{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:37:33Z","timestamp":1792831053079,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2025-MS-266"],"award-info":[{"award-number":["2025-MS-266"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013099","name":"Scientific Research Fund of Liaoning Provincial Education Department","doi-asserted-by":"publisher","award":["LJ212410163058"],"award-info":[{"award-number":["LJ212410163058"]}],"id":[{"id":"10.13039\/501100013099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903511"],"award-info":[{"award-number":["81903511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574291"],"award-info":[{"award-number":["82574291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22507082"],"award-info":[{"award-number":["22507082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018559","name":"Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program","doi-asserted-by":"publisher","award":["RC240665"],"award-info":[{"award-number":["RC240665"]}],"id":[{"id":"10.13039\/501100018559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bioorg.2026.110611","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:17:09Z","timestamp":1791587829000},"page":"110611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Novel sesquiterpene lactone derivatives as covalent TrxR1 inhibitors: synthesis, anti-tumor activity, mechanistic investigation"],"prefix":"10.1016","volume":"183","author":[{"given":"Hui","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanshan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjiao","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bensong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Dong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bioorg.2026.110611_bb0005","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/acel.12154","article-title":"The conserved mediator subunit MDT-15 is required for oxidative stress responses in Caenorhabditis elegans","volume":"13","author":"Goh","year":"2014","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.bioorg.2026.110611_bb0010","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aav4570","article-title":"The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62","volume":"5","author":"Xu","year":"2019","journal-title":"Sci. Adv."},{"issue":"8","key":"10.1016\/j.bioorg.2026.110611_bb0015","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41419-019-1825-5","article-title":"Avenanthramide a triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3","volume":"10","author":"Fu","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.110611_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.962742","article-title":"Single-cell transcriptomics uncover the key ferroptosis regulators contribute to cancer progression in head and neck squamous cell carcinoma","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110611_bb0025","first-page":"3243","article-title":"PEDF improves cardiac function in rats subjected to myocardial ischemia\/reperfusion injury by inhibiting ROS generation via PEDF-R","volume":"41","author":"Zhao","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110611_bb0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13045-018-0575-7","article-title":"Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma","volume":"11","author":"Zheng","year":"2018","journal-title":"J. Hematol. Oncol."},{"issue":"16","key":"10.1016\/j.bioorg.2026.110611_bb0035","doi-asserted-by":"crossref","first-page":"7309","DOI":"10.1021\/acs.jmedchem.8b01595","article-title":"Targeting the thioredoxin system as a strategy for cancer therapy","volume":"62","author":"Bian","year":"2019","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2026.110611_bb0040","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1039\/c9mt00133f","article-title":"The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase","volume":"11","author":"Li","year":"2019","journal-title":"Metallomics"},{"issue":"8","key":"10.1016\/j.bioorg.2026.110611_bb0045","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/13543776.2021.1899160","article-title":"Thioredoxin reductase inhibitors: updated patent review (2017\u2013present)","volume":"31","author":"Chupakhin","year":"2021","journal-title":"Expert Opin. Ther. Pat."},{"issue":"12","key":"10.1016\/j.bioorg.2026.110611_bb0050","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1089\/ars.2012.4650","article-title":"Thioredoxin system in cell death progression","volume":"17","author":"Lu","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bioorg.2026.110611_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102351","article-title":"Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma","volume":"54","author":"Xu","year":"2022","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110611_bb0060","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1038\/s41467-019-10807-8","article-title":"A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110611_bb0065","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1021\/acs.jmedchem.2c01798","article-title":"Tumor-targeting NHC-au(I) complex induces immunogenic cell death in hepatocellular carcinoma","volume":"66","author":"Yang","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110611_bb0070","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.redox.2017.09.014","article-title":"Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity","volume":"14","author":"Zheng","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioorg.2026.110611_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113897","article-title":"Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR","volume":"227","author":"Yan","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110611_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104814","article-title":"Synthesis and biological evaluation of disulfides as anticancer agents with thioredoxin inhibition","volume":"110","author":"Wei","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"19","key":"10.1016\/j.bioorg.2026.110611_bb0085","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1021\/acs.jmedchem.0c01128","article-title":"Design and SAR of withangulatin a analogues that act as covalent TrxR inhibitors through the Michael addition reaction showing potential in cancer treatment","volume":"63","author":"Wang","year":"2020","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110611_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfutfo.2024.01.001","article-title":"Recent advcances on plant-based bioengineered nanoparticles using secondary metabolites and their potential in lung cancer management","volume":"5","author":"Islam","year":"2025","journal-title":"J. Future Foods"},{"key":"10.1016\/j.bioorg.2026.110611_bb0095","article-title":"Co-assembly strategies of natural plant compounds for improving their bioavailability","volume":"2","author":"Miao","year":"2025","journal-title":"Food Med. Homol."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110611_bb0100","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/st9.0000000000000070","article-title":"Drug innovation via integration of traditional Chinese and Western medicine","volume":"3","author":"Li","year":"2025","journal-title":"Sci. Tradit. Chin. Med."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110611_bb0105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jab.2014.01.008","article-title":"Elephantopus scaber Linn.: a review on its ethnomedical, phytochemical and pharmacological profile","volume":"12","author":"Hiradeve","year":"2014","journal-title":"J. Appl. Biomed."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110611_bb0110","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1021\/acs.jnatprod.1c00936","article-title":"Semisynthesis and non-small-cell lung cancer cytotoxicity evaluation of germacrane-type sesquiterpene lactones from Elephantopus scaber","volume":"85","author":"Ren","year":"2022","journal-title":"J. Nat. Prod."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110611_bb0115","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1021\/acs.jmedchem.4c02334","article-title":"Design of ROS-triggered sesquiterpene lactone SC prodrugs as TrxR1 covalent inhibitors for the treatment of non-small cell lung cancer","volume":"68","author":"Ren","year":"2025","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826011478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826011478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:06:42Z","timestamp":1792829202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826011478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":23,"alternative-id":["S0045206826011478"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110611","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel sesquiterpene lactone derivatives as covalent TrxR1 inhibitors: synthesis, anti-tumor activity, mechanistic investigation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110611","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110611"}}