin prevents herpes simplex virus encephalitis by modulating SESN2 to regulate the Keap1\/Nrf2 and AMPK\/Nox pathways to inhibit neuro-oxidative damage in mice","volume":"150","author":"Yang","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.110563_bb0105","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12890-025-03526-y","article-title":"Rhoifolin improves bleomycin-induced fibrosis in vivo and cell damage in vitro both related to NRF2\/HO-1 pathway","volume":"25","author":"Wang","year":"2025","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.bioorg.2026.110563_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1216086","article-title":"Network pharmacology- and molecular docking-based analyses of the antihypertensive mechanism of Ilex kudingcha","volume":"14","author":"Liao","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.bioorg.2026.110563_bb0115","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1124\/jpet.110.176925","article-title":"Kaempferol attenuates 4-hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase","volume":"337","author":"Jang","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bioorg.2026.110563_bb0120","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.3390\/ijms23084470","article-title":"Dendrobium nobile Lindley administration attenuates atopic dermatitis-like lesions by modulating immune cells","volume":"23","author":"Hong","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110563_bb0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molimm.2023.07.002","article-title":"Jing-Fang powder ethyl acetate extracts attenuate atopic dermatitis by modulating T-cell activity","volume":"160","author":"Zhao","year":"2023","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0130","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2133.2007.08112.x","article-title":"Practical issues on interpretation of scoring atopic dermatitis: the SCORAD index, objective SCORAD and the three-item severity score","volume":"157","author":"Oranje","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154318","article-title":"Terminalia chebula Retz. Extract ameliorates the symptoms of atopic dermatitis by regulating anti-inflammatory factors in vivo and suppressing STAT1\/3 and NF-\u0138B signaling in vitro","volume":"104","author":"Kim","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2026.110563_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114453","article-title":"Effects of chloroform fraction of Fritillariae Thunbergii Bulbus on atopic symptoms in a DNCB-induced atopic dermatitis-like skin lesion model and in vitro models","volume":"281","author":"Kim","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0145","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.imbio.2017.10.047","article-title":"Protective role of peroxisome proliferator-activated receptor \u03b1 agonists in skin barrier and inflammation","volume":"223","author":"Furue","year":"2018","journal-title":"Immunobiology"},{"key":"10.1016\/j.bioorg.2026.110563_bb0150","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-026-08640-1","article-title":"PPAR\u03b1 deficiency causes skin dysbiosis and triggers innate immunity in keratinocytes","volume":"17","author":"Blunder","year":"2026","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.110563_bb0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2165\/00128071-200809010-00002","article-title":"Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases","volume":"9","author":"Sertznig","year":"2008","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0160","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jdermsci.2015.09.012","article-title":"Stimulation of PPAR\u03b1 normalizes the skin lipid ratio and improves the skin barrier of normal and filaggrin deficient reconstructed skin","volume":"80","author":"Wallmeyer","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.bioorg.2026.110563_bb0165","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.abi5934","article-title":"Dying cells fan the flames of inflammation","volume":"374","author":"Newton","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.bioorg.2026.110563_bb0170","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41590-024-01788-y","article-title":"Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components","volume":"25","author":"Mencarelli","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bioorg.2026.110563_bb0175","doi-asserted-by":"crossref","first-page":"32048","DOI":"10.1074\/jbc.274.45.32048","article-title":"Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1","volume":"274","author":"Delerive","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2026.110563_bb0180","doi-asserted-by":"crossref","DOI":"10.1080\/08916934.2024.2310269","article-title":"The role of NLRP3 inflammasome in type 2 inflammation related diseases","volume":"57","author":"Xu","year":"2024","journal-title":"Autoimmunity"},{"key":"10.1016\/j.bioorg.2026.110563_bb0185","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41420-025-02630-6","article-title":"IL-33-primed NLRP3 inflammasome in basophils drives IL-1\u03b2 production and initiates atopic dermatitis inflammation","volume":"11","author":"Gunji","year":"2025","journal-title":"Cell Death Discov."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826010990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826010990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:23:19Z","timestamp":1791260599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826010990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":37,"alternative-id":["S0045206826010990"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110563","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rhoifolin attenuates atopic dermatitis-like symptoms in mice by regulating PPAR\u03b1-mediated NF-\u03baB\/NLRP3 inflammation and pyroptosis processes","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110563","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110563"}}