{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:41:32Z","timestamp":1792410092711,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-RC-2026-01-14"],"award-info":[{"award-number":["ORF-RC-2026-01-14"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bioorg.2026.110619","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:26:38Z","timestamp":1791613598000},"page":"110619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Novel sulfonamide-containing dihydropyrimidine derivatives as potent inhibitors of tumor-associated carbonic anhydrase isoforms IX\/XII: Design, synthesis, and anticancer evaluation"],"prefix":"10.1016","volume":"184","author":[{"given":"Basima A.A.","family":"Saleem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aly M.","family":"Waseem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasim Sakran","family":"Abass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Br\u00e4se","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghallab","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alkhammash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman A.","family":"Almehizia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Naglah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110619_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27133965","article-title":"Modeling of anticancer Sulfonamide derivatives lipophilicity by chemometric and quantitative structure-retention relationships approaches","volume":"27","author":"Pastewska","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110619_bb0010","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/ml500140t","article-title":"Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives","volume":"5","author":"Pichake","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110619_bb0015","article-title":"Sulfonamides as a promising scaffold in drug discovery: an insightful review on FDA-approved molecules, synthesis strategy, medical indication, and their binding mode","volume":"22","author":"slam","year":"2025","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bioorg.2026.110619_bb0020","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.4155\/fmc.14.68","article-title":"Sulfonamides and their isosters as carbonic anhydrase inhibitors","volume":"6","author":"Carta","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0025","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ejmech.2015.09.021","article-title":"Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII","volume":"103","author":"Ibrahim","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0030","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1080\/14756366.2022.2124409","article-title":"Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII","volume":"37","author":"Al-Warhi","year":"2022","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107881","article-title":"Novel benzenesulfonamide derivatives as potential selective carbonic anhydrase IX, XII inhibitors with anti-proliferative activity: design, synthesis and in silico studies","volume":"153","author":"Fadaly","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.136020","article-title":"A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: synthesis, mechanistic studies and diverse biological activities of dihydropyrimidines","volume":"1291","author":"Faizan","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.110619_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107154","article-title":"Design, synthesis and in silico insights of novel 1,2,3-triazole benzenesulfonamide derivatives as potential carbonic anhydrase IX and XII inhibitors with promising anticancer activity","volume":"144","author":"Abdelhakeem","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/17568919.2025.2453420","article-title":"A series of benzensulfonamide derivatives as new potent carbonic anhydrase IX and XII inhibitors","volume":"17","author":"Nencetti","year":"2025","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107096","article-title":"Novel 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide based thiosemicarbazides as potent and selective inhibitors of tumor-associated human carbonic anhydrase IX and XII: synthesis, cytotoxicity, and molecular modelling studies","volume":"144","author":"Demir-Yaz\u0131c\u0131","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.138134","article-title":"Unveiling the impact: a decade review on dihydropyrimidinones (DHPMs) to combat breast cancer","volume":"1308","author":"Nikam","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.110619_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.137802","article-title":"Biginelli dihydropyrimidines carrying azole rings: synthesis, computational studies, and evaluation of alpha-glucosidase inhibitory and antimicrobial activities","volume":"1306","author":"Ko\u00e7ak Aslan","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.110619_bb0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1021\/ml500433j","article-title":"Structural insights for the optimization of Dihydropyrimidin-2(1H)-one based mPGES-1 inhibitors","volume":"6","author":"Terracciano","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.110619_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/ph15070773","article-title":"Design and synthesis of hepatitis B virus (HBV) capsid assembly modulators and evaluation of their activity in mammalian cell model","volume":"15","author":"Spunde","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bioorg.2026.110619_bb0080","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S1074-5521(02)00212-0","article-title":"Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5","volume":"9","author":"Maliga","year":"2002","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.110619_bb0085","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2174\/1389557521666210920120457","article-title":"An overview of synthesis and biological activity of Dihydropyrimidine derivatives","volume":"22","author":"Dudhe","year":"2022","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0090","doi-asserted-by":"crossref","first-page":"905","DOI":"10.4155\/fmc-2024-0010","article-title":"The anticancer therapeutic potential of pyrimidine\u2013sulfonamide hybrids","volume":"16","author":"Zhang","year":"2024","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114004","article-title":"Application of the dual-tail approach for the design and synthesis of novel thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors","volume":"228","author":"Abdel-Mohsen","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0100","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1016\/j.bmc.2016.06.005","article-title":"Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine\u2013benzenesulfonamides acting as carbonic anhydrase inhibitors","volume":"24","author":"Vullo","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0105","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1039\/D4MD00101J","article-title":"Benzenesulfonamide decorated dihydropyrimidin(thi)ones: carbonic anhydrase profiling and antiproliferative activity","volume":"15","author":"Aslan","year":"2024","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0110","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.14233\/ajchem.2015.18615","article-title":"A green approach to synthesize dihydropyrimidinone derivatives by using anhydrous ZnCl2 catalyst under refluxing condition in heptane-toluene medium via Biginelli reaction","volume":"27","author":"Akhter","year":"2015","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0115","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1002\/chem.201204314","article-title":"The Biginelli reaction with an imidazolium\u2013tagged recyclable iron catalyst: kinetics, mechanism, and antitumoral activity","volume":"19","author":"Ramos","year":"2013","journal-title":"Chem. - Eur. J."},{"key":"10.1016\/j.bioorg.2026.110619_bb0120","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1007\/s11164-022-04764-z","article-title":"A facile one-pot three component synthesis of 3, 4-dihydropyrimidin-2(1H)-ones or thiones promoted by a polymer-supported BF3 under solvent-free conditions","volume":"48","author":"Karimi Zarchi","year":"2022","journal-title":"Res. Chem. Intermed."},{"key":"10.1016\/j.bioorg.2026.110619_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.201700299","article-title":"Design, synthesis, and molecular docking of novel indole scaffold-based VEGFR-2 inhibitors as targeted anticancer agents","volume":"351","author":"Roaiah","year":"2018","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bioorg.2026.110619_bb0130","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/prac.19620170507","article-title":"Quartern\u00e4re Triphenylphosphoniumverbindungen","volume":"17","author":"F\u00fcrst","year":"1962","journal-title":"J. Prakt. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.201700299","article-title":"Design, synthesis, and molecular docking of novel indole scaffold-based VEGFR-2 inhibitors as targeted anticancer agents","volume":"351","author":"Roaiah","year":"2018","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bioorg.2026.110619_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2025.1606848","article-title":"A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin\/carbonic anhydrase IX inhibitor with anticancer activity","volume":"13","author":"Khasawneh","year":"2025","journal-title":"Front. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0145","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.7150\/thno.20982","article-title":"Cancer radiotheranostics targeting carbonic anhydrase-IX with 111In- and 90Y-labeled ureidosulfonamide scaffold for SPECT imaging and radionuclide-based therapy","volume":"8","author":"Iikuni","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bioorg.2026.110619_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107096","article-title":"Novel 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide based thiosemicarbazides as potent and selective inhibitors of tumor-associated human carbonic anhydrase IX and XII: synthesis, cytotoxicity, and molecular modelling studies","volume":"144","author":"Demir-Yaz\u0131c\u0131","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0155","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1021\/acs.jmedchem.6c01549","article-title":"Design and synthesis of Bendamustine-carbonic anhydrase inhibitors with antiproliferative effects in clear cell renal cell carcinoma","volume":"69","author":"Renzi","year":"2026","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0160","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1021\/acsomega.2c07459","article-title":"Tail-approach-based design and synthesis of coumarin-monoterpenes as carbonic anhydrase inhibitors and anticancer agents","volume":"8","author":"Zengin Kurt","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.bioorg.2026.110619_bb0165","doi-asserted-by":"crossref","first-page":"12596","DOI":"10.1073\/pnas.95.21.12596","article-title":"Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes","volume":"95","author":"Ivanov","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioorg.2026.110619_bb0170","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1021\/acs.jmedchem.5c03157","article-title":"Targeting metabolic and pH regulatory pathways in Cancer via dual inhibition of nicotinamide Phosphoribosyltransferase and carbonic anhydrases IX and XII","volume":"69","author":"Paoletti","year":"2026","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0175","doi-asserted-by":"crossref","first-page":"22450","DOI":"10.1039\/D6RA02423H","article-title":"New benzochromene-based compounds as potential EGFR-TK inhibitors: synthesis, anti-proliferative activity, molecular docking studies, and ADME profiles","volume":"16","author":"Hekal","year":"2026","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2026.110619_bb0180","doi-asserted-by":"crossref","DOI":"10.1007\/s11030-026-11543-0","article-title":"Quinazoline-sulfonamide hybrids as multitarget anticancer agents: inhibition of carbonic anhydrase IX\/XII isoforms and VEGFR-2 with in vitro and in silico validation","author":"Zeidan","year":"2026","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bioorg.2026.110619_bb0185","doi-asserted-by":"crossref","DOI":"10.1039\/D5MD01147G","article-title":"Structure-based design of potent pyrazolo[1,5-a]pyrimidine CDK4\/6 inhibitors: biological evaluation and computational validation","author":"Binjubair","year":"2026","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/molecules31060917","article-title":"Discovery of a novel coumarin\/thiazole chalcone hybrid as a potent dual inhibitor of tubulin and carbonic anhydrases IX & XII with promising anti-proliferative activity","volume":"31","author":"Saleem","year":"2026","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.110619_bb0195","doi-asserted-by":"crossref","first-page":"9004","DOI":"10.1021\/acs.jmedchem.5b01343","article-title":"Efficient expression and crystallization system of Cancer-associated carbonic anhydrase isoform IX","volume":"58","author":"Leitans","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0200","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1021\/acs.jmedchem.3c00007","article-title":"Atropo\/tropo flexibility: a tool for design and synthesis of self-adaptable inhibitors of carbonic anhydrases and their antiproliferative effect","volume":"66","author":"Ivanova","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110619_bb0205","doi-asserted-by":"crossref","first-page":"W422","DOI":"10.1093\/nar\/gkae236","article-title":"ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support","volume":"52","author":"Fu","year":"2024","journal-title":"Nucleic Acids Res."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826011557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826011557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:51:27Z","timestamp":1792407087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826011557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":41,"alternative-id":["S0045206826011557"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110619","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel sulfonamide-containing dihydropyrimidine derivatives as potent inhibitors of tumor-associated carbonic anhydrase isoforms IX\/XII: Design, synthesis, and anticancer evaluation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110619"}}