{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:37:23Z","timestamp":1792831043751,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370419"],"award-info":[{"award-number":["32370419"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["MS2025005"],"award-info":[{"award-number":["MS2025005"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","award":["2026234"],"award-info":[{"award-number":["2026234"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bioorg.2026.110624","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:19:00Z","timestamp":1791213540000},"page":"110624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Opeturins I-XIV, structurally diverse resin glycosides from Operculina turpethum and their biological activities"],"prefix":"10.1016","volume":"183","author":[{"given":"Xin","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Ni","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Die","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yu","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Tong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Zhong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Yi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110624_bb0005","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1080\/14786419.2018.1539979","article-title":"Identification of anti-nociceptive constituents from the pollen of Typha angustifolia L. using effect-directed fractionation","volume":"34","author":"Zeng","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2026.110624_bb0010","doi-asserted-by":"crossref","DOI":"10.1186\/s13020-023-00745-5","article-title":"A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example","volume":"18","author":"Hu","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.bioorg.2026.110624_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00530","article-title":"Anticancer activity and mechanism of xanthohumol: a prenylated flavonoid from hops (Humulus lupulus L.)","volume":"9","author":"Jiang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110624_bb0020","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1002\/med.21916","article-title":"Chemistry and biological activity of resin glycosides from Convolvulaceae species","volume":"42","author":"Fan","year":"2022","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bioorg.2026.110624_bb0025","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1021\/acs.jnatprod.4c01182","article-title":"Controlins I-X, resin glycosides from the seeds of Convolvulus tricolor and their biological activities","volume":"88","author":"Li","year":"2025","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.110624_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2025.114494","article-title":"Isolation of pentasaccharide resin glycosides from the whole plants of Ipomoea biflora and their cytotoxic activities","volume":"236","author":"Gu","year":"2025","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2026.110624_bb0035","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/acs.jnatprod.5c00713","article-title":"Tetrasaccharide resin glycosides with nitric oxide production inhibitory activity from Cuscuta campestris","volume":"88","author":"Han","year":"2025","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.110624_bb0040","first-page":"227","article-title":"Two novel resin glycosides isolated from Ipomoea cairica with \u03b1-glucosidase inhibitory activity","volume":"14","author":"Li","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.bioorg.2026.110624_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/biom15101465","article-title":"Resin glycosides with \u03b1-glucosidase and protein tyrosine phosphatase 1B inhibitory activities from the seeds of Cuscuta japonica","volume":"15","author":"Guo","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioorg.2026.110624_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2025.106714","article-title":"Further new resin glycosides from Convolvulus tricolor seeds and their neuroprotective activities","volume":"185","author":"Fan","year":"2025","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bioorg.2026.110624_bb0055","article-title":"UHPLC-Q-TOF-MS\/MS profiling of resin glycosides and their lipase inhibitory activity in leaves of selected sweet potato (Ipomoea batatas L.) cultivars","volume":"13","author":"Lin","year":"2026","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bioorg.2026.110624_bb0060","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1021\/acs.jnatprod.5c01273","article-title":"Resin glycosides from Ipomoea funis as inhibitors of P-glycoprotein in multidrug-resistant breast carcinoma cells","volume":"89","author":"Flores-Tafoya","year":"2026","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.110624_bb0065","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.2147\/DDDT.S494417","article-title":"Traditional uses, phytochemistry, pharmacology and toxicology of Ruta graveolens L.: a critical review and future perspectives","volume":"18","author":"Luo","year":"2024","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bioorg.2026.110624_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140154","article-title":"Extraction, purification, structural characterization, and anti-inflammatory activity of a polysaccharide from Lespedeza formosa","volume":"300","author":"Tan","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2026.110624_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.139095","article-title":"Physicochemical characterization and antitumor activity in vitro of a polysaccharide from Christia vespertilionis","volume":"290","author":"Xiao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2026.110624_bb0080","doi-asserted-by":"crossref","first-page":"494","DOI":"10.26599\/FSHW.2022.9250043","article-title":"A comparison study on structure-function relationship of polysaccharides obtained from sea buckthorn berries using different methods: antioxidant and bile acid-binding capacity","volume":"13","author":"Li","year":"2024","journal-title":"Food Sci. Human Wellness"},{"key":"10.1016\/j.bioorg.2026.110624_bb0085","series-title":"Common chinese materia medica","first-page":"127","article-title":"Medicinal angiosperms of Convolvulaceae","volume":"8","author":"Ye","year":"2022"},{"key":"10.1016\/j.bioorg.2026.110624_bb0090","first-page":"594","article-title":"Chemical constituents of Zhuang medicine Operculina turpethum","volume":"45","author":"Li","year":"2022","journal-title":"J. Chin. Med. Mat."},{"key":"10.1016\/j.bioorg.2026.110624_bb0095","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4103\/phrev.phrev_6_17","article-title":"Operculina turpethum (Linn.) Silva Manso as a medicinal plant species: a review on bioactive components and pharmacological properties","volume":"11","author":"Gupta","year":"2017","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.bioorg.2026.110624_bb0100","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1021\/np200274m","article-title":"Bioactive dammarane-type saponins from Operculina turpethum","volume":"74","author":"Ding","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.110624_bb0105","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.phytochem.2012.05.010","article-title":"Resin glycosides from the aerial parts of Operculina turpethum","volume":"81","author":"Ding","year":"2012","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2026.110624_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.archoralbio.2017.03.015","article-title":"Operculina turpethum extract inhibits growth and proliferation by inhibiting NF-\u03baB, COX-2 and cyclin D1 and induces apoptosis by up regulating P53 in oral cancer cells","volume":"80","author":"Arora","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bioorg.2026.110624_bb0115","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3329\/icpj.v1i9.11618","article-title":"Comparative antidiabetic activity of methanolic extract of Operculina turpethum stem and root against healthy and streptozotocin induced diabetic rats","volume":"1","author":"Pulipaka","year":"2012","journal-title":"Int. Curr. Pharm. J."},{"key":"10.1016\/j.bioorg.2026.110624_bb0120","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cbi.2009.06.021","article-title":"Operculina turpethum attenuates N-nitrosodimethylamine induced toxic liver injury and clastogenicity in rats","volume":"181","author":"Ahmad","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bioorg.2026.110624_bb0125","doi-asserted-by":"crossref","first-page":"453","DOI":"10.18203\/2319-2003.ijbcp20150015","article-title":"Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice","volume":"4","author":"Ezeja","year":"2015","journal-title":"Int. J. Basic Clin. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110624_bb0130","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1080\/14786419.2019.1672069","article-title":"Arvensic acids K and L, components of resin glycoside fraction from Convolvulus arvensis","volume":"35","author":"Lu","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2026.110624_bb0135","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1080\/14786419.2020.1736067","article-title":"Isolation of evolvulic acids B and C, two new components of crude resin glycoside fraction from Evolvulus alsinoides","volume":"35","author":"Xu","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2026.110624_bb0140","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1016\/j.tet.2017.03.059","article-title":"Pharesinosides A-G, acylated glycosidic acid methyl esters derivatized by NH2 silica gel on-column catalyzation from the crude resin glycosides of Pharbitis semen","volume":"73","author":"Bai","year":"2017","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bioorg.2026.110624_bb0145","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1021\/acs.jnatprod.9b00056","article-title":"Glycosidic acids with unusual aglycone units from Convolvulus arvensis","volume":"82","author":"Fan","year":"2019","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.110624_bb0150","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1080\/14786419.2020.1839465","article-title":"Isolation of a new monoterpenoid glycoside from Anhua dark tea based on an NMR-guided method and its cytotoxic activity against MDA-MB-231 and SH-SY5Y cell lines","volume":"36","author":"Zhang","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2026.110624_bb0155","article-title":"Two new limonoid glycosides from the seeds of Citrus limon and their PDE4D inhibitory activities","author":"Fu","year":"2024","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2026.110624_bb0160","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1021\/ja00479a014","article-title":"Determination of the absolute configuration of a secondary hydroxy group in a chiral secondary alcohol using glycosidation shifts in carbon-13 nuclear magnetic resonance spectroscopy","volume":"100","author":"Seo","year":"1978","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2026.110624_bb0165","doi-asserted-by":"crossref","first-page":"8450","DOI":"10.1021\/jacs.8b13506","article-title":"Ipomoeassin F binds Sec61\u03b1 to inhibit protein translocation","volume":"141","author":"Zong","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2026.110624_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2025.114454","article-title":"UPLC-TOF-MS\/MDF oriented isolation of calonyctins K-R: resin glycosides from Ipomoea muricata with cytotoxic and multidrug resistance reversal activities","volume":"235","author":"Li","year":"2025","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2026.110624_bb0175","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41589-023-01337-y","article-title":"A common mechanism of Sec61 translocon inhibition by small molecules","volume":"19","author":"Itskanov","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.110624_bb0180","article-title":"Truncated Dyrk1A aggravates neuronal apoptosis by inhibiting ASF-mediated Bcl-x exon 2b inclusion","volume":"30","author":"Zhang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bioorg.2026.110624_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.116916","article-title":"Sulforaphane inhibits the migration and invasion of BPDE-induced lung adenocarcinoma cells by regulating NLRP12","volume":"485","author":"Wang","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110624_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2023.105688","article-title":"\u03b1-Glucosidase inhibitors from the husks of rice Oryza sativa L","volume":"171","author":"Wang","year":"2023","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bioorg.2026.110624_bb0195","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1021\/jm0702478","article-title":"Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site","volume":"50","author":"Wilson","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110624_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2025.109624","article-title":"Glycosidic acids with \u03b1-glucosidase inhibitory activity as the alkaline hydrolysis products of resin glycoside fractions from Convolvulus tricolor and Ipomoea biflora","volume":"556","author":"Fan","year":"2025","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bioorg.2026.110624_bb0205","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1111\/cns.14250","article-title":"Super-high procoagulant activity of gecko thrombin: a gift from sky dragon","volume":"29","author":"Liang","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bioorg.2026.110624_bb0210","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat. Methods"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826011600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826011600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:03:18Z","timestamp":1792828998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826011600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":42,"alternative-id":["S0045206826011600"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110624","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Opeturins I-XIV, structurally diverse resin glycosides from Operculina turpethum and their biological activities","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110624"}}