{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T09:57:34Z","timestamp":1776765454153,"version":"3.51.2"},"reference-count":134,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.biopha.2006.11.001","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T10:10:51Z","timestamp":1164881451000},"page":"390-399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Implication of the transcription factor E2F-1 in the modulation of neuronal apoptosis"],"prefix":"10.1016","volume":"61","author":[{"given":"Ester","family":"Verdaguer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garc\u00eda","family":"de Arriba Susana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allgaier","family":"Clemens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merc\u00e8","family":"Pall\u00e0s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Camins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2006.11.001_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0188-4409(01)00316-2","article-title":"The molecular bases of Alzheimer's disease and other neurodegenerative disorders","volume":"32","author":"Maccioni","year":"2001","journal-title":"Arch Med Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJMra022366","article-title":"Apoptosis and caspases in neurodegenerative diseases","volume":"348","author":"Friedlander","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biopha.2006.11.001_bib3","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/j.biocel.2004.04.011","article-title":"Apoptosis, autophagy and more","volume":"36","author":"Lockshin","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.biopha.2006.11.001_bib4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1586\/14737175.4.6.995","article-title":"Therapeutic potential of oxidant mechanisms in Alzheimer's disease","volume":"4","author":"Moreira","year":"2004","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.biopha.2006.11.001_bib5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1089\/ars.2005.7.685","article-title":"Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease","volume":"7","author":"Przedborski","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.biopha.2006.11.001_bib6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1124\/jpet.102.035840","article-title":"Drugs targeting Alzheimer's disease: some things old and some things new","volume":"304","author":"Michaelis","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.biopha.2006.11.001_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/10298420290015872","article-title":"Neuroprotective potential of ionotropic glutamate receptor antagonists","volume":"4","author":"Danysz","year":"2002","journal-title":"Neurotox Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib8","first-page":"75","article-title":"Glumate receptor dysfunction and Alzheimer's disease","volume":"13","author":"Olney","year":"1998","journal-title":"Restor Neurol Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib9","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","article-title":"Oxidative damage is the earliest event in Alzheimer disease","volume":"60","author":"Nunomura","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopha.2006.11.001_bib10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.arr.2004.01.002","article-title":"Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease","volume":"3","author":"Castellani","year":"2004","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.biopha.2006.11.001_bib11","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.physiol.60.1.619","article-title":"The mitochondrial death\/life regulator in apoptosis and necrosis","volume":"60","author":"Kroemer","year":"1998","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.biopha.2006.11.001_bib12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0300-483X(02)00457-2","article-title":"History of the events leading to the formulation of the apoptosis concept","volume":"181\u2013182","author":"Kerr","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.biopha.2006.11.001_bib13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/sj.cdd.4400265","article-title":"Energy supply and the shape of death in neurons and lymphoid cells","volume":"4","author":"Nicotera","year":"1997","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.biopha.2006.11.001_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1009625323388","article-title":"Apoptosis in Alzheimer's disease. An update","volume":"5","author":"Shimohama","year":"2000","journal-title":"Apoptosis"},{"key":"10.1016\/j.biopha.2006.11.001_bib15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.mito.2004.07.018","article-title":"Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease","volume":"4","author":"Aliev","year":"2004","journal-title":"Mitochondrion"},{"key":"10.1016\/j.biopha.2006.11.001_bib16","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/sj.cdd.4401088","article-title":"The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet","volume":"9","author":"Van Loo","year":"2002","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.biopha.2006.11.001_bib17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S1471-4914(01)02026-3","article-title":"Apoptosis-regulating proteins as targets for drug discovery","volume":"7","author":"Reed","year":"2001","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.biopha.2006.11.001_bib18","doi-asserted-by":"crossref","first-page":"32608","DOI":"10.1074\/jbc.273.49.32608","article-title":"Inhibition of human caspases by peptide-based and macromolecular inhibitors","volume":"273","author":"Garcia-Calvo","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2006.11.001_bib19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/ana.10680","article-title":"Caspase activation in the limbic cortex of subjects with early Alzheimer's disease","volume":"54","author":"Gastard","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopha.2006.11.001_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jnr.10294","article-title":"Caspases on the brain","volume":"69","author":"Troy","year":"2002","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib21","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1523\/JNEUROSCI.19-15-06235.1999","article-title":"Caspase-dependent and\u00a0-independent death of camptothecin-treated embryonic cortical neurons","volume":"19","author":"Stefanis","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.mrfmmm.2005.02.014","article-title":"Activation of DNA damage signalling","volume":"577","author":"Ljungman","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1471-4159.2001.00380.x","article-title":"Role of DNA-dependent protein kinase in neuronal survival","volume":"78","author":"Chechlacz","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopha.2006.11.001_bib24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0027-5107(02)00222-1","article-title":"DNA repair in neural cells: basic science and clinical implications","volume":"509","author":"Brooks","year":"2002","journal-title":"Mutat Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/sj.cdd.4401572","article-title":"DNA repair in post-mitotic neurons: a gene-trapping strategy","volume":"12","author":"Merlo Merlo","year":"2005","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.biopha.2006.11.001_bib26","unstructured":"Fishel ML, Vasko MR, Kelley MR. DNA repair in neurons: So if they don't divide what's to repair? Mutat Res, in press."},{"key":"10.1016\/j.biopha.2006.11.001_bib27","unstructured":"Nouspikel T. DNA repair in differentiated cells: Some new answers to old questions. Neuroscience, in press."},{"key":"10.1016\/j.biopha.2006.11.001_bib28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3233\/JAD-2002-4316","article-title":"Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle","volume":"4","author":"Bowser","year":"2002","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.biopha.2006.11.001_bib29","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1523\/JNEUROSCI.18-08-02801.1998","article-title":"Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain","volume":"18","author":"Busser","year":"1988","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2004.11.005","article-title":"Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease","volume":"49","author":"Chong","year":"2005","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.biopha.2006.11.001_bib31","first-page":"731","article-title":"The cell division cycle and the pathophysiology of Alzheimer's disease","volume":"87","author":"Nagy","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2006.11.001_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"Neurodegenerative diseases and oxidative stress","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biopha.2006.11.001_bib33","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI200318182","article-title":"Oxidative stress, cell cycle, and neurodegeneration","volume":"111","author":"Klein","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biopha.2006.11.001_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1474-4422(04)00707-0","article-title":"Alzheimer's disease: the two-hit hypothesis","volume":"3","author":"Zhu","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.biopha.2006.11.001_bib35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature01034","article-title":"The harlequin mouse mutation downregulates apoptosis-inducing factor","volume":"419","author":"Klein","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2006.11.001_bib36","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.dnarep.2004.03.029","article-title":"DNA damage-induced activation of ATM and ATM-dependent signalling pathways","volume":"3","author":"Kurz","year":"2004","journal-title":"DNA repair"},{"key":"10.1016\/j.biopha.2006.11.001_bib37","first-page":"2173","article-title":"Functional links between transcription, DNA repair and apoptosis","volume":"61","author":"Berardi","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.biopha.2006.11.001_bib38","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1108297","article-title":"ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex","volume":"308","author":"Lee","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biopha.2006.11.001_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbrainres.2004.05.023","article-title":"Deficency of the Mre11 repair complex in Alzheimer's diseases brains","volume":"128","author":"Jacobsen","year":"2004","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib40","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.mrfmmm.2005.03.006","article-title":"To die or not to die: DNA repair in neurons","volume":"577","author":"McMurray","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib41","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/j.1471-4159.2005.03676.x","article-title":"The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons","volume":"96","author":"Wyttenbach","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopha.2006.11.001_bib42","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1046\/j.1471-4159.2003.01629.x","article-title":"An age-related increase in resistance to DNA damage-induced apoptotic cell death is associated with development of DNA repair mechanisms","volume":"84","author":"Romero","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopha.2006.11.001_bib43","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.brainresrev.2004.12.023","article-title":"Preservation of DNA integrity and neuronal degeneration","volume":"48","author":"Francisconi","year":"2005","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.biopha.2006.11.001_bib44","doi-asserted-by":"crossref","first-page":"37782","DOI":"10.1074\/jbc.M304049200","article-title":"Ataxia telangiectasia-mutated protein can regulate p53 and neuronal cell death independent of Chk2 in response to DNA damage","volume":"39","author":"Keramis","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2006.11.001_bib45","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nm1228","article-title":"An essential function for NBS1 in the prevention of ataxia and cerebellar defects","volume":"11","author":"Frappart","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.biopha.2006.11.001_bib46","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.brainresrev.2004.12.023","article-title":"Preservation of DNA integrity and neuronal degeneration","volume":"48","author":"Francisconi","year":"2005","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.biopha.2006.11.001_bib47","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.molmed.2006.07.007","article-title":"DNA damage-induced cell death by apoptosis","volume":"12","author":"Roos","year":"2006","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.biopha.2006.11.001_bib48","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/hipo.20123","article-title":"DNA damage and non homologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures","author":"Neema","year":"2005","journal-title":"Hippocampus"},{"key":"10.1016\/j.biopha.2006.11.001_bib49","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/cercor\/bhh171","article-title":"Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in KU70-deficient mice","volume":"15","author":"Narasimhaiah","year":"2005","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopha.2006.11.001_bib50","doi-asserted-by":"crossref","first-page":"769","DOI":"10.4161\/cc.3.6.901","article-title":"Why do neurons enter the cell cycle?","volume":"3","author":"Kruman","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biopha.2006.11.001_bib51","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0896-6273(04)00017-0","article-title":"Cell cycle activation linked to neuronal cell death initiated by DNA damage","volume":"41","author":"Kruman","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.biopha.2006.11.001_bib52","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00001756-200302100-00011","article-title":"Reduced NMDA-induced\u00a0apoptosis in neurons lacking ataxia telangiectasia mutated protein","volume":"14","author":"Macleod","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.biopha.2006.11.001_bib53","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1023\/B:JOBB.0000041755.22613.8d","article-title":"Deadly conversations: nuclear-mitochondrial cross-talk","volume":"36","author":"Dawson","year":"2004","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.biopha.2006.11.001_bib54","doi-asserted-by":"crossref","first-page":"10963","DOI":"10.1523\/JNEUROSCI.3461-04.2004","article-title":"Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death","volume":"24","author":"Wang","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib55","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1096\/fasebj.13.15.2225","article-title":"Mitotic signaling by beta-amyloid causes neuronal death","volume":"13","author":"Copani","year":"1999","journal-title":"FASEB J"},{"key":"10.1016\/j.biopha.2006.11.001_bib56","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1096\/fj.02-0422fje","article-title":"Erratic expression of DNA polymerases by beta-amyloid causes neuronal death","volume":"16","author":"Copani","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.biopha.2006.11.001_bib57","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1523\/JNEUROSCI.3347-04.2004","article-title":"Divide and die: cell cycle events as triggers of nerve cell death","volume":"24","author":"Herrup","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib58","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1038\/sj.onc.1209569","article-title":"Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage","volume":"25","author":"Vakifahmetoglu","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2006.11.001_bib59","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.bbrc.2005.03.191","article-title":"Caspase-2 function in response to DNA damage","volume":"331","author":"Zhivotovsky","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopha.2006.11.001_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2003.12.005","article-title":"Cell cycle regulation of neuronal apoptosis in development and disease","volume":"72","author":"Becker","year":"2004","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.biopha.2006.11.001_bib61","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3233\/JAD-2003-5409","article-title":"Cyclin-dependent kinases in neural development and degeneration","volume":"5","author":"Lim","year":"2003","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.biopha.2006.11.001_bib62","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0166-2236(00)01663-5","article-title":"Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?","volume":"24","author":"Copani","year":"2001","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib63","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s007020050104","article-title":"Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease","volume":"105","author":"Arendt","year":"1998","journal-title":"J Neural Transm"},{"key":"10.1016\/j.biopha.2006.11.001_bib64","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/jnen\/64.2.93","article-title":"Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence","volume":"6","author":"Atwood","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopha.2006.11.001_bib65","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3233\/JAD-2002-4315","article-title":"Re-expression of cell cycle proteins induces neuronal cell death during Alzheimer's disease","volume":"4","author":"Herrup","year":"2002","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.biopha.2006.11.001_bib66","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/jnen\/62.1.68","article-title":"Expression patterns of retinoblastoma protein in Parkinson disease","volume":"62","author":"Jordan-Sciutto","year":"2003","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopha.2006.11.001_bib67","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/jnen\/61.4.358","article-title":"Altered distribution of cell cycle transcriptional regulators during Alzheimer disease","volume":"61","author":"Jordan-Sciutto","year":"2002","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopha.2006.11.001_bib68","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3233\/JAD-1999-1605","article-title":"Increased Cyclin G1 Immunoreactivity during Alzheimer's disease","volume":"1","author":"Jordan-Sciutto","year":"1999","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.biopha.2006.11.001_bib69","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1523\/JNEUROSCI.22-06-02185.2002","article-title":"Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis","volume":"22","author":"Jordan-Sciutto","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib70","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0002-9440(10)64561-0","article-title":"Induction of cell-cycle regulators in simian immunodeficiency virus encephalitis","volume":"157","author":"Jordan-Sciutto","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biopha.2006.11.001_bib71","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0002-9440(10)63879-5","article-title":"Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis","volume":"162","author":"Ranganathan","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biopha.2006.11.001_bib72","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1523\/JNEUROSCI.21-08-02661.2001","article-title":"DNA replication precedes neuronal cell death in Alzheimer's disease","volume":"21","author":"Yang","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib73","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1523\/JNEUROSCI.23-07-02557.2003","article-title":"Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease","volume":"23","author":"Yang","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib74","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0047-6374(01)00334-7","article-title":"Altered subcellular distribution of transcriptional regulators in response to Abeta peptide and during Alzheimer's disease","volume":"123","author":"Jordan-Sciutto","year":"2001","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.biopha.2006.11.001_bib75","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2003.09.004","article-title":"Neuronal expression of cell cycle-related proteins after brain ischaemia in man","volume":"353","author":"Love","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopha.2006.11.001_bib76","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0006-8993(01)02535-5","article-title":"Up-regulation of E2F-1 in Down's syndrome brain exhibiting neuropathological features of Alzheimer-type dementia","volume":"905","author":"Motonaga","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib77","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0002-9440(10)63347-0","article-title":"Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann\u2013Pick Type C mice","volume":"165","author":"Zhang","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biopha.2006.11.001_bib78","first-page":"167","article-title":"Evidence for oxidative DNA damage in the hippocampus of elderly patients with chronic schizophrenia","volume":"12","author":"Nisbioka","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopha.2006.11.001_bib79","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4161\/cc.3.3.706","article-title":"Emerging pathogenic role for cyclin dependent kinases in neurodegeneration","volume":"3","author":"Smith","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biopha.2006.11.001_bib80","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pharmthera.2005.09.005","article-title":"The cell cycle as a therapeutic target for Alzheimer's disease","volume":"111","author":"Neve","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.biopha.2006.11.001_bib81","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00001756-200203250-00010","article-title":"Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entry","volume":"13","author":"Verdaguer","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.biopha.2006.11.001_bib82","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1385\/JMN:26:1:071","article-title":"Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons","volume":"26","author":"Verdaguer","year":"2005","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib83","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1124\/jpet.103.057497","article-title":"Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment","volume":"308","author":"Verdaguer","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.biopha.2006.11.001_bib84","doi-asserted-by":"crossref","first-page":"8747","DOI":"10.1523\/JNEUROSCI.19-20-08747.1999","article-title":"Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis","volume":"19","author":"Padmanabhan","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib85","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0169-328X(03)00253-5","article-title":"Involvement of the transcription factor E2F1\/Rb in kainic acid-induced death of murine cerebellar granule cells","volume":"116","author":"Smith","year":"2003","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib86","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1016\/j.febslet.2005.07.028","article-title":"Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats","volume":"579","author":"Wen","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biopha.2006.11.001_bib87","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molbrainres.2004.08.020","article-title":"Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia\/ischemia in vitro and in vivo","volume":"132","author":"Wu Chen","year":"2004","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib88","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cub.2005.12.042","article-title":"TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model","volume":"16","author":"Khurana","year":"2006","journal-title":"Curr Biol"},{"key":"10.1016\/j.biopha.2006.11.001_bib89","doi-asserted-by":"crossref","first-page":"8819","DOI":"10.1523\/JNEUROSCI.2593-06.2006","article-title":"The Chk1\/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin","volume":"26","author":"Zhang","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib90","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.lfs.2006.01.032","article-title":"Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons","volume":"79","author":"Appert-Collin","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.biopha.2006.11.001_bib91","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1523\/JNEUROSCI.18-03-00830.1998","article-title":"Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress","volume":"18","author":"Park","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib92","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1523\/JNEUROSCI.17-04-01256.1997","article-title":"G1\/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis","volume":"17","author":"Park","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib93","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0197-4580(00)00220-7","article-title":"Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment","volume":"21","author":"Park","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopha.2006.11.001_bib94","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.4161\/cc.4.9.1996","article-title":"Role of the cell cycle in the pathobiology of central nervous system trauma","volume":"4","author":"Cernak","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biopha.2006.11.001_bib95","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1523\/JNEUROSCI.4637-04.2005","article-title":"Cell-cycle re-entry and cell death in transgenic mice expressing nonmutant human tau isoforms","volume":"25","author":"Andorfer","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib96","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00004647-200202000-00005","article-title":"Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat","volume":"22","author":"Wang","year":"2002","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.biopha.2006.11.001_bib97","doi-asserted-by":"crossref","first-page":"10254","DOI":"10.1073\/pnas.170144197","article-title":"Cyclin-dependent kinases as a therapeutic target for stroke","volume":"97","author":"Osuga","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biopha.2006.11.001_bib98","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1523\/JNEUROSCI.21-14-05045.2001","article-title":"Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death","volume":"21","author":"Katchanov","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib99","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0002-9440(10)63347-0","article-title":"Vincent I Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann\u2013Pick Type C mice","volume":"165","author":"Zhang","year":"2004","journal-title":"Am J\u00a0Pathol"},{"key":"10.1016\/j.biopha.2006.11.001_bib100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.molmed.2006.02.002","article-title":"E2F1-induced apoptosis: turning killers into therapeutics","volume":"12","author":"Stanelle","year":"2006","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.biopha.2006.11.001_bib101","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1038\/sj.onc.1208612","article-title":"The E2F transcriptional network: old acquaintances with new faces","volume":"24","author":"Dimova","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2006.11.001_bib102","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1471-4159.2000.0750091.x","article-title":"The transcription factor E2F1 modulates apoptosis of neurons","volume":"75","author":"Hou","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopha.2006.11.001_bib103","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-3940(01)01909-7","article-title":"Increased expression of the transcription factor E2F1 during dopamine-evoked, caspase-3-mediated apoptosis in rat cortical neurons","volume":"306","author":"Hou","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopha.2006.11.001_bib104","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1471-4159.2001.00402.x","article-title":"The transcription factor E2F1 promotes dopamine-evoked neuronal apoptosis by a mechanism independent of transcriptional activation","volume":"78","author":"Hou","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopha.2006.11.001_bib105","doi-asserted-by":"crossref","first-page":"19011","DOI":"10.1074\/jbc.274.27.19011","article-title":"Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death","volume":"274","author":"Giovanni","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2006.11.001_bib106","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1074\/jbc.275.16.11553","article-title":"E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3","volume":"275","author":"Giovanni","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2006.11.001_bib107","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1046\/j.1471-4159.2001.00423.x","article-title":"Attenuation of neurotoxicity in cortical cultures and hippocampal slices from E2F1 knockout mice","volume":"78","author":"Gendron","year":"2001","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.biopha.2006.11.001_bib108","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1097\/01.WCB.0000084249.20114.FA","article-title":"Absence of the transcription factor E2F1 attenuates brain injury and improves behavior after focal ischemia in mice","volume":"23","author":"MacManus","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.biopha.2006.11.001_bib109","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1097\/00001756-199909090-00004","article-title":"Decreased brain infarct following focal ischemia in mice lacking the transcription factor E2F1","volume":"10","author":"MacManus","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.biopha.2006.11.001_bib110","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M001725200","article-title":"Induction and modulation of cerebellar granule neuron death by E2F-1","volume":"275","author":"O'Hare","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2006.11.001_bib111","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1006\/mcne.2002.1176","article-title":"Impaired adult neurogenesis in mice\u00a0lacking the transcription factor E2F1","volume":"21","author":"Cooper-Kuhn","year":"2002","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib112","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0896-6273(01)00495-0","article-title":"Regulation of neuronal survival and death by E2F-dependent gene repression and derepression","volume":"32","author":"Liu","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.biopha.2006.11.001_bib113","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/375694a0","article-title":"Interaction between the retinoblastoma protein and the oncoprotein MDM2","volume":"375","author":"Xiao","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2006.11.001_bib114","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/emboj\/18.1.22","article-title":"Association of p19 (ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53","volume":"18","author":"Honda","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.biopha.2006.11.001_bib115","doi-asserted-by":"crossref","first-page":"10003","DOI":"10.1523\/JNEUROSCI.2114-04.2004","article-title":"p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death","volume":"24","author":"Cregan","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib116","doi-asserted-by":"crossref","first-page":"28706","DOI":"10.1074\/jbc.M400376200","article-title":"The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1","volume":"279","author":"Fortin","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2006.11.001_bib117","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neulet.2004.04.083","article-title":"Roles of cyclin-dependent kinase 4 and p53 in neuronal cell death induced by doxorubicin on cerebellar granule neurons in mouse","volume":"365","author":"Otsuka","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopha.2006.11.001_bib118","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1074\/jbc.M312866200","article-title":"Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis","volume":"279","author":"Hershko","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2006.11.001_bib119","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/35036614","article-title":"Role for the p53 homologue p73 in E2F-1-induced apoptosis","volume":"407","author":"Irwin","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2006.11.001_bib120","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/sj.cdd.4401205","article-title":"Increased DeltaN-p73 expression in tumors by upregulation of the E2F1-regulated, TA-promoter-derived DeltaN\u2032-p73 transcript","volume":"10","author":"Putzer","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.biopha.2006.11.001_bib121","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1523\/JNEUROSCI.23-05-01649.2003","article-title":"The E2F-Cdc2 cell-cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons","volume":"23","author":"Konishi","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib122","doi-asserted-by":"crossref","first-page":"54140","DOI":"10.1074\/jbc.M410493200","article-title":"A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2006.11.001_bib123","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M200805200","article-title":"Apaf-1 is a mediator of E2F-1-induced apoptosis","volume":"277","author":"Furukawa","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2006.11.001_bib124","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/ncb868","article-title":"Direct coupling of the cell cycle and cell death machinery by E2F","volume":"4","author":"Nahle","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.biopha.2006.11.001_bib125","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S1097-2765(00)80387-1","article-title":"E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways","volume":"4","author":"Phillips","year":"1999","journal-title":"Mol Cell"},{"key":"10.1016\/j.biopha.2006.11.001_bib126","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1046\/j.1471-4159.2001.00134.x","article-title":"NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaBbeta phosphorylation with cell survival","volume":"76","author":"Koulich","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopha.2006.11.001_bib127","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1124\/mol.56.2.254","article-title":"Intrastriatal dopamine injection induces apoptosis through oxidation-involved activation of transcription factors AP-1 and NF-kappaB in rats","volume":"56","author":"Luo","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biopha.2006.11.001_bib128","doi-asserted-by":"crossref","first-page":"8720","DOI":"10.1523\/JNEUROSCI.1821-04.2004","article-title":"B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage","volume":"24","author":"Liu","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib129","doi-asserted-by":"crossref","first-page":"6983","DOI":"10.1038\/sj.onc.1204892","article-title":"Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1","volume":"20","author":"Eischen","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2006.11.001_bib130","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1093\/nar\/gkl150","article-title":"Novel link between E2F1 and Smac\/DIABLO: proapoptotic Smac\/DIABLO is transcriptionally upregulated by E2F1","volume":"34","author":"Xie","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biopha.2006.11.001_bib131","doi-asserted-by":"crossref","first-page":"8349","DOI":"10.1523\/JNEUROSCI.1570-05.2005","article-title":"Bim is a direct target of a neuronal E2F-dependent apoptotic pathway","volume":"25","author":"Biswas","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2006.11.001_bib132","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/sj.cdd.4401532","article-title":"A novel mitochondrial protein DIP mediates E2F-induced apoptosis independently of p53","volume":"12","author":"Stanelle","year":"2005","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.biopha.2006.11.001_bib133","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0028-3908(03)00204-1","article-title":"Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis","volume":"45","author":"Jorda","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2006.11.001_bib134","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.mehy.2004.03.047","article-title":"Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases","volume":"64","author":"Pallas","year":"2005","journal-title":"Med Hypotheses"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332206003143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332206003143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:39:15Z","timestamp":1760092755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332206003143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":134,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0753332206003143"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2006.11.001","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implication of the transcription factor E2F-1 in the modulation of neuronal apoptosis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2006.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}