{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:37:38Z","timestamp":1792831058217,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073739"],"award-info":[{"award-number":["82073739"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477140"],"award-info":[{"award-number":["22477140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bioorg.2026.110647","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:09:56Z","timestamp":1791846596000},"page":"110647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Natural product-like phenanthroquinolizidines: asymmetric synthesis and anti-glioblastoma activity evaluation"],"prefix":"10.1016","volume":"183","author":[{"given":"Ru-Bing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Shan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110647_bb0005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2026.110647_bb0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/acs.jnatprod.5c01368","article-title":"The role of natural product chemistry in drug discovery: two decades of progress and perspectives","volume":"89","author":"Butler","year":"2026","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2026.110647_bb0015","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ejmech.2012.02.048","article-title":"Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents","volume":"51","author":"Wang","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0020","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.1021\/acs.jmedchem.5b00764","article-title":"Design, synthesis, and biological activity of sulfonamide analogues of antofine and cryptopleurine as potent and orally active antitumor agents","volume":"58","author":"Kwon","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0025","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.2174\/1871520615666150520143600","article-title":"Recent advances in phenanthroindolizidine and phenanthroquinolizidine derivatives with anticancer activities","volume":"15","author":"Pereira","year":"2015","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0030","first-page":"2365","article-title":"Isolation, total synthesis and biological activity of phenanthroindolizidine and phenanthroquinolizidine alkaloids","author":"Li","year":"2001","journal-title":"Synthesis"},{"key":"10.1016\/j.bioorg.2026.110647_bb0035","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1039\/b516152e","article-title":"Expedient synthesis and structure\u2013activity relationships of phenanthroindolizidine and phenanthroquinolizidine alkaloids","volume":"4","author":"Chuang","year":"2006","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0040","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1016\/j.bmc.2008.04.032","article-title":"Total synthesis of phenanthroindolizidine alkaloids (\u00b1)-antofine, (\u00b1)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity","volume":"16","author":"Su","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0045","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.ejmech.2015.01.038","article-title":"Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2","volume":"92","author":"Christodoulou","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0050","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1021\/acs.jmedchem.6b01502","article-title":"6-OH-Phenanthroquinolizidine alkaloid and its derivatives exert potent anticancer activity by delaying s phase progression","volume":"60","author":"Liu","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0055","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/10286020.2011.566868","article-title":"Anticancer effect and neurotoxicity of S-(+)-deoxytylophorinidine, a new phenanthroindolizidine alkaloid that interacts with nucleic acids","volume":"13","author":"Liu","year":"2011","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2026.110647_bb0060","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1021\/ac400009s","article-title":"Air flow-assisted ionization imaging mass spectrometry method for easy whole-body molecular imaging under ambient conditions","volume":"85","author":"Luo","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0065","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3892\/ijo.2015.2977","article-title":"The novel anti-neuroblastoma agent PF403, inhibits proliferation and invasion in vitro and in brain xenografts","volume":"47","author":"Li","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bioorg.2026.110647_bb0070","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.canlet.2016.07.030","article-title":"CAT3, a novel agent for medulloblastoma and glioblastoma treatment, inhibits tumor growth by disrupting the Hedgehog signaling pathway","volume":"381","author":"Chen","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2026.110647_bb0075","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.2147\/OTT.S163535","article-title":"CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression","volume":"11","author":"Ji","year":"2018","journal-title":"Onco. Targets Ther."},{"key":"10.1016\/j.bioorg.2026.110647_bb0080","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1002\/ptr.7099","article-title":"Natural products: a lead for drug discovery and development","volume":"35","author":"Chopra","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bioorg.2026.110647_bb0085","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/17460441.2016.1272757","article-title":"The structural modification of natural products for novel drug discovery","volume":"12","author":"Yao","year":"2017","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.bioorg.2026.110647_bb0090","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1021\/acs.accounts.4c00820","article-title":"Diversity-Generating Skeletal Editing Transformations","volume":"58","author":"Wu","year":"2025","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bioorg.2026.110647_bb0095","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/s41557-024-01668-w","article-title":"Diversified ring expansion of saturated cyclic amines enabled by azlactone insertion","volume":"16","author":"Wu","year":"2024","journal-title":"Nat. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.apsb.2016.06.003","article-title":"The modification of natural products for medical use","volume":"7","author":"Guo","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2026.110647_bb0105","doi-asserted-by":"crossref","first-page":"607","DOI":"10.31635\/ccschem.025.202506288","article-title":"Skeletal editing of cyclic scaffolds","volume":"8","author":"Bi","year":"2026","journal-title":"CCS Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0110","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1021\/ja01537a044","article-title":"Aromatic cyclodehydration. XXXVI.1,2 the synthesis of (\u00b1)-cryptopleurine","volume":"80","author":"Bradsher","year":"1958","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2026.110647_bb0115","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0040-4020(01)92177-5","article-title":"Chemical examination of tylophora asthmatica\u2014IV: synthesis of tylophorine","volume":"14","author":"Govindachari","year":"1961","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bioorg.2026.110647_bb0120","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1021\/jo500013e","article-title":"Collective asymmetric aynthesis of (\u2212)-antofine, (\u2212)-cryptopleurine, (\u2212)-tylophorine, and (\u2212)-tylocrebrine with tert-butanesulfinamide as a chiral auxiliary","volume":"79","author":"Zheng","year":"2014","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0125","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1039\/C5OB02624E","article-title":"Concise asymmetric syntheses of novel phenanthroquinolizidines","volume":"14","author":"Anton-Torrecillas","year":"2016","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0130","doi-asserted-by":"crossref","first-page":"11902","DOI":"10.1021\/acs.joc.9b01768","article-title":"Total synthesis of phenanthroquinolizidine alkaloids using a building block strategy","volume":"84","author":"Jo","year":"2019","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0135","doi-asserted-by":"crossref","first-page":"29301","DOI":"10.1039\/C8RA04511A","article-title":"A novel and practical synthesis of CAT3: a phenanthroindolizidine alkaloid with potential in treating glioblastoma","volume":"8","author":"Wang","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2026.110647_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108752","article-title":"Discovery of 1,2,3-triazole derivatives of phenanthroindolizidine to reverse temozolomide resistance in glioblastoma","volume":"163","author":"Feng","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0145","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1021\/acs.jmedchem.5b00270","article-title":"Design, synthesis, and structure\u2013activity relationship studies of 3-(phenylethynyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives as a new class of src inhibitors with potent activities in models of triple negative breast cancer","volume":"58","author":"Zhang","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0150","doi-asserted-by":"crossref","first-page":"12022","DOI":"10.1021\/acs.jmedchem.1c00678","article-title":"Discovery, synthesis, and evaluation of highly selective vascular endothelial growth factor receptor 3 (VEGFR3) inhibitor for the potential treatment of metastatic triple-negative breast cancer","volume":"64","author":"Li","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0155","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1021\/acs.jmedchem.2c00940","article-title":"Boronic acid: a novel pharmacophore targeting Src Homology 2 (SH2) domain of STAT3","volume":"65","author":"Deng","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115538","article-title":"Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer","volume":"258","author":"Eldehna","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.110647_bb0165","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3390\/ijms23031123","article-title":"EN1 regulates cell growth and proliferation in human glioma cells via hedgehog signaling","volume":"23","author":"Chang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110647_bb0170","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1007\/s13277-015-3442-y","article-title":"The hedgehog antagonist HHIP as a favorable prognosticator in glioblastoma","volume":"37","author":"Chang","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.bioorg.2026.110647_bb0175","doi-asserted-by":"crossref","first-page":"200","DOI":"10.15252\/embj.201489213","article-title":"Gli1\/DNA interaction is a druggable target for Hedgehog-dependent tumors","volume":"34","author":"Infante","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.bioorg.2026.110647_bb0180","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12935-017-0491-x","article-title":"Hedgehog\/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma","volume":"17","author":"Wang","year":"2017","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bioorg.2026.110647_bb0185","doi-asserted-by":"crossref","first-page":"27000","DOI":"10.18632\/oncotarget.25467","article-title":"Investigating the role of Hedgehog\/Gli1 signaling in glioblastoma cell response to temozolomide","volume":"9","author":"Melamed","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.bioorg.2026.110647_bb0190","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2217\/cns.12.5","article-title":"State of the art and perspectives in the treatment of glioblastoma","volume":"1","author":"Grimm","year":"2012","journal-title":"CNS Oncol."},{"key":"10.1016\/j.bioorg.2026.110647_bb0195","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2174\/1570159X18666200626204005","article-title":"Temozolomide: an updated overview of resistance mechanisms, nanotechnology advances and clinical applications","volume":"19","author":"Ortiz","year":"2021","journal-title":"Curr. Neuropharmacol."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826011831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826011831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:06:36Z","timestamp":1792829196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826011831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":39,"alternative-id":["S0045206826011831"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110647","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural product-like phenanthroquinolizidines: asymmetric synthesis and anti-glioblastoma activity evaluation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110647"}}