{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:47:41Z","timestamp":1792255661020,"version":"4.4.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bioorg.2026.110650","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:12:55Z","timestamp":1792105975000},"page":"110650","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Carboplatin-derived dinuclear Pt(IV) prodrug linked by 1,6-Diaminohexane: Design, synthesis, reduction chemistry, DNA interaction, and antitumor activity"],"prefix":"10.1016","volume":"184","author":[{"given":"Hosein","family":"Keivanshekooh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboube","family":"Eslami Moghadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Ghassemzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Jafarkhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.110650_bb0005","series-title":"Global cancer burden growing, amidst mounting need for service","author":"World Health Organization","year":"2024"},{"issue":"3","key":"10.1016\/j.bioorg.2026.110650_bb0010","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bioorg.2026.110650_bb0015","doi-asserted-by":"crossref","unstructured":"C. Stewart, C. Ralyea, Lockwood, Ovarian cancer: an integrated review, Semin. Oncol. Nurs., WB Saunders, 35 (2) (2019) 151\u2013156, Doi: https:\/\/doi.org\/10.1016\/j.soncn.2019.02.001.","DOI":"10.1016\/j.soncn.2019.02.001"},{"key":"10.1016\/j.bioorg.2026.110650_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/20503121211034366","article-title":"New approaches and procedures for cancer treatment: current perspectives","volume":"9","author":"Debela","year":"2021","journal-title":"SAGE Open Med."},{"issue":"15","key":"10.1016\/j.bioorg.2026.110650_bb0025","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1021\/acs.jcim.2c00367","article-title":"Graph neural network with self-supervised learning for noncoding rna\u2013drug resistance association prediction","volume":"62","author":"Zheng","year":"2022","journal-title":"J. Chem. Inf. Model."},{"issue":"5","key":"10.1016\/j.bioorg.2026.110650_bb0030","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.7150\/thno.69424","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"issue":"19","key":"10.1016\/j.bioorg.2026.110650_bb0035","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1039\/C8DT00838H","article-title":"The side effects of platinum-based chemotherapy drugs: a review for chemists","volume":"47","author":"Oun","year":"2018","journal-title":"Dalton Trans."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.62382\/jcbt.v2i1.32","article-title":"Therapeutic efficacy of platinum based medicines combined with various nanoparticles in the treatment of colorectal cancer: a comprehensive review","volume":"2","author":"Meng","year":"2025","journal-title":"J. Cancer Biomol. Ther."},{"issue":"9","key":"10.1016\/j.bioorg.2026.110650_bb0045","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1002\/cbdv.201200019","article-title":"Diamminetetrakis (carboxylato) platinum (IV) complexes\u2013synthesis, characterization, and cytotoxicity","volume":"9","author":"Hoffmeister","year":"2012","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bioorg.2026.110650_bb0050","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jinorgbio.2012.06.013","article-title":"What do we know about the reduction of Pt (IV) pro-drugs?","volume":"117","author":"Wexselblatt","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2026.110650_bb0055","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2026.110650_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2023.121388","article-title":"An overview of recent advancements in anticancer Pt(IV) prodrugs: new smart drug combinations, activation, and delivery strategies","volume":"548","author":"Marotta","year":"2023","journal-title":"Inorg. Chim. Acta"},{"issue":"24","key":"10.1016\/j.bioorg.2026.110650_bb0065","doi-asserted-by":"crossref","first-page":"11052","DOI":"10.1021\/jm301645g","article-title":"Unsymmetric mono-and dinuclear platinum (IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity","volume":"55","author":"Pichler","year":"2012","journal-title":"J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2026.110650_bb0070","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nrd.2018.46","article-title":"The expanding role of prodrugs in contemporary drug design and development","volume":"17","author":"Rautio","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1734-1140(13)70959-9","article-title":"Prodrugs: a challenge for the drug development","volume":"65","author":"Zawilska","year":"2013","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bioorg.2026.110650_bb0080","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.1021\/acs.inorgchem.0c00445","article-title":"Multiaction Pt(IV) carbamate complexes can codeliver Pt(II) drugs and amine-containing bioactive molecules","volume":"59","author":"Babu","year":"2020","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bioorg.2026.110650_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.213991","article-title":"Recent advances in the synthesis, stability, and activation of platinum (IV) anticancer prodrugs","volume":"442","author":"Xu","year":"2021","journal-title":"Coord. Chem. Rev."},{"issue":"02","key":"10.1016\/j.bioorg.2026.110650_bb0090","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4236\/ijmpcero.2018.72020","article-title":"Current status for oral platinum (IV) anticancer drug development","volume":"7","author":"Mi","year":"2018","journal-title":"Int. J. Med. Phys. Clin. Eng. Radiat. Oncol."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110650_bb0095","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1039\/C4SC01892C","article-title":"Encapsulation of Pt (IV) prodrugs within a Pt (II) cage for drug delivery","volume":"6","author":"Zheng","year":"2015","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioorg.2026.110650_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.141394","article-title":"Reduction of anticancer prodrugs cis-diamminetetrachloroplatinum (IV) and ormaplatin by a large series of thiols: phenomenal structure-reactivity correlations","volume":"1329","author":"Xia","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2026.110650_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110349","article-title":"Multi-target activity of copper complexes: antibacterial, DNA binding, and molecular docking with SARS-CoV-2 receptor","volume":"373","author":"Arthi","year":"2023","journal-title":"Chem. Biol. Interact."},{"issue":"76","key":"10.1016\/j.bioorg.2026.110650_bb0110","doi-asserted-by":"crossref","first-page":"11271","DOI":"10.1039\/D0CC01846E","article-title":"Imidazole-modified Pt (IV) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance","volume":"56","author":"Kang","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioorg.2026.110650_bb0115","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.msec.2018.10.092","article-title":"Delivery of platinum (II) drugs with bulky ligands in trans-geometry for overcoming cisplatin drug resistance","volume":"96","author":"Yang","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioorg.2026.110650_bb0120","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.actbio.2023.02.012","article-title":"NIR-II light evokes DNA cross-linking for chemotherapy and immunogenic cell death","volume":"160","author":"Huang","year":"2023","journal-title":"Acta Biomater."},{"issue":"23","key":"10.1016\/j.bioorg.2026.110650_bb0125","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01972-20","article-title":"Diamine biosynthesis: research progress and application prospects","volume":"86","author":"Wang","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110650_bb0130","doi-asserted-by":"crossref","first-page":"112","DOI":"10.7251\/jepm1902112h","article-title":"Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from benzidine and 1, 3-diphenyl-1, 3-propanedione","volume":"11","author":"Horozi\u0107","year":"2019","journal-title":"Journal of Engineering & Processing Management"},{"key":"10.1016\/j.bioorg.2026.110650_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.tetlet.2020.152706","article-title":"Synthesis, characterisation and cytotoxic activity evaluation of new metal-salen complexes based on the 1, 2-bicyclo [2.2. 2] octane bridge","volume":"63","author":"Milbeo","year":"2021","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2026.110650_bb0140","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.cjche.2020.12.009","article-title":"The production of biobased diamines from renewable carbon sources: current advances and perspectives","volume":"30","author":"Wang","year":"2021","journal-title":"Chin. J. Chem. Eng."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110650_bb0145","first-page":"4900","article-title":"Identification of metabolites of the cell-differentiating agent hexamethylene bisacetamide in humans","volume":"46","author":"Callery","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2026.110650_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.148013","article-title":"Pt (IV) prodrugs containing aliphatic amine in axial ligands with anticancer properties: advanced synthesis, solubility, reduction, cytotoxicity, cell mechanism, DNA interaction, molecular docking, and molecular dynamics simulations","author":"Sadeghi","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2026.110650_bb0155","article-title":"High cancer selectivity and improving drug release from mesoporous silica nanoparticles in the presence of human serum albumin in cisplatin, carboplatin, oxaliplatin, and oxalipalladium treatment","volume":"187","author":"Moghadam","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"issue":"19","key":"10.1016\/j.bioorg.2026.110650_bb0160","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1063\/1.470117","article-title":"A smooth particle mesh Ewald method","volume":"103","author":"Essmann","year":"1995","journal-title":"J. Chem. Phys."},{"issue":"10","key":"10.1016\/j.bioorg.2026.110650_bb0165","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1021\/ic971047x","article-title":"Reduction and anticancer activity of platinum (IV) complexes","volume":"37","author":"Choi","year":"1998","journal-title":"Inorg. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2026.110650_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22083817","article-title":"Pt (IV) prodrugs with NSAIDs as axial ligands","volume":"22","author":"Spector","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110650_bb0175","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1039\/D3QI02032K","article-title":"Kowol, Stepwise optimization of tumor-targeted dual-action platinum (IV)-gemcitabine prodrugs","volume":"11","author":"Kastner","year":"2024","journal-title":"Inorg. Chem. Front."},{"issue":"3","key":"10.1016\/j.bioorg.2026.110650_bb0180","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1021\/acs.jcim.0c00002","article-title":"DNA structural distortions induced by a monofunctional trinuclear platinum complex with various cross-links using molecular dynamics simulation","volume":"60","author":"Li","year":"2020","journal-title":"J. Chem. Inf. Model."},{"issue":"8","key":"10.1016\/j.bioorg.2026.110650_bb0185","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.1021\/acs.jmedchem.3c02393","article-title":"Promising anticancer prodrugs based on Pt (IV) complexes with bis-organosilane ligands in axial positions","volume":"67","author":"Navas","year":"2024","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2026.110650_bb0190","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1021\/ar100140e","article-title":"Metal complexes as DNA intercalators","volume":"44","author":"Liu","year":"2011","journal-title":"Acc. Chem. Res."},{"issue":"12","key":"10.1016\/j.bioorg.2026.110650_bb0195","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1080\/00032719.2010.546027","article-title":"HPLC method for the determination of the purity of K [Pt (NH3)Cl3], a precursor of the platinum complexes with cytostatic activity","volume":"44","author":"Potuck\u00e1","year":"2011","journal-title":"Anal. Lett."},{"key":"10.1016\/j.bioorg.2026.110650_bb0200","article-title":"New anticancer potential Pt complex with tertamyl dithiocarbamate ligand: synthesis, DNA targeting behavior, molecular dynamics, and biological activity","volume":"379","author":"Moghadam","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioorg.2026.110650_bb0205","doi-asserted-by":"crossref","unstructured":"G. Liang, T. Sadhukhan, S. Banerjee, D. Tang, H. Zhang, M. Cui, N. Montesdeoca, J. Karges, H. Xiao, Reduction of platinum (IV) prodrug hemoglobin nanoparticles with deeply penetrating ultrasound radiation for tumor-targeted therapeutically enhanced anticancer therapy, Angew. Chem. Int. Ed. 62 (22) (2023) e202301074, Doi: https:\/\/doi.org\/10.1002\/anie.202301074.","DOI":"10.1002\/anie.202301074"},{"issue":"8","key":"10.1016\/j.bioorg.2026.110650_bb0210","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1021\/cr4004314","article-title":"Synthetic methods for the preparation of platinum anticancer complexes","volume":"114","author":"Wilson","year":"2014","journal-title":"Chem. Rev."},{"issue":"11","key":"10.1016\/j.bioorg.2026.110650_bb0215","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1039\/D3SC03092J","article-title":"Tuning the photoactivated anticancer activity of Pt (IV) compounds via distant ferrocene conjugation","volume":"15","author":"Shi","year":"2024","journal-title":"Chem. Sci."},{"issue":"16","key":"10.1016\/j.bioorg.2026.110650_bb0220","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1016\/j.cell.2024.05.059","article-title":"Guidelines for minimal information on cellular senescence experimentation in vivo","volume":"187","author":"Ogrodnik","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2026.110650_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.124809","article-title":"Effect of geometric isomerism on the anticancer property of new platinum complexes with glycine derivatives as asymmetric N, O donate ligands against human cancer","volume":"322","author":"Kadivar","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0230","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/0471142700.nc0711s11","article-title":"Characterization of DNA structures by circular dichroism","volume":"11","author":"Bishop","year":"2002","journal-title":"Curr. Protoc. Nucleic Acid Chem."},{"issue":"13","key":"10.1016\/j.bioorg.2026.110650_bb0235","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1039\/D4DT03067B","article-title":"Water-soluble luminescent platinum (ii) complexes for guanine quadruplex binding","volume":"54","author":"Kroos","year":"2025","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2026.110650_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.117853","article-title":"DNA\/BSA binding affinity studies of new pd(II) complex with SS and NN donor mixed ligands via experimental insight and molecular simulation: preliminary antitumor activity, lipophilicity, and DFT perspective","volume":"344","author":"Feizi-Dehnayebi","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioorg.2026.110650_bb0245","article-title":"Biological interaction of Pt complex with imidazole derivative as an anticancer compound with DNA: experimental and theoretical studies","volume":"249","author":"Moghadam","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0250","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/0471250953.bi0814s24","article-title":"Using autodock for ligand-receptor docking","volume":"24","author":"Morris","year":"2008","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.bioorg.2026.110650_bb0255","article-title":"Tropisetron-induced apoptosis: a study on SKOV3 cell viability and gene expression","author":"Tavakoli","year":"2024","journal-title":"Iran. J. Pediatr. Hematol."},{"issue":"2","key":"10.1016\/j.bioorg.2026.110650_bb0260","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202301367","article-title":"Toxicity evaluation of anti-cholinesterasic amphibian extracts by MTT and an optimized Artemia salina test","volume":"21","author":"Spinelli","year":"2024","journal-title":"Chem. Biodivers."},{"issue":"18","key":"10.1016\/j.bioorg.2026.110650_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/polym13183153","article-title":"Simulation, in vitro, and in vivo cytotoxicity assessments of methotrexate-loaded pH-responsive nanocarriers","volume":"13","author":"Barani","year":"2021","journal-title":"Polymers"},{"issue":"10","key":"10.1016\/j.bioorg.2026.110650_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14102013","article-title":"In vitro and in vivo relevant antineoplastic activity of platinum (II) complexes toward triple-negative MDA-MB-231 breast cancer cell line","volume":"14","author":"Maciel","year":"2022","journal-title":"Pharmaceutics"},{"issue":"14","key":"10.1016\/j.bioorg.2026.110650_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16142544","article-title":"Anticancer effect of PtIIPHENSS, PtII5MESS, PtII56MESS and their platinum (IV)-dihydroxy derivatives against triple-negative breast cancer and cisplatin-resistant colorectal cancer","volume":"16","author":"Elias","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.bioorg.2026.110650_bb0280","series-title":"The Protein Protocols Handbook","first-page":"17","article-title":"The Bradford method for protein quantitation","author":"Kruger","year":"2009"},{"key":"10.1016\/j.bioorg.2026.110650_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2023.131872","article-title":"Exploring the effects of micro-nano surface topography on MG63 osteoblast-like cell responses: an in vitro study","volume":"675","author":"Jafarkhani","year":"2023","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0290","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1038\/s41598-023-32075-9","article-title":"Modulation of cytotoxic amyloid fibrillation and mitochondrial damage of \u03b1-synuclein by catechols mediated conformational changes","volume":"13","author":"Zohoorian-Abootorabi","year":"2023","journal-title":"Sci. Rep."},{"issue":"8002","key":"10.1016\/j.bioorg.2026.110650_bb0295","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41586-023-07009-0","article-title":"Genetic determinants of micronucleus formation in vivo","volume":"627","author":"Adams","year":"2024","journal-title":"Nat"},{"key":"10.1016\/j.bioorg.2026.110650_bb0300","doi-asserted-by":"crossref","first-page":"14948","DOI":"10.1021\/acs.jmedchem.3c01516","article-title":"Structural patterns enhancing the antibacterial activity of metallacarborane-based antibiotics","volume":"66","author":"Cebula","year":"2023","journal-title":"J. Med. Chem."},{"issue":"47","key":"10.1016\/j.bioorg.2026.110650_bb0305","doi-asserted-by":"crossref","first-page":"14404","DOI":"10.1039\/C2DT31366A","article-title":"Novel tetracarboxylatoplatinum (IV) complexes as carboplatin prodrugs","volume":"41","author":"Varbanov","year":"2012","journal-title":"Dalton Trans."},{"issue":"23","key":"10.1016\/j.bioorg.2026.110650_bb0310","doi-asserted-by":"crossref","first-page":"8167","DOI":"10.1039\/D1DT00214G","article-title":"Multifunctional Pt (IV) prodrug candidates featuring the carboplatin core and deferoxamin","volume":"50","author":"Harringer","year":"2021","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2026.110650_bb0315","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jorganchem.2019.06.034","article-title":"Synthesis and characterization of binuclear Pt (IV) complexes and tetranuclear mixed valence complexes of platinum (II)-platinum (IV)","volume":"897","author":"Casas","year":"2019","journal-title":"J. Organomet. Chem."},{"issue":"15","key":"10.1016\/j.bioorg.2026.110650_bb0320","doi-asserted-by":"crossref","first-page":"8572","DOI":"10.1021\/acsomega.9b04421","article-title":"DFT-calculated IR spectrum amide I, II, and III band contributions of N-methylacetamide fine components","volume":"5","author":"Ji","year":"2020","journal-title":"ACS Omega"},{"issue":"23","key":"10.1016\/j.bioorg.2026.110650_bb0325","doi-asserted-by":"crossref","first-page":"15586","DOI":"10.1039\/D3CP01150J","article-title":"The current status in computational exploration of Pt (IV) prodrug activation by reduction","volume":"25","author":"Ponte","year":"2023","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bioorg.2026.110650_bb0330","article-title":"Binding interaction between human serum albumin and cisplatin analogs substituted with different amine ligands: multi-spectroscopic investigation, molecular docking, and molecular dynamics simulations","author":"Moghadam","year":"2026","journal-title":"Arch. Biochem. Biophys."},{"issue":"09","key":"10.1016\/j.bioorg.2026.110650_bb0335","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1055\/s-2007-981458","article-title":"Liquid chromatography tandem-mass spectrometry (LC-MS\/MS) technique and applications in endocrinology","volume":"115","author":"Vogeser","year":"2007","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"10","key":"10.1016\/j.bioorg.2026.110650_bb0340","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1039\/C2DT32360E","article-title":"Molecular interaction fields vs. quantum-mechanical-based descriptors in the modelling of lipophilicity of platinum (IV) complexes","volume":"42","author":"Ermondi","year":"2013","journal-title":"Dalton Trans."},{"issue":"7","key":"10.1016\/j.bioorg.2026.110650_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072325","article-title":"Platinum (IV) complexes of trans-1, 2-diamino-4-cyclohexene: prodrugs affording an oxaliplatin analogue that overcomes cancer resistance","volume":"21","author":"Papadia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.110650_bb0350","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0162-0134(01)00360-9","article-title":"Studies of the binding of a series of platinum (IV) complexes to plasma proteins","volume":"88","author":"Dolman","year":"2002","journal-title":"J. Inorg. Biochem."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110650_bb0355","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1039\/C1CC16647F","article-title":"Pt (IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate","volume":"48","author":"Zhang","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioorg.2026.110650_bb0360","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jinorgbio.2016.03.005","article-title":"The role of the equatorial ligands for the redox behavior, mode of cellular accumulation, and cytotoxicity of platinum (IV) prodrugs","volume":"160","author":"G\u00f6schl","year":"2016","journal-title":"J. Inorg. Biochem."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0365","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0165-022X(88)90100-5","article-title":"In the absence of catalytic metals, ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals","volume":"16","author":"Buettner","year":"1988","journal-title":"J. Biochem. Biophys. Methods"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0370","doi-asserted-by":"crossref","first-page":"20225","DOI":"10.1038\/s41598-022-24580-0","article-title":"Ascorbic acid does not necessarily interfere with the electrochemical detection of dopamine","volume":"12","author":"Rantataro","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.bioorg.2026.110650_bb0375","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1021\/acs.inorgchem.8b03486","article-title":"Antitumor platinium (IV) prodrugs: a systematic computational exploration of their reduction mechanism by L-ascorbic acid","volume":"58","author":"Dabbish","year":"2019","journal-title":"Inorg. Chem."},{"issue":"11","key":"10.1016\/j.bioorg.2026.110650_bb0380","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1021\/acs.inorgchem.1c00410","article-title":"Strongly luminescent Pt (IV) complexes with a Mesoionic N-heterocyclic carbene ligand: tuning their photophysical properties","volume":"60","author":"Vivancos","year":"2021","journal-title":"Inorg. Chem."},{"issue":"44","key":"10.1016\/j.bioorg.2026.110650_bb0385","doi-asserted-by":"crossref","first-page":"39794","DOI":"10.1021\/acsomega.2c03776","article-title":"Biological activity of two anticancer Pt complexes with a cyclohexylglycine ligand against a colon cancer cell line: theoretical and experimental study","volume":"7","author":"Hosseini-Hashemi","year":"2022","journal-title":"ACS Omega"},{"issue":"18","key":"10.1016\/j.bioorg.2026.110650_bb0390","doi-asserted-by":"crossref","first-page":"9694","DOI":"10.1021\/ic300957v","article-title":"Dependence of the reduction products of platinum(IV) prodrugs upon the configuration of the substrate, bulk of the carrier ligands, and nature of the reducing agent","volume":"51","author":"Sinisi","year":"2012","journal-title":"Inorg. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110650_bb0395","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00775-020-01789-w","article-title":"A multi-methodological inquiry of the behavior of cisplatin-based Pt(IV) derivatives in the presence of bioreductants with a focus on the isolated encounter complexes","volume":"25","author":"Corinti","year":"2020","journal-title":"JBIC"},{"key":"10.1016\/j.bioorg.2026.110650_bb0400","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0162-0134(03)00136-3","article-title":"Platinum (II) catalysis and radical intervention in reductions of platinum (IV) antitumor drugs by ascorbic acid","volume":"95","author":"Weaver","year":"2003","journal-title":"J. Inorg. Biochem."},{"issue":"13","key":"10.1016\/j.bioorg.2026.110650_bb0405","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26136270","article-title":"\u201cNon-classical\u201d platinum complexes: a concise review","volume":"26","author":"Bakalova","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110650_bb0410","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1080\/07391102.2020.1731601","article-title":"Interaction of bis (alkylamine) dichloropalladium (II) complexes with CT-DNA and BSA; their synthesis, characterization, antitumor, and antibacterial evaluations","volume":"39","author":"Mohammadlou","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.bioorg.2026.110650_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.125972","article-title":"Copper complexes with bis-mercaptobenzimidazoles: synthesis, crystal structures, biological activity, DNA binding, DFT and docking","volume":"413","author":"Kia","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioorg.2026.110650_bb0420","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00775-020-01770-7","article-title":"New minor groove covering DNA binding mode of dinuclear Pt (II) complexes with various pyridine-linked bridging ligands and dual anticancer-antiangiogenic activities","volume":"25","author":"Franich","year":"2020","journal-title":"JBIC J. Biol. Inorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0425","doi-asserted-by":"crossref","DOI":"10.1186\/s13065-025-01472-8","article-title":"Synthesis, crystal structural description, DNA binding, molecular docking, and anticancer evaluation of the novel platinum (IV) supramolecular complex","volume":"19","author":"Domyati","year":"2025","journal-title":"BMC Chem."},{"key":"10.1016\/j.bioorg.2026.110650_bb0430","article-title":"Anticancer activity of new oxaliplatin analogs with aliphatic glycine ligands","author":"Moghadam","year":"2026","journal-title":"J. Mol. Liq."},{"issue":"4","key":"10.1016\/j.bioorg.2026.110650_bb0435","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29040746","article-title":"Current status of novel multifunctional targeted Pt (IV) compounds and their reductive release properties","volume":"29","author":"Xu","year":"2024","journal-title":"Mol"},{"key":"10.1016\/j.bioorg.2026.110650_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2025.127126","article-title":"Novel anticancer agents, Pt complex with 1-pyrrolidineacetic acid ligand: synthesis, biological activity, DNA interaction, molecular docking, and dynamic study","volume":"424","author":"Kadivar","year":"2025","journal-title":"J. Mol. Liq."},{"issue":"15","key":"10.1016\/j.bioorg.2026.110650_bb0445","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13153855","article-title":"Interaction of adenosine, modified using carborane clusters, with ovarian cancer cells: a new anticancer approach against chemoresistance","volume":"13","author":"Bednarska-Szczepaniak","year":"2021","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.bioorg.2026.110650_bb0450","first-page":"7131","article-title":"Oxidative stress induced by carboplatin promotes apoptosis and inhibits migration of HN-3 cells","volume":"16","author":"He","year":"2018","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0455","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41420-025-02435-7","article-title":"ABCB1 confers resistance to carboplatin by accumulating stem-like cells in the G2\/M phase of the cell cycle in p53null ovarian cancer","volume":"11","author":"Lee","year":"2025","journal-title":"Cell Death Discov."},{"issue":"15","key":"10.1016\/j.bioorg.2026.110650_bb0460","doi-asserted-by":"crossref","first-page":"11364","DOI":"10.1021\/acs.jmedchem.1c00706","article-title":"Are Pt (IV) prodrugs that release combretastatin A4 true multi-action prodrugs?","volume":"64","author":"Schmidt","year":"2021","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0465","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/187152007779314071","article-title":"Preclinical and clinical studies on the use of platinum complexes for breast cancer treatment","volume":"7","author":"Ott","year":"2007","journal-title":"Anti Cancer Agents Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2026.110650_bb0470","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25051110","article-title":"In vitro MCF-7 cells apoptosis analysis of carboplatin-loaded silk fibroin particles","volume":"25","author":"Galam","year":"2020","journal-title":"Mol"},{"issue":"1","key":"10.1016\/j.bioorg.2026.110650_bb0475","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.prp.2012.10.003","article-title":"Carboplatin delays mammary cancer 4T1 growth in mice","volume":"209","author":"de Souza","year":"2013","journal-title":"Pathol. Res. Pract."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826011867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826011867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:34:32Z","timestamp":1792254872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826011867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":95,"alternative-id":["S0045206826011867"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110650","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carboplatin-derived dinuclear Pt(IV) prodrug linked by 1,6-Diaminohexane: Design, synthesis, reduction chemistry, DNA interaction, and antitumor activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.110650","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110650"}}