{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:49:17Z","timestamp":1778759357746,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.biopha.2008.01.015","type":"journal-article","created":{"date-parts":[[2008,2,22]],"date-time":"2008-02-22T11:56:41Z","timestamp":1203681401000},"page":"194-201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["A pioneer study on the anti-ulcer activities of copper nicotinate complex [CuCl (HNA)2] in experimental gastric ulcer induced by aspirin-pyloris ligation model (Shay model)"],"prefix":"10.1016","volume":"63","author":[{"given":"Muobarak Jaber F.-A.","family":"Tuorkey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolin Kamel","family":"Abdul-Aziz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2008.01.015_bib1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1053\/bega.2001.0184","article-title":"Pharmacological and pharmacodynamic essentials of H2-receptor antagonists and proton pump inhibitors for the practising physician","volume":"15","author":"Huang","year":"2001","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.biopha.2008.01.015_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0163-7258(03)00015-9","article-title":"Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future","volume":"98","author":"Takeshi","year":"2003","journal-title":"Pharmacol Therap"},{"issue":"4","key":"10.1016\/j.biopha.2008.01.015_bib3","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0016-5085(90)90610-D","article-title":"Gastrin stimulates the self-replication rate of enterochromaffinlike cells in the rat stomach. Effects of omeprazole, ranitidine, and gastrin-17 in intact and antrectomized rats","volume":"99","author":"Ryberg","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2008.01.015_bib4","series-title":"Inflammatory diseases and copper","first-page":"289","author":"Sorenson","year":"1982"},{"issue":"12","key":"10.1016\/j.biopha.2008.01.015_bib5","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1021\/jm00378a040","article-title":"Bis(3,5-diisopropylsalicylato)copper(II), a potent radioprotectant with superoxide dismutase mimetic activity","volume":"27","author":"Sorenson","year":"1984","journal-title":"J Med Chem"},{"key":"10.1016\/j.biopha.2008.01.015_bib6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0079-6468(08)70246-7","article-title":"Copper complexes offer a physiological approach to treatment of chronic diseases","volume":"26","author":"Sorenson","year":"1989","journal-title":"Prog Med Chem"},{"issue":"Suppl. I","key":"10.1016\/j.biopha.2008.01.015_bib7","first-page":"249","article-title":"Significance of blood flow for vascular pedicled multi-tissue flaps in critical perfusion conditions","volume":"115","author":"Rucker","year":"1998","journal-title":"Langenbecks Arch Chir Suppl Kongressbd"},{"key":"10.1016\/j.biopha.2008.01.015_bib8","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/jn\/129.7.1251","article-title":"A delicate balance: homeostatic control of copper uptake and distribution","volume":"129","author":"Pena","year":"1999","journal-title":"J Nutr"},{"issue":"6","key":"10.1016\/j.biopha.2008.01.015_bib9","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/0006-2952(93)90665-J","article-title":"The protective effect of copper complexes against gastric mucosal ulcer in rats","volume":"46","author":"el-Saadani","year":"1993","journal-title":"Biochem Pharmacol"},{"issue":"2\u20133","key":"10.1016\/j.biopha.2008.01.015_bib10","first-page":"54","article-title":"Studies on restraint ulcers in rats in conditions of acute copper deficiency","volume":"33","author":"Velinov","year":"2001","journal-title":"Vutr Boles"},{"issue":"10","key":"10.1016\/j.biopha.2008.01.015_bib11","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.cgh.2007.06.009","article-title":"Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial","volume":"5","author":"Goldstein","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.biopha.2008.01.015_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/phrs.1999.0476","article-title":"Effect of ulceration on rat gastric tissue polyamine contents in response to different procedures; inhibition of these effects by cimetidine","volume":"40","author":"Othman","year":"1999","journal-title":"Pharmacol Res"},{"issue":"10","key":"10.1016\/j.biopha.2008.01.015_bib13","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0006-2952(99)00009-X","article-title":"Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine, clomipramine, and citalopram and the effects on these changes by Bcl-2 and Bcl-X(L)","volume":"57","author":"Xia","year":"1999","journal-title":"Biochem Pharmacol"},{"issue":"20","key":"10.1016\/j.biopha.2008.01.015_bib14","doi-asserted-by":"crossref","first-page":"10964","DOI":"10.1073\/pnas.96.20.10964","article-title":"Caspase activation: the induced-proximity model","volume":"96","author":"Salvesen","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biopha.2008.01.015_bib15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.plipres.2003.10.001","article-title":"Lipid peroxidation cannot be used as a universal criterion of oxidative stress","volume":"43","author":"Dotan","year":"2004","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.biopha.2008.01.015_bib16","doi-asserted-by":"crossref","first-page":"L13","DOI":"10.1016\/S0020-1693(00)88352-8","article-title":"Crystal structure of a polymetric 2:1 complex of nicotinic acid with copper(I) chloride","volume":"127","author":"Goher","year":"1987","journal-title":"Inorg Chem Acta"},{"key":"10.1016\/j.biopha.2008.01.015_bib17","first-page":"43","article-title":"A simple method for the uniform production of gastric ulceration","volume":"5","author":"Shay","year":"1945","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2008.01.015_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0160-5402(82)90005-5","article-title":"Testing for drugs inhibiting the formation of gastric ulcers","volume":"8","author":"West","year":"1982","journal-title":"J Pharmacol Methods"},{"key":"10.1016\/j.biopha.2008.01.015_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejogrb.2004.04.012","article-title":"Measurement of the total antioxidant response in preeclampsia with a novel automated method","volume":"118","author":"Harma","year":"2005","journal-title":"Eur J Obst Gyn Reprod Biol"},{"key":"10.1016\/j.biopha.2008.01.015_bib20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.clinbiochem.2003.10.014","article-title":"A novel automated method to measure total antioxidant response against potent free radical reactions","volume":"37","author":"Erel","year":"2004","journal-title":"Clin Biochem"},{"issue":"1","key":"10.1016\/j.biopha.2008.01.015_bib21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1128\/IAI.67.1.22-29.1999","article-title":"Lipopolysaccharide stimulates butyric acid-induced apoptosis in human peripheral blood mononuclear cells","volume":"67","author":"Kurita-Ochiai","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.biopha.2008.01.015_bib22","series-title":"First principles of gastroenterology: the basis of disease and an approach to management","first-page":"145","article-title":"Stomach and duodenum","author":"Salena","year":"2000"},{"issue":"Suppl. 2","key":"10.1016\/j.biopha.2008.01.015_bib23","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S1590-8658(01)80155-9","article-title":"Selective cyclo-oxygenase-2 inhibitors: cardiovascular and gastrointestinal toxicity","volume":"33","author":"Wallace","year":"2001","journal-title":"Digest Liver Dis"},{"key":"10.1016\/j.biopha.2008.01.015_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/284271a0","article-title":"Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa","volume":"284","author":"Whittle","year":"1980","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biopha.2008.01.015_bib25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1476-5381.1977.tb07522.x","article-title":"Mechanisms underlying gastric mucosal damage induced by indomethacin and bile salts, and the action of prostaglandins","volume":"60","author":"Whittle","year":"1977","journal-title":"Brit J Pharmacol"},{"issue":"1\u20134","key":"10.1016\/j.biopha.2008.01.015_bib26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000104167","article-title":"Aspirin can elicit the recurrence of gastric ulcer induced with acetic acid in rats","volume":"20","author":"Wang","year":"2007","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.biopha.2008.01.015_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0378-8741(87)90089-4","article-title":"Effect of banana powder (Musa sapientum var. paradisiaca) on gastric mucosal shedding","volume":"21","author":"Mukhopadhyay","year":"1987","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"10.1016\/j.biopha.2008.01.015_bib28","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1078\/S0944-7113(04)70060-4","article-title":"Prophylactic and curative effects of Bacopa monniera in gastric ulcer models","volume":"8","author":"Sairam","year":"2001","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2008.01.015_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-8741(02)00041-7","article-title":"Anti-ulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study","volume":"82","author":"Sairam","year":"2002","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"10.1016\/j.biopha.2008.01.015_bib30","first-page":"183","article-title":"Apoptosis in the gastric ulceration \u201cShay Rat-Model\u201d: role of IL-6 modulation by the cytoprotectant copper-glycinate and-nicotinate complexes","volume":"31","author":"El-Metwally","year":"2007","journal-title":"Assiut Med J"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332208000322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332208000322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:43:09Z","timestamp":1760092989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332208000322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0753332208000322"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2008.01.015","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pioneer study on the anti-ulcer activities of copper nicotinate complex [CuCl (HNA)2] in experimental gastric ulcer induced by aspirin-pyloris ligation model (Shay model)","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2008.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}